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| Number | Title | Issue Date |
| 5698516 | Biologically active vasopressin analogues Vasopressin analogues of formula (I) ##STR1## wherein X is (S)-2-amino-2-methyl-butanoic acid (CaMeAbu) or Valine (Val), Y is Thienylalanine (Thi) or Methionine (Met), Z is D-Phenylalanine (D-Phe) or D-Thienylalanine (Thi) or D-Tyrosine (D-Tyr), are ... | 12/16/1997 |
| 4876243 | Vasopressin compounds Vasopressin-like peptide whose structures have been modified by an alpha-methyl amino acid at the 4 or 7 position are set forth. These compounds have potent vasopressin antagonist activities.... | 10/24/1989 |
| 4829051 | N-substituted derivatives of 1-desaminovasopressin Novel analogs of biologically active vasopressin and its synthetic analogs having improved activity are represented by the structural formula: ##STR1## wherein A hydrogen; is hydroxy or lower alkoxy, especially methoxy, B is the peptide residue of ph... | 05/09/1989 |
| 4826613 | Lubricating oil containing dispersant viscosity index improver Lubricating oil of improved dispersancy and viscosity index contains ethylene-propylene polymer bearing glycidyl methacrylate graft which as been functionalized with mercaptoacetic acid.... | 05/02/1989 |
| 4810778 | Intermediates for preparing 1,6-dicarba-vasopressin compounds New compounds which have potent V2 -vasopressin antagonistic activity are prepared by a 1,6-cyclization using peptide bond formation. The structures of the compounds are characterized by the Pas1,6 or Tas1,6 cyclized unit.... | 03/07/1989 |
| 4801575 | Chimeric peptides for neuropeptide delivery through the blood-brain barrier Chimeric peptides adapted for delivering neuropharmaceutical agents, such as neuropeptides into the brain by receptor-mediated transcytosis through the blood-brain barrier. The chimeric peptides include a peptide which by itself is capable of crossing the... | 01/31/1989 |
| 4772586 | Novel derivatives of arginine vasopressin antagonists Compounds acting as antagonists of the antidiuretic/and or vasopressor activity of arginine vasopressin are those of the formula ##STR1## wherein n is 4 or 5; X is (D- or L-)Tyr(R), D-Phe, D-Val, D-Leu, D-Ile, D-Nva, D-Nle, D-Cha, D-Abu, D-Thr, D-Asn... | 09/20/1988 |
| 4766108 | Tyr-Arg-vasopressin antagonists Vasopressin antagonists which have a dipeptide tail composed of a neutral and basic amino acid unit demonstrate potent V1 and V2 -antagonist activity. Two species of this invention, which are prepared by solid phase peptide synthesis... | 08/23/1988 |
| 4762820 | Therapeutic treatment for congestive heart failure A novel therapeutic method for treating human and animal subjects afflicted with congestive heart failure is provided by administering effective dosages of a selective antagonist for arginine vasopressin to the subject. The antagonist is an effective and ... | 08/09/1988 |
| 4760052 | 1,6-dicarba-vasopressin compounds New compounds which have potent V2 -vasopressin antagonistic activity are prepared by a 1,6-cyclization using peptide bond formation. The structures of the compounds are characterized by a Pas1,6 or Tas1,6 cyclized unit. A... | 07/26/1988 |
| 4749782 | Vasopressin compounds Certain vasopressin-like compounds whose structures have a ଲ,ଲ-diethyl-ଲ-mercaptopropionic acid at position 1 have unexpectedly potent V2 -antagonist activity. A species of the group is [1-ଲ,ଲ-diethyl-ଲ-merca... | 06/07/1988 |
| 4742154 | GLN- or ASN-vasopressin compounds Peptides whose structures resemble those of vasopressin antagonists but have both a carboxamido amino acid unit and a basic amino acid unit in the side chain have good antagonist activity. A species of the invention is [1-(ଲ-mercapto-ଲ,ଲ... | 05/03/1988 |
| 4724229 | Arg-arg-arg-vasopressin antagonists Vasopressin antagonists which have a tripeptide side chain comprised of three basic amino acids, such as arginine, lysine or ornithine, demonstrate potent V1 and V2 -antagonist activity. A species of the invention, which is prepared ... | 02/09/1988 |
| 4719199 | Diuretic compositions and methods of producing diuresis 2- or 3-ଲ-Indolylalanyl and ଲ-indolylglycyl vasopressins are prepared by standard peptide synthetic methods. These 2- or 3-TRP vasopressins have vasopressin antagonist activity.... | 01/12/1988 |
| 4717715 | ARG7 -ARG8 -vasopressin antagonists Vasopressin antagonists which have a dipeptide side chain comprised of two basic amino acids demonstrate potent V1 and V2 -antagonist activity. A species of the invention, which is prepared by conventional peptide sequencing, is ... | 01/05/1988 |
| 4714696 | Novel derivatives of arginine vasopressin antagonists Compounds acting as antagonists of the antidiuretic/and or vasopressor activity of arginine vasopressin are those of the formula ##STR1## wherein n is 4 or 5; X is (D- or L-)Tyr(R), D-Phe, D-Val, D-Leu, D-Ile, D-Nva, D-Nle, D-Cha, D-Abu, D-Thr, D-Asn... | 12/22/1987 |
| 4711877 | 6-pen-vasopressin compounds Vasopressin derivatives having unexpected VSP site binding activity whose structures are characterized by a Mpr unit at position 1 and a Pen unit at position 6 are prepared by standard peptide synthetic methods also using an oxidative cyclization of a lin... | 12/08/1987 |
| 4687758 | Des-proline-N-methylarginine vasopressins Peptides having vasopressin antagonist activity are prepared by a peptide synthesizer to insert a N-methylarginine at the 7-position of the structure. An example of this series of compounds is [1-(ଲ-mercapto-ଲ,ଲ-cyclopentamethylenepropio... | 08/18/1987 |
| 4684621 | Methods of producing vasodilation or antioxytocic activity Certain vasopressin-like peptides, which have an acyclic unit at position 1 and which have an ω-amino- or guanidinoalkyl substituent attached to the cysteine in the 6-position of the ring, have V1 -vasopressin and oxytocin antagonist activity.... | 08/04/1987 |
| 4684716 | Polypeptide intermediates 2- or 3-ଲ-Indolylalanyl and ଲ-indolylglycyl vasopressins are prepared by standard peptide synthetic methods. These 2- or 3-TRP vasopressins have vasopressin antagonist activity.... | 08/04/1987 |
| 4684622 | Compositions and methods for producing vasodilation and antioxytocic activity Vasopressin derivatives having V1 and oxytocin antagonist activity whose structures are characterized by a Mpa unit at position 1 and a des-Pro unit at position 7 are prepared by standard peptide synthetic methods also using an oxidative cycliz... | 08/04/1987 |
| 4658015 | Polypeptide intermediates Certain vasopressin-like peptides, which have an acyclic unit at position 1 and which have an ω-amino- or guanidinoalkyl substituent attached to the cysteine in the 6-position of the ring, have V1 -vasopressin and oxytocin antagonist activity.... | 04/14/1987 |
| 4656248 | Cupric oxidation of 1,6-dimercapto-containing peptides The preparation of [1-(ଲ-mercapto-ଲ,ଲ-cyclopentamethylenepropionic acid)-2-(O-ethyl-D-tyrosine)-4-valine-8-arginine-9-desglycine]vasopressin by oxidation of the corresponding dimercaptan is improved by using a copper II salt.... | 04/07/1987 |
| 4649130 | Novel derivatives of arginine vasopressin antagonists Compounds acting as antagonists of the antidiuretic/and or vasopressor activity of arginine vasopressin are those of the formula ##STR1## wherein n is 4 or 5; X is (D- or L-)Tyr(R), D-Phe, D-Val, D-Leu, D-lle, D-Nva, D-Nle, D-Cha, D-Abu, D-Thr, D-Asn... | 03/10/1987 |
| 4639512 | Conjugates of haptenes and muramyl-peptides, endowed with immunogenic activity and compositions containing them The invention relates to an immunogenic principle containing a specific antigen determinant of a predetermined native antigen. This immunogenic principle is constituted by a conjugate between a hapten bearing said antigenic site and a muramyl-peptide, ess... | 01/27/1987 |
| 4631270 | Therapeutically useful pseudopeptides, compositions containing the same and methods of preparation and use Therapeutically useful pseudopeptides characterized by the replacement of at least one peptide group, both in a naturally occurring peptide or protein by a thiomethylene group are useful in the treatment of various metabolic malfunctions.... | 12/23/1986 |
| 4624943 | Aromatic basic-tailed vasopressin antagonists Certain new vasopressin-like peptides which have structures characterized by having a bisaminoalkylbenzene present in the vasopressin tail at the 7- or 8-position retain vasopressin antagonist activity. A species of the invention is [1-ଲ-mercapto-&#... | 11/25/1986 |
| 4623640 | Peptides The present invention relates to peptides having psychopharmacological properties, of the formula: ##STR1## wherein A represents the aminoacid residue Arg, Lys or Leu and R represents ##STR2## as well as the functional derivatives thereof.... | 11/18/1986 |
| 4623716 | Process for the preparation and purification of peptides Peptides, such as calcitonin, having two cysteine residues connected by a disulfide bond are prepared by a process which includes the step of cyclizing the cysteines at a pH of 8.5 to 9.0, and a concentration of 0.4 to 1.8 mg of peptide per ml of solution... | 11/18/1986 |
| 4604378 | Basic V1 -vasopressin antagonists Certain vasopressin-like peptides, which have an acyclic unit at position 1 and which have an ω-amino- or guanidinoalkyl substituent attached to the cysteine in the 6-position of the ring, have V1 -vasopressin and oxytocin antagonist activity.... | 08/05/1986 |
| 4597901 | ଲ-indolylalanyl or ଲ-indolylglycinyl vasopressin antagonists 2- or 3-ଲ-Indolylalanyl and ଲ-indolylglycyl vasopressins are prepared by standard peptide synthetic methods. These 2- or 3-TRP vasopressins have vasopressin antagonist activity.... | 07/01/1986 |
| 4596819 | Modified tripeptides Modified oxytocin-vasopressin di- or tri-peptides wherein an amide group is replaced by a group selected from ##STR1## --CH2 NH--, --CH2 O--, --CH2 S--, --CH2 SO--, --CH2 SO2 --, --CH | 06/24/1986 |
| 4587045 | Intermediates for preparing octapeptide vasopressin antagonists Certain octapeptides, which have structures characterized by being a six unit cyclic peptide ring with a dipeptide tail which lacks a glycine unit at position 9, have potent vasopressin antagonist activity. The compounds here claimed are in general charac... | 05/06/1986 |
| 4551445 | Derivatives of arginine vasopressin antagonists Compounds acting as antagonists of the an The invention described herein was made in the course of work under a grant or award from the Department of Health and Human Services.... | 11/05/1985 |
| 4543349 | Basic heptapeptide vasopressin antagonists Certain cyclic vasopressin-like peptides, which have an ω-amino- or guanidinoalkyl substituent attached to the cysteine in the 6-position of the ring, have vasopressin antagonist activity. A species of this series of new compounds is [1-(ଲ-mer... | 09/24/1985 |
| 4542124 | Octapeptide vasopressin antagonists Certain octapeptides, which have structures characterized by being a six unit cyclic peptide ring with a dipeptide tail which lacks a glycine unit at position 9, have potent vasopressin antagonist activity. The compounds here claimed are in general charac... | 09/17/1985 |
| 4515920 | Synthesis of peptides and proteins Solid phase synthesis of peptides and proteins have been improved by the use of a trifunctional segment, one functional group of which is bound to a solid support, the other two functional groups being available as substrates upon which identical proteins... | 05/07/1985 |
| 4508645 | Analogs of neurohypophysial hormones with inhibition effects The invention pertains to analogs of neurohypophysial hormones evidencing inhibition effects of the chemical formula I ##STR1## where A is CH3 CO or H, V is a residue of penicilamine or cysteine, B is CH3 or H, X is a residue of... | 04/02/1985 |
| 4504469 | Vasotocin derivatives Novel vasotocin derivatives having an inhibitory effect on uterine contractions, pharmaceutical compositions containing these derivatives, and the use thereof in the therapeutical treatment of excessive muscle contractions in the uterus and described. The... | 03/12/1985 |
| 4491577 | Antagonists of the antidiuretic action of arginine vasopressin Compounds acting as antagonists of the antidiuretic activity of arginine vasopressin are those of the formula ##STR1## wherein X is (D- or L-)Tyr(R), D-Tyr, D-Phe, D-Val, D-Leu D-Ile, D-Arg, D-Gln, D-Asn, D-NVa, D-Nle, D-Cha, D-Abu, D-Thr or D-Met; R... | 01/01/1985 |
