Celebrity Inventors
Glam girl Heddy Lamar may have used her good looks to good effect on the silver screen, but she put her smarts to better use as an inventor. During World War II, she co-patented a frequency-switching system for torpedo guidance that was considered years ahead of its time.
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| Number | Title | Issue Date |
| 7148034 | Bioactive whey protein hydrolysate The present invention relates to a process of preparing a whey protein hydrolysate from a WPI substrate having improved flavour, functionality and ACE-I inhibiting properties. ... | 12/12/2006 |
| 7125702 | Process for the preparation of angiotensis converting enzyme (ACE) inhibitors and its use The invention is a process for the preparation of angiotensin converting enzyme (ACE) inhibitors and the use thereof. ... | 10/24/2006 |
| 6919314 | Bioactive whey protein hydrolysate The invention relates to a partial hydrolysate of whey protein which contains bioactive peptides but does not have a bitter flavor. The hydrolysate is carried out using selective enzymes which produce the active peptides and is terminated at a degree of hydrolysis b... | 07/19/2005 |
| 4864017 | Novel renin inhibiting peptides having a dihyroxyethylene isostere transition state insert The present invention provides novel renin-inhibiting peptides of the formula X-A6 -B7 -C8 -D9 -E10 -F11 -G12 -H13 - I14 -Z, wherein the E10 -F11... | 09/05/1989 |
| 4859654 | Homocyclostatine and cyclostatine containing polypeptides as antihypertensive agents Polypeptides and derivatives thereof containing homocyclostatine and cyclostatine are useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin.... | 08/22/1989 |
| 4855285 | Antigenic modification of polypeptides Endogenous and exogenous proteins, and fragments thereof, are chemically modified outside the body of an animal so that when injected into the animal they produce more antibodies against the unmodified protein than would injection of the unmodified protei... | 08/08/1989 |
| 4855303 | Fluorine containing renin inhibitors Polypeptides containing fluorinated cyclostatine derivatives as antihypertensive agents.... | 08/08/1989 |
| 4835253 | Specific inhibitors of tissue kallikrein A unique class of tissue kallikrein inhibitors is provided which are specific for tissue kallikreins and do not substantially cross-react with plasma kallikreins or other serine proteases in-vivo. These inhibitors are substrate analogues of low molecular ... | 05/30/1989 |
| 4833152 | Anti-hypertensive agents Novel inhibitors of angiotensin coverting enzyme having the general formula R - A - S - Z are disclosed as potent inhibitors of angiotensin converting enzyme and are useful anti-hypertensive agents.... | 05/23/1989 |
| 4814342 | Nor-statine and nor-cyclostatine polypeptides Polypeptides and derivatives thereof containing nor-statine and nor-cyclostatine are useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin.... | 03/21/1989 |
| 4782043 | Renin inhibitors containing a C-terminal amide cycle Renin inhibitory peptides of the formula ##STR1## and analogs thereof inhibit renin and are useful for treating various forms of renin-associated hypertension and hyperaldosteronism.... | 11/01/1988 |
| 4772684 | Peptides affecting blood pressure regulation Peptides of the formula: ##STR1## wherein: NH is the amino group of amino acid AA1 ; ##STR2## is the carbonyl group of amino acid AA7 ; X is H--, ##STR3## GLU-VAL-, or VAL-TYR-HIS-GLU-VAL; Y is --OH, --NH | 09/20/1988 |
| 4766110 | Novel complex amido and imido derivatives of carboxyalkyl peptides Novel inhibitors of angiotensin converting enzyme are disclosed which have the general formula ##STR1## wherein R1 and/or R3 form complex amides and imides thereof, R4 and R5 form with --N--C-- a 4-6 member... | 08/23/1988 |
| 4758584 | Antihypertensive 5-amino-4-hydroxyvaleryl derivatives substituted by sulphur-containing groups Compounds of the formula ##STR1## in which R1 represents acyl substituted by a thio, sulphinyl or sulphonyl group, A represents an optionally N-alkylated -amino acid residue that is bonded N-terminally to R1 and C-termina... | 07/19/1988 |
| 4749687 | Renin inhibitors containing statine or derivatives thereof A series of novel peptide and polypeptide derivatives containing statine or derivatives thereof (e.g., aminostatine, cyclostatine) are disclosed that are useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin. Of particular interest... | 06/07/1988 |
| 4734420 | Anti-hypertensive agents Novel inhibitors of angiotensin converting enzyme having the general formula R - A - S - Z are disclosed as potent inhibitors of angiotensin converting enzyme and are useful anti-hypertensive agents.... | 03/29/1988 |
| 4729985 | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues A series of novel polypeptide derivatives, containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues, which are useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin. Particularly valuable precursors for many of these c... | 03/08/1988 |
| 4713445 | Renin inhibitors and treatments using them Renin-inhibiting analogues of formula ##STR1## where X and W are terminal groups optionally with further amino acyl residues; D, E, B and Z (of which any one or except with `reduced` analogues any two may be absent) are aromatic, lipophilic or in the... | 12/15/1987 |
| 4705846 | Novel renin inhibiting peptides having a gamma lactam pseudo dipeptide insert The present invention provides novel renin-inhibiting peptides of the formula X-A6 -B7 -C8 -D9 -E10 -F11 -G12 -H13 -I14 -Z, having a lactam pseudo-dipeptide at C... | 11/10/1987 |
| 4692458 | Anti-hypertensive agents Novel inhibitors of angiotensin converting enzyme having the general formula R--A--S--Z are disclosed as potent inhibitors of angiotensin converting enzyme and are useful anti-hypertensive agents.... | 09/08/1987 |
| 4692437 | Anti-hypertensive agents Inhibitors of angiotensin converting enzyme which are physiologically acceptable salts of compounds which have the formula: ##STR1## wherein R is hydrogen, formyl, acetyl, propanoyl, butanoyl, phenylacetyl, phenylpropanoyl, benzoyl, cyclopentanecarbo... | 09/08/1987 |
| 4692459 | Anti-hypertensive agents Inhibitors of angiotensin converting enzyme which have the formula: ##STR1## wherein R is hydrogen, formyl, acetyl propanoyl, butanoyl, phenylacetyl, phenylpropanoyl, benzoyl, cyclopentanecarbonyl, tert-butyloxycarbonyl, cyclopentanecarbonyl-L-lysyl,... | 09/08/1987 |
| 4690936 | Anti-hypertensive agents Novel inhibitors of angiotensin converting enzyme having the general formula R--A--S--Z are disclosed as potent inhibitors of angiotensin converting enzyme and are useful anti-hypertensive agents.... | 09/01/1987 |
| 4672054 | Process for the preparation of angiotensin-II analogues substituted in the 1-, 5- and 8- positions The invention relates to octapeptides of the formula wherein X is a sarcosyl, lactoyl or hydroxyacetyl radical, Y is cyclopentylglycyl or cyclohexylglycyl, and W is an alanine radical or lactic acid radical having angiotensine-II antagonistic activity.... | 06/09/1987 |
| 4668769 | Oxa- and azahomocyclostatine polypeptides Polypeptides and derivatives thereof containing oxa- and azahomocyclostatine are useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin.... | 05/26/1987 |
| 4668770 | Renin inhibitory tripeptides Renin inhibitory peptides of the formula ##STR1## and analogs thereof inhibit renin and are useful for treating various forms of renin-associated hypertension and hyperaldosteronism.... | 05/26/1987 |
| 4668663 | Renin inhibitors containing homophe8 Renin inhibitory peptides of the formula ##STR1## and analogs thereof inhibit renin and are useful for treating various forms of renin-associated hypertension and hyperaldosteronism.... | 05/26/1987 |
| 4650661 | Enzyme inhibitors Renin inhibitory polypeptide analogues derived from the natural N-terminal substrate sequence by replacing the amino acid at position 10 with statine or a residue related to it.... | 03/17/1987 |
| 4613676 | Substituted 5-amino-4-hydroxyvaleryl derivatives Compounds of the formula ##STR1## in which R1 represents hydrogen or acyl, X1 represents an optionally N-alkylated amino acid residue that is bonded N-terminally to R1 and C-terminally to X2, X2 ... | 09/23/1986 |
| 4610847 | Conversion flask for sequential performance apparatus Conversion flask for use is an apparatus for the sequential performance of chemical processes on a sample of chemical material. The flask includes at least three capillary tubes and a large bore tube extending into the interior thereof for the introductio... | 09/09/1986 |
| 4609643 | Renin inhibitors, treatments and dipeptide synthesis Preparation of renin inhibitors based on the structure of natural renin substrate at residues 6 to 13 from the amino terminal thereof, the inhibitors being polypeptide analogues having in particular an isosteric non-peptide link corresponding to the 10, 1... | 09/02/1986 |
| 4595677 | Substituted tetrapeptides Tetrapeptides of the formula I, ##STR1## in which R1 represents hydrogen or acyl, R2 represents alkyl or aralkyl, R3 represents free or functionally modified hydroxy, R4 represents free or substituted amino... | 06/17/1986 |
| 4585586 | Partially retro-inverted decapeptide as a specific renin inhibitor with high resistance to enzymatic hydrolysis Synthesis of an analogue of the (5-14) decapeptide of equine angiotensinogen partially retro-inverted at the Phe-Phe bond, of formula: ##STR1## The retro-inverso analogue inhibits renin with high resistance to enzymatic degradation, and can be used i... | 04/29/1986 |
| 4574079 | Radiolabeled angiotensin converting enzyme inhibitors for radiolabeling mammalian organ sites Radiolabeled angiotensin converting enzyme inhibitors having the general formula: ##STR1## wherein X is a radiolabeling substituent, preferably a radiolabeling halogen substituent such as 123 I, 125 I, 131 I, 75 | 03/04/1986 |
| 4560505 | Retro-inverso analog of the (5-14) decapeptide of equine angiotensinogen, as a specific renin inhibitor with high resistance to enzymatic hydrolysis There is provided an analog of the (5-14) decapeptide of equine angiotensinogen which is partially inverted at the Phe-Val bond, and which has the formula ##STR1## This retro-inverso analog inhibits renin with high resistance to enzymatic degrad... | 12/24/1985 |
| 4478827 | Renin inhibitors A compound of the formula wherein the Xs are the same or different and selected from the group consisting of an aromatic, a chlorinated aromatic, an aliphatic and a chlorinated aliphatic amino acid residue; Y is a positively or negatively charged amino acid re... | 10/23/1984 |
| 4477441 | Renin inhibitors containing a C-terminal disulfide cycle Renin inhibitory peptides of the formula ##STR1## and analogs thereof inhibit renin and are useful for treating various forms of renin-associated hypertension and hyperaldosteronism.... | 10/16/1984 |
| 4424207 | Enzyme inhibitors Preparation of renin inhibitors based on the structure of natural renin substrate at residues 6 to 13 from the amino terminal thereof, the inhibitors being polypeptide analogues having in particular an isosteric non-peptide link corresponding to the 10, 1... | 01/03/1984 |
| 4424242 | Containers having improved gas barrier properties The present invention provides novel multilayer packaging materials having improved resistance to gas permeability. The present invention also provides containers which are formed from the novel packaging material. The multilayer packaing material compris... | 01/03/1984 |
| 4423242 | Pharmaceutical amides, and preparation, formulations and use of thereof Compounds of the general formula ##STR1## wherein Ph is a phenyl group which is optionally substituted by one or more substituents selected from halo (i.e. fluoro, chloro, bromo or iodo), C1-4 alkyl, amino, C1-4 alkylamino, di-C... | 12/27/1983 |
