Class 800/18 - Mouse

Subclass of Class 800 - Multicellular living organisms and unmodified parts thereof and related processes
Definition: Subject matter wherein the mammal is a mouse.
No. of patents: 718
Last issue date: 04/03/2012

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Number	Title	Issue Date
6734336	Gene-targeted non-human mammal with human fad presenilin mutation and generational offspring The present invention provides a gene-targeted, non-human mammal having a gene encoding a mutant protein product of a mutated FAD presenilin-1 (PS-1) gene, a human FAD Swedish mutation, and a humanized Aβ mutation, and generational offspring thereof and a gene-targ...	05/11/2004
6730821	Transgenic mice containing retina-specific nuclear receptor gene disruptions The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in genes, which are useful as models for d...	05/04/2004
6727405	Transgenic animals secreting desired proteins into milk A DNA sequence containing a gene encoding a protein, the gene being under the transcriptional control in the DNA sequence of a mammalian milk protein promoter which does not naturally control the transcription of the gene, such DNA sequence including DNA enabling se...	04/27/2004
6723893	Mice having a mutant SOD-1-encoding transgene Disclosed is the family of genes responsible for the neurodegenerative diseases, particularly Amyotrophic Lateral Sclerosis. Methods and compounds for the diagnosis, prevention, and therapy of the disease are also disclosed. ...	04/20/2004
6720472	HMGI proteins in cancer and obesity The present invention relates to HMGI genes and proteins and methods of using the same. Embodiments of the invention pertain to methods for treating obesity, methods for treating a tumor, methods for producing a transgenic non-human mammal, methods for screening can...	04/13/2004
RE38490	Method for identifying metastatic sequences The invention relates to methods for the identification of metastatic sequences. Cells from a cell line or an animal tissue are treated to form a cell line predisposed to metastasis. Treated cells are implanted in an animal of at a primary site and incubated for a p...	04/06/2004
6717031	Method for selecting a transgenic mouse model of alzheimer's disease The construction of transgenic animal models of human Alzheimer's disease, and methods of using the models to screen potential Alzheimer's disease therapeutics, are described. The models are characterized by pathologies similar to pathologies observed in Alzheimer's...	04/06/2004
6717032	Transgenic mice containing DEZ orphan receptor gene disruptions The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a DEZ receptor gene. Such transgenic mice...	04/06/2004
6713662	Production of collagen in the milk of transgenic mammals The invention provides transgenic nonhuman mammals capable secreting exogenous procollagen or collagen into their milk. The mammals are healthy and capable of producing procollagen or collagen at high levels, usually in trimeric form. Suitable transgenes for incorpo...	03/30/2004
6710226	Transgenic mouse assay to determine the effect of Aβ antibodies and Aβ Fragments on alzheimer's disease characteristics The invention provides compositions and methods for treatment of amyloidogenic diseases. Such methods entail administering an agent that induces a beneficial immune response against an amyloid deposit in the patient. The methods are particularly useful for prophylac...	03/23/2004
6693226	Transgenic mice expressing human p25 The invention provides transgenic, non-human animals and transgenic non-human mammalian cells harboring a transgene encoding a p25 (activator of the protein kinase cdk 5) polypeptide. The two neuropathological lesions associated with Alzheimer's disease (...	02/17/2004
6689936	Method for evaluating a compound for its effect on skin The invention provides methods of evaluating a treatment for its effect on skin. The invention also provides non-human transgenic animals, e.g., mice, having a reporter gene coupled to a skin-metabolism promoter....	02/10/2004
6689937	Transgenic mouse model of basal cell carcinoma The present invention provides transgenic non-human animal models of basal cell carcinoma which allows for the characterization of the disease as well as for providing a system for the development and testing of potential treatments....	02/10/2004
6677501	P2X7 receptor-deficient mice and uses thereof The invention provides non-human, genetically-modified mammals and genetically modified animals cells having a functionally disrupted P2×7 receptor gene. Also provided are methods for producing genetically modified mice in which one or both P	01/13/2004
6677499	Modulation of memory, learning and/or anxiety states This invention relates to the modification of long-term potentiation (LTP), learning, memory and/or anxiety states. More particularly, it relates to methods of prophylactically or therapeutically treating LTP, learning, memory and/or anxiety disorders in ...	01/13/2004
6677299	Method to increase cerebral blood flow in amyloid angiopathy The present invention provides a method for decreasing cerebral vasoconstriction in a subject suffering from chronic or acute cerebral amyloid angiopathy which comprises administering to the subject an inhibitor of receptor for advanced glycation endprodu...	01/13/2004
6673986	Generation of xenogeneic antibodies The subject invention provides non-human mammalian hosts characterized by inactivated endogenous Ig loci and functional human Ig loci for response to an immunogen to produce human antibodies or analogs thereof. The hosts are produced by multiple genetic m...	01/06/2004
6673768	Transgenic animal models for cardiac hypertrophy and methods of use thereof (treating) Transgene constructs for generating transgenic animals, wherein the transgene encodes a gene product which modulates transcription of a hypertrophy-sensitive gene, are provided. Further provided are recombinant vectors comprising the transgenes of the inv...	01/06/2004
6664443	Pathogenic Tau mutations in transgenic mice Isolated nucleic acid molecules that include a tau gene sequence are described. The tau gene sequences have a mutation linked to a Tau pathology. Transgenic non-human mammals that develop a Tau pathology also are described....	12/16/2003
6664442	Selecting compounds to reduce inflammation associated with Alzheimer's disease The invention includes identification of specific markers, the elevation of which in central nervous tissue is associated with Alzheimer's Disease. The invention also includes improved assay methods for selecting compounds useful in reducing or preventing...	12/16/2003
6662039	Optical probing of neuronal connections with fluorescent indicators This invention provides methods of identifying a connection between a first neuron and a second neuron or plurality of neurons in a neural tissue slice with a fluorescent indicator. This invention also provides a method of detecting the effect of a neurom...	12/09/2003
6660906	Tpl2 transgenic knockout mice The present invention is directed to animal having functionally disrupted endogenous Tpl2. These animals are resistant to Lps induced endotoxin shock and TNF଱-mentioned inflammatory disease. A method of identifying Tpl2 specific inhibitors of endoto...	12/09/2003
6657104	Transgenic mouse model for cardiac hypertrophy and methods of use thereof Transgene constructs for generating transgenic animals, wherein the transgene encodes a gene product which modulates transcription of a hypertrophy-sensitive gene, are provided. Further provided are recombinant vectors comprising the transgenes of the inv...	12/02/2003
6657105	Prion gene modified mouse which exhibits heart anomalies The present invention relates to a method for detecting an aberrant animal-derived prion gene wherein the method comprises steps of introducing a prion gene of an animal into a mouse to produce a prion gene modified mouse and determining that the prion ge...	12/02/2003
6657103	Human antibodies derived from immunized xenomice Antibodies with fully human variable regions against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci ha...	12/02/2003
6653526	Transgenic mice exhibiting increased susceptibility to seizures The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a ubiquitin-specific protease ...	11/25/2003
6653113	High efficiency gene targeting in mouse embryonic stem cells The present invention provides novel methods for modifying the genome of an animal cell which typically comprise the steps of: constructing a DNA molecule in which desired sequence modifications are contained in a segment of DNA (a "targeting DNA") that i...	11/25/2003
6649811	Transgenic mouse expressing the human cyclooxygenase-2 gene and neuronal cell cultures derived therefrom The invention provides for transgenic mice whose genomes comprise a gene encoding human cyclooxygenase-2 under the control of a neuron-specific promoter. The transgenic mice of the instant invention express human cyclooxygenase-2 mRNA in neuronal cells of...	11/18/2003
6642433	Fgl-2 knockout mice A knockout mouse in which the Fgl-2 gene has been suppressed is described. The mouse is useful in studying the role of Fgl-2 in normal and disease states including viral hepatitis, allograph rejection, fetal loss, inflammatory bowel disease, lupus glomeru...	11/04/2003
6639121	Inducible cancer model to study the molecular basis of host tumor cell interactions in vivo A non-human mammal having incorporated into its genome an expression construct in which nucleic acid encoding an oncogene is operably linked to an inducible promoter; the mammal further has a genetic mutation that causes it to have an increased susceptibi...	10/28/2003
6639123	Melanocortin-3 receptor deficient cells, non-human trangenic animals and methods of selecting compounds which regulate body weight Cells and non-human transgenic animals have been engineered to be deficient in the gene encoding the melcanocortin-3 receptor protein (MC-3R). MC-3R deficient transgenic animals have increased fatmass and reduced lean body mass, showing that the MC-3R pro...	10/28/2003
6632978	Transgenic animals for studying regulation of genes A transgenic non-human animal (e.g., a transgenic mouse) comprising a polynucleotide encoding a soluble marker protein functionally linked to a regulatory sequence of an endogenous gene encoding E-selectin. Also described are methods for detecting modulat...	10/14/2003
6632976	Chimeric mice that are produced by microcell mediated chromosome transfer and that retain a human antibody gene A chimeric, non-human animal can be produced by a method that entails providing a microcell that contains one or more foreign chromosomes or fragment(s) thereof and then fusing the microcell with a pluripotent cell, thereby introducing the foreign chromos...	10/14/2003
6632977	Transgenic animal whose expression of the opiate receptors is modified The invention concerns the use of a non-human transgenic mammal whose expression of a gene coding for an opiate receptor is modified, particularly in the nerve tissues with respect to a normal expression, in particular in the nerve tissues, for producing ...	10/14/2003
6632979	Rodent HER2 tumor model The invention concerns HER2-transgenic non-human mammals, animal models for screening drug candidates for the treatment of diseases and disorders associated with the overexpression of HER2. In particular, the invention concerns animal models designed to t...	10/14/2003
6630613	Transgenic animals and lats genes The present invention relates to a tumor suppressor gene, termed large tumor suppressor (lats), and methods for identifying tumor suppressor genes. The method provides nucleotide sequences of lats genes, and amino acid sequences of their encoded proteins,...	10/07/2003
6630612	5-HT3 receptor assay using transgenic mammal The invention relates to transgenic mammals characterized by 5-HT3 receptor over-expression in the central nervous system (CNS). The mammals have particular utility as models for studying the role of 5-HT3 receptors in the CNS, espec...	10/07/2003
6627792	Human T cell-engrafted mouse, method for developing same and use thereof The present invention provides a method for developing a human T cell-engrafted mouse, which includes transplanting a human-derived bone tissue into an inbred line mouse deficient in immune cells, and a human T cell-engrafted mouse obtainable by the metho...	09/30/2003
6613958	Transgenic mouse model for degeneration of type II collagen in joints The present invention provides animal model systems for cartilage-degenerative disease, which comprise transgenic animals which can express recombinant matrix-degrading enzymes (MDEs), particularly matrix metalloproteinases (MMPs), in a temporally and spa...	09/02/2003
6610905	Transgenic mouse model for Kaposi's sarcoma The present invention relates to a non-human transgenic mouse containing a constitutively active G-protein coupled receptor, which produces Kaposi's sarcoma-like symptoms. The transgenic mouse is useful in identification of reagents for the prevention, tr...	08/26/2003

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Class 800/18 - Mouse