...that the Band-Aid Bandage was invented by a Johnson & Johnson employee whose wife had cut herself? Earl Dickson's wife was rather accident prone, so he set out to develop a bandage that she could apply without help. He placed a small piece of gauze in the center of a small piece of surgical tape, and what we know today as the Band Aid bandage was born!
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| Number | Title | Issue Date |
| 7001982 | Non-natural C-linked carbo-β-peptides with robust secondary structures Nonnatural C-linked carbo-β-peptides with robust secondary structures, which involves the synthesis of a new class of β-peptides called C-linked carbo-β-peptides. The compounds are favorably disposed for the formation of stable helical structures and are useful a... | 02/21/2006 |
| 6908619 | Camp factor of streptococcus uberis The CAMP factor gene of Streptococcus uberis (S. uberis) is described, as well as the recombinant production of CAMP factor therefrom. CAMP factors can be used in vaccine compositions for the prevention and treatment of bacterial infections. ... | 06/21/2005 |
| 6790448 | Surface proteins from gram-positive bacteria having highly conserved motifs and antibodies that recognize them Isolated peptide sequences and proteins containing these sequences are provided which are useful in the prevention and treatment of infection caused by Gram-positive bacteria. The peptide sequences have been shown to be highly conserved motifs in the surface protein... | 09/14/2004 |
| 5773574 | Polypeptides for promoting cell attachment Novel polypeptides derived from human fibronectin are described which bind to integrin receptors expressed by cells. The receptor binding site of human fibronectin begins at amino acid residue 1394 and ends at residue 1400 of fibronectin. The polypeptides... | 06/30/1998 |
| 5674977 | Branched synthetic peptide conjugate The invention is a branched synthetic peptide conjugate which can be designed to bind to a target cell surface receptor, to penetrate into target cells, and to deliver a diagnostic probe or cytotoxic functionality to a desired site of action. The inventio... | 10/07/1997 |
| 5633230 | Treatment of cytomegalovirus infection Described herein are anti-cytomegalovirus peptides. In a preferred embodiment, the peptide is acetyl-[D-Arg]9 -NH2. The use of these peptides, either per se or in combination with other anti-CMV compounds, is disclosed as an effectiv... | 05/27/1997 |
| 5512660 | Purified ICAM-2 and fragment thereof The present invention relates to intercellular adhesion molecules (ICAM-2) which are involved in the process through which lymphocytes recognize and migrate to sites of inflammation as well as attach to cellular substrates during inflammation. The inventi... | 04/30/1996 |
| 5338724 | Antimicrobial proteins, compositions containing same and uses thereof The present invention provides a composition of matter useful as an antimicrobial agent. This composition of matter comprises at least two polypeptides selected from the group consisting of human polymorphonuclear leukocyte, polypeptides having on apparen... | 08/16/1994 |
| 5087561 | Humoral hypercalcemic factor antagonists modified at position 13 by biotin The present invention relates to the use of peptide analogues as inhibitors of their respective naturally occurring peptides. The structure of the peptide hormone analogues is exemplified by human humoral hypercalcemic factor (hHCF), wherein Lys13 | 02/11/1992 |
| 5087562 | Humoral hypercalcemic factor antagonists with modification at position 13 . . . The present invention relates to the use of peptide analogues as inhibitors of their respective naturally occurring peptides. The structure of the peptide hormone analogues is exemplified by human humoral hypercalcemic factor (hHCF), wherein Lys13 | 02/11/1992 |
| 4871716 | Magnetically responsive, hydrophilic microspheres for incorporation of therapeutic substances and methods of preparation thereof Novel magnetically responsive hydrophilic protein or polypeptide microspheres prepared by dispersing an aqueous solution or dispersion of protein or polypeptide and particulate magnetically responsive material in an organic solvent solution of a high mole... | 10/03/1989 |
| 4870055 | Segmented polypeptide bioelastomers to modulate elastic modulus A method of increasing the modulus of elasticity of a biopolymer is disclosed, which comprises incorporating a hexameric unit of the formula wherein A is a peptide-forming residue of L-alanine; P is a peptide-forming residue of L-proline; G is a peptide-forming res... | 09/26/1989 |
| 4867974 | Agent for preventing plant virus diseases Agent for preventing plant virus diseases such as tobacco mosaic viruses, potato viruses, cucumber mosaic viruses, etc. of this invention is obtained from a new agent containing polylysine as an active component. Polylysine can be used -polylysine ... | 09/19/1989 |
| 4868287 | Inhibition of mineral deposition by polyanionic/hydrophobic peptides and derivatives thereof having a clustered block copolymer structure A poly-amino acid compound capable of inhibiting mineral deposition, which has the structure: where each X is a residue independently selected from the group consisting of aspartic acid, glutamic acid, phosphoserine, phosphohomoserine, phosphotyrosine, an... | 09/19/1989 |
| 4863900 | Method for reducing viral transmission with poly-L-histidine A composition for reducing the transmissability of viral infection from a subject infected therewith which comprises a topically applicable, pharmaceutically acceptable carrier and a viricidally effective amount of a polypeptide of between 24 and 500 amin... | 09/05/1989 |
| 4808702 | Decapeptides produced from bioadhesive polyphenolic proteins Methods are described for the preparation and isolation of novel decapeptides of the formula: ##STR1## wherein each X is independently selected from the group comprising hydroxyl and hydrogen, wherein each R is independently selected from the gr... | 02/28/1989 |
| 4783523 | Temperature correlated force and structure development of elastin polytetrapeptides and polypentapeptides A bioelastomer containing elastomeric units comprising tetrapeptide, or pentapeptide or units thereof modified by hexapeptide repeating units and mixtures thereof, wherein said repeating units comprise amino acid residues selected from the group consistin... | 11/08/1988 |
| 4757364 | Light emitting element A light emitting element formed of a metal-insulator-semiconductor junction, the improvement wherein the insulator is a Langmuir-Blodgett film of an organic substance containing at least one of a synthetic protein and a natural protein. According to the e... | 07/12/1988 |
| 4755462 | Analytical process and agents for the detection of esterolytic and/or proteolytic enzymes Agent for the detection of esterolytic and/or proteolytic enzymes, containing (a) an amino acid ester or peptide ester of a phenol, as the chromogenic enzyme substrate, and (b) a substance which accelerates the enzymatic cleavage of the amino acid ester o... | 07/05/1988 |
| 4728639 | Type-specific opsonic antibodies evoked with a synthetic peptide of streptococcal M protein conjugated to polylysine without adjuvant A polypeptide having the formula Asn-Phe-Ser-Thr-Ala-Asp-Ser-Ala-Lys-Ile-Lys-Thr-Leu-Glu-Ala-Glu-Lys-Ala-Al a-Leu-Ala-Ala-Arg-Lys-Ala-Asp-Leu-Glu-Lys-Ala-Leu-Glu-Gly-Ala-Met is conjugated to polylysine.... | 03/01/1988 |
| 4722899 | Producing highly specific, low cross-reactive antibody by immunizing with copolymer of D-glutamic acid and lysine A process for producing an antibody having a high specificity to a first antigen and a low cross-reactivity with at least one second antigen, said first antigen comprising a desired antigenic determinant and said second antigen comprising at least one ant... | 02/02/1988 |
| 4713366 | Antigenic modification of polypeptides Endogenous and exogenous proteins, and fragments thereof, are chemically modified outside the body of an animal so that when injected into the animal they produce more antibodies against the unmodified protein than would injection of the unmodified protei... | 12/15/1987 |
| 4707357 | Immunologically active peptides capable of inducing immunization against malaria and genes encoding therefor An immunologically active substantially pure peptide capable of inducing in human an immune response which is cross reactive with and protective against infection by a malaria parasite, wherein the peptide contains at least 2 consecutive repeats of a sequ... | 11/17/1987 |
| 4696286 | Coated transplants and method for making same Transplants, such as pancreatic islets, are made suitable for transplantation into a genetically dissimilar individual by coating the transplant with a surface-conforming bonding bridge layer of a multifunctional material that binds chemically to a surfac... | 09/29/1987 |
| 4680338 | Bifunctional linker A selective bifunctional sequential linker has the formula wherein Q is a homoaromatic or heteroaromatic ring system; A is a single bond or an unsubstituted or substituted divalent C1-30 bridging group; Y is O or S; and Z is Cl, Br, I, N3... | 07/14/1987 |
| 4675381 | Biodegradable polypeptide and its use for the gradual release of drugs Biodegradable acyloxymethyl polyaspartate and polyglutamate as drug carrier in an encapsulated or incorporated state in the matrix of the copolymer. The polypeptide loaded in this way decomposes enzymatically in the organ where it has been placed and thus... | 06/23/1987 |
| 4673566 | Microencapsulation of living tissue and cells Living tissue or cells, for example, islets of Langerhans, are microencapsulated for implantation in the body for long term treatment of diabetes or other disease requiring organ transplantation. The microcapsules take the form of a biocompatible semi-per... | 06/16/1987 |
| 4639456 | Vinblastin-23-oyl amino acid derivatives Vinblastine derivatives of the formula ##STR1## wherein R1 is an ester of a -aminoacid selected from the group consisting of glycine, alanine, valine, leucine, isoleucine, serine, threonine, aspartic acid, glutamic acid, aspargine, ... | 01/27/1987 |
| 4638045 | Non-peptide polyamino acid bioerodible polymers A novel bioerodible polymeric composition is provided comprising a plurality of monomer units of two or three amino acids which are polymerized via hydrolytically labile bonds at their respective side chains rather than at the amino or carboxylic acid ter... | 01/20/1987 |
| 4605413 | Stimulation of chemotaxis by chemotactic peptides A method of stimulating chemotaxis toward a prosthetic device is disclosed, which method comprises incorporating a chemotactic peptide of the formula wherein A is a peptide-forming residue of L-alanine; P is a peptide-forming residue of L-proline; G is a peptide-fo... | 08/12/1986 |
| 4587046 | Drug-carrier conjugates Biologically active drugs, e.g. catecholamine hormones, are coupled to carrier molecules, e.g. monodisperse peptides to produce conjugate molecules. The conjugate molecules retain biological activity, but the pharmacokinetic, pharmacodynamic and/or potenc... | 05/06/1986 |
| 4534881 | Inhibition of inorganic or biological CaCO3 deposition by poly amino acid derivatives The present invention relates to a method of inhibiting the formation of CaCO3 -containing deposits on a surface by applying a composition comprising an anti calcification-effective amount of a poly amino acid, a poly amino acid amide or deriva... | 08/13/1985 |
| 4526888 | Nephrotoxicity inhibitors for aminoglycoside antibiotics This invention relates to the conjoint use of asparagine or aspartic acid polymers, e.g. poly-l-asparagine or poly-l-aspartic acid polymers, or copolymers thereof, with aminoglycoside antibiotics to inhibit the nephrotoxicity associated with aminoglycosid... | 07/02/1985 |
| 4500700 | Elastomeric composite material comprising a polypentapeptide having an amino acid of opposite chirality in position three An elastomeric material comprising an elastomeric polypeptide, where the polypeptide comprises pentapeptide repeating units formed of amino acid residues selected from the group consisting of hydrophobic amino acid and glycine residues where the third ami... | 02/19/1985 |
| 4485039 | Synthetic analogues of -melanotropin Cyclic analogues of the tridecapeptide hormone, -melanotropin. (-melanocyte stimulating hormone, -MSH), wherein a physiologically stable intramolecular interaction exists (1) between the amino acid residue at position 4 and an amino a... | 11/27/1984 |
| 4474757 | Synthetic vaccine and process for producing same There is provided a synthetic vaccine against influenza virus infections consisting of a synthetic peptide corresponding to a relevant antigenic fragment of the virus, which fragment is attached to a suitable carrier, such as a macromolecule. Effective va... | 10/02/1984 |
| 4454121 | Synthetic peptides corresponding to antigenic determinants of the M protein of Streptococcus pyogenes Synthetic peptides corresponding to antigenic determinants of the M protein of streptococcus pyogenes are disclosed. These peptides are useful for vaccination against streptococcus pyogenes bacteria.... | 06/12/1984 |
| 4427582 | Antimicrobial disulfide prodrugs A series of prodrugs is described which have improved antimicrobial activity and physico-chemical properties. The structures of the biologically active ingredients are characterized by having a selected oligopeptide backbone attached, via the -carb... | 01/24/1984 |
| 4427660 | Formyl-methionyl chemotatic peptide antibiotic conjugates useful in treating infections A group of synthetic N-formyl methionine tri and tetra peptides in covalent combination with antibiotics are useful in treating infections. These peptideantibiotic conjugates exhibit a high degree of chemotactic activity for polymorphonuclear leukocytes a... | 01/24/1984 |
| 4415492 | Lysine polymers which may be used as supports for the preparation of products of diagnosis and products obtained The present invention relates to lysine polymers of one of the following formulae: ##STR1## in which n is a whole number from 8 to 20 and n' a whole number from 4 to 10, to their process of preparation and to their use for the preparation of pro... | 11/15/1983 |