Did You Know...
...that the video game, Pong, was invented by a guy who graduated at the bottom of his engineering class? Nolan Bushnell spent more time running the games at a local amusement park than he did on his studies at the University of Utah. His dreams of working for Disney's amusement empire were dashed when the company wouldn't hire him. Taking a boring job, Nolan daydreamed about electronic versions of popular games. He invented Pong, the first video game, and went on to found Atari Co.
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| Number | Title | Issue Date |
| 6248574 | Polypeptides selectively reactive with antibodies against human immunodeficiency virus and vaccines comprising the polypeptides Highly conserved polypeptide sequences derived from gp41 and gp120, preferably from eleven to twenty-one amino acids in length, are joined (for example, via DNA recombinant techniques) to a non-HIV protein or polypeptide sequence comprising an amino-acid ... | 06/19/2001 |
| 6013506 | Feline leukemia virus vaccines Disclosed are recombinant baculovirus expressing the gag, gp70, and gp85 genes of feline leukemia virus. Also disclosed are vaccines based on protein expressed from these recombinants. Also disclosed is a combined mucosal/parenteral inoculation method.... | 01/11/2000 |
| 5801056 | Nucleic acid encoding HIV-1 tat protein Nucleic acid encoding a functional HTLV-III/LAV (HIV-1) protein having trans-activating ability, and expression vectors comprising this nucleic acid are described.... | 09/01/1998 |
| 5747324 | Self-assembled, defective, non-self-propagating lentivirus particles The present invention provides recombinant DNA viral vectors which co-express lentivirus genes encoding structural and enzymatic polypeptides capable of assembling into defective nonself-propagating viral particles. The viral DNA vectors as well as the vi... | 05/05/1998 |
| 5736391 | HIV gp41 mutants Nucleic acid constructs encoding mutated human immunodeficiency virus gp41 polypeptides are described. The mutated polypeptides are effective to disrupt viral replication of HIV or disrupt the assembly of viral Env proteins in an HIV infected cell.... | 04/07/1998 |
| 5707864 | Nucleic acids encoding mutated human immunodeficiency virus matrix proteins Nucleic acid constructs encoding mutated human immunodeficiency virus matrix proteins are described. The mutated proteins lower the incorporation of envelope polypeptides in viral particles, disrupt viral assembly or disrupt viral entry into uninfected ce... | 01/13/1998 |
| 5637488 | HIV protease gene and method for its expression The invention is a synthetic DNA sequence for encoding a specific enzyme or protease. The protease is essential for the completion (replication) of an infective human immunodeficiency virus (HIV). The invented gene is desirable for the expression of the p... | 06/10/1997 |
| 5631154 | Self assembled, defective, non-self-propagating lentivirus particles Recombinant avipox viral vectors which express heterologous polypeptides capable of assembling into defective nonself-propagating viral particles are disclosed. The recombinant avipox viruses can be used to produce significant amounts of the heterologous ... | 05/20/1997 |
| 5622703 | Immunodominant sites of HTLV-I envelope protein The invention relates to peptides representing CTL epitopes from the HTLV-I envelope protein. The invention further relates to compositions, comprising the peptides, for priming a T-cell response in a subject. Furthermore, methods for priming a T-cell res... | 04/22/1997 |
| 5614404 | Self-assembled, defective, non-self-propagating lentivirus particles Recombinant viral vectors which coexpress heterologous polypeptides capable of assembling into defective nonself-propagating viral particles are disclosed. The viral vectors as well as the viral particles can be used as immunogens and for targeted deliver... | 03/25/1997 |
| 5519114 | Retroviral superantigens, superantigen peptides, and methods of use The subject invention concerns novel superantigen proteins and peptides and methods of use of these superantigens. Specifically exemplified are peptide agonists from mouse mammary tumor virus, feline immunodeficiency virus and human immunodeficiency virus... | 05/21/1996 |
| 5500355 | Protease, reverse transcriptase and endonuclease of HIV-1 and RSV method for producing these enzymes Disclosed is a method for producing retroviral proteins which are protease, everse transcriptase and endonuclease. The method is characterized by the consecutive expression and processing of retroviral genes by the stepwise cultivation of hosts transformed... | 03/19/1996 |
| 5482708 | Fusion protein from feline leukaemia virus GP70 as vaccine A vaccine against feline leukaemia virus (FeLV) comprises a protein formed of two proteins derived from FeLV gp70 which are not adjacent in the native protein, particularly VR1 and VR5 and effective fragments thereof. VR5 is preferably attached to the car... | 01/09/1996 |
| 5420026 | Self-assembling replication defective hybrid virus particles The invention pertains to self-assembled replication defective hybrid virus-like particles having capsid and membrane glycoproteins from at least two different virus types and method of making same. Recombinant viral vectors as well as the viral particles... | 05/30/1995 |
| 5374518 | Monoclonal antibody for differentiating HIV-2 from HIM-1 seropositive individuals A mouse monoclonal antibody is provided which detects HIV-2 seropositive individuals and differentiates them from HIV-1 seropositive individuals. The monoclonal antibody is specific for an epitope of HIV-2 gp41 which lies outside the characterized immunod... | 12/20/1994 |
| 5364757 | Methods of supporting a diagnosis of systemic lupus erythematosus The present invention relates to the discovery of a novel retroviral particle associated with autoimmune disease. New methods of diagnosis and treatment of autoimmune disease, novel cell lines comprising the new retrovirus, assay systems that may be used ... | 11/15/1994 |
| 5356772 | Process for preparing an improved western blot immunoassay The present invention encompasses an improved immunoassay method which involves the simultaneous transfer of multiple antigens onto a single solid support. The antigens which may be utilized by this method may be either naturally or recombinantly produced... | 10/18/1994 |
| 5352576 | Method of determining the presence and titers of anti HIV-1 ag27bodies Disclosed is a method for determining the presence in mammalian serum of antibodies against specific strains of HIV through the use of SP-10 peptides. The method incorporates the use of SP-10 peptides derived from the following HIV strains: IIIB, MN, RF, ... | 10/04/1994 |
| 5350835 | Cellular nucleic acid binding protein and uses thereof in regulating gene expression and in the treatment of aids The invention relates to a cellular protein which is specific and has high affinity for nucleic acid sequences characteristic of an intact TAR RNA loop sequence of the HIV LTR TAR region. The invention also relates to a between 1,000-10,000-fold purified,... | 09/27/1994 |
| 5344774 | Human intracisternal A-type retroviral particles associated with sjogren's syndrome The present invention relates to purified preparations of a novel retrovirus, to methods of diagnosis and treatment of Sjogren's syndrome, novel cell lines, and model systems for the study of autoimmune diseases and AIDS. It is based, in part, on the disc... | 09/06/1994 |
| 5328835 | Expression of immunologically reactive HIV envelope proteins A method for expressing proteins which are immunologically reactive with antibodies to lymphadenopathy-associated virus (LAV), now known as Human Immunodeficiency Virus (HIV), is disclosed. The proteins are produced by bacterial host cells transformed wit... | 07/12/1994 |
| 5320940 | Methods and compositions for identifying and characterizing individuals having autoimmune rheumatic diseases Diagnostic assays wherein sera from a patient suspected of having an ill defined autoimmune rheumatic disease is reacted with antigens specific to the human immunodeficiency virus (HIV) core proteins (gag protein products p24 or p17) and envelope proteins... | 06/14/1994 |
| 5321124 | Art (rev) protein of human T-cell leukemia virus A gene and gene product that regulates the expression of the capsidal envelope genes of HTLV-III/LAV and that can be used to regulate the expression of heterologous (non-viral) genes as well is disclosed. This art gene consists of two exons and can be use... | 06/14/1994 |
| 5312902 | Dimer of the precursor of HIV-2 envelope glycoprotein Four glycoproteins of apparent molecular weights 300,000, 140,000, 125,000, and 36,000 (gp300, gp140, gp125, and gp36) are detectable in human immunodeficiency virus type 2 (HIV-2) infected cells. The gp125 and gp36 are the external and transmembrane comp... | 05/17/1994 |
| 5260189 | Synthetic HIV-like peptides their compositions and uses Highly immunoreactive regions of gp41 of HIV-1, gp32 of HIV-2 and p24 of HIV-1 were identified using synthetic peptides. Superior immunoassay performance is obtained with these peptides linked to carrier proteins as compared to use of the free peptides. A... | 11/09/1993 |
| 5256554 | Expression of human immunodeficiency virus (HIV) reverse transcriptase This invention describes pHRT25, a plasmid containing a modified pol gene of the Human Immunodeficiency Virus Type 1 (HIV-1), formerly HTLV-III, under control of an inducible trp promoter. Methods of expressing reverse transcriptase activity using pHRT25 ... | 10/26/1993 |
| 5229490 | Multiple antigen peptide system Multiple antigen peptide systems are described in which a large number of antigens are bound to the functional groups of a dendritic core molecule providing a high concentration of antigen in a low molecular volume. The products are useful for producing c... | 07/20/1993 |
| 5223423 | Characterization of replication competent human immunodeficiency type 2 proviral clone HIV-2SBL/ISY A complete genomic clone of HIV-2 designated HIV-2SBL/ISY was cloned from DNA of the neoplastic human cell line HUT78 infected with the HIV-2SBL6669 viral isolate. The clone was sequenced and the sequence compared with those of known... | 06/29/1993 |
| 5217861 | Antigen of a human retrovirus, namely p18 protein of human immunodeficiency virus (HIV), compositions containing the antigen, a diagnostic method for detecting acquired immune deficiency syndrome (AIDS) and pre-AIDS and a kit therefor Protein compositions containing proteins of the lymphadenopathy virus, which compositions are used for diagnosis of antibodies of such protein in biological fluids, especially blood serum, for the detection or absence of infection. Such compositions conta... | 06/08/1993 |
| 5210181 | T-lymphotropic retrovirus peptide The instant invention relates to monoclonal antibodies, the cell lines producing those antibodies, the peptides that comprise the epitopes of those antibodies and assays using those antibodies and peptides for the detection of HIV-1 and HIV-2 gene product... | 05/11/1993 |
| 5204259 | Methods and systems for producing HIV antigens The present invention relates to a DNA segment encoding a recombinant HIV p24 protein or HIV p24-gp41 fusion protein and a recombinant DNA (rDNA) molecule capable of expressing either protein. Cells transformed with the rDNA, methods for producing the fus... | 04/20/1993 |
| 5204258 | Gene expressing VPT protein and vectors expressing this protein Viral protein T from Human Immunodeficiency Virus Type 1 (HIV-1) is disclosed. The protein has a molecular weight of approximately 17 kD and is produced by the vpt gene of HIV-1. This protein is antigenic. Vectors capable of expressing the vpt protein are... | 04/20/1993 |
| 5185147 | Short polypeptide sequences useful in the production and detection of antibodies against human immunodeficiency virus Polypeptides in the size range 6-11 amino acids from discrete regions of the human immunodeficiency virus p17 protein are immunogenic and form the basis for diagnosis and therapy of HIV-related disease.... | 02/09/1993 |
| 5169763 | Viral vector coding glycoprotein of HIV-1 A viral vector comprising at least a portion of the genome of the HIV virus, a gene coding gp160 glycoprotein of the envelope of the HIV virus, as well as the elements providing for the expression of the glycoprotein in cells, wherein the gp160 is express... | 12/08/1992 |
| 5142025 | Recombinant HTLV-III proteins and uses thereof Novel recombinant HTLV-III fusion proteins denoted R10, PB1, 590, KH1, and the HIV portion of each of these proteins are useful in the diagnosis, prophylaxis or therapy of AIDS. Protein R10 is a 95 kD fusion protein; protein PB1 is a 26 kD fusion protein;... | 08/25/1992 |
| 5110906 | Derivatives of soluble T-4 This invention provides a therapeutic agent capable of specifically forming a complex with human immunodeficiency virus envelope glycoprotein which comprises a polypeptide. In one embodiment of the invention, the amino acid sequence of the polypeptide com... | 05/05/1992 |
| 5075211 | Synthetic antigen for the detection of AIDS-related disease Novel peptides are provided having substantially the same sequence as immunologically significant fragments of AIDS-related viruses. The polypeptides can be used as reagents in the determination of exposure of a human host to the virus. Of particular inte... | 12/24/1991 |
| 5051496 | Peptides related to human immunodeficiency virus II (HIV-2) A method for diagnosing an HIV-2 (LAV-II) infection and a kit containing reagents for the same is disclosed. These reagents include cDNA probes which are capable of hybridizing to at least a portion of the genome of HIV-2. In one embodiment, the DNA probe... | 09/24/1991 |
| 5030449 | Synthetic vaccine against AIDS virus The invention relates to peptide antigens which stimulate helper T lympocytes which specifically recognize HIV envelope protein, thereby enhancing antibody production and cytotoxic T cells to inhibit expression of an infection caused by HIV virus.... | 07/09/1991 |
| 4983387 | HIV related peptides, immunogenic antigens, and use therefor as subunit vaccine for AIDS virus Vaccines effective in the inhibition of infection caused by the family of retroviruses, HTLV-III, Human T-Cell Leukemia Virus, LAV, Lymphadenopathy-associated virus, ARV-2, AIDS-Related Virus, (AIDS and AIDS-Related Complex) have been developed from an an... | 01/08/1991 |
