Did You Know...
...Daniel Webster invented a "bull plow" to pull out tree stumps. It didn't catch on because it was huge and required four oxen to pull it!
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 6673769 | Lanthionine bridged peptides Disclosed are lanthionine bridged peptides having the structure ##STR1## methods of their preparation and their use as pharmacologically active agents.... | 01/06/2004 |
| 6028168 | Lanthionine bridged peptides Disclosed are lanthionine peptides having the structure ##STR1## methods of their preparation and use as pharmacologically active agents.... | 02/22/2000 |
| 5169833 | Substituted cyclic pentapeptides The present invention provides substituted cyclic pentapeptide compounds of general Formula I: ##STR1## and the pharmaceutically-acceptable slats, esters and amides thereof, which are useful for inducing analgesia in animals, pharmaceutical comp... | 12/08/1992 |
| 4863857 | Polypeptide complementary to peptides or proteins having an amino acid sequence or nucleotide coding sequence at least partially known A method for determining the amino acid sequence of a polypeptide complementary to at least a portion of an original peptide or protein. In one aspect the method involves: (a) determining a first nucleotide sequence of a first nucleic acid coding for the ... | 09/05/1989 |
| 4824850 | Brain-specific drug delivery The subject compounds, which are adapted for the site-specific/sustained delivery of centrally acting drug species to the brain, are: (a) compounds of the formula wherein [D] is a centrally acting drug species, and [DHC] is the reduced, biooxidizable, blood-b... | 04/25/1989 |
| 4801575 | Chimeric peptides for neuropeptide delivery through the blood-brain barrier Chimeric peptides adapted for delivering neuropharmaceutical agents, such as neuropeptides into the brain by receptor-mediated transcytosis through the blood-brain barrier. The chimeric peptides include a peptide which by itself is capable of crossing the... | 01/31/1989 |
| 4801614 | Process for using endogenous enkephalins and endorphins to inhibit growth of tumerous cells A process for the therapeutic treatment of cancer patients involving stimulation and promotion of the natural immune system (both T cell and NK cell activity) resisting and inhibiting tumorous growth (cancer) as well as resisting infections (viral, bacter... | 01/31/1989 |
| 4794150 | Synthesis of peptide analogs A novel polymeric disc, wafer or similarly shaped resin for carrying out the synthsis of peptide analogs via solid phase peptide synthesis techniques is provided. The polymeric disc or wafer of the invention may be made out of those resin materials presen... | 12/27/1988 |
| 4757049 | Process for using endogenous enkephalins and endorphins to stimulate the immune system of patients with aids A process for the therapeutic treatment of AIDS (acquired immune deficiency syndrome) involving stimulation and promotion of the natural immune system (both T cell and NK cell activity) resisting and inhibiting tumorous growth (cancer) as well as resistin... | 07/12/1988 |
| 4725645 | Process for synthesising peptides The process enables peptides to be synthesized from amino acids with the participation of trialkylcyanosilanes. The peptides obtained by this synthesis route are used, in particular, in pharmaceutical applications.... | 02/16/1988 |
| 4707468 | Polypeptide A novel polypeptide is defined by the below shown formula and is useful as an analgesic. ##STR1## wherein R1 and R2 may be the same or different and each represents a hydrogen atom or a lower alkyl or lower alkenyl group, A ... | 11/17/1987 |
| 4704359 | Protease and process for production and use thereof Disclosed is a new protease having the following properties: (1) it is able to hydrolitically cleave a peptide bond between two adjacent basic amino acids in a peptide chain; (2) it has a molecular weight of about 43,000 as determined by electrophoresis; ... | 11/03/1987 |
| 4684624 | Method of treating cerebral ischemia A method of treatment for patients suffering from cerebral ischemia is provided by administering an opioid peptide. Particulary preferred is the administration of dynorphin, or dynorphin-related peptides, in the acid or amidated form. Practice of the inve... | 08/04/1987 |
| 4681871 | Pharmacologically active peptides Pharmacologically active peptides with opiate-like activity are provided having stability to proteases. The products can be obtained by enzymatic digestion of casein. The active peptides have the grouping Tyr-Pro-A where Tyr is tyrosine, Pro is proline an... | 07/21/1987 |
| 4680276 | Metal polypeptides The present invention relates to novel peptide compounds, of which the chemical structure is related to that of the polypeptide hormone having a thymic activity, isolated from the blood serum of pig, and the application of these novel compounds for therap... | 07/14/1987 |
| 4657892 | Pharmacologically active peptides Pharmacologically active peptides of the following formulas are described: in which L--Tyr is the N-terminal amino acid residue L-tyrosine, X any amino acid residue of the D-form, L--Phe is the amino acid L-phenylalanine, A and B are any desired amino acid res... | 04/14/1987 |
| 4652639 | Manufacture and expression of structural genes Described are rapid and highly efficient procedures for the total synthesis of linear, double stranded DNA sequences of up to about 200 base pairs, which sequences may comprise entire structural genes. Illustratively disclosed is the preparation and expre... | 03/24/1987 |
| 4650763 | Protease and process for production and use thereof Disclosed is a new protease having the following properties: (1) it is able to hydrolitically cleave a peptide bond between two adjacent basic amino acids in a peptide chain; (2) it has a molecular weight of about 43,000 as determined by electrophoresis; ... | 03/17/1987 |
| 4631270 | Therapeutically useful pseudopeptides, compositions containing the same and methods of preparation and use Therapeutically useful pseudopeptides characterized by the replacement of at least one peptide group, both in a naturally occurring peptide or protein by a thiomethylene group are useful in the treatment of various metabolic malfunctions.... | 12/23/1986 |
| 4610816 | Substituted dipeptides as inhibitors of enkephalinases A method for inhibiting the action of enkephalinases in a mammal to thereby elicit an analgesic effect in said mammal is described. Novel compounds and compositions useful for accomplishing the method of the invention are also described.... | 09/09/1986 |
| 4603121 | Enkephalin analogs The invention relates to novel enkephalin analogs of the formula: ##STR1## which are useful as analgesic agents.... | 07/29/1986 |
| 4593098 | Piperazinone and piperazine polypeptides Piperazinone polypeptides which are useful as analgesics and psychotherapeutic agents as well as processes to produce them are described.... | 06/03/1986 |
| 4593017 | Methods of treating patients using a pharmaceutical preparation containing an -endorfine fragment The invention relates to the use of (2-9)--endorfine for dopaminergic and vasopressin-releasing properties.... | 06/03/1986 |
| 4587233 | Use of Arg-Phe-amide derivatives A method is provided for elevating blood pressure in mammals comprising the step of administering a polypeptide containing the C-terminal residue L-Arg-L-Phe or C-terminal esters or amides thereof.... | 05/06/1986 |
| 4552866 | Use of diamino alcohols as analgesic agents An enkephalin-degrading aminopeptidase enzyme is inhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salt thereof, wherein R1 and R2 are each independently hydrogen, alkyl, carboxyalkyl, halo subst... | 11/12/1985 |
| 4551273 | Analgesic peptide and process for the preparation thereof A novel peptide having the primary structure: N-Me-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-D.Ile-Arg-Pro-Lys-D.Leu-Lys-Trp-NH2 (in which D.Ile and D.Leu represent a D-Ile and a D-Leu residue respectively, other abbreviations of amino acids represent each a... | 11/05/1985 |
| 4551372 | Laminated safety glass A laminated safety glass is disclosed which is comprised of first and second glass sheets, the second glass sheet being smaller than the first, the peripheral edges of each sheet defining between them a stairstep structure. The face of the larger glass sh... | 11/05/1985 |
| 4546082 | E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins A method for producing secretable and processable biologically useful polypeptides in yeast is provided utilizing vectors including at least a segment of the gene coding for S. cerevisiae alpha-factor.... | 10/08/1985 |
| 4540564 | Brain-specific drug delivery The subject compounds, which are adapted for the site-specific/sustained delivery of centrally acting drug species to the brain, are: (a) compounds of the formula wherein [D] is a centrally acting drug species, and [DHC] is the reduced, biooxidizable, blood-b... | 09/10/1985 |
| 4537878 | Process for using endogenous enkephalins and endorphins to stimulate the immune system A process of stimulating and promoting the natural immune system (T cells and NK cells) resisting and inhibiting the growth of tumorous cells as well as resisting infections (virus bacteria, and fungi) is disclosed. Endogenous endorphins are disclosed as ... | 08/27/1985 |
| 4535169 | 5H-6-oxo-2,3,4,4a,7,7a-hexahydropyrano[2,3-b]pyrrole and the preparation thereof Conformationally restricted peptide analogs incorporating a rigid ଲ-bend are formed by replacing a portion of the peptide backbone chain with a bicyclic heterocycle, 5H-6-oxo-2,3,4,4a,7,7a-hexahydropyrano[2,3-b]pyrrole. Properly substituted der... | 08/13/1985 |
| 4534897 | Piperazinone, piperazine, 1,4-diazepin-2-one and 1,4-diazepine intermediate compounds The compounds of the following formulas ##STR1## where W is hydrogen, benzyloxycarbonyl, or t-butoxycarbonyl useful as intermediates for preparing piperazine, piperazinone, 1,4-diazepine and 1,4-diazepin-2-one polypeptide compound.... | 08/13/1985 |
| 4518711 | Conformationally constrained cyclic enkephalin analogs with delta receptor specificity Novel compounds which are capable of binding with enhanced specificity to the delta receptor are disclosed. The compounds are a series of cyclic, conformationally constrained analogs of enkephalins which display exceptional delta receptor specificity. The... | 05/21/1985 |
| 4510082 | Pharmacologically active peptides Compounds of the formula ##STR1## and pharmaceutically acceptable non-toxic acid addition salts thereof, in which R is hydrogen, methyl, ethyl, cyclopropylmethyl, or allyl; A is a residue of a D-amino acid selected from the goup consisting of Ala, Ab... | 04/09/1985 |
| 4507230 | Peptide synthesis reagents and method of use A method of releasing a functional group present in an amino acid or amino acyl residue from a resin or protecting residue which is bonded to the functional group by a linkage having proton affinity, which comprises: reacting the functional group bonded t... | 03/26/1985 |
| 4495178 | Enkephalin analogs The invention relates to novel enkephalin analogs of the formula: ##STR1## which are useful as analgesic agents.... | 01/22/1985 |
| 4490363 | Metorphamide--a novel morphine-like peptide A morphine-like amidated opioid octapeptide metorphamide having the struce Try-Gly-Gly-Phe-Met-Arg-Arg-Val-NH2 has been isolated from bovine caudate nucleus extracts and synthesized by solid phase peptide synthesis methods. Metorphamide is thu... | 12/25/1984 |
| 4481138 | Heptadecapeptide A substance having opiate and analgesic activity is obtained from swine duodenum. The opioid substance of the present invention comprises a heptadecapeptide having the following primary amino acid structure: Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu... | 11/06/1984 |
| 4481191 | Method for controlling blood pressure A method is provided for treating high blood pressure and disturbances of cardiac function by administering a therapeutically effective dosage of dynorphin-related opioid peptides, such as dynorphin(1-13) and dynorphin(1-10) amide, having at least ten ami... | 11/06/1984 |
| 4476117 | Dimers of peptide amides Compounds of the formula: ##STR1## wherein R1 and R2 stand for alk-2-enyl radicals of not more than 6 carbon atoms, A stands for Gly or Azgly, B stands for Leu or Met, J stands for --(CH2)n --, wherein n st... | 10/09/1984 |
