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| Number | Title | Issue Date |
| 7919699 | Nanotubes as mitochondrial uncouplers A method of uncoupling mitochondria in a subject including administering nanotubes to the subject in a therapeutically effective amount, wherein the nanotubes are self-rectifying is provided. A method of decreasing reactive oxygen species and decreasing detrimental ... | 04/05/2011 |
| 7425582 | Stabilized dispersions comprising excipient surface-modified organic nanoparticles and medicament particles In one aspect, the invention provides a stable dispersion comprising a continuous phase comprising a continuous liquid phase and a plurality of organic nanoparticles; and a dispersed phase comprising particles dispersed in the continuous phase. ... | 09/16/2008 |
| 6702744 | Agents that stimulate therapeutic angiogenesis and techniques and devices that enable their delivery A method including positioning a catheter at a location in a blood vessel; imaging a thickness of a portion of a wall of the blood vessel at the location; identifying a treatment site; advancing a needle a distance into the wall of the blood vessel to the... | 03/09/2004 |
| 6680068 | Drug delivery formulations and targeting The invention is based on the discovery that angiogenic vessels have heterogeneous surface charge and that cationic liposomes actually target human tumor blood vessels only in irregularly shaped patches. The invention thus features methods for delivering ... | 01/20/2004 |
| 6664039 | Methods and compositions for modulating neurodegeneration Disclosed are polypeptides and polynucleotides having very long chain fatty acid coA synthetase activity. The polypeptides and polynucleotides are useful in identifying and modulating neurodegeneration.... | 12/16/2003 |
| 6660286 | Emulsion vehicle for poorly soluble drugs An emulsion of tocopherol incorporating a co-solvent and, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans by various routes is d... | 12/09/2003 |
| 6656966 | Nitrosated and nitrosylated taxanes, compositions and methods of use The present invention describes novel nitrosated and/or nitrosylated taxanes, and novel compositions comprising at least one nitrosated and/or nitrosylated taxane, and, optionally, at least one compound that donates, transfers or releases nitric oxide, el... | 12/02/2003 |
| 6652833 | Functionalized active-nucleus complex sensor A functionalized active-nucleus complex sensor that selectively associates with one or more target species, and a method for assaying and screening for one or a plurality of target species utilizing one or a plurality of functionalized active-nucleus comp... | 11/25/2003 |
| 6642273 | Unsaturated derivatives at the 4-position of 6-tert-butyl-1,1-dimethylindane and their use in human and veterinary medicine and in cosmetics An unsaturated derivative at the 4-position of 6-tert-butyl-1,1-dimethylindane corresponding to the following formula: ##STR1## in which: X represents: a divalent radical of formula: ##STR2## and Y represents a divalent radical of following formul... | 11/04/2003 |
| 6638522 | Microemulsion concentrate composition of cyclosporin The present invention is directed to a pharmaceutical composition comprising a pharmaceutically effective amount of Cyclosporin, in association with a pharmaceutical carrier, said carrier comprising a cyclosporin solubilizing effective amount of a propyle... | 10/28/2003 |
| 6638907 | Laminin 8 and methods for its use The present invention provides substantially purified laminin 8, methods for making recombinant laminin 8, cells that express recombinant laminin 8, and methods for using the recombinant laminin 8 to accelerate the healing of injuries to vascular tissue a... | 10/28/2003 |
| 6638932 | 2,4-disubstituted triazine derivatives This invention concerns the use of the compounds of formula ##STR1## the N-oxides, the pharmaceutically acceptable addition salts, quaternary amines and the stereochemically isomeric forms thereof, wherein --a1.dbd.a.sup.2 --a3.dbd.a.sup.4... | 10/28/2003 |
| 6638521 | Oral liquid mucoadhesive compositions The present invention relates to a per oral, oral, or intranasal pharmaceutical mucoretentive, aqueous liquid composition comprising from about 2% to about 50%, by weight of the composition, of colloidal particles of silica, titanium dioxide, clay, and mi... | 10/28/2003 |
| 6632671 | Nanoparticle encapsulation system and method The present invention generally relates to nanocapsules and methods of preparing these nanocapsules. The present invention includes a method of forming a surfactant micelle and dispersing the surfactant micelle into an aqueous composition having a hydroph... | 10/14/2003 |
| 6632790 | Laminin 2 and methods for its use The present invention provides substantially purified laminin 2, methods for making recombinant laminin 2, cells that express recombinant laminin 2, and methods for using the substantially purified laminin 2 to accelerate peripheral nervous system nerve r... | 10/14/2003 |
| 6630171 | Particles based on polyamino-acid(s) and methods for preparing same The invention concerns delivery particles (DP's) for active principles (AP's) based on linear amphiphilic polyamino-acids (PAA's), with -peptide chains, capable of being spontaneously formed by contacting PAA's with a liquid medium, preferably with... | 10/07/2003 |
| 6624293 | Modified protein kinase A-specific oligonucleotides and methods of their use Disclosed are synthetic, modified oligonucleotides complementary to, and capable of down-regulating the expression of, nucleic acid encoding protein kinase A subunit RI. The modified oligonucleotides have from about 15 to about 30 nucleo... | 09/23/2003 |
| 6613801 | Method for the synthesis of compounds of formula I and their uses thereof This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction betw... | 09/02/2003 |
| 6241975 | Method for preparation of plant extract powder The present invention relates to a method for preparation of plant extract powder and oral compositions containing plant extract powder prepared by the same. More particularly, the present invention could provide a method for preparation of plant extract ... | 06/05/2001 |
| 6238859 | Virus protein antigens of the JC virus The invention concerns new virus-like particles composed of the VP1 protein of the JC virus, a process for their production and their use in analytical, diagnostic and therapeutic methods.... | 05/29/2001 |
| 4865836 | Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport A brominated perfluorocarbon emulsion non-toxic for internal and intravenous use in animals including humans for use as an oxygen transport medium and as a tumor and other element contrast enhancement medium is stable with very small size characteristics ... | 09/12/1989 |
| 4683100 | Copolymerizable ethylenically unsaturated surfactants for latex preparation Disclosed herein are compounds of the formula ##STR1## wherein M is a cation selected from the group consisting of alkali metal, ammonium, amino, and hydrogen; and wherein x and y are independently selected from 0 to 2. These compounds are disclosed ... | 07/28/1987 |
| 4501726 | Intravascularly administrable, magnetically responsive nanosphere or nanoparticle, a process for the production thereof, and the use thereof An intravascularly administrable, magnetically responsive nanosphere or nanoparticle made up of a crystalline carbohydrate matrix, preferably starch, enclosing a magnetic material, is described. The nanosphere or nanoparticle is produced by dissolving a c... | 02/26/1985 |
| 4269821 | Biological materials There are described processes for the preparation of submicroscopic particles of physiologically acceptable polymer associated with a biologically active material, by polymerizing a monomer in the presence of the biologically active material or by adsorbi... | 05/26/1981 |
| 4107288 | Injectable compositions, nanoparticles useful therein, and process of manufacturing same Particles in the size range from about 10 to about 1000 nm, preferably less than about 500 nm, which comprise a crosslinked matrix of macromolecules of natural origin. A biologically or pharmacodynamically active material may be supported on or incorporat... | 08/15/1978 |
