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| Number | Title | Issue Date |
| 7074761 | Peptides and production and use thereof The peptides and precursors thereof, inclusive salts thereof, of the present invention are useful as a pharmaceutical composition, for example as therapeutic or prophylactic agents for hormone-producing tumors, acromegaly, gigantism, dementia, gastric ulcer and the ... | 07/11/2006 |
| 6579967 | Receptor-selective somatostatin analogs Analogs of SRIF which are selective for SSTR3 in contrast to the other cloned SRIF receptors. These analogs are useful in determining the tissue and cellular expression of the receptor SSTR3 and its biological role in the endocrine, exocrine and nervous s... | 06/17/2003 |
| 6521599 | Stable pharmaceutical formulation for intravenous or intramuscular administration of active peptide compounds A stable pharmaceutical formulation for intravenous or intramuscular administration of Octreotide, which is characterized in that the vehicle for injection of the peptide or pharmaceutically acceptable salts thereof contains glycine in concentrations rang... | 02/18/2003 |
| 6123916 | Therapeutic use of somatostatin peptides The invention relates to a new pharmaceutical use of somatostatin peptides comprising on the terminal amino group a polyamino polycarboxylic group, in free form or in a pharmaceutically acceptable salt form, particularly in the manufacture of a medicament... | 09/26/2000 |
| 6001960 | Synthetic somatostatin mimics Relatively small cyclic peptides that mimic the biological and/or chemical activity of larger cyclic peptide such as somatostatin, as well as synthetic methods therefor. In certain embodiments, cyclic peptides of the invention have structure: ##STR1#... | 12/14/1999 |
| 5965694 | Somatostatin mimics and synthetic methods therefor Relatively small cyclic peptides that mimic the biological and/or chemical activity of larger cyclic peptide such as somatostatin, as well as synthetic methods therefor. In certain embodiments, cyclic peptides of the invention have structure: ##STR1#... | 10/12/1999 |
| 5833942 | Technetium-99m labeled somatostatin-derived peptides for imaging and therapeutic uses This invention relates to therapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic agents. Specifically, the invention relates to peptide derivatives and analogs of somatostatin, and embod... | 11/10/1998 |
| 5820845 | Somatostatin-derived peptides for imaging and therapeutic uses This invention relates to therapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic agents. Specifically, the invention relates to peptide derivatives and analogs of somatostatin, and embod... | 10/13/1998 |
| 5753618 | Somatostatin analogue composition and use in treating breast cancer The invention provides a pharmaceutical composition containing a somatostatin analogue, and its use in the treatment of breast cancer. The pharmaceutical composition preferably contains lactic acid in addition to the somatostatin analogue and is better to... | 05/19/1998 |
| 5708135 | Cyclic peptide analogs of somatostatin A cyclic peptide analog of somatostatin wherein a disulfide bond links the N-terminus residue and the C-terminus residue.... | 01/13/1998 |
| 5700905 | Synthetic somatostatin mimics Relatively small cyclic peptides that mimic the biological and/or chemical activity of larger cyclic peptide such as somatostatin, as well as synthetic methods therefor. In certain embodiments, cyclic peptides of the invention have structure: ##STR1#... | 12/23/1997 |
| 5633263 | Linear somatostatin analogs Linear peptide analogs of somatostatin having the formula: ##STR1## As an example, D-Phe-Phe-Phe-D-Trp-Lys-Thr-Phe-Thr is covered by the above formula (i.e., R1 is H, R2 is H, A1 is D-Phe, A2 is Phe, A... | 05/27/1997 |
| 5556939 | TC or RE radionuclide labelled chelate, hexapeptide complexes useful for diagnostic or therapeutic applications Technetium or rhenium radionuclide labelled chelate-hexapeptide complexes are useful for the selective detection or treatment of tumors with somatostatin receptors. In particular, compounds of formula: ##STR1## (wherein R, R1, R3 | 09/17/1996 |
| 5506339 | Octapeptide analogs of somatostatin having threonine at the sixth position A compound of the formula: ##STR1## wherein each A1 and A2, independently, is H, C1-12 alkyl, C7-10 phenylalkyl, R1 CO (where R1 is C1-20 alkyl, C3-20 alkenyl, C | 04/09/1996 |
| 5439688 | Process for preparing a pharmaceutical composition A pharmaceutical composition is prepared in the form of microparticles or of an implant comprising a biodegradable polymer selected from poly-1,4-butylene succinate, poly-2,3-butylene succinate, poly-1,4-butylene fumarate and poly-2,3-butylene succinate, ... | 08/08/1995 |
| 4871717 | Peptides Heptapeptide analogs of somatastatin which inhibit secretion of growth hormone.... | 10/03/1989 |
| 4853371 | Therapeutic somatostatin analogs An octapeptide of the formula: ##STR1## wherein each A1 and A2, independently, is H, C1-12 alkyl, C7-10 phenylalkyl, R1 CO (where R1 is C1-20 alkyl, C3-20 alkenyl... | 08/01/1989 |
| 4843006 | RecA promoter dependent polypeptide production This invention relates to the expression and accumulation in bacterial cells of heterologous polypeptides under the control of the recA promoter/operator region. One such polypeptide comprises a recA/somatostatin fusion polypeptide. This fusion polypeptid... | 06/27/1989 |
| 4837303 | Novel somatostatin derivatives Somatostatin derivatives of general Formula I ##STR1## wherein at least one of the residues X represents a moiety, bound to the free amino group of alanine or lysine, of Formula II ##STR2## with R meaning an alkyl group containing 7-23 carbon at... | 06/06/1989 |
| 4816438 | Insulin-selective somatostatin analogs Anglerfish somatostatin-28 has the formula: ##STR1## Anglerfish somatostation-28 is insulin-selective when administered in vivo and is useful for the treatment of insulinoma. The 14-residue C-terminal peptide may also be used.... | 03/28/1989 |
| 4812554 | Somatostatin peptide conjugate The specification discloses: 1. Recombinant microbial cloning vehicles comprising heterologous DNA coding for the expression of mammalian hormone (e.g., somatostatin) and other polypeptides, including plasmids suited for the transformation of bacterial ho... | 03/14/1989 |
| 4801575 | Chimeric peptides for neuropeptide delivery through the blood-brain barrier Chimeric peptides adapted for delivering neuropharmaceutical agents, such as neuropeptides into the brain by receptor-mediated transcytosis through the blood-brain barrier. The chimeric peptides include a peptide which by itself is capable of crossing the... | 01/31/1989 |
| 4798821 | Antihypertensive therapy for diabetics Process and compositions for lowering blood pressure in diabetic by employing a cyclopeptide compound is described.... | 01/17/1989 |
| 4764475 | Pancreas dependant immunoassay for determining subpopulations of monoclonal antibodies to somatostatin. A correlation has been demonstrated between the ability of an antibody to block the inhibitory action of somatostatin on the gastric inhibitory peptide(GIP)-stimulated release of insulin from the pancreas in vitro and the ability to stimulate growth in vi... | 08/16/1988 |
| 4748153 | Compounds having somatostatin-like activity useful as local anti-inflammatory agents Compounds having somatostatin-like activity have been found to be useful as local anti-inflammatory agents in the treatment of such conditions as, for example, psoriasis, eczema, seborrhea, and other localized inflammatory and allergic conditions. Particu... | 05/31/1988 |
| 4728638 | Somatostatine derivatives Somatostatine derivatives of the general formula ##STR1## wherein either (a) A is ##STR2## W is -CO-N(A4) or -N(A5)-CO- and Y1 and Y2 are H or together a bond or (b) A is H, alkyl, phenylalkyl or RCO a... | 03/01/1988 |
| 4725577 | Biologically active lysine containing octapeptides Novel compositions of the formula ##STR1## wherein A represents an L, D or DL amino-acid selected from the group consisting of Ala, Val, Phe, p-Cl-Phe, Trp, Pro, Ser, Thr, Glu, Gly, Beta Ala, Abu, N-Me Ala, 5-F-Trp, 5-Br-Trp, 5-Cl-Trp, their acetylat... | 02/16/1988 |
| 4704362 | Recombinant cloning vehicle microbial polypeptide expression The Specification discloses: 1. Recombinant microbial cloning vehicles comprising heterologous DNA coding for the expression of mammalian hormone (e.g., somatostatin) and other polypeptides, including plasmids suited for the transformation of bacterial ho... | 11/03/1987 |
| 4703034 | Novel cyclic tetrapeptide There is disclosed a series of novel cyclic tetrapeptides related to somatostatin. The compounds have surprisingly been found to have the activity of increasing blood glucose when administered. The compounds are prepared using the solid phase or mixed anh... | 10/27/1987 |
| 4684620 | Cyclic polypeptides having mu-receptor specificity Novel compounds which are capable of binding with enhanced specificity to the mu opioid receptor are disclosed. The compounds are analogs of somatostain and have the formula: ##STR1## wherein X is CONH2 or CH2 OH; Y and Z are in... | 08/04/1987 |
| 4663435 | Bridged cyclic hexapeptide somatostatin analogs Somatostatin analogs are prepared wherein a cyclic hexapeptide contains a bridged grouping which replaces eight of the ring amino acids of somatostatin. The bridged cyclic hexapeptides are easier to synthesize, have a longer duration of activity, and many... | 05/05/1987 |
| 4650787 | Biologically active octapeptides Novel compositions of the formula ##STR1## wherein A represents an L, D or DL amino-acid selected from the group consisting of Ala, Val, Phe, p-Cl-Phe, Trp, Pro, Ser, Thr, Glu, Gly, Beta Ala, Abu, N-Me Ala, 5-F-Trp, 5-Br-Trp, 5-Cl-Trp, their acetylat... | 03/17/1987 |
| 4639510 | (1-S-acetamidomethyl cysteine, 7-alanine)calcitonin New peptides are disclosed which have biological activity of the same type as known calcitonins and which have an S-acetamidomethyl cysteine at one and an alanine at seven, or an alanine at one and an S-acetamidomethyl cysteine at seven. Also resin peptid... | 01/27/1987 |
| 4639512 | Conjugates of haptenes and muramyl-peptides, endowed with immunogenic activity and compositions containing them The invention relates to an immunogenic principle containing a specific antigen determinant of a predetermined native antigen. This immunogenic principle is constituted by a conjugate between a hapten bearing said antigenic site and a muramyl-peptide, ess... | 01/27/1987 |
| 4623716 | Process for the preparation and purification of peptides Peptides, such as calcitonin, having two cysteine residues connected by a disulfide bond are prepared by a process which includes the step of cyclizing the cysteines at a pH of 8.5 to 9.0, and a concentration of 0.4 to 1.8 mg of peptide per ml of solution... | 11/18/1986 |
| 4621073 | Cyclic peptides having somatostatin activity The invention relates to cyclic hexapeptides of the general formula III ##STR1## in which X represents the radical of an L-aminoacid of the general formula IIIa ##STR2## in which A and B are identical or different and denote alkyl having 1 to 3 ... | 11/04/1986 |
| 4612302 | Clinical use of somatostatin analogues A method of increasing the clearance of particles from the blood stream of a vertebrate, which comprises administering to a vertebrate having a surplus of particles in the blood stream of the vertebrate an amount of a somatostatin analogue sufficient to i... | 09/16/1986 |
| 4612366 | Cyclic hexapeptide somatostatin analogs Somatostatin analogs are prepared wherein a cyclic hexapeptide contains a secondary amino acid which replaces seven of the ring amino acids of somatostatin. The cyclic hexapeptides are easier to synthesize, have a longer duration of activity, and many hav... | 09/16/1986 |
| 4611054 | Cyclic hexapeptide somatostatin analogs Cyclic hexapeptide somatostatin analogs are prepared wherein a peptide surrogate replaces eight of the ring amino acids of somatostatin. The cyclic hexapeptides are easier to synthesize, have a longer duration of activity, and many have a greater level of... | 09/09/1986 |
| 4603120 | Cyclic octapeptides and pharmaceutical preparations thereof, as well as processes for their manufacture, and their use Cyclic octapeptides of the formula ##STR1## in which Aaa represents a radical of a straight-chained ,ω-diaminoalkanoic acid having from 4 to 7 carbon atoms, trp represents a radical L-Trp or, especially, D-Trp, or a radical derived therefrom,... | 07/29/1986 |
