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| Number | Title | Issue Date |
| 7919672 | Suppression of B-cell apoptosis in transgenic animals expressing humanized immunoglobulin The invention provides a novel approach to increase immunoglobulin expression in non-human transgenic animals. For instance, the invention provides a method to increase humanized immunoglobulin production in animals genetically engineered to express one or several h... | 04/05/2011 |
| 7799969 | Methods for cloning rats by nuclear transfer The invention relates to a method for cloning in the rat by nuclear transfer. The invention further relates to the rats obtained thus, in the foetal or adult state, as well as use thereof for the production of molecules of interest or as study models. ... | 09/21/2010 |
| 7737325 | Antibody composition-producing cell The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-modulated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region ... | 06/15/2010 |
| 7718846 | Animal models of long QT syndrome and uses thereof Provided are animal models of long QT syndrome (LQTS). The animal models are useful, for example, in screening of drugs for adverse effects in subjects with LQTS, in screening candidate therapeutics for the treatment or prevention of LQTS, and in determining gene ex... | 05/18/2010 |
| 7667089 | Transgenic mammal secreting B-domain deleted human FVII in its milk Hemophilia A is one of the major inherited bleeding disorders caused by a deficiency or abnormality in coagulation factor VIII (FVIII). Hemophiliacs have been treated with whole plasma or purified FVIII concentrates. The risk of transmitting blood-borne viruses and ... | 02/23/2010 |
| 7501553 | Non-human transgenic mammal comprising a modified MSP-1 nucleic acid The invention provides modified recombinant nucleic acid sequences (preferably DNA) and methods for increasing the mRNA levels and protein expression of malarial surface protein MSP-1 which is known to be difficult to express in cell culture systems, mammalian cell ... | 03/10/2009 |
| 7501554 | Transgenic animals producing low-lactose milk and newly identified human small intestinal extracellular lactase-phlorizin hydrolase (ecLPH) gene The invention provides a transgenic animal producing low-lactose milk, which is transformed with a gene encoding an extracellular lactase-hydrolyzing enzyme cloned from a human small intestinal cDNA library. The invention also provides a new extracellular lactase-ph... | 03/10/2009 |
| 7453021 | Transgenic animal model for degenerative diseases of cartilage The present invention provides animal model systems for cartilage-degenerative disease, which comprise transgenic animals which can express recombinant matrix-degrading enzymes (MDEs), particularly matrix metalloproteinases (MMPs), in a temporally and spatially regu... | 11/18/2008 |
| 7435872 | Role of p62 in aging-related disease The application discloses a role of p62 in aging-related disease, such as development of obesity, type 2 diabetes mellitus, non-alcoholic fatty liver, various tumors, increased male mortality, intracellular inclusion named sequestosome, and redox regulation. In part... | 10/14/2008 |
| 7435869 | Transgenic nonhuman mammals producing fibrinogen in milk and methods of producing fibrin A transgenic, non-human mammalian animal is capable of expressing a heterologous gene for human or other recombinant physiologically functional fibrinogen holoprotein or individual subunit chain polypeptides thereof or a modified or fusion fibrinogen in mammary glan... | 10/14/2008 |
| 7414171 | PD-1-lacking mouse and use thereof The invention relates to BALB/c mice that are deficient in the programmed cell death-1 receptor (PD-1), a screening method for autoimmune disease medicine using these mice, an IgG self-reactive antibody that the mice produce, a protein that specifically reacts to th... | 08/19/2008 |
| 7411111 | Method for cloning of the rat by nuclear transfer The invention relates to a method for cloning in the rat by nuclear transfer. The invention further relates to the rats obtained thus, in the foetal or adult state, as well as use thereof for the production of molecules of interest or as study models. ... | 08/12/2008 |
| 7402725 | WIP, a WASP-associated protein Described herein is a novel gene and its product, WIP, which associates with WASP. The subject invention relates to the isolated WIP gene or cDNA and transgenic mammals that have the WIP gene disrupted in their genome. Also the subject of this invention are methods ... | 07/22/2008 |
| 7402724 | Longevity and PAPP-A This document provides materials and methods related to PAPP-A polypeptides, aging, and transgenic non-human mammals whose genomes comprise a disrupted PAPP-A allele. Methods for making such transgenic non-human mammals, and using them and other mammals to identify ... | 07/22/2008 |
| 7399902 | Mouse cardiac conduction system model The present invention relates to a transgenic mouse which has integrated a reporter gene in the locus of the Cx40 gene, wherein said reporter gene is expressed in the different components of the cardiac conduction system (CCS) including the atrio-ventricular node (A... | 07/15/2008 |
| 7378569 | Transgenic pigs carrying both hHO-1 and hDAF transgenes for xenotransplantation The invention provides a transgenic animal carrying two transgenes, one encoding a human decay accelerating factor (hDAF) and the other encoding a human heme oxygenase-1 (hHO)-1, which are useful for providing cells, tissues or organs therefrom for xenotransplantati... | 05/27/2008 |
| 7371920 | Transgenic mouse model of neurodegenerative disorders The present invention provides a transgenic animal model of Alzheimer's Disease designated TgCRND8 as well as a method for making such model, which allows for the characterization of the etiology of the disease as well as for provide a system for the development and... | 05/13/2008 |
| 7365239 | In vivo models for rabGEF1-dependent signaling and functions Non-human transgenic animal models and cells derived therefrom are provided for RabGEF1 function. RabGEF1 is a negative regulator of FcεRI-dependent mast cell activation and T cell activation via the T cell receptor and a lack of RabGEF1 results in the development ... | 04/29/2008 |
| 7361481 | Diagnosis of lysosomal storage disorders using saposins and other markers Methods for assaying a lysosomal enzyme activity present in a blood sample obtained from a patient. The method combines the blood or plasma sample in a buffer with at least one binding reagent capable of reacting with alpha-glucosidase present in the blood sample to... | 04/22/2008 |
| 7358277 | Use of a lactate salt for the treatment and prophylaxis of atherosclerosis The use of a lactate metal salt, in particular an L-lactate, for the treatment of atheroscloerosis and/or for the prophylaxis or treatment of diseases caused by atherosclerosis is disclosed. ... | 04/15/2008 |
| 7354594 | Merozoite surface protein 1 lacking glycosylation sites The invention provides modified recombinant nucleic acid sequences (preferably DNA) and methods for increasing the mRNA levels and protein expression of malarial surface protein MSP-1 which is known to be difficult to express in cell culture systems, mammalian cell ... | 04/08/2008 |
| 7355093 | Model animal with overexpression of regucalcin The present invention provides an animal model which overexpresses regucalcin, a calcium-binding protein that is inherently expressed in the liver and the like of the higher animal, and which is characterized by a showing of bone pathology typified by osteoporosis. ... | 04/08/2008 |
| 7353152 | Method and apparatus for computer modeling diabetes The present invention relates generally to a mathematical and computer model of diabetes related disorders (e.g., human type 2 diabetes) within the framework of multiple macronutrient metabolism. The model includes a representation of complex physiological control m... | 04/01/2008 |
| 7335811 | Method for collecting cells in M phase or Gphase and method for nuclear transplantation using the cells Methods for collecting cells in M phase or G1 phase, by which the percentage of M phase or G1 phase cells is higher than that attained by the conventional methods are disclosed. ... | 02/26/2008 |
| 7332646 | Transgenic animal model for degenerative diseases of cartilage The present invention provides animal model systems for cartilage-degenerative disease, which comprise transgenic animals which can express recombinant matrix-degrading enzymes (MDEs), particularly matrix metalloproteinases (MMPs), in a temporally and spatially regu... | 02/19/2008 |
| 7329796 | Serial nuclear transfer of ungulate embryos A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at the time of transfer, so that the donor nucleus is kept exposed to th... | 02/12/2008 |
| 7326238 | Method and apparatus for treating vulnerable plaque An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has a medical device to treat an occlusive plaque, and is also adapted to release a biologically active agent to treat vulnerable plaque located downstream from the occlusive plaque... | 02/05/2008 |
| 7323620 | Activation of equine oocytes A method for activating an equine oocyte comprising exposing oocyte to a medium containing a concentration of calcium of at least about 4 mM. Preferably the oocyte is exposed to this concentration of calcium during activation. ... | 01/29/2008 |
| 7323619 | Method for producing transgenic birds and fish The present invention relates to methods for producing transgenic animals, particularly transgenic birds and fish, using retroviral constructs engineered to carry the transgene(s) of interest. ... | 01/29/2008 |
| 7323189 | Liquid and low melting coatings for stents A method for forming liquid coatings for medical devices such as stents and angioplasty balloons is provided. The liquid coatings can be made from biodegradable materials in liquid, low melting solid, or wax forms, which preferably degrade in the body without produc... | 01/29/2008 |
| 7316926 | Immortalized vascular adventital cell line To provide an immortalized capillary pericyte line which maintains the original function/property of the cell line-deriving tissue, its establishment method, and the screening method for useful substance using the immortalized capillary pericyte line. Cerebral tissu... | 01/08/2008 |
| 7312373 | Nonhuman model animal lacking the ability to control lymphocyte migration The present invention provides a animal model useful in identifying a molecule controlling in a lymphocyte-specific manner migration and thus elucidating immune-related diseases and pathogenic conditions such as allergy, autoimmune diseases, GvH and graft rejections... | 12/25/2007 |
| 7309812 | Perlecan transgenic animals and methods of identifying compounds for the treatment of amyloidoses The invention provides a transgenic non-human animal expressing a perlecan encoding transgene. Also provided is a double-transgenic non-human animal expressing a perlecan and an amyloid encoding transgene. A method of screening for a compound which alters the rate o... | 12/18/2007 |
| 7309693 | Preventives and remedies for pulmonary hypertension The present invention provides a prophylactic and/or therapeutic agent for pulmonary hypertension, comprising an antagonistic mutein of MCP-1 or a salt thereof, a DNA molecule comprising a nucleotide sequence encoding the antagonistic mutein of MCP-1, or a neutraliz... | 12/18/2007 |
| 7304203 | Transgenic TIEG non-human animals Materials and methods related to a transgenic non-human animal (e.g., a transgenic non-human mammal) whose genome comprises a disrupted TIEG allele are provided. Methods for making such transgenic non-human animals, and using them to identify and characterize agents... | 12/04/2007 |
| 7282620 | Type III allergic inflammation model animal The present invention provides an experimental model animal which does not develop anaphylaxis, a type I allergy, can specifically induce Arthus reaction, a type III allergy, is not affected by type I allergy and evaluates type III allergy inflammation individually,... | 10/16/2007 |
| 7276644 | Transgenic mouse comprising a myosin heavy chain atpase loop 1 mutation The invention provides a transgenic mouse that is a model for myocardial function. Also provided are methods for using the transgenic mouse model to study heart muscle, cardiac disease and identify compounds effective in treating or preventing cardiac disease. ... | 10/02/2007 |
| 7273963 | Malarial animal model having a chimeric human liver The present invention features a non-human animal model of malaria, e.g., Plasmodium, particularly Plasmodium falciparum. The model is based on a non-human, immunocompromised transgenic animal having a human-mouse chimeric liver, where the transgene pr... | 09/25/2007 |
| 7265260 | Transgenic non-human mammals expressing constitutively activated tyrosine kinase receptors A transgenic non-human mammal whose germ cells and somatic cells contain a constructively activated tyrosine kinase receptor introduced into the mammal, or an ancestor of the mammal, at an embryonic stage. The transgenic non-human mammals can be used as ligand-indep... | 09/04/2007 |
| 7262336 | Transgenic animal A transgenic rat containing in its genome a nucleotide sequence encoding a Ga subunit protein, which Ga protein subunit is uncoupled from regulation by Regulators of G-Protein Signaling (RGS) proteins, which Gx subunit protein is eventually the dominant-negative G18... | 08/28/2007 |
