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| Number | Title | Issue Date |
| 7001982 | Non-natural C-linked carbo-β-peptides with robust secondary structures Nonnatural C-linked carbo-β-peptides with robust secondary structures, which involves the synthesis of a new class of β-peptides called C-linked carbo-β-peptides. The compounds are favorably disposed for the formation of stable helical structures and are useful a... | 02/21/2006 |
| 6887845 | Polypeptoid pulmonary surfactants The present invention provides spreading agents based on sequence-specific oligomers comprising a peptoid, a peptide-peptoid chimera, a retropeptoid or a retro(peptoid-peptide) chimera, and methods for using the same, including for the treatment of respiratory distr... | 05/03/2005 |
| 6743778 | Apo-AI/AII peptide derivatives The present invention concerns therapeutic agents that mimic the activity of Apo-AI amphipathic helix peptide. In accordance with the present invention, the compounds of the invention comprise: a. a Apo-AI amphipathic helix peptide or Apo-AI amphipathic helix... | 06/01/2004 |
| 6218364 | Fluorinated neurokinin A antagonists Peptide derivatives which are antagonists of neurokinin A. The derivatives have a modified peptide bond having a reduced amide and a fluorinated alkyl attached to the nitrogen atom of the modified peptide bond. For example, Asp-Ser-Phe-Val-Gly-Leu.PSI.[CH... | 04/17/2001 |
| 6046166 | Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders The present invention provides peptides and peptide analogues that mimic the structural and pharmacological properties of human ApoA-I. The peptides and peptide analogues are useful to treat a variety of disorders associated with dyslipidemia.... | 04/04/2000 |
| 5990276 | Synthetic inhibitors of hepatitis C virus NS3 protease An inhibitor of the HCV NS3 protease. The inhibitor is a subsequence of a substrate of the NS3 protease or a subsequence of the NS4A cofactor. Another inhibitor of the present invention contains a subsequence of a substrate linked to a subsequences of the... | 11/23/1999 |
| 5849866 | Peptidase inhibitors This invention relates to analogs of peptidase substrates in which the amide group containing the scissile amide bond of the substrate peptide has been replaced by an activated electrophilic ketone moiety. These analogs of the peptidase substrates provide... | 12/15/1998 |
| 5686416 | Increasing blood-brain barrier permeability with permeabilizer peptides Peptides called receptor mediated permeabilizers (RMP) increase the permeability of the blood-brain barrier to molecules such as therapeutic agents or diagnostic agents. The permeabilizer A-7 or conformational analogues can be intravenously co-administere... | 11/11/1997 |
| 5646244 | Cyclodepsipeptide compound A compound of the formula: ##STR1## wherein A is benzyl group which has suitable substituent (s), Aa, B and D are each lower alkyl, C is hydrogen or lower alkyl, or a salt thereof. The compound or its salt of the present invention has excellent... | 07/08/1997 |
| 5574132 | Peptides and mixtures thereof for detecting antibodies to hepatitis C virus (HCV) This invention relates to novel peptides and mixtures thereof useful for detecting HCV infections. These peptides are also useful as active ingredients in vaccines against HCV infection.... | 11/12/1996 |
| 5563121 | Peptide linkage unit A peptide linkage unit is employed for joining peptide and pseudopeptide sequences, including peptides and pseudopeptides that inhibit aspartic proteinase enzymes. The peptide linkage unit includes a phosphinate methylene ammonium linkage in place of a pe... | 10/08/1996 |
| 5556836 | Use of D-glucopyranuronic acids and their derivatives for incorporation in pharmacologically active peptides and their salts Use of 7-amino-L-glycero-L-gulo-2,6-anhydro-7-desoxy-heptonic acid and 2-benzoxycarbonylamino-01 -methyl-2-desoxy-ଲ-glucopyranuronic acid, their derivatives and the enantiomorphous compounds for incorporation and for manufacture in pharma... | 09/17/1996 |
| 5529984 | Endoparasiticidal compositions based on open-chain hexadepsipeptides This invention relates to a method of combatting endoparasites which comprises administering an endoparasiticidally effective amount of a hexadepsipetide of the formula ##STR1## to a human or animal in need thereof.... | 06/25/1996 |
| 5525591 | Endoparasiticidal compositions based on open-chain octadepsipeptides The present invention relates to the use of open-chain octadepsipeptides of the general formula (I) ##STR1## which are used for combating endoparsites in medicine and veterinary medicine.... | 06/11/1996 |
| 5385889 | Bradykinin antagonist peptides The substitution of the L-Pro at the 7-position of the peptide hormone bradykinin or other substituted analogs of bradykinin with a D-configuration hydroxyproline ether or thioether converts bradykinin agonists into bradykinin antagonists. The invention f... | 01/31/1995 |
| 5229490 | Multiple antigen peptide system Multiple antigen peptide systems are described in which a large number of antigens are bound to the functional groups of a dendritic core molecule providing a high concentration of antigen in a low molecular volume. The products are useful for producing c... | 07/20/1993 |
| 5162497 | Bradykinin analogs with non-peptide bond A bradykinin analog which contains nine or ten amino acid residues and at least one [CH2 NH] pseudopeptide bond, the analog being useful as an antagonist or agonist of the naturally occuring bradykinin.... | 11/10/1992 |
| 4866040 | Aminocarnitine directed pharmaceutical agents Carnitine, aminocarnitine and cysteic acid serve as carriers to bring pharmaceutically active compounds to desired sites in the body, e.g. skeletal muscle or the heart. The pharmaceutically active compound can be a protease inhibitor, a cardioactive drug ... | 09/12/1989 |
| 4839465 | Di-(D-tryptophyl and/or tetrahydropyridoindolylcarbonyl)-containing peptide amides and process for preparation thereof Di(D-tryptophyl and/or tetrahydropyridoindolylcarbonyl)-containing peptide amides useful as Substance P agonists and/or antagonists and as antihypertensives and/or analgesics and a process for preparing them are disclosed.... | 06/13/1989 |
| 4833152 | Anti-hypertensive agents Novel inhibitors of angiotensin coverting enzyme having the general formula R - A - S - Z are disclosed as potent inhibitors of angiotensin converting enzyme and are useful anti-hypertensive agents.... | 05/23/1989 |
| 4818748 | Renin inhibitors and aminoacid and aminoaldehyde derivatives Anti-hypertensive compounds of the formula ##STR1## in which A represents hydrogen, C1 -C8 -alkyl, C7 -C14 -aralkyl, phenylsulphonyl, tolylsulphonyl or C1 -C8 -alkylsulfphonyl, or repr... | 04/04/1989 |
| 4803261 | Method for synthesizing a peptide containing a non-peptide This invention features a method for the solid phase synthesis of non-peptide bonds (CH2 --NH) in polypeptide chains. These polypeptides are synthesized by standard procedures and the non-peptide bond synthesized by reacting an amino aldehyde a... | 02/07/1989 |
| 4758551 | Methods for combatting renal toxicity due to metals or nephrotoxic drugs and for selectively modulating in vivo formation of leukotriene types The present invention relates to a method for combatting renal toxicity due to metals or nephrotoxic drugs. More specifically, the present invention relates to the administration of gamma-glutamyl amino acids to a subject so as to combat renal toxicity du... | 07/19/1988 |
| 4757050 | Ureido renin inhibitors Compounds of the formula ##STR1## are disclosed. These compounds intervene in the conversion of angiotensinogen to angiotensin II by inhibiting renin and thus are useful as antihypertensive agents.... | 07/12/1988 |
| 4755592 | Statine-containing peptides useful in medicaments New peptides of the formula I wherein X, Z, W, E, W' and Y are as defined herein and their salts inhibit the activity of human plasma renin.... | 07/05/1988 |
| 4755558 | Using internal marker A method is provided for quantitatively monitoring the deprotection and coupling reactions employed in the solid phase synthesis of peptides. The method entails synthesizing a peptide on a support matrix that has a first marker associated therewith. The a... | 07/05/1988 |
| 4749691 | Peptide, process for preparation thereof and use thereof The invention relates to novel peptides of enhanced pharmacological activity of the formula: ##STR1## wherein R1 is hydroxyalkanoyl, R2 and Rq are each hydrogen, carboxy, protected carboxy, or a group of the formula: ... | 06/07/1988 |
| 4746648 | Peptide derivatives which inhibit renin and acid proteases The invention relates to peptide derivatives modeled on the basis of pepstatin. These derivatives inhibit renin and acid proteases.... | 05/24/1988 |
| 4745124 | Orally effective anti-hypertensive agents Novel thiolester compounds are disclosed which are orally effective angiotensin converting enzyme inhibitors useful in the treatment of mammalian hypertension. They have the formula, wherein Z denotes -B-A2, R1 is H or an acyl group, A | 05/17/1988 |
| 4735933 | Renin inhibitors III The invention concerns novel renin-inhibitory peptides which are useful for treating renin associated hypertension and hyperaldosteronism. Processes for preparing the peptides, compositions containing them and methods of using them are included. Also incl... | 04/05/1988 |
| 4735651 | Novel phytotoxic and plant growth regulating oligopeptide The following novel oligopeptide compounds which possess phytotoxic and plant growth regulating properties and methods for their use are disclosed: R1 -N(R2)-D,L-Ala-D,L-Leu-N(R2)ƊPhe-Gly-OR3 ; in which R | 04/05/1988 |
| 4734420 | Anti-hypertensive agents Novel inhibitors of angiotensin converting enzyme having the general formula R - A - S - Z are disclosed as potent inhibitors of angiotensin converting enzyme and are useful anti-hypertensive agents.... | 03/29/1988 |
| 4732970 | Antitumor amino acid and peptide derivatives of 1,4-bis(aminoalkyl and hydroxy-aminoalkyl)amino)-5,8-dihydroxyanthraquinones Antitumor amino acid and peptide derivatives of 1,4-bis[(aminoalkyl and hydroxyaminoalkyl)amino]-5,8-dihydroxyanthraquinones.... | 03/22/1988 |
| 4728725 | Retro-inverted peptides analogues of Bradykinin Potentiator BPP5a Retro-inverted peptides, analogues of Bradykinin Potentiator Pentapeptide (BPP5a), definable by the general formula (I) ##STR1## useful as antihypertensives and diagnostics.... | 03/01/1988 |
| 4727036 | Antibodies for use in determining hemoglobin A1c Monoclonal antibodies specific for the glucosylated N-terminal peptide residue in Hb A1c, a method for producing such antibodies, hybridoma cell lines secreting such antibodies and a method for their production, and immunoassay methods and reag... | 02/23/1988 |
| 4719289 | Glycopeptides, process for their preparation and their use Compounds of the general formula I, II or III are described, in which R1 is a hydrogen atom, an alkoxycarbonyl or arylalkoxycarbonyl group conventionally used for protecting amino groups, or CH3 --(CH2)m --CO, in whi... | 01/12/1988 |
| 4719288 | Substituted 5-amino-4-hydroxyvaleryl derivatives Compounds of the formula ##STR1## in which R1 represents hydrogen or acyl, X1 represents an optionally N-alkylated amino acid residue that is bonded N-terminally to R1 and C-terminally to X2, X2 ... | 01/12/1988 |
| 4694070 | Water soluble xanthylium derivatives substrates Water soluble xanthylium derivative substrates of rhodamine 110 and rhodol permit spectrophotometric and fluorescent measurements of trypsin-like enzymes without the addition of organic solvent additives and/or special water solubilizing agents. These nov... | 09/15/1987 |
| 4692437 | Anti-hypertensive agents Inhibitors of angiotensin converting enzyme which are physiologically acceptable salts of compounds which have the formula: ##STR1## wherein R is hydrogen, formyl, acetyl, propanoyl, butanoyl, phenylacetyl, phenylpropanoyl, benzoyl, cyclopentanecarbo... | 09/08/1987 |
| 4668661 | Sleep inducing agents A compound capable of inducing sleep in mammals comprising a peptidoglycan monomer obtained by lysozyme digestion of linear non-crosslinked peptidoglycan polymer chains present in culture fluids of penicillin-treated Brevibacterium divaricatum mutant NRRL... | 05/26/1987 |
