Did You Know...
...that power steering was invented by independent inventor Francis W. Davis? As chief engineer in the 1920s of the truck division of the Pierce Arrow Motor Car Company, he saw how hard it was to steer heavy vehicles. So that he would be able to keep the profits from his future invention, Davis left his job, rented a small engineering shop in Waltham, Mass., and developed a hydraulic power steering system that led to power steering.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7285533 | Apo-2 ligand A novel cytokine, designated Apo-2 ligand, which induces mammalian cell apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including Apo-2 ligand chimeras, nucleic acid encoding Apo-2 ligand, and antibodies to... | 10/23/2007 |
| 6998116 | Apo-2 ligand A novel cytokine, designated Apo-2 ligand, which induces mammalian cell apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including Apo-2 ligand chimeras, nucleic acid encoding Apo-2 ligand, and antibodies to... | 02/14/2006 |
| 6800280 | Methods for treating HIV-infected patients by the administration of GM-CSF and a protease inhibitor Provided are methods for inducing an increase in the number of CD4+ T-lymphocytes in HIV-infected patients by administering human GM-CSF. The GM-CSF may be administered concurrently with at least one antiretroviral agent. ... | 10/05/2004 |
| 6776984 | Induced regeneration and repair of damaged neurons and nerve axon myelin A method of treatment of and composition for human degenerative neurologic diseases discloses the administration of therapeutically amounts of an enhancement agent, such as thrombopoietin, to enhance the repair of neurons, including re-myelinization. A regulatory ag... | 08/17/2004 |
| 6746668 | Apo-2 ligand A novel cytokine, designated Apo-2 ligand, which induces mammalian cell apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including Apo-2 ligand chimeras, nucleic acid encoding Apo-2 ligand, and antibodies to... | 06/08/2004 |
| 6713052 | Method of mobilizing stem cells with chemokine β-8 Novel chemokines for mobilizing stem cells are provided. Methods of mobilizing stem cells are also provided. ... | 03/30/2004 |
| 6599719 | Nucleic acid molecules encoding tumor necrosis factor-gamma-alpha Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit ce... | 07/29/2003 |
| 6576231 | Methods for treating HIV-Infected Patients by the Administration of GM-CSF and a protease inhibitor Provided are methods for inducing an increase in the number of CD4+ T-lymphocytes in HIV-infected patients by administering human GM-CSF. The GM-CSF may be administered concurrently with at least one antiretroviral agent.... | 06/10/2003 |
| 6344192 | Use of interleukin-15 The invention relates to the use of IL-15 or active variants thereof and/or IL-15 activity enhancing compounds for the manufacture of a pharmaceutical composition for manipulating memory cells of the immune system, such as manipulating viability ad/or res... | 02/05/2002 |
| 6268482 | Recombinant cytokine designated LERK-6 The invention is directed to LERK-6 as a purified and isolated protein, the DNA encoding the LERK-6, host cells transfected with cDNAs encoding LERK-6.... | 07/31/2001 |
| 6261549 | Human mesenchymal stem cells from peripheral blood Disclosed is a method for recovering peripheral blood containing a population of cells enhanced in human mesenchymal stem cells from an individual by (i) administering to said individual at least one growth factor and, thereafter, (ii) recovering peripher... | 07/17/2001 |
| 6204020 | DNA encoding N.gradient.2 CSF-1 (short form) and carboxy truncated fragment thereof A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system, is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombina... | 03/20/2001 |
| 6174995 | Human chemokines, CK댤 and CK/MCP-4 Human chemokine polypeptides and DNA/(RNA) encoding such chemokine polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemokine polypeptides for the treatment ... | 01/16/2001 |
| 6146851 | DNA encoding NV2 (long form) and carboxy truncated fragments thereof A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombinan... | 11/14/2000 |
| 6143866 | Tumor necrosis factor (TNF) inhibitor and method for obtaining the same At least two substantially purified tumor necrosis factor (TNF) inhibitors are disclosed which are glycoproteins that are active against TNF. The isolation of 3O kDa and 40 KDa TNF inhibitor from urine is disclosed. The deglycosylated form of the 3O kDa T... | 11/07/2000 |
| 6139832 | Leukocyte adhesion inhibitor-1 (LAI-1) Polypeptides There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human chemokine beta-11 (Ck beta-11) polypeptide and a human leukocyte adhesion inhibitor-1 (LAI-1) polypeptide (previously termed chemokine 댑... | 10/31/2000 |
| 6117422 | N.gradient.2-CSF-1(long form) and carboxy truncated fragments thereof A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system. is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombina... | 09/12/2000 |
| 6103224 | N.gradient.2 CSF-1 (short form) and carboxy truncated fragments thereof A colony stimulating factor, CSF-1, is a lymphokine useful in regulating the immune system. is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombina... | 08/15/2000 |
| 6084071 | Human L105 polypeptides and polynucleotides encoding same A chemokine, human L105, is disclosed.... | 07/04/2000 |
| 6030945 | Apo-2 ligand A novel cytokine, designated Apo-2 ligand, which induces mammalian cell apoptosis is provided. The Apo-2 ligand is believed to be a member of the TNF cytokine family. Compositions including Apo-2 ligand chimeras, nucleic acid encoding Apo-2 ligand, and an... | 02/29/2000 |
| 6015883 | Rantes homolog from prostate The present invention provides a polynucleotide (PTEC) isolated from a prostate cDNA library which identifies and encodes a novel human rantes homolog PTEC (prostate expressed chemokine). The invention provides for genetically engineered expression vector... | 01/18/2000 |
| 6001968 | OB polypeptides, modified forms and compositions The present invention relates generally to the control of body weight of animals including mammals and humans, and more particularly to materials identified herein as modulators of body weight, and to diagnostic and therapeutic uses of such modulators. In... | 12/14/1999 |
| 6001606 | Polynucleotides encoding myeloid progenitor inhibitory factor-1 (MPIF-1) and polypeptides encoded thereby There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine 댨(CK댨 or ckb-8)); a human mono... | 12/14/1999 |
| 5989836 | Method for measuring the binding sites for macrophage-derived inflammatory mediator (MIP-1 and MIP-1ଲ) An inflammatory cytokine is disclosed which has been isolated from cells that have been incubated with a stimulator material. The inflammatory cytokine comprises a protein that is capable of binding to heparin, inducing localized inflammation characterize... | 11/23/1999 |
| 5945511 | Class II cytokine receptor Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise an extracellular domain of a cell-surface receptor that is expressed in kidneys, pancreas, prostate, adre... | 08/31/1999 |
| 5945506 | Chemokine expressed in fetal spleen and its production The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (FSEC) from human fetal spleen cells. The present invention also provides for antisense molecules to the nucleotide sequences which enc... | 08/31/1999 |
| 5936068 | Liver expressed chemokine-1 The present invention provides nucleotide and amino acid sequences that identify and encode novel expressed chemokines (ECs) from liver and pituitary gland tissues. The present invention also provides for antisense molecules to the nucleotide sequences wh... | 08/10/1999 |
| 5932703 | Macrophage derived chemokine and chemokine analogs The present invention provides purified and isolated polynucleotide sequences encoding a novel human macrophage-derived C--C chemokine designated MDC, and polypeptide analogs thereof. Also provided are materials and methods for the recombinant production ... | 08/03/1999 |
| 5891998 | Interleukin-6 receptor agonists Disclosed are interleukin-6 receptor agonists. These receptor agonists were enerated by mutating amino acid positions 175, 176, 177, 181, and/or 183 of human interleukin-6.... | 04/06/1999 |
| 5874075 | Stable protein: phospholipid compositions and methods The invention relates to stable compositions of proteins and related methods wherein a protein capable of transitioning into the molten globular state is contacted with a negatively charged lipid vesicle, thereby stabilizing the protein against thermally-... | 02/23/1999 |
| 5861150 | Recombinant human CSF-1 dimer and compositions thereof The present invention is directed to a biologically active CSF-1 dimer comprising a first CSF-1 monomer and a second CSF-1 monomer, wherein at least one of the monomers is truncated at the C-terminus after residue position 223. The dimers also include poi... | 01/19/1999 |
| 5844084 | Chemokine expressed in inflamed adenoid The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (ADEC) from inflamed adenoid tissue. The present invention also provides for antisense molecules to the nucleotide sequences which enco... | 12/01/1998 |
| 5795569 | Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation Disclosed are novel proteins, referred to as megakaryocyte growth and development factors (MGDFs; also generally referred to as Mpl ligands or thrombopoietin, that have a biological activity of stimulating the growth of megakaryocytes and augmenting the d... | 08/18/1998 |
| 5789552 | Interleukin-6 receptor antagonists Disclosed are interleukin-6 receptor antagonists. These receptor antagonists are generated by mutating amino acid positions 31, 35, 118, 121, 175, 176 and/or 183 of human interleukin-6.... | 08/04/1998 |
| 5773582 | Tumor necrosis factor muteins Muteins of human tumor necrosis factor (hTNF), a process for production thereof, and DNAs encoding these muteins are found to have a superior antitumor activity and lower acute lethal toxicity compared to the wild-type human tumor necrosis factor.... | 06/30/1998 |
| 5766581 | Method for treating mammals with monopegylated proteins that stimulates megakaryocyte growth and differentiation Disclosed are novel proteins, referred to as megakaryocyte growth and development factors (MGDFs; also generally referred to as Mpl ligands), that have a biological activity of stimulating the growth of megakaryocytes and augmenting the differentiation or... | 06/16/1998 |
| 5723585 | Method of purifying cardiac hypertrophy factor Isolated CHF, isolated DNA encoding CHF, recombinant or synthetic methods of preparing CHF, and a method of purifying CHF are disclosed. These CHF molecules are shown to influence hypertrophic activity and neurological activity. Accordingly, these compoun... | 03/03/1998 |
| 5686577 | T cell factors influencing B cell development The present invention relates to an isolated protein or polypeptide capable of production by T cells and capable of ultimately activating production of B cells. The present invention further provides an isolated DNA molecule encoding the protein or polype... | 11/11/1997 |
| 5681723 | Mutant interleukin 6 with improved biological activity over wild interleukin 6 The present invention is drawn to mutant interleukin 6, which has the amino acid arginine in position 176, replacing serine in position 176 with wild-type interleukin 6. The mutant interleukin 6 of the present invention has greater biological activity tha... | 10/28/1997 |
| 5670625 | Elk ligand fusion proteins elk ligand (elk-L) polypeptides as well as DNA sequences, vectors and transformed host cells useful in providing elk-L polypeptides. The elk-L polypeptide binds to a cell surface receptor that is a member of the tyrosine kinase receptor family.... | 09/23/1997 |
