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Penn Jillette of Penn and Teller fame has patented a "Hydro-Therapeutic Stimulator", which uses a hot tub for stimulation.
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| Number | Title | Issue Date |
| 7402407 | Chemically targeted positional identification of post-translationally phosphorylated peptides Methods are provided for determining the position of a post-translationally modified (PTM) amino acid residue such as a phosphorylated amino acid residue or an O-glycosylated amino acid residue in a peptide. Also provided are methods for determining the identity of ... | 07/22/2008 |
| 7176292 | Ghrelin variant protein The present invention concerns a protein produced from an alternative splice form of the human Ghrelin gene, an obesity and/or diabetes related gene. ... | 02/13/2007 |
| 7125842 | Anti-fungal compounds and methods of use The invention relates to compounds including peptides and peptidomimetics having anti-fungal activity alone, and in combination with other agents that have anti-fungal activity. The invention includes the use of cell cycle G2 checkpoint abrogators as anti-fungal age... | 10/24/2006 |
| 7115562 | Peptides and their use to ameliorate cell death The present invention relates to a method of reducing cell death in a warm-blood animal wherein said cell death associated with a neurodegenerative disorder, an immune disease, a neoplastic disorder, an inflammatory disorder, or a viral disease. The method comprises... | 10/03/2006 |
| 6995135 | Peptides and peptidomimetics having anti-proliferative activity and/or that augment nucleic acid damaging agents or treatments This invention provides compounds including peptides and peptidomimetics that can be used to treat cell proliferative disorders, such as those associated with benign and malignant tumor cells. While the invention is not limited to any particular mechanism, the compo... | 02/07/2006 |
| 6943233 | Cyclic peptides and aids vaccines Cyclic peptides which comprise, as a constituent chain or chains thereof, one or two amino acid sequences selected from the amino acid sequence Asn-Val-Ser-Glu-Ala-Asp-Asp-Arg-Tyr-Ile and the amino acid sequence Arg-Ser-Gln-Lys-Glu-Gly-Leu-His-Tyr-Thr, and AIDS vacc... | 09/13/2005 |
| 6887845 | Polypeptoid pulmonary surfactants The present invention provides spreading agents based on sequence-specific oligomers comprising a peptoid, a peptide-peptoid chimera, a retropeptoid or a retro(peptoid-peptide) chimera, and methods for using the same, including for the treatment of respiratory distr... | 05/03/2005 |
| 6841532 | Peptides and their use to ameliorate cell death There is disclosed novel peptides, fragments or analogues thereof and polynucleotides encoding the same, obtained from streptokinase suitable for use in the amelioration of cell death and methods related thereto. ... | 01/11/2005 |
| 6790448 | Surface proteins from gram-positive bacteria having highly conserved motifs and antibodies that recognize them Isolated peptide sequences and proteins containing these sequences are provided which are useful in the prevention and treatment of infection caused by Gram-positive bacteria. The peptide sequences have been shown to be highly conserved motifs in the surface protein... | 09/14/2004 |
| 6762280 | High throughput assays for the proteotytic activities of clostridial neurotoxins In this application is described substrates for high-throughput assays of clostridial neurotoxin proteolytic activities. Two types of substrates are described for use in assays for the proteolytic activities of clostridial neurotoxins: (1) modified peptides or prote... | 07/13/2004 |
| 6414114 | Disulfides and thiol compounds The present invention is directed to novel disulfides and thiols that are of up to about eighteen amino acids. One example, is a compound of the formula (1): A--B--C--S--S--D--E--F, wherein: A and F are selected from the group consisting of hydrogen, an a... | 07/02/2002 |
| 6306663 | Controlling protein levels in eucaryotic organisms The invention relates to novel compounds comprising a ubiquitination recognition element and a protein binding element. The invention also relates to the use of said compounds for modulating the level and/or activity of a target protein. The compounds are... | 10/23/2001 |
| 5998580 | Photosensitive caged macromolecules Disclosed is a method for preparing a photosensitive peptide which is capable of being activated or deactivated in a biological system, including the steps of: (a) providing an amino acid including a photolabile molecule; and (b) incorporating the amino a... | 12/07/1999 |
| 5968904 | Modified arginine containing lytic peptides and method of making the same by glyoxylation A non-neurotoxin, arginine residue-containing non-naturally occurring lytic peptide comprising a sequence of amino acid residues in sufficient number and arrangement to confer lytic activity to the peptide, wherein the guanido groups of the arginine resid... | 10/19/1999 |
| 5965699 | Assay for the proteolytic activity of serotype a from clostridium botulinum A label-based assay is described, through modifications of substrate strure and derivatization of serum albumin, which can be used to determine type A proteolytic activity without separation of products.... | 10/12/1999 |
| 5792466 | Mimetic insect kinin analogs for insect control Novel pseudopeptide analogs of the insect kinin neuropeptide family which possess biological activity mimicking that of the naturally occurring neuropeptides are disclosed. By substituting a sterically hindered amino acid which is compatible with a turn c... | 08/11/1998 |
| 5714467 | Antibacterial and antimalarial hybrid peptides The invention relates to antibacterial and antimalarial peptides which are hybrids peptides which a of naturally occurring peptides such as cecropins, attacins, magainins, sarcotoxin, sapecin, bactenecins, alamethidicins, defensins and PGLa, and toxins su... | 02/03/1998 |
| 5643877 | Compounds comprising gonadotropin releasing hormone (GnRH) and methods for controlling reproduction in fish Novel peptide hormones which influence the release of gonadotropins by the pituitary gland in fish are disclosed. Methods in which such peptides may be administered to fish to control their reproduction are also described. Furthermore, novel isolated cDNA... | 07/01/1997 |
| 5273886 | Determination of isoaspartate in proteins The invention relates to methods and means for quantitative determination of the isoaspartyl content of polypeptides via selective methylation of their fragments, catalyzed by a protein L-isoaspartyl methyltransferase enzyme. Since deamidation of asparagi... | 12/28/1993 |
| 5232912 | Anticoagulant peptides This invention relates to peptide derivatives which are useful anticoagulant agents.... | 08/03/1993 |
| 5212154 | Preparation for treating complications in diabetes Preparation for preventing or combating complications in diabetes, characterized in that it comprises: (a) insulin or a salt or complex thereof, and (b) a peptide of the general formula I: H-L-Met(X)-L-Glu-L-His-L-Phe-D-Lys-L-Phe-Y or a salt or a N-acyl derivative ... | 05/18/1993 |
| 5206343 | Oligopetides with cyclic proline-analogous amino acids The invention relates to compounds of the formula I ##STR1## in which A denotes an optionally substituted radical from the series comprising alkyl, acyl, cycloalkyl, aryl and heteroaryl; Cyc represents an optionally substituted heterocyclic carbonyl ... | 04/27/1993 |
| 5190922 | Terminally modified tri-, tetra- and pentapeptide anaphylatoxin receptor ligands Oligopeptide compounds or oligopeptide analogue compounds of the formula A-B-D-E-G-J-L are ligands for the anaphylatoxin receptor and are useful in the treatment of inflammatory disease states. Also disclosed are anaphylatoxin receptor ligand compositions... | 03/02/1993 |
| 5140103 | Peptide fragments containing HP and LP cross-links A method of determining collagen degradation in vivo, including quantitating the concentration of a peptide in a body fluid, the peptide being a C-terminal type II collagen telopeptide containing a hydroxylysyl pyridinoline cross-link or a type III collag... | 08/18/1992 |
| 5109111 | CRF antagonists Several known members of the corticotropin releasing factor (CRF) family have been synthesized and tested, including human and rat CRF which have the formula: H-Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His- Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-A... | 04/28/1992 |
| 4876243 | Vasopressin compounds Vasopressin-like peptide whose structures have been modified by an alpha-methyl amino acid at the 4 or 7 position are set forth. These compounds have potent vasopressin antagonist activities.... | 10/24/1989 |
| 4866160 | Therapeutic decapeptides A decapeptide of the formula: N-Ac-A1 -A2 -A3 -Ser-A4 -A5 -A6 -A7 -A8 -A9, wherein each A1, A2, and A3, independently, is D-�... | 09/12/1989 |
| 4866038 | Method of stimulating integumental melanocytes by topical application of analogs of alpha-msh A method for stimulating integumental melanocytes by the topical application of alpha-MSH analogs, and compositions comprising said analogs for use in the method are described.... | 09/12/1989 |
| 4866161 | Inhibition of tartar deposition by polyanionic/hydrophobic peptides and derivatives thereof which have a clustered block copolymer structure A method of treating a tooth so as to inhibit deposition of a mineral thereon, which comprises contacting the tooth with a mineral deposition inhibitory effective amount of a poly-amino acid compound which has the structure: where each X is a residue inde... | 09/12/1989 |
| 4863903 | Substituted 5-amino-4-hydroxyvaleryl derivatives Compounds of the formula ##STR1## in which R1 represents hydrogen or acyl, X1 represents an optionally N-alkylated amino acid residue that is bonded N-terminally to R1 and C-terminally to X2, X2 ... | 09/05/1989 |
| 4863905 | Renin inhibitors II The invention concerns novel renin-inhibiting peptides which are modified as isosteres. These peptides are useful for treating renin-associated hypertension and hyperaldosteronism. Processes for preparing the peptides, compositions containing them and met... | 09/05/1989 |
| 4861755 | Peptides with vasorelaxant, natriuretic and diuretic effects a process for their preparation, agents containing them, and their use The invention relates to new peptides of the formula ##STR1## in which X, A, B, C, N', E, F, G and Z have the meanings indicated in the description, to a process for their preparation, to agents containing them, and to their use.... | 08/29/1989 |
| 4859736 | Synthetic polystyrene resin and its use in solid phase peptide synthesis A synthetic resin based on a polystyrene that can be used as a support for solid phase peptide synthesis and that has been cross-linked with from 0 to 5 mol % of divinyl benzene, characterized in that it has been substituted at benzene rings of its skelet... | 08/22/1989 |
| 4859654 | Homocyclostatine and cyclostatine containing polypeptides as antihypertensive agents Polypeptides and derivatives thereof containing homocyclostatine and cyclostatine are useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin.... | 08/22/1989 |
| 4857508 | Novel platelet-aggregation inhibitor peptide derivatives Novel tetrapeptide derivatives are provided which have useful activity as inhibitors of platelet aggregation. These compounds have the sequence X-Gly-Asp-Y wherein X is illustrated by arginine and Y is illustrated by O-methyltyrosine amide.... | 08/15/1989 |
| 4855486 | Blocked, marked amino acids A method is provided for quantitatively monitoring the deprotection and coupling reactions employed in the solid phase synthesis of peptides. The method entails synthesizing a peptide on a support matrix that has a first marker associated therewith. The a... | 08/08/1989 |
| 4855285 | Antigenic modification of polypeptides Endogenous and exogenous proteins, and fragments thereof, are chemically modified outside the body of an animal so that when injected into the animal they produce more antibodies against the unmodified protein than would injection of the unmodified protei... | 08/08/1989 |
| 4855303 | Fluorine containing renin inhibitors Polypeptides containing fluorinated cyclostatine derivatives as antihypertensive agents.... | 08/08/1989 |
| 4855406 | Oncogene-related peptides Disclosed are an oncogene-related peptide characterized in that the peptide comprises a portion of the amino acid sequence of a gene product coded for by an oncogene, an antigen or immunogen formed from the oncogene-related peptide and a carrier, an antib... | 08/08/1989 |
| 4855238 | Recombinant gamma interferons having enhanced stability and methods therefor The present invention relates to novel, stable recombinant gamma interferons exhibiting in greater or less degree the antiviral and antiproliferative activity in humans and pH 2 labile properties characteristic of native human gamma interferon. The amino ... | 08/08/1989 |
