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| Number | Title | Issue Date |
| 7414105 | Peptides that bind to the erythropoietin receptor The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell pr... | 08/19/2008 |
| 7128913 | Erythropoietin conjugates The present invention refers to conjugates of erythropoietin with poly(ethylene glycol) comprising an erythropoietin glycoprotein having an N-terminal α-amino group and having the in vivo biological activity of causing bone marrow cells to increase production of re... | 10/31/2006 |
| 7084245 | Peptides that bind to the erythropoietin receptor The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell pr... | 08/01/2006 |
| 7012130 | Methods of purifying recombinant human erythropoietin from cell culture supernatants The present invention relates, in general, to a method of purifying recombinant human erythropoietin (EPO). The present invention also relates to a substantially pure EPO. The method comprises a differential precipitation, an hydrophobic interaction chromatography, ... | 03/14/2006 |
| 6930086 | Diglycosylated erythropoietin This invention is directed to an erythropoietin mutein having in vivo biological activity for causing bone marrow cells to increase production of reticulocytes and red blood cells, in that the mutein is N-glycosylated at Asn38 and Asn83 but not N-glycosylated at Asn... | 08/16/2005 |
| 6784154 | Method of use of erythropoietin to treat ischemic acute renal failure Recombinant erythropoietin is used in a method to prevent ischemic acute renal failure in patients at risk for developing ischemic acute renal failure and to treat fully-developed ischemic acute renal failure. The method is also used to prevent harmful cell apoptosi... | 08/31/2004 |
| 6642353 | Peptide ligands for the erythropoietin receptor Clones isolated from phage display libraries that bound to an erythropoietin (EPO) receptor probe are disclosed. Peptides encoded by sequences of those clones that bound to the EPO receptor are disclosed. A 12-mer amino acid consensus sequence, CXXGWVGXCX... | 11/04/2003 |
| 6555343 | Chimpanzee erythropoietin (CHEPO) polypeptides and nucleic acids encoding the same The present invention is directed to novel chimpanzee erythropoietin polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide mole... | 04/29/2003 |
| 6391633 | Production of erythropoietin by endogenous gene activation The invention relates to human cells which are capable, on the basis of an activation of the endogenous human EPO gene, of producing EPO in a sufficient amount and purity to make possible a cost-effective production of human EPO as a pharmaceutical prepar... | 05/21/2002 |
| 4703008 | DNA sequences encoding erythropoietin Disclosed are novel polypeptides possessing part or all of the primary structural conformation and one or more of the biological properties of mammalian erythropoietin ("EPO") which are characterized in preferred forms by being the product of procaryotic ... | 10/27/1987 |
| 4677195 | Method for the purification of erythropoietin and erythropoietin compositions A method for purifying erythropoietin is described. The method comprises treating partially purifying erythropoietin by reverse phase high performance liquid chromatography to obtain homogeneous erythropoietin having a molecular weight of about 34,000 dal... | 06/30/1987 |
| 4590168 | Protein immunoassaying and purification Protein immunoassay or purification using an antibody raised to an antigen comprising a polypeptide corresponding to a fragment (but not all) of the protein being assayed; the antibody is capable of binding separately both to the protein as a whole and to... | 05/20/1986 |
| 4558006 | A.T.C.C. HB8209 and its monoclonal antibody to erythropoietin Disclosed is a new mouse-mouse hybridoma tumor cell line A.T.C.C. No. HB8209. A monoclonal antibody produced by said cell line is specifically immunologically reactive with erythropoietin and with a polypeptide whose amino acid sequence is substantially d... | 12/10/1985 |
