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| Number | Title | Issue Date |
| 5675060 | Transgenic arthritic mice expressing a T-cell receptor transgene A transgenic animal model for arthritis is disclosed. The arthritic condition results from genetic (or immunologic) manipulations that result in the T cell receptor (TCR) repertoire of the animal being substantially limited relative to the TCR repertoire ... | 10/07/1997 |
| 5672805 | Transgenic mice expressing the neurotoxic C-terminus of ଲ-amyloid precursor protein The present invention provides non-human, transgenic animals for use as a model for the study of Alzheimer's Disease. The animals exhibit pathology associated with Alzheimer's Disease. The phenotype is conferred in the animals by the introduction of an am... | 09/30/1997 |
| 5663482 | Transgenic mice expressing a mutated human collagen gene The invention is transgenic mice substantially all of whose cells contain a mutated human collagen gene. Methods for testing therapies for the treatment of osteogenesis imperfecta, osteoporosis, and chondrodysplasia are provided.... | 09/02/1997 |
| 5643551 | Small animal metastasis model A method for initiating metastasis of human tumor cells under experimental conditions is provided. Immunocompromised non-human mammals having a viable, xenogeneic organ or tissue are used as a host for human tumor cells. The cells are introduced into the ... | 07/01/1997 |
| 5639440 | Method for evaluating immunogenicity Biological effects of agents for diagnostic or therapeutic use are evaluated by administration of the agents to transgenic animals which are transformed with heterologous DNA and which are immune tolerant to the expression product of the heterologous DNA.... | 06/17/1997 |
| 5633426 | In vivo use of human bone marrow for investigation and production Chimeric immunocompromised hosts are provided, comprising human bone marrow of at least 4 weeks from the time of implantation. The bone marrow is found to assume the normal population of bone marrow except for erythrocytes. The bone marrow may be used to ... | 05/27/1997 |
| 5631407 | Transgenic mouse expressing DNA sequences encoding the human poliovirus receptor The subject invention provides an isolated nucleic acid molecule which comprises nucleic acid encoding a polypeptide which has the biological activity of a receptor for poliovirus and in addition, provides a purified polypeptide which has this activity. T... | 05/20/1997 |
| 5625124 | Animal model for helicobacter pylori infection Transgenic non-human animals are described which serve as a model for H. pylori infection of epithelial cells of the stomach and small intestine. The gut epithelial cells of the transgenic animals express one or more surface carbohydrate antigens which ac... | 04/29/1997 |
| 5625123 | Neurotrophin-3-deficient embryonic stem cells and mice and their use The present invention provides mouse embryonic stem cells and homozygous mutant mice carrying disruptions in the neurotrophin-3 (NT-3) gene generated by homologous recombination which results in the insertion of a reporter gene or a drug-resistance gene i... | 04/29/1997 |
| 5625125 | Phospholipase A2 expressing transgenic animals The present invention concerns transgenic animals that express an abnormaly high level of phospholipase A2 in their serum, liver, lung, kidney and skin. More particularly rats and mice expressing human non-pancreatic, low molecular weight phosp... | 04/29/1997 |
| 5602300 | Process for detecting mutations, transgenic mammal transgenic mammalian cell, and process for testing agents or conditioning for mutagenic properties Detection of mutations in a lacZ gene including lacZ operator sequence functioning as marker gene located in a plasmid whereof one or more copies are introduced into the DNA of a mammal or of a mammalian cell, by isolating the DNA, cutting the plasmid out... | 02/11/1997 |
| 5602307 | Non-human animal having predefined allele of a cellular adhesion gene A transgenic mouse which contains a predefined, specific and desired alteration in at least one of its two chromosomal alleles of a cellular adhesion gene, such that at least one of these alleles contains a mutation which alters the expression of the alle... | 02/11/1997 |
| 5589155 | Mutagenesis testing using transgenic non-human animals carrying test DNA sequences An assay for monitoring and assessing the mutagenic potential of agents which involves creating transgenic non-human animals carrying a test DNA-sequence or sequences that can be quickly recovered and examined for mutations following exposure to one or mo... | 12/31/1996 |
| 5574205 | Homologous recombination for universal donor cells and chimeric mammalian hosts Homologous recombination is employed to inactivate genes, particularly genes associated with MHC antigens. Particularly, each of the 댢- microglobulin gene and the IFN-γR gene is inactivated for reducing or eliminating the expression of ... | 11/12/1996 |
| 5565186 | Method of detecting prions in a sample and transgenic animal used for same Prions are protein based infectious material that cause of variety of diseases such as Scrapie, bovine spongiform encephalopathy (also known as "Mad Cow" disease), Creutzfeldt Jakob Disease, Kuru, and fatal familial insomnia. The invention is directed to ... | 10/15/1996 |
| 5557032 | Knockout mice Mice lacking expression of CD28 or particular CD45 isoforms in certain cells of the immune system are provided. Also provided are methods of using these mice.... | 09/17/1996 |
| 5556782 | Transformed mammalian cells capable of expressing cecropin b Novel means have been discovered for increasing the resistance of a mammalian host (including humans) to diseases caused by intracellular bacteria, protozoa, and viruses. Novel means have also been found for treating tumors. Augmentation of the host's def... | 09/17/1996 |
| 5530179 | Transgenic immunodeficient animal models The invention features a transgenic mouse having a substantial deficiency in functionally active natural killer cells and T lymphocytes which is useful as a model system for immune diseases, tumorigenesis and transplant rejection.... | 06/25/1996 |
| 5510099 | Mutagenesis testing using transgenic non-human animals carrying test DNA sequences An assay for monitoring and assessing the mutagenic potential of agents which involves creating transgenic non-human animals carrying a test DNA sequence or sequences that can be quickly recovered and examined for mutations following exposure to one or mo... | 04/23/1996 |
| 5174986 | Method for determining oncogenic potential of a chemical compound Methods are provided for determining the oncogenic potential of chemical compounds which utilizes a transgenic mouse predisposed to T-cell lymphomas. The transgenic mouse expresses a pim-1 oncogene and as a consequence is predisposed to the spontaneous on... | 12/29/1992 |
