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...Daniel Webster invented a "bull plow" to pull out tree stumps. It didn't catch on because it was huge and required four oxen to pull it!
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| Number | Title | Issue Date |
| 8188334 | Injecting embryos The present invention provides systems that allow reliable multiplexed transformation of Drosophila embryos. The present invention provides methods and reagents that allow preparation of injection-quality nucleic acid samples and that allow simultaneous prepa... | 05/29/2012 |
| 8008540 | Transgenic non-human animal for use in research models for studying Parkinson's disease The invention relates to a transgenic mouse model with deficient respiratory chain function in dopamine (DA) neurons. By suppressing or deleting the mitochondrial transcription factor A (Tfam) in DA neurons, a mouse model is obtained, which reproduces key pathophysi... | 08/30/2011 |
| 7732659 | Injecting embryos The present invention provides systems that allow reliable multiplexed transformation of Drosophila embryos. The present invention provides methods and reagents that allow preparation of injection-quality nucleic acid samples and that allow simultaneous prepa... | 06/08/2010 |
| 7622630 | Chimeric cancer models Chimeric nonhuman mammals useful as inducible spontaneous cancer models are disclosed. The nonhuman mammals are obtained by introducing one or more genetically modified embryonic stem (ES) cells into an early stage embryo, and then implanting the manipulated embryo ... | 11/24/2009 |
| 7608750 | Nonhuman model animal unresponsive to immunopotentiating synthetic compound The present invention relates to provide a non-human animal model unresponsive to a synthetic compound wherein a gene function encoding TLR7 that recognizes an immunopotentiating synthetic compound such as imidazoquinoline lacks on is genomic locus. Whole or part of... | 10/27/2009 |
| 7420099 | Transgenic animals and uses thereof In general, the invention features genetically modified non-human mammals (e.g., bovines and other ungulates), and methods of making these mammals. In particular, the invention features transgenic ungulates having reduced levels of endogenous IgM heavy chain and/or ... | 09/02/2008 |
| 7414170 | Transgenic bovines capable of human antibody production The invention features novel methods for the production of large quantities of xenogenous antibodies, such as human antibodies. Preferably, this result is effected by inactivation of IgM heavy chain expression and, optionally, by inactivation of Ig light chain expre... | 08/19/2008 |
| 7405342 | Transgenic mice expressing heterologous complement receptor type 1 (CR1) molecules on erythrocytes and uses therefor The present invention is directed, at least in part, to mice which express exogenous complement receptor type 1 (CR1) on red blood cells. The invention also pertains to genetic constructs encoding heterologous CR1 for expression on red blood cells. Methods of using ... | 07/29/2008 |
| 7365182 | Plant (VIP) genes, proteins, and methods of use The present invention relates to plant genes involved in regulating flowering, and especially to genes involved in the induction of flowering in response to cold, or vernalization. In particular, the present invention provides the identification, cloning, and charac... | 04/29/2008 |
| 7358416 | Transgenic mouse expressing human FcRn protein Disclosed is a transgenic knockout mouse whose genome comprises a homozygous disruption in its endogenous FcRn gene. The homozygous RcRn disruption prevents the expression of a functional FcRn protein, resulting in a transgenic knockout mouse in which exogenously ad... | 04/15/2008 |
| 7355095 | Method for producing heart-specific fluorescence of non-human eukaryotic animals A method of expressing in vivo heart-specific fluorescence in transgenic line of zebrafish is developed, which provides a research model for studying heart-related gene functions and performing gene therapies in the future. The method comprises the following steps. ... | 04/08/2008 |
| 7351813 | Liver-specific gene expression cassettes, and methods of use In one aspect, the present invention provides nucleic acid expression cassettes that are predominantly expressed in the mammalian liver. The present invention also provides vectors comprising a nucleic acid expression cassette that is predominantly expressed in the ... | 04/01/2008 |
| 7351875 | FcγRIIa transgenic animal model for autoimmune disease The present invention provides a FcγRIIa transgenic non-human animal model for autoimmune disease, particularly arthritis. This invention also provides a method of using this model to screen compounds that can reduce aberrant immune activity including aberrant immu... | 04/01/2008 |
| 7341871 | Nucleotide sequences for gene regulation and methods of use thereof The invention provides nucleic acid sequences which regulate expression of a nucleotide sequence of interest. In particular, the invention provides nucleic acid sequences which regulate expression of a nucleotide sequence of interest in an age-related manner and/or ... | 03/11/2008 |
| 7335743 | Human anti-IFN-γ neutralizing antibodies as selective IFN-γ pathway inhibitors This invention provides antibodies that interact with or bind to human interferon-gamma (IFN-γ) and methods for treating IFN-γ mediated diseases by administering a pharmaceutically effective amount of antibodies to IFN-γ. Methods of detecting the amount of IFN-γ... | 02/26/2008 |
| 7323616 | Genetically altered mice deficient in functional caspase-9 The invention relates to genetically manipulated animals that are deficient in the expression of Caspase-9, a protein involved in programmed cell death. The invention further relates to methods for preventing specific types of cell death associated with Caspase-9 ac... | 01/29/2008 |
| 7323618 | Tissue specific expression of exogenous proteins in transgenic chickens Transgenes encoding exogenous proteins are stably integrated into embryonic stem cells and are present in the somatic tissue of transgenic or chimeric birds. The transgenes encode exogenous proteins and are expressed in any of endodermal, ectodermal, mesodermal, or ... | 01/29/2008 |
| 7309811 | Transgenic mice knockouts of BACE-1 The invention provides transgenic animals that are heterozygous or homozygous for a nonfunctional allele of BACE-1. These animals show normal development indicating that BACE-1 is not necessary for development and hence is an appropriate therapeutic target. The tran... | 12/18/2007 |
| 7294754 | Method for generating an animal homozygous for a genetic modification Methods of generating modified embryos and mammals by introduction of donor cells into an early stage embryo are provided, such that the resulting embryo and animal generated therefrom has a significant or complete contribution to all tissues from the donor cells an... | 11/13/2007 |
| 7288251 | Antibodies to CD40 The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also relates to human anti-CD40 antibodies and antigen-binding portions thereof.... | 10/30/2007 |
| 7282621 | Somatic recombination Recombination in mammalian somatic cell chromosomes is promoted and marked by a method called mosaic analysis with double marker (MADM). Mouse “knock-in” techniques are used to create pairs of chromosomes in which recombinase target sites are placed at homologou... | 10/16/2007 |
| 7271311 | Mammalian model for diabetes An object of the present invention is to provide a model mammal for diabetes onset, being useful for elucidating the onset mechanism of diabetes caused by a blockage of signal transduction from insulin, and for the development of a remedy for said diabetes, and to p... | 09/18/2007 |
| 7265259 | GSK-3β expressed in a transgenic mouse A transgenic animal in which GSK-3β protein is over-expressed is useful as a model for neurodegenerative disease. ... | 09/04/2007 |
| 7253334 | Methods for cloning non-human mammals using reprogrammed donor chromatin or donor cells The invention provides methods for cloning mammals that allow the donor chromosomes or donor cells to be reprogrammed prior to insertion into an enucleated oocyte. The invention also features methods of inserting chromosomes or nuclei into recipient cells. ... | 08/07/2007 |
| 7250551 | Transgenic mice expressing inducible human p25 Disclosed are improved methods of treating individuals with Alzheimer's disease (AD) as well as methods to diagnose AD in an individual. Also included are compounds and methods of identifying compounds to treat AD. The present invention also discloses methods for de... | 07/31/2007 |
| 7247766 | Double transgenic mice overexressing human beta secretase and human APP-London The present invention relates to a novel animal model for amyloidopathies, especially Alzheimer' disease overexpressing human BACE and human APP London. This novel animal model exhibits several aspects of amyloidopathy. The present invention also relates to a method... | 07/24/2007 |
| 7244874 | Stearoyl CoA desaturase transgenic non-human animals The present invention provides transgenic, non-human animals that include a transgene that encodes a fatty acid desaturase, e.g., stearoyl-CoA desaturase, and methods for producing such animals. The invention further provides an expression cassette that includes a c... | 07/17/2007 |
| 7235709 | Transgenic animals with increased slow-twitch muscle fibers and methods of using such animals Transgenic non-human mammals over-expressing MHCI in skeletal muscle are provided herein, as are methods of using these transgenic non-human mammals for screening candidate compounds for treating type 2 diabetes, and methods for altering the ratio of MHCI to MHCII i... | 06/26/2007 |
| 7230156 | Method for preparing a sterile transgenic carp The present application disclosed a method for preparing a sterile transgenic fish, comprising constructing antisense RNA expression vector of salmon-type gonadotropin-releasing hormone, introducing the recombinant DNA fragment into carp oosperm by microinjection, a... | 06/12/2007 |
| 7227052 | GFP expression vector localized in mitochondria A system for observing the behaviors of mitochondria during ontogeny and the dynamics of mitochondria in various tissues during pathological development is provided. A pCAGGS expression vector containing green fluorescent protein (GFP) gene and a transgenic animal c... | 06/05/2007 |
| 7214850 | Transgenic mouse expressing Prkag3 Transgenic non-human animals that express the γ3 subunit of PRKAG are described, as well as methods of using the transgenic non-human animals as models for improving treatment, prevention, or diagnosis of diseases related to energy metabolism, including obesity, dy... | 05/08/2007 |
| 7208576 | Non-glycosylated human alpha-fetoprotein, methods of production, and uses thereof The invention features non-glycosylated human alpha-fetoprotein, methods of production, and uses thereof. ... | 04/24/2007 |
| 7205148 | Genome mutation by intron insertion into an embryonic stem cell genome Methods of creating mutations in genomic exons by inserting introns into the genomic exons via homologous recombination. Also, methods are provided for introducing modifications into genomic exons by inserting introns into the genomic exons via homologous recombinat... | 04/17/2007 |
| 7202344 | Secreted factors The invention concerns new secreted factors encoded by clones P00184_D11 (SEQ ID NO: 1), P00185_D11 (SEQ ID NO: 3), P00188_D12 (SEQ ID NO: 5), P00188_E01 (SEQ ID NO: 7), P00194_G01 (SEQ ID NO: 9), P00194_G05 (SEQ ID NO: 11), P00194_H10 (SEQ ID NO: 13), P00199_D08 (S... | 04/10/2007 |
| 7199280 | Homologous recombination in mismatch repair inactivated eukaryotic cells A mammalian cell having a mismatch repair-deficient phenotype is provided, where one or both alleles of a gene essential for mismatch repair, such as an Msh gene, are inactivated. Using this cell in a gene knock-out methodology advantageously allows efficient homolo... | 04/03/2007 |
| 7199281 | Method of generating a transgenic livestock animal The present invention provides methods of producing transgenic livestock animals. The methods generally involve first introducing a nucleoprotein made up of nucleic acid and a recombinase into a totipotent or pluripotent cell to produce a recombinant totipotent or p... | 04/03/2007 |
| 7196243 | Transgenic animal containing CD200 and uses therefor The present invention is directed toward a transgenic non-human animal and uses thereof, wherein each of the cells of the animal contain a transgene comprising a nucleic acid sequence encoding CD200. ... | 03/27/2007 |
| 7186883 | In vitro propagation of embryonic stem cells The present invention relates to the use of leukemia inhibitory factor (LIF) in the isolation and propagation of embryonic stem cells in vitro. ... | 03/06/2007 |
| 7186882 | Transgenic mouse over-expressing calreticulin (CRT) in vascular smooth muscle cells A transgenic mouse whose genome comprises a transcriptional control region operably linked to a cDNA encoding calreticulin (CRT) is described. ... | 03/06/2007 |
| 7145057 | Chimeric bird from embryonic stem cells Sustained cultures of avian embryonic stem cells are provided. Injection of avian embryonic stem cells into recipient embryos yields chimeras with a significant contribution from the embryonic stem cell phenotype. Transgene encoding exogenous proteins are stably int... | 12/05/2006 |
