Did You Know...
...that the inventor of the electric motor was a blacksmith named Thomas Davenport? Described as "a brilliantly unsuccessful inventor", Davenport invented the first rotary electric motor. In 1836 he headed out -- on foot -- from his Vermont home to file a patent application at the Patent Office in Washington, D.C. By the time he got there, he had squandered away his money and couldn't afford the $30 filing fee so he turned around and went home. When he later mailed in his application with money he'd raised, the Patent office was destroyed in a fire. He did finally get credit for his invention on Feb. 5, 1837.
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| Number | Title | Issue Date |
| 5574206 | Transgenic mouse carrying a non-infectious HIV genome Disclosed herein is a transgenic mouse carrying a transgene which expresses non-infectious HIV ribonucleic acid, and the complementary proteins thereof. The transgenic mouse is useful as a source for obtaining the complementary proteins, and as an animal ... | 11/12/1996 |
| 5569825 | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes The invention relates to transgenic non-human animals capable of producing heterologous antibodies of multiple isotypes. Heterologous antibodies are encoded by immunoglobulin heavy chain genes not normally found in the genome of that species of non-human ... | 10/29/1996 |
| 5569812 | Nude mouse model for human neoplastic disease A nude mouse model for human neoplastic disease having histologically intact human neoplastic tissue transplanted onto an organ of the mouse which corresponds to the human organ from which the tissue is obtained.... | 10/29/1996 |
| 5569824 | Transgenic mice containing a disrupted p53 gene A desired non-human animal or an animal cell or human cell which contains a predefined, specific and desired alteration in at least one of its two p53 chromosomal alleles, such that at least one of these alleles contains a mutation which alters the expres... | 10/29/1996 |
| 5569827 | Transgenic mouse for the neuronal expression of HIV gp160 The present invention relates to a transgenic non-human mammal, whose germ cells and somatic cells contain a recombinant env gene sequence which is operably linked to a promoter effective for the expression of the gene in the neuronal tissues of the mamma... | 10/29/1996 |
| 5565186 | Method of detecting prions in a sample and transgenic animal used for same Prions are protein based infectious material that cause of variety of diseases such as Scrapie, bovine spongiform encephalopathy (also known as "Mad Cow" disease), Creutzfeldt Jakob Disease, Kuru, and fatal familial insomnia. The invention is directed to ... | 10/15/1996 |
| 5557032 | Knockout mice Mice lacking expression of CD28 or particular CD45 isoforms in certain cells of the immune system are provided. Also provided are methods of using these mice.... | 09/17/1996 |
| 5556782 | Transformed mammalian cells capable of expressing cecropin b Novel means have been discovered for increasing the resistance of a mammalian host (including humans) to diseases caused by intracellular bacteria, protozoa, and viruses. Novel means have also been found for treating tumors. Augmentation of the host's def... | 09/17/1996 |
| 5550316 | Transgenic animal model system for human cutaneous melanoma The present invention relates to transgenic animal model systems for human cutaneous melanoma. It is based, at least in part, on the discovery that, in susceptible transgenic mice, accelerated formation of melanoma tumors occurred near the wound borders o... | 08/27/1996 |
| 5545807 | Production of antibodies from transgenic animals Chimaeric or wholly foreign immunoglobulin is obtained from cells or body fluid of a transgenic animal which has had inserted into its germline genetic material that encodes for at least part of an immunoglobulin, of foreign origin or that can rearrange t... | 08/13/1996 |
| 5545806 | Ransgenic non-human animals for producing heterologous antibodies The invention relates to transgenic non-human animals capable of producing heterologous antibodies and transgenic non-human animals having inactivated endogenous immunoglobulin genes. In one aspect of the invention, endogenous immunoglobulin genes are sup... | 08/13/1996 |
| 5530177 | Transgenic mice producing bovine -lactalbumin in their milk The present invention relates to the use of a mammary specific -lactalbumin regulatory sequence to assist in the production of recombinant proteins in mammals' milk. The invention also relates to the genetically engineered mammal that produces the ... | 06/25/1996 |
| 5530179 | Transgenic immunodeficient animal models The invention features a transgenic mouse having a substantial deficiency in functionally active natural killer cells and T lymphocytes which is useful as a model system for immune diseases, tumorigenesis and transplant rejection.... | 06/25/1996 |
| 5530178 | Mutant mouse lacking CD8 surface marker A mutant mouse strain without CD8 (Lyt-2 and Lyt-3) expression on the cell surface has been generated by disrupting the Lyt-2 gene using embryonic stem cell technology. In these mammals, for example, mice, CD8+ T lymphocytes are not present in... | 06/25/1996 |
| 5516977 | Xenogeneic tissue implant in ear pinna Immunocompromised hosts comprising xenogeneic fetal lymph node tissue implanted in the ear pinna are provided. The chimeric hosts are prepared by inserting the xenogeneic lymph node tissue into the ear pinna and closing the incision. The tissue is found t... | 05/14/1996 |
| 5491284 | Nude mouse model for neoplastic disease A nude mouse model for human neoplastic disease having histologically intact human neoplastic tissue transplanted onto an organ of the mouse which corresponds to the human organ from which the tissue is obtained.... | 02/13/1996 |
| 5491283 | BRC/ABL transgenic animals as models for Philadelphia chromosome positive chronic myelogenous and acute lymphoblastic leukemia The present invention relates to non-human transgenic animals which contain a transgene comprising a BCR/ABL gene fusion and which develop leukemia. In a preferred embodiment of the present invention, the transgenic animals exhibit a rapid induction of ac... | 02/13/1996 |
| 5489743 | Transgenic animal models for thrombocytopenia Transgenic mice and methods of preparing such mice are disclosed. The mice exhibit decreased platelet counts and/or megakaryocyte leukemia.... | 02/06/1996 |
| 5476996 | Human immune system in non-human animal Laboratory non-human animals in which the immune system of a human donor is induced in and thrives in vivo and expresses the immune response of the human donor in a recipient non-human animal, and wherein malignant immune system cells of the human donor c... | 12/19/1995 |
| 5434340 | Transgenic mice depleted in mature T-cells and methods for making transgenic mice Transgenic mice having a phenotype characterized by the substantial absence of mature T lymphocytes otherwise naturally occurring in said mice. The phenotype is conferred in the transgenic mouse by a transgene contained in at least the precursor stem cell... | 07/18/1995 |
| 5434341 | Xenogeneic lymph node in mammary fat pad Methods and chimeric immunocompromised hosts comprising functional xenogeneic organs are provided, particularly hematopoietic organs, where the xenogeneic organ is engrafted into a mammary fat pad. Exemplary is the engrafting of lymph node with mesenteric... | 07/18/1995 |
| 5416260 | Homologous recombination for universal donor cells and chimeric mammalian hosts Homologous recombination is employed to inactivate genes, particularly genes associated with MHC antigens. Particularly, the 댢 -microglobulin gene is inactivated for reducing or eliminating Class I MHC antigens. The resulting cells may b... | 05/16/1995 |
| 5387742 | Transgenic mice displaying the amyloid-forming pathology of alzheimer's disease Cloned recombinant or synthetic DNA sequences related to the pathology of Alzheimer's disease are injected into fertilized mouse eggs. The injected eggs are implanted in pseudo pregnant females and are grown to term to provide transgenic mice whose cells ... | 02/07/1995 |
| 5347075 | Mutagenesis testing using transgenic non-human animals carrying test DNA sequences An assay for monitoring and assessing the mutagenic potential of agents which involves creating transgenic non-human animals carrying a test DNA sequence or sequences that can be quickly recovered and examined for mutations following exposure to one or mo... | 09/13/1994 |
| 5221778 | Multiplex gene regulation A transgenic mouse offspring produced by the mating of a first transgenic mouse carrying a transresponder transgene whose expression is regulated by a viral gene product of HSV-1 and a second transgenic mouse carrying a transactivator transgene. A process... | 06/22/1993 |
| 5175383 | Animal model for benign prostatic disease A male transgenic mouse containing germ cells and somatic cells which contain a recombinant gene which is a vertebrate gene in the int-2/FGF family which is capable of promoting benign prostatic hyperplasia or hypertrophy in said transgenic mouse, said ge... | 12/29/1992 |
| 5175384 | Transgenic mice depleted in mature T-cells and methods for making transgenic mice Transgenic mice having a phenotype characterized by the substantial absence of mature T lymphocytes otherwise naturally occurring in said mice. The phenotype is conferred in the transgenic mouse by a transgene contained in at least the precursor stem cell... | 12/29/1992 |
| 5175385 | Virus-resistant transgenic mice A transgenic mouse with enhanced viral resistance transmissible to its offspring is prepared by introduction of a gene encoding a human interferon having antiviral activity into a host mouse. The gene encodes the interferon of a different animal species a... | 12/29/1992 |
| 4873316 | Isolation of exogenous recombinant proteins from the milk of transgenic mammals This invention relates to the production of recombinant proteins in mammals' milk. Particularly, this invention relates to an expression system comprising the mammal's casein promoter which when transgenically incorporated into a mammal permits the female... | 10/10/1989 |
| 4736866 | Transgenic non-human mammals A transgenic non-human eukaryotic animal whose germ cells and somatic cells contain an activated oncogene sequence introduced into the animal, or an ancestor of the animal, at an embryonic stage.... | 04/12/1988 |
