Bizarre Patents
Crispy Chip Sandwich and Process of Producing a Sandwich Product
A food product comprising a multilayer cookie or snack having outer layers formed from a crispy type edible food product such as a potato chip or corn chip, etc. with an intermediate marshmallow layer being in contact with the inner surface of each crispy chip and one or more filler substances.
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| Number | Title | Issue Date |
| 7332645 | IL-21 as a regulator of immunoglobin production A transgenic mouse is disclosed herein whose somatic and germ cells comprise a disrupted IL-21 receptor gene, the disruption being sufficient to inhibit the binding of IL-21 to an IL-21 receptor, and a disrupted IL-4 gene, the disruption being sufficient to inhibit ... | 02/19/2008 |
| 7198909 | Myeloid precursor cell useful for gene therapy and for modulation of immune responses A long-lived, myeloid-committed stem cell population is disclosed. Also disclosed are methods and compositions for targeting this population with retrovirus vectors in gene therapy protocols for correcting congenital disorders of myeloid system and for potentiating ... | 04/03/2007 |
| 7074983 | Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin The present invention relates to the production of a transgenic bovine which comprises a genetic modification that results in inactivation and loss of expression of its endogenous antibodies, and the expression of xenogenous antibodies, preferably human antibodies. ... | 07/11/2006 |
| 7067127 | GIcNAc phosphotransferase of the lysosomal targeting pathway The present invention provides nucleotide and amino sequences of the lysosomal targeting pathway enzyme GlcNAc-phosphotransferase, methods of producing and methods of purifying this enzyme. ... | 06/27/2006 |
| 7041871 | Transgenic non-human animals capable of producing heterologous antibodies The invention relates to transgenic non-human animals capable of producing heterologous antibodies and methods for producing human sequence antibodies which bind to human antigens with substantial affinity. ... | 05/09/2006 |
| 6906237 | Vivo assay for anti angiogenic compounds We report the use of telomerase-immortalized human microvascular endothelial cells in the formation of functional capillary blood vessels in vivo. Previously we showed the superior in vitro survival of human telomerase reverse transcriptase (hTERT)-transduced human ... | 06/14/2005 |
| 6905856 | Soluble GlcNAc phosphotransferase The present invention relates to a soluble GlcNAc phosphotransferase, a method of making the same and a method of phosphorylating with the same. ... | 06/14/2005 |
| 6660904 | HIV and CD4 transgenic animals and uses therefor The invention provides transgenic animals comprising a lentiviral transgene, such as an HIV transgene. Also within the scope of the invention are cells and eggs from the transgenic animal. Further included are methods for identifying therapeutic compounds... | 12/09/2003 |
| 6627792 | Human T cell-engrafted mouse, method for developing same and use thereof The present invention provides a method for developing a human T cell-engrafted mouse, which includes transplanting a human-derived bone tissue into an inbred line mouse deficient in immune cells, and a human T cell-engrafted mouse obtainable by the metho... | 09/30/2003 |
| 6610905 | Transgenic mouse model for Kaposi's sarcoma The present invention relates to a non-human transgenic mouse containing a constitutively active G-protein coupled receptor, which produces Kaposi's sarcoma-like symptoms. The transgenic mouse is useful in identification of reagents for the prevention, tr... | 08/26/2003 |
| 6593511 | Models of chronic and acute inflammatory diseases Methods and compositions are provided for the creation and screening of non-human animal models having chronic inflammation. Immunocompromised host animals are injected with a population of immunocompetent effector cells, depleted of CD25+ T cells. The ef... | 07/15/2003 |
| 6563014 | Self-contained system for sustained viral replication Transgenic non-human animals are described comprising a transgene for a species-specific pathogen and transgene(s) for at least one receptor restricting infection of the pathogen to the host species. Also described is a method for creating the transgenic ... | 05/13/2003 |
| 6455756 | Long term xenogeneic myeloid and lymphoid cell production in chimeric immunocompromised mice Immunocompromised mammalian hosts are sub-cutaneously implanted with a combination of human fetal bone and spleen. The chimeric animals can produce human B-cells, myeloid cells and T-cells for up to 9 months in vivo when supplied with an allogeneic human ... | 09/24/2002 |
| 6444872 | Large animal model of invasive pulmonary aspergillosis in an immunocompromised host A model of systemic mold/Aspergillus infection in a profoundly immunocompromised host has been established in the beagle dog. The beagle was rendered immunosuppressed using a combination of total body irradiation and daily steroids, which provided a windo... | 09/03/2002 |
| 6384298 | Transgenic mice depleted in a mature lymphocytic cell-type Transgenic mice having a phenotype characterized by the substantial depletion of a mature lymphocytic cell type otherwise naturally occurring in the species from which the transgenic mouse is derived. The phenotype is conferred in the transgenic mouse by ... | 05/07/2002 |
| 6316691 | Atrichia mouse The invention relates to an atrichia mouse which grows juvenile hair but is deficient in the ability to grow pelage hair and, more particularly, to an atrichia mouse such that the spontaneous prevalence of wet and dry skin lesions is not less than 70%. at... | 11/13/2001 |
| 6307122 | Infection of human neural xenografts Immunocompromised or immunosuppressed non-primate chimeric mammalian hosts comprising a neuronal graft in the eye are provided for studying various events associated with humans. Particularly, the chimeric host may have solely human fetal neuronal xenogra... | 10/23/2001 |
| 6248721 | Method of using mouse model for evaluation of HIV vaccines The present invention provides animals and methods for the evaluation of vaccines. In particular, the present invention provides humanized animal models for the evaluation of vaccines designed to confer immunity against human pathogens, including vaccines... | 06/19/2001 |
| 6232522 | Non-human animal model for systemic lupus erythematosis A specific method has been developed to produce an autoimmune response and resulting clinical symptoms for a particular disease process. Peptides or other structures derived from an autoantigen and which are bound by auto antibody or T cell receptors are ... | 05/15/2001 |
| 6184436 | Transgenic mice expressing HIV-1 in immune cells The present invention relates to a transgenic mouse to serve as a small animal model of AIDS which comprises at least a DNA sequence coding for HIV-1 nef or a HIV-1 DNA genome essentially consisting in entire HIV-1 coding sequences under the control of th... | 02/06/2001 |
| 6172278 | Ikaros transgenic cells and mice Transgenic cells, transgenic mice having an Ikaros transgene and methods for the use thereof.... | 01/09/2001 |
| 6156952 | HIV transgenic animals and uses therefor The invention provides transgenic animals comprising a lentiviral transgene, such as an HIV transgene. Also within the scope of the invention are cells and eggs from the transgenic animal. Further included are methods for identifying therapeutic compounds... | 12/05/2000 |
| 6060643 | Mouse model with human immune system The present invention provides a non-human genetically immunodeficient mammal the peripheral blood of which contains a non-lethal percent of T-cells of human origin which is at least 20% as well as a non-human genetically immunodeficient mammal having a l... | 05/09/2000 |
| 6054116 | Chimeric mouse for human and mouse immune systems This invention is directed to a chimeric mouse capable of mounting murine cellular and humoral immune response, where the chimeric mouse is tolerant of human tissue implanted therein. The chimeric mouse of this invention is capable of developing murine T ... | 04/25/2000 |
| 6023010 | Transgenic non-human animals depleted in a mature lymphocytic cell-type Transgenic mice having a phenotype characterized by the substantial depletion of a mature lymphocytic cell type otherwise naturally occurring in the species from which the transgenic mouse is derived. The phenotype is conferred in the transgenic mouse by ... | 02/08/2000 |
| 6002066 | H2-M modified transgenic mice A transgenic mouse with alterations in the H2-Ma gene is prepared by introduction of an altered H2-Ma gene into a host mouse. The resulting transgenic mice do not produce functional H2-M molecules.... | 12/14/1999 |
| 5981829 | ƊNur77 transgenic mouse The present invention provides a transgenic mouse containing a transgene, said transgene comprising a truncated Nur77 (ƊNur77) gene. Also provided is a double transgenic mouse, wherein said double transgenic mouse comprises the ƊNur77 transgenic mouse b... | 11/09/1999 |
| 5959172 | Gender-specific fading down turkey breed The present invention relates to a method of rapidly determining the gender of fowl. The present invention further relates to a new breed of turkey.... | 09/28/1999 |
| 5936138 | Gene encoding mutant L3T4 protein which facilitates HIV infection and transgenic mouse expressing such protein Disclosed are (1) a DNA sequence encoding a mutant L3T4 protein which, when expressed on the surface of a cell, is capable of facilitating infection of the cell by human immunodeficiency virus; the mutant protein includes at least one amino acid residue s... | 08/10/1999 |
| 5925802 | Functional reconstitution of SCID-bo mice with bovine fetal hematopoietic tissues The present invention provides a non-human chimeric mammal, comprising a severe-combined immunodeficient mammal engrafted with bovine immune system tissues, wherein said chimeric mammal is functionally reconstituted. Also provided is a method of producing... | 07/20/1999 |
| 5877396 | Mice mutant for functional Fc receptors and method of treating autoimmune diseases Disclosed herein is a non-naturally occurring non-human vertebrate animal incapable of expressing a functional Fc receptor which may optionally be capable of expressing a protein which comprises a domain of a human Fc receptor, as well as DNA encoding suc... | 03/02/1999 |
| 5859314 | Mice with targeted tyrosine kinase, lyn, disruption A non-human animal carrying a disruption of a gene encoding a lyn protein tyrosine kinase provides a convenient system for the study of diseases associated with or caused by lyn deficiency, and for the testing of therapeutic agents for the treatment or pr... | 01/12/1999 |
| 5859307 | Mutant RAG-1 deficient animals having no mature B and T lymphocytes Immunodeficient animals are generated by introducing a mutation in RAG-1 into the germline of the animals via gene targeting in embryonic stem cells. The production of mutant RAG-1 deficient mice is detailed. RAG-1 deficient mice have no mature B and T ly... | 01/12/1999 |
| 5850001 | Transgenic mouse for the neuronal expression of HIV gp160 The present invention relates to a transgenic non-human mammal, whose germ cells and somatic cells contain a recombinant env gene sequence which is operably linked to a promoter effective for the expression of the gene in the neuronal tissues of the mamma... | 12/15/1998 |
| 5850004 | Transgenic mouse deficient in inducible nitric oxide synthase The present invention provides an inducible nitric oxide synthase ("iNOS")-deficient transgenic mouse, novel replacement vectors designed for the disruption of the iNOS gene, embryonic stem (ES) cells which are singly allelic relative to the deficient iNO... | 12/15/1998 |
| 5849994 | Animal model for HIV-1 induced disease HIV-1 does not cause disease in any non-human species. Thus, there is no animal model system to evaluate the efficacy of strategies aimed at preventing or ameliorating disease caused by this virus. The instant invention provides an animal model for HIV-1 ... | 12/15/1998 |
| 5847257 | Transgenic mouse deficient in T-cells The present invention relates to a transgenic mouse deficient in T-cells, which is provided by fusing human heat shock protein (Hsp) gene with H2K promoter and transferring it to a mouse. Transgenic mouse line with a shrunken thymus and edficient in T-cel... | 12/08/1998 |
| 5831142 | Regulatory elements controlling tissue-specific gene expression The invention includes recombinant DNA regulatory elements which control expression of the CD19 gene in a B-lineage-restricted manner.... | 11/03/1998 |
| 5777193 | Animals with targeted gene disruption The invention provides transgenic non-human animals in which genes encoding colony-stimulating factors have been specifically disrupted, so that the animals do not express the respective factors. In specific embodiments the invention provides mice in whic... | 07/07/1998 |
| 5731490 | Mutant mouse lacking the expression of interferon regulatory factor 1 (IRF-1) Interferon regulatory factor-1 (IRF-1) is implicated in the regulation of type I interferons (IFN) and cell growth. The invention is a mutant mouse lacking expression of the IRF-1 gene. Mice lacking IRF-1 did not differ from normal mice in size, behaviour... | 03/24/1998 |
