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| Number | Title | Issue Date |
| 7331920 | Glycopeptide antibiotics, combinational libraries of glycopeptide antibiotics and methods of producing same Methods for preparing a glycopeptide are disclosed. The methods comprise the steps of selecting a protected glycopeptide of the formula A1-A2-A3-A4-A5-A6-A7, wherein the groups A1 | 02/19/2008 |
| 7326782 | Metabolic engineering of viomycin biosynthesis The invention provides a nucleic acid molecule comprising at least a functional fragment of the viomycin biosynthetic gene cluster, functional proteins encoded by the cluster, expression cassettes and recombinant host cells comprising a functional fragment of the vi... | 02/05/2008 |
| 6982247 | Compounds exhibiting an antibiotic activity The present invention relates to compounds having antibiotic activity which are obtained from body fluids of mollusks, namely of certain West-African snails, to therapeutic drugs comprising these compounds, and to the use thereof for the preparation of a therapeutic... | 01/03/2006 |
| 6809177 | Process for the conversion of echinocandin class of peptides to their c4-homotyrosine monodeoxy analogues The invention relates to a process for the conversion of echinocandin class of peptides to their C4-homotyrosine monodeoxy analogues, particularly mulundocandin to deoxymulundocandin, which consists of a single step selective reduction of C4-htyr (homotyrosine) hydr... | 10/26/2004 |
| 6565854 | Antimicrobial histone H1 compositions, kits, and methods of use thereof The invention includes antibiotic pharmaceutical compositions comprising eukaryotic histone H1 protein and methods of using eukaryotic histone H1 protein to kill or to inhibit the growth of microorganisms, including, but not limited to, human pathogenic b... | 05/20/2003 |
| 5869449 | 38-decarboxy-38-hydroxymethyl derivatives of teiocoplanin antibiotics and a process for preparing them The present invention is directed to novel 38-decarboxy-38-hydroxymethyl derivatives of teicoplanin antiobiotics and a process for preparing them which includes submitted the corresponding lower alkyl ester precursor to a reduction reaction in the presenc... | 02/09/1999 |
| 5750509 | Amide derivatives of antibiotic A 40926 The present invention is directed to novel antibiotic A 40926 derivatives characterized by having a carboxy, (C1 -C4) alkoxy-carbonyl, aminocarbonyl, (C1 -C4) alkylaminocarbonyl, di (C4 -C4... | 05/12/1998 |
| 5643876 | Biologically active synthetic magainin peptides A class of broad spectrum bioactive polypeptides termed "Magainin" have been described. These peptides have a molecular weight of about 2500 or less, are highly water soluble, amphiphilic and non-hemolytic.... | 07/01/1997 |
| 5451570 | Antibiotic, balhimycin, a process for its production and its use as pharmaceutical Balhimycin, a compound of the molecular formula C66 H73 Cl2 N9 O24, is a novel Glycopeptide antibiotic and has the following structure (SEQ. ID. No. 1): ##STR1##... | 09/19/1995 |
| 5338724 | Antimicrobial proteins, compositions containing same and uses thereof The present invention provides a composition of matter useful as an antimicrobial agent. This composition of matter comprises at least two polypeptides selected from the group consisting of human polymorphonuclear leukocyte, polypeptides having on apparen... | 08/16/1994 |
| 5242902 | Defensin peptide compositions and methods for their use A method for treating cutaneous and corneal wounds as well as certain microbial-related diseases comprises topically applying a defensin peptide to the affected tissue. The compositions comprise a natural, synthetic, or analog defensin molecule having bot... | 09/07/1993 |
| 5239059 | Ion-channel forming peptides A biologically active peptide which includes the following structure: R1 --R1 --R1 --R3 --R5 --R1 --R1 --R1 --R1 --R1 --R2 --R2 --R | 08/24/1993 |
| 5164484 | De-(acetylglucosaminyl-di(dehydro)-deoxy teicoplanin derivatives The present invention is directed to new de-(acetylglucosaminyl)-di(dehydro)deoxy teicoplanin derivatives which possess antibiotic activity mainly against gram positive bacteria. The new compounds are obtained by chemical modification of a teicoplanin ant... | 11/17/1992 |
| 5112806 | Antibiotic, mersacidin, a process for the preparation thereof and the use thereof as a pharmaceutical Mersacidin, a cyclic peptide of the formula I ##STR1## has antibiotic activity.... | 05/12/1992 |
| 4868171 | Antibiotic A 40926 N-acylaminoglucuronyl aglycons and antiobiotic A 40926 aglycon The present invention concerns new antibiotic substances denominated antibiotic A 40926 N-acylaminoglucuronyl aglycon complex AB, antibiotic A 40926 N-acylaminoglucuronyl aglycon factor A, antibiotic A 40926 N-acylaminoglucuronyl aglycon factor B, antibio... | 09/19/1989 |
| 4822608 | Methods and compositions for the treatment of mammalian infections employing medicaments comprising hymenoptera venom or proteinaceous or polypeptide components thereof Methods and compositions are described for the treatment of mammalian infections, including bacterial, viral and cancerous infections, in which hymenoptera venom or proteinaceous or polypeptide components thereof are employed to enhance the activity of pr... | 04/18/1989 |
| 4816559 | Biologically active peptides TAN-866 The iron-containing biologically active peptide TAN-866 produced by microorganisms belonging to the genus Pseudomonas and its iron free compounds have antibacterial activity mainly against gram-negative bacteria. These peptides can be used as a therepeuti... | 03/28/1989 |
| 4810777 | Antimicrobial compounds A new class of broad spectrum antibiotic polypeptides termed "Magainin" have been described. These peptides have a molecular weight of about 2500 or less, are highly water soluble, non-cytolyic to animal cells including red-blood cells and are amphiphilic... | 03/07/1989 |
| 4798827 | Synergistin derivatives and pharmaceutical compositions which contain them The invention provides new synergistin derivatives of formula ##STR1## in which Y is hydrogen or dimethylamino and R is a 3- or 4-quinuclidinyl radical, the isomers thereof and their mixtures, and their salts, also the preparation thereof. These comp... | 01/17/1989 |
| 4798823 | New cyclosporin analogs with modified "C-9 amino acids" New cyclosporin analogs with modified "C-9 amino acids" have been made and are found to be effective immunosuppressive agents.... | 01/17/1989 |
| 4795740 | Antiviral peptides and means for treating herpes infections Disclosed herein are antiviral peptides of the formula A-R8 -R9 -R10 -R11 -R12 -R13 -R14 -R15 -B wherein A is from zero up to seven amino acid residues and includes a termi... | 01/03/1989 |
| 4789661 | De-(acetylglucosaminyl)-di(dehydro)-deoxy teicoplanin derivatives The present invention is directed to new de-(acetylglucosaminyl-di(dehydro)deoxy teicoplanin derivatives which possess antibiotic activity mainly against gram positive bacteria. The new compounds are obtained by chemical modification of a teicoplanin anti... | 12/06/1988 |
| 4782135 | Composition of matter and process Novel antibiotics didemnins A, B and C (didemnins), and nordidemnins A, B and C (nordidemnins) which can be obtained from a marine organism. These antibiotics are active against a variety of DNA and RNA viruses; thus, they can be used in various environme... | 11/01/1988 |
| 4782042 | Antibiotic A 40926 mannosyl aglycon The present invention concerns a new antibiotic substance denominated antibiotic A 40926 mannosyl aglycon and the addition salts thereof, a process for preparing it from antibiotic A 40926 complex or a factor thereof, and its use in the treatment of infec... | 11/01/1988 |
| 4778846 | Affinity chromatography sorbent A novel process for the isolation and purification of vancomycin class antibiotics which utilized affinity chromatography by the formation of a sorption complex between the antibiotic and an immobilizing ligand selected from -D-alanyl-D-alanine or -X-D-al... | 10/18/1988 |
| 4771121 | Substance GIF-2 and process for production of the same A substance GIF-2 having bacteriostatic activities and a process for producing the same are disclosed. GIF-2 is produced by culturing bacteria capable of producing GIF-2 and belonging to genus Bacillus, and isolating GIF-2 from the culture medium. GIF-2 i... | 09/13/1988 |
| 4771122 | Novel cyclosporins Cylosporins e.g. of formula II ##STR1## in which X is -MeBmt- or -dihydro-MeBmt- and Y is -u-, -Thr-, -Val- or -Nva-, wherein the residue at the 3-position, i.e. the residue Z in formula II, is an optically active, -N-methylated -am... | 09/13/1988 |
| 4764503 | Novel cyclosporins Cyclosporins wherein the amino acid residue at the 8-position is a (D)-acyloxy--amino acid residue, typically of formula ##STR1## wherein X=--MeBmt-- or --dihydro--MeBmt--, Y=--u--, --Ala--, --Thr--, --Val-- or --Nva--, Z=--Val-- or -... | 08/16/1988 |
| 4754018 | Antibiotic prepared from lysobacter sp. SC 14,067 and analogs thereof A novel antibiotic substance EM5587 is prepared by cultivation of a strain of the microorganism Lysobacter sp. SC 14,067, A.T.C.C. No. 53042. Chemical analogs of EM5587 are prepared by chemical synthesis.... | 06/28/1988 |
| 4742045 | Glycopeptide antibiotics Novel glycopeptide antibiotics of the CWI-785 complex are produced by the Actinomycete SKF-CWI-785.... | 05/03/1988 |
| 4725668 | Process for transforming teicoplanin factor A2 component 1 into teicoplanin factor A2, component 3 The present invention refers to a process for transforming teicoplanin factor A2 component 1 into teicoplanin factor A2 component 3 by means of a chemical reaction which includes the catalytical hydrogenation of the substrate.... | 02/16/1988 |
| 4717714 | A-51568B antibiotic The novel glycopeptide antibiotic A-51568B is produced by submerged, aerobic fermentation of Nocardia orientalis NRRL 15232. A-51568B demonstrates antibiotic activity against gram-positive bacteria.... | 01/05/1988 |
| 4713331 | Microbial production of A41030 antibiotics Antibiotic A41030, a complex of 7 individual factors, is produced by submerged, aerobic fermentation of new Streptomyces virginiae NRRL 12525, and Streptomyces virginiae NRRL 15156. The antibiotic factors are separated and possess antibacterial activity a... | 12/15/1987 |
| 4705777 | Cationic oligopeptides having microbicidal activity Novel microbicidal compositions are provided which find use as preservatives, disinfectants, antigens and the like. Particularly, cationic oligopeptides of up to about thirty-five amino acids are provided having amino acid sequences substantially comparab... | 11/10/1987 |
| 4703033 | Novel cyclosporins Cyclosporins e.g. of formula II ##STR1## in which X is -MeBmt- or -dihydro-MeBmt- and Y is -u-, -Thr-, -Val- or -Nva-, wherein the residue at the 3-position, i.e. the residue Z in formula II, is an optically active, -N-methylated -a... | 10/27/1987 |
| 4699977 | Antibiotic L 17046 and process for preparing it The present invention is directed to a new antibiotic substance arbitrarily denominated antibiotic L 17046. This antibiotic substance is obtained from the known antibiotic substance called teicoplanin (formerly teichomycin) by chemical treatment. The new ... | 10/13/1987 |
| 4698327 | Novel glycopeptide derivatives Novel glycopeptide antibiotics of formula (I) can be prepared from the glycopeptide antibiotics vancomycin, A51568A, A51568B, M43A and M43D by reaction with a ketone or aldehyde followed, if appropriate, by reduction. The new glycopeptide derivatives are ... | 10/06/1987 |
| 4698418 | Process for preparing antibiotic L 17046 This invention relates to a process for converting a teicoplanin-like compound into antibiotic L 17046 characterized in that a teicoplanin-like compound selected from teicoplanin complex, any further purified preparation thereof, teicoplanin factor A... | 10/06/1987 |
| 4695545 | Culture and process for producing A41030 antibiotics A hitherto undescribed microorganism, Streptomyces virginiae NRRL 12525, which upon culturing produces the A41030 antibiotic complex comprising several factors. The A41030 antibiotics produced show antibacterial activity against the gram-positive genera S... | 09/22/1987 |
| 4694069 | Kibdelosporangium aridum SK&F-AAD-609 A novel subspecies of Kibdelosporangium aridum, subsp. largum (SK&F-AAD-609) produces AAD-216 antibiotics and AAD-609 antibiotics, the ADD-609 antibiotics differing from the AAD-216 antibiotics in presence of glucosamine in the glycolipid radical in place... | 09/15/1987 |
