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| Number | Title | Issue Date |
| 7129329 | Heme proteins hemAT-Hs and hemAT-Bs and their use in medicine and microsensors The present invention provides an isolated archael and bacterial heme binding protein which reversibly binds oxygen with a low affinity. The heme binding protein may be utilized as a blood substitute. The invention also provides a method for controlled storage of ox... | 10/31/2006 |
| 7118749 | Transferrin receptor genes Purified and isolated nucleic acid is provided which encodes a transferrin receptor protein of a strain of Haemophilus or a fragment or an analog of the transferrin receptor protein. The nucleic acid sequence may be used to produce peptides free of contaminan... | 10/10/2006 |
| 7115268 | Peptides useful for reducing symptoms of toxic shock syndrome and septic shock This invention relates to compositions and methods which provide protection against, or reduce the severity of toxic shock and septic shock from bacterial infections. More particularly it relates to peptides derived from homologous sequences of the family of staphyl... | 10/03/2006 |
| 6846667 | Virulence genes and proteins, and their use The present invention is based on the identification of a series of virulence genes in E. coli K1, the products of which may be implicated in the pathogenicity of the organisms. The identification of the genes allows them, or their expressed products, to be u... | 01/25/2005 |
| 6835818 | Mutants of Streptococcal toxin C and methods of use This invention is directed to mutant SPE-C toxins or fragments thereof, vaccine and pharmaceutical compositions, and methods of using the vaccine and pharmaceutical compositions. The preferred SPE-C toxin has at least one amino acid change and is substantially non-l... | 12/28/2004 |
| 6790448 | Surface proteins from gram-positive bacteria having highly conserved motifs and antibodies that recognize them Isolated peptide sequences and proteins containing these sequences are provided which are useful in the prevention and treatment of infection caused by Gram-positive bacteria. The peptide sequences have been shown to be highly conserved motifs in the surface protein... | 09/14/2004 |
| 6783764 | Actinobacillus pleuropneumoniae subunit vaccine The present invention relates to live attenuated bacteria of the genus Actinobacillus pleuropneumoniae that have a mutation in an apxIV gene such that no functional ApxIV toxin can be produced. The invention also relates to methods for the production of such ... | 08/31/2004 |
| 6774218 | Mutants of streptococcal toxin C and methods of use This invention is directed to mutant SPE-C toxins or fragments thereof, vaccine and pharmaceutical compositions, and methods of using the vaccine and pharmaceutical compositions. The preferred SPE-C toxin has at least one amino acid change and is substantially non-l... | 08/10/2004 |
| 6517844 | Compositions and method for immunizing polutry The present invention is directed to vaccine compositions and methods for immunizing poultry. The vaccine compositions comprise inactivated bacterial organisms which can be administered to the poultry through oral intake of water.... | 02/11/2003 |
| 6495661 | DNA encoding the outer membrane protein of Pasteurella multocida An isolated nucleic acid molecule encoding the outer membrane protein of Pasteurella multocida is provided. Also provided are methods to detect the presence of the nucleic acid molecule, and antibodies specific for the polypeptide encoded by the nucleic a... | 12/17/2002 |
| 6440424 | High molecular weight major outer membrane protein of moraxella An isolated and purified outer membrane protein of a Moraxella strain, particularly M. catarrhalis, has a molecular mass of about 200 kDa. The about 200 kDa outer membrane protein as well as nucleic acid molecules encoding the same are useful in diagnosti... | 08/27/2002 |
| 6406705 | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant The present invention relates generally to adjuvants, and in particular to methods and products utilizing a synergistic combination of immunostimulatory oligonucleotides having at least one unmethylated CpG dinucleotide (CpG ODN) and a non-nucleic acid ad... | 06/18/2002 |
| 6348446 | Method for selectively purging CD77+ cells from bone marrow or peripheral blood A method for the selective purging ex vivo of CD77 positive cells from bone marrow or peripheral blood containing stem cells prior to autologous transplantation is described. The method involves treating the bone marrow or blood sample with shiga toxin or... | 02/19/2002 |
| 6335424 | ribG The invention provides ribG polypeptides and polynucleotides encoding ribG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribG polypeptides to screen for antibacterial compounds.... | 01/01/2002 |
| 6326462 | RibH The invention provides ribH polypeptides and polynucleotides encoding ribH polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribH polypeptides to screen for antibacterial compounds.... | 12/04/2001 |
| 6287566 | Protective peptides neurotoxin of C. botulinum Methods for developing vaccines to protect from neurotoxins of C. botulinum have been developed. Truncated BoNT/A proteins of about 15-30 kDa in size produced immune responses that provided protection from neuronal damage by botulinum neurotoxins.... | 09/11/2001 |
| 6262235 | Leptospiral outer membranes protein, LipL46 An antigenic preparation is provided containing an outer membrane protein associated with pathogenic strains of Leptospira. The protein has been designated "LipL46" for "lipoprotein from Leptospira" and because the isolated polypeptide migrates to a posit... | 07/17/2001 |
| 6160093 | Compounds and methods for treatment and diagnosis of mycobacterial infections The present invention provides polypeptides comprising an immunogenic portion of a M. vaccae protein and DNA molecules encoding such polypeptides, together with methods for their use in the diagnosis and treatment of mycobacterial infection. Methods for e... | 12/12/2000 |
| 5985654 | Recombinant poxvirus and streptococcal M protein vaccine Viruses of the family poxviridae such as vaccinia or fowlpox viruses are modified to contain a gene which expresses a protein corresponding to the conserved exposed region of the M6 protein. The modified products are useful as vaccines against streptococc... | 11/16/1999 |
| 5948889 | Compositions and methods for screening antimicrobials A method for screening compounds for antimicrobial activity is described that utilizes bacterial protein-protein binding in vitro. The method may be performed using immobilized elements and the immobilization may be carried out using a variety of immobili... | 09/07/1999 |
| 5871742 | Recombinant Avipox virus encoding polypeptide of mycoplasma gallisepticum, and utilized a live vaccine A polypeptide exhibiting the antigenicity of Mycoplasma gallisepticum, a fused polypeptide comprising the above polypeptide and, connected to the N-terminus thereof, a signal membrane anchor of a type II outer-membrane polypeptide of a virus that infects ... | 02/16/1999 |
| 5854395 | Cloned borrelia burgdorferi virulence protein The present invention provides EppA polypeptide, a Borrelia burgdorferi virulence protein. This 17-kD outer membrane protein has been designated EppA for exported plasmid protein A.... | 12/29/1998 |
| 5840846 | Fibronectin binding protein as well as its preparation The present invention relates to a new recombinant hybrid-DNA-molecule comprising a nucleotide sequence from S. aureus coding for a protein, or polypeptide, having fibronectin binding properties.... | 11/24/1998 |
| 5804190 | Recombinant vaccine for porcine pleuropneumonia This invention discloses the DNA sequences coding for the Actinobacillus pleuropneumonia hemolysin(s). It further discloses a method of producing the A. pleuropneumoniae hemolysin(s) from recombinant cells. It also provides a method of using the hemolysin... | 09/08/1998 |
| 5801145 | Method for selectively purging CD77+ cells from bone marrow A method for the selective purging ex vivo of CD77 positive cells from bone marrow prior to autologous transplantation is described. The method involves treating the bone marrow with shiga toxin or shiga-like toxin-1 to kill CD77+ cells or to r... | 09/01/1998 |
| 5696232 | Listeria monocytogenes specific proteins, and uses thereof The present invention is directed to Listeria monocytogenes specific protein that is encoded by nucleotide sequence of FIG. 1, the complementary sequence of which hybridizes to the nucleotide sequence of FIG. 1 at 5-6x SSC and 42°-60° C. A Listeria mono... | 12/09/1997 |
| 5670365 | Identification of, and uses for, nematicidal bacillus thuringiensis genes, toxins, and isolates Disclosed and claimed are novel nucleotide primers for the identification of genes encoding toxins active against nematodes and coleopterans. The primers are useful in PCR techniques to produce gene fragments which are characteristic of genes encoding the... | 09/23/1997 |
| 5652217 | Fibronectin binding protein The present invention relates to a new recombinant hybrid-DNA-molecule comprising a nucleotide sequence from S. aureus coding for a protein, or polypeptide, having fibronectin binding properties.... | 07/29/1997 |
| 5643754 | Nucleic acids encoding a leptospira outer membrane protein An antigenic preparation is provided which contains a 63 Kd outer membrane protein from Leptospira which can be used immunologically as a vaccine for leptospirosis caused by this organism. Also provided in the invention are polynucleotides encoding the pr... | 07/01/1997 |
| 5606022 | Cloning and identification of a two component signal transducing regulatory system from Bacteroides fragilis This invention relates to a purified isolated DNA fragment of Bacteroides fragilis comprising a sequence for an operon containing two genes designated rprX and rprY. These genes encode two signal transducing regulatory proteins designated RprX and RprY. T... | 02/25/1997 |
| 5602095 | Recombinant pseudomonas exotoxin with increased activity This invention relates to the production and use of recombinant Pseudomonas-derived toxins modified to increase their toxicity and potency in therapy. More particularly, the invention relates to certain deletions in domain II of the amino acid sequence of... | 02/11/1997 |
| 5601826 | Peptide which produces protective immunity against tetanus The invention provides an immunogen against tetanus toxin including a peptide having a single, linear, antigenic, tetanus-toxin-specific epitope. The epitope is derived from the heavy chain C fragment of the toxin. In a preferred embodiment, the immunogen... | 02/11/1997 |
| 5489430 | Poultry mycoplasma antigen, gene thereof and recombinant vectors containing the gene as well as vaccines utilizing the same A highly effective vaccine for Mycoplasma gallisepticum infection utilizing a substantially pure protein capable of reacting with Mycoplasma gallisepticum immunized serum or Mycoplasma gallisepticum infected serum, having a molecular weight of about 40 ki... | 02/06/1996 |
| 5397695 | Attachment of compounds to polymeric particles using carbamoylonium compounds and a kit containing same Useful materials for diagnostic tests, affinity chromatography, enzymatic reactions and immunoassays are prepared by covalently attaching reactive compounds containing reactive amino or sulfhydryl groups to polymeric particles having pendant carboxyl grou... | 03/14/1995 |
| 5348940 | Cyclohexapeptidyl hydroxypropionitrile compounds Certain propionitrile compounds which have a cyclohexapeptidyl nucleus and which are found to have antibiotic activity with physical properties suitable for use in therapeutic compositions are described. A novel process for their preparation is also descr... | 09/20/1994 |
| 5308835 | Production of the E. coli LT-B enterotoxin subunit Methods and compositions are provided for the cloning and expression of genes coding for the non-toxic subunit of the heat-labile enterotoxin (LT-B) of E. coli. The LT-B thus produced may be formulated for use as an immunogen in vaccines. Specific antibod... | 05/03/1994 |
| 5300629 | Bactericidal and/or bacteriostatic peptides isolated from hemolymph of honeybees New bactericidal and/or bacteriostatic, thermostable peptides which are isolated from hemolymph of immune honeybees and which are distinct from lysozymes, attacins, cecropins, diptericins and magainins. The peptides feature at least the 10 C-terminal amin... | 04/05/1994 |
| 5238821 | Endo F-free PNGase An enzyme sample having Peptide-N4 -(N-acetyl-ଲ-N-glucosaminyl) asparagine Aminidase F (PNGase F) activity completely free from Endo-ଲ-N-acetylglucosaminidase F (Endo F) activity.... | 08/24/1993 |
| 5225193 | Bordetella toxin peptides and vaccines The following new polypeptides are described: (a) H-X1 -Asp-Asp-Pro-Pro-Ala-Thr-Val-Tyr-Arg-Tyr-Asp-Ser-Arg-Pro-Pro-Glu-Asp-X.sup .2 -Y, (b) H-X1 -Ser-Glu-Tyr-Leu-Ala-His-Arg-Arg-Ile-Pro-Pro-Glu-Asn-Ile-Arg-Arg-Val-Thr-A rg-Val-X | 07/06/1993 |
| 5196512 | Synthetic peptides useful as universal carriers for the preparation of immunogenic conjugates and their use in the development of synthetic vaccines The synthetic peptide TT3, the amino acid sequence of which corresponds to the region 947-967 of the tetanus toxin is recognized by different human Th cell clones in association with a wide range of alleles of the human major histocompatibility complex (M... | 03/23/1993 |
