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| Number | Title | Issue Date |
| 5008419 | Novel platinum complex A platinum complex having the following formula (I) is disclosed, ##STR1## wherein R1 and R2 may be the same or different and each independently represents a methyl group or an ethyl group, and the configuration of 1,2-diaminocy... | 04/16/1991 |
| 4996337 | Synthesis of cisplatin analogs This disclosure sets forth a novel process for producing cisplatin analogs which possess antitumor activity.... | 02/26/1991 |
| 4992553 | Diamine-platinum (II) complex compounds A compound of the general formula: ##STR1## wherein R1 is hydrogen, a hydroxy group or a C2 -C6 alkanoyloxy group, R2 is hydrogen or a halogen atom, R3 is hydrogen or a C1 -C6 | 02/12/1991 |
| 4987246 | Novel platinum complexes A diamine platinum (II) complex represented by the general formula ##STR1## [wherein R1 and R2 are each a lower alkyl group; and two X's are each a halogen atom or jointly form a group represented by ##STR2## (wherein R | 01/22/1991 |
| 4980347 | Platinum complex, process for preparing same and antitumor agent A platinum complex represented by the formula: ##STR1## where X is ##STR2## wherein R1 is a (C1-18) alkyl group, a (C1-18)alkenyl group or a group --Z--R4 in which Z is --CH.dbd.CH-- or a (C1-5)alkylene group, and R | 12/25/1990 |
| 4970324 | Aminoalkyl-substituted azetidine platinum(II) complexes Square-planar four-coordinate complexes of cis-platinum(II) with neutral bidentate aminoalkyl-substituted cycloalkylamine ligands and bromo-, chloro-, iodo-, nitrato-, oxalato-, or malanato-ligands possess antimicrobial activity as well as activity agains... | 11/13/1990 |
| 4968800 | Novel platinum complex, antineoplastic agent containing the same, and intermediate therefor A platinum complex of the formula ##STR1## wherein n is 1 or 2 and X is chlorine, bromine or iodine is described, which is useful intermediate; thus, it can be reacted with silver nitrate or silver sulfate and the resulting compound can be treated wi... | 11/06/1990 |
| 4968825 | Novel platinum complex A platinum complex having a superior antitumor activity is disclosed. The platinum complex has a structure represented by the formula: ##STR1## wherein A and B independently represent a lower alkanoyloxy group which may have a halogen atom substituen... | 11/06/1990 |
| 4968826 | Platinum complexes and antitumor agents containing them as an active ingredient Novel platinum complexes of the formula: ##STR1## wherein R1 and R2 each identically of differently is lower alkyl, or R1 and R2 taken together form --(CH2)m--, and m is an integer from 2 to 5, a... | 11/06/1990 |
| 4956459 | Platinum compounds suitable for use as pharmaceuticals Compounds of the formula: ##STR1## wherein each of R1 and R2 is independently selected from the group consisting of halogen, hydroxy, or mono carboxylic acid or R1 and R2 together is a multifunctional carbo... | 09/11/1990 |
| 4956454 | Monoclonal antibody - platinum co-ordination compound complex Platinum co-ordination compounds comprising at least one amine ligand and a functional group remotely bonded to the amine ligand, which functional group may be linkable to a monoclonal antibody to provide a moiety which stabilizes the antibody against in ... | 09/11/1990 |
| 4952676 | Monoclonal antibody-platinum co-ordination compound complex A platinum co-ordination compound linkable to a monoclonal antibody by a functional group which forms part of a moiety which stabilizes the antibody against in vivo hydrolysis. Also the use of such compounds in the treatment of cancer.... | 08/28/1990 |
| 4946954 | Platinum pharmaceutical agents Platinum compounds useful in the treatment of cancer are disclosed. Compositions containing these compounds and methods of using the same are also discussed. Compounds having the formula ##STR1## wherein n is 0 or 1 and when n is 1 R1 is H... | 08/07/1990 |
| 4939256 | Novel platinum complex, antineoplastic agent containing the same, and intermediate therefor Novel platinum complex of the formula: ##STR1## wherein n is an integer of 1 or 2 and A is a ligand of the formula: ##STR2## which has excellent antineoplastic activity and is useful as an antineoplastic agent for the treatment of various malign... | 07/03/1990 |
| 4937262 | Platinum derivatives and cancer treatments Derivatives of platinum group metals, particularly platinum itself, wherein the metal is linked to one or more pharmaceutically acceptable steroid, fatty acid or other lipophilic residues aiding transport of the metal across cell membranes in the body, pa... | 06/26/1990 |
| 4937358 | Synthesis of cisplatin analogs This disclosure sets forth a novel process for producing cisplatin analogs which possess antitumor activity.... | 06/26/1990 |
| 4931553 | Platinum-polymer complexes and their use as antitumor agents Platinum(amine) complexes, when covalently linked to a water-soluble, biodegradable or biostable polymer, exhibit high antitumor activity at low dosages of platinum against L1210 and solid tumors. The complexes are platinum square planar complexes and oct... | 06/05/1990 |
| 4921973 | Platinum complexes and the like A (+)-charged dye transition metal complex, particularly a complex of platinum and a (+)-charged dye such as rhodamine 123. These products demonstrate antitumor and radio-sensitizing activity.... | 05/01/1990 |
| 4921963 | Platinum complexes with one radiosensitizing ligand Complexes of platinum II containing a single radiosensitizer ligand and an amino or ammine substituent shows superior binding to DNA and are useful in chemotherapy and sensitization of hypoxic tumors to radiation. The chemotherapeutic value of these compo... | 05/01/1990 |
| 4921944 | Method of pharmaceutic production The object of the invention is a method for preparing a compound of formula I ##STR1## wherein Mem+ is a lanthanide and n is a number from 1-3, is used for diagnosis of neoplasms. The compound is prepared by adding an aqueous solution... | 05/01/1990 |
| 4921984 | Novel platinum complexes A diamine platinum (II) complex represented by the general formula ##STR1## [wherein R1, R2, R3 and R4 are each a hydrogen atom or a lower alkyl group; and two X's are each a halogen atom or jointly form a ... | 05/01/1990 |
| 4912100 | Platinum complex, process for preparing same and antitumor agent A platinum complex represented by the formula: ##STR1## wherein R1 is a (Cl-18) alkyl group, a (Cl-18)-alkenyl group or a group ----X--R5 in which X is --CH.dbd.CH-- or a (Cl-5)alkylene group, and R5 is a phenyl group... | 03/27/1990 |
| 4904809 | Platinum complex A platinum complex having a superior antitumor activity is disclosed. The platinum complex has a structure represented by the formula: ##STR1## wherein A and B independently represent a lower alkanoyloxy group which may have a halogen atom substituen... | 02/27/1990 |
| 4902797 | Ammine-alicyclic amine-platinum complexes and antitumor agents A compound of the formula (I): ##STR1## (wherein R is C1 -C6 alkyl, hydroxy, carboxy, C1 -C6 alkoxy, halogen or oxo; m is an integer from 2 to 7; X and Y each is chlorine or nit-rato ligand, or taken togeth... | 02/20/1990 |
| 4900756 | (2,2-bis(aminomethyl)-1,3-propranediol-N,N')platinum complexes Organic-platinum complexes useful as anti-cancer agents in the treatment of tumors sensitive to the subject compounds are described.... | 02/13/1990 |
| 4895935 | Platinum pharmaceuticals Platinum compounds of the formulae: ##STR1## are disclosed. Compositions containing these compounds and methods of using the same in the treatment of tumors are also discussed.... | 01/23/1990 |
| 4895936 | Platinum pharmaceuticals Platinum compounds useful in the treatment of cancer are disclosed. Compositions containing these compounds and methods of using the same are also discussed. The compound have the formula: ##STR1## wherein n is 0 or 1, R1 is selected from ... | 01/23/1990 |
| 4886894 | Novel Organic platinum complex and process for the preparation thereof Novel organic platinum complex of the formula: ##STR1## wherein R1 is hydrogen atom or a lower alkyl group; R2 is hydrogen atom, a substituted or unsubstituted lower alkyl group, a lower alkenyl group, a lower alkynyl agroup, a ... | 12/12/1989 |
| 4885376 | New types of organometallic reagents and catalysts for asymmetric synthesis New chiral catalysts for asymmetric synthesis reactions. The catalysts induce chirality in desired fashion in product molecules. The catalysts are rigid quadruped or triped ligands which provide a rigid asymmetric enantio-face at the active catalyst cite,... | 12/05/1989 |
| 4882447 | Novel organic platinum complex and process for the preparation thereof Novel organic platinum complex of the formula: ##STR1## wherein R1 is hydrogen atom or a lower alkyl group, R2 is a substituted or unsubstituted lower alkyl group, a lower alkenyl group, a lower alkanoyl group, a mono- or di-low... | 11/21/1989 |
| 4880790 | (Gem-heterocyclodimethanamine-N,N')platinum complexes Organic platinum complexes active as anti-tumor agents in warm-blooded animals, and methods for synthesis of same, are described.... | 11/14/1989 |
| 4871729 | Bisplatinum complexes as chemotherapeutic agents A bis-platinum complex having the structure: ##STR1## wherein X and Y are the same or different ligands and are halide, sulphate, phosphate, nitrate, carboxylate, substituted carboxylate or dicarboxylate. B and C are the same or different and are pri... | 10/03/1989 |
| 4870062 | Organo-platinum complex and use thereof as anti-tumor agent A removable rating plug for a circuit breaker provides an active variable impedance in series with a reference resistor between the sensing terminals of the circuit breaker trip circuit to adjust the sensing voltage produced in response to the input curre... | 09/26/1989 |
| 4870070 | Water soluble platinum complexes of novel malonate derivatives This disclosure describes water soluble platinum complexes of novel malonate derivatives which possess the property of inhibiting the growth of tumors in mammals.... | 09/26/1989 |
| 4866092 | Platinum complexes of amines with novel dibasic acids Novel organic compounds of the formula ##STR1## where R1 and R2 are individually selected from the group consisting of hydrogen and alkyl(C1 -C6); or R1 and R2 taken together are selec... | 09/12/1989 |
| 4864043 | Platinum complexes A diamine platinum (II) complex represented by the general formula ##STR1## [wherein R1, R2, R3 and R4 are each a hydrogen atom or a lower alkyl group; and two X's are each a halogen atom or jointly form a ... | 09/05/1989 |
| 4861905 | Platinum complexes A diamine platinum (II) complex represented by the general formula ##STR1## [wherein R1 and R2 are each a lower alkyl group; and two X's are each a halogen atom or jointly form a group represented by ##STR2## (wherein R | 08/29/1989 |
| 4853380 | Coordination complexes of platinum useful as antiproliferative agents Platinum complexes are disclosed in which the platinum cation is coordinated to heterocyclic sulfur compounds as well as monodentate or bidentate amines. The complexes have the formula: ##STR1## wherein L1 and L2 are individuall... | 08/01/1989 |
| 4845124 | Platinum (IV) complexes New platinum (IV) complexes are now provided, which exhibit antitumor activity as shown by the tests on mouse leukemia, L-1210 cell in mice. These new platinum (IV) complexes contain 1,2-cyclohexanediamine or 2-(aminomethyl)cyclohexyl-amine as a ligand.... | 07/04/1989 |
| 4843161 | Platinum-intercalative complexes for the treatment of cancer Anticancer drug compositions are provided by chemically linking a platinum anticancer drug to an intercalative drug with a linking group that does not inactivate either drug.... | 06/27/1989 |
