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| Number | Title | Issue Date |
| 8137411 | Thin collagen tissue for medical device applications This invention relates to processes of preparing heterogeneous graft material from animal tissue. Specifically, the invention relates to the preparation of animal tissue, in which the tissue is cleaned and chemically cross-linked using both vaporized and liquid cros... | 03/20/2012 |
| 7918899 | Variably crosslinked tissue Non-glutaraldehyde fixation of an organ or a prosthesis for implantation in a mammal is based upon carbodiimide treatment. A solution containing a sterilizing agent, such as EDC, in combination with a coupling enhancer, such as Sulfo-NHS, and a high concentration of... | 04/05/2011 |
| 7479164 | Calcification-resistant fixation Non-glutaraldehyde fixation of an organ or a prosthesis for implantation in a mammal is based upon carbodiimide treatment. An aqueous solution containing a coupling agent, such as EDC, in combination with a coupling enhancer, such as sulfo-NHS, and a high concentrat... | 01/20/2009 |
| 7422607 | Anti-calcification treatments for heart valves and vascular grafts The present invention provides processes for fixation of biological tissue and/or post-fixation treatment of such tissue that result in modified tissues with reduced susceptibility to in vitro calcification when used in prosthetic devices. The invention also relates... | 09/09/2008 |
| 7367984 | Methods and apparatus for sizing fresh donor heart valves A fresh donor tissue valve isolation annulus size comprising a handle and trigger or crank knob manipulated by the user moves a movable probe into proximity with a stationary probe so that the probes can be inserted into the tissue valve lumen. The user releases the... | 05/06/2008 |
| 7358284 | Particulate acellular tissue matrix A method of processing an acellular tissue matrix to give a particulate acellular tissue matrix includes: cutting sheets of dry acellular tissue matrix into strips; cryofracturing the dry acellular tissue matrix strips at cryogenic temperatures; separating the resul... | 04/15/2008 |
| 7354749 | Decellularisation of matrices A method of preparing matrices or tissue engineered biomaterials for implantation, and in particular to a method of improving decellularisation of matrices or tissue engineered biomaterials prior to implantation. The method employs a single anionic detergent in comb... | 04/08/2008 |
| 7338517 | Tissue scaffold having aligned fibrils and artificial tissue comprising the same A tubular tissue scaffold is described which comprises a tube having a wall, wherein the wall includes biopolymer fibrils that are aligned in a helical pattern around the longitudinal axis of the tube where the pitch of the helical pattern changes with the radial po... | 03/04/2008 |
| 7326564 | Flow system for medical device evaluation and production In some embodiments, a flow system includes a medical device mount, fluid and a conduit containing the fluid and medical device mount. The conduit is mounted on an assembly that moves the conduit along with the medical device mount to induce relative motion of the f... | 02/05/2008 |
| 7323189 | Liquid and low melting coatings for stents A method for forming liquid coatings for medical devices such as stents and angioplasty balloons is provided. The liquid coatings can be made from biodegradable materials in liquid, low melting solid, or wax forms, which preferably degrade in the body without produc... | 01/29/2008 |
| 7318998 | Tissue decellularization The present invention relates, in general, to tissue decellularization and, in particular to a method of treating tissues, for example, heart valves, tendons and ligaments, so as to render them acellular and thereby limit mineralization and/or immunoreactivity upon ... | 01/15/2008 |
| 7294144 | Preserved implantable vessel derived from a human umbilical cord or placenta A preserved vessel isolated from a human umbilical cord or placenta and lyophilized for use as an allograft which improves blood supply to human tissue without antigenicity. ... | 11/13/2007 |
| 7214344 | Method for treatment of biological tissues to mitigate post-implantation calcification and thrombosis A method of treating a biological tissue including contacting the biological tissue with an aqueous sterilizing solution, and maintaining the aqueous sterilizing solution at a temperature of about 50° C. for a time period of about 1 to 2 days. The method of treatin... | 05/08/2007 |
| 7156881 | Counteracting bioprosthetic calcification Adapting crosslinking with triglycidyl amine (TGA) to incorporate the use of a particular type of anti-calcification agent provides a broad-reaching solution to the problem in vivo bioprosthesis calcification. The anti-calcification agent in question includes a poly... | 01/02/2007 |
| 7141062 | Longitudinally flexible stent An intravascular stent especially suited for implanting in curved arterial portions. The stent retains longitudinal flexibility after expansion. The stent is formed of intertwined meander patterns forming triangular cells. The triangular cells are adapted to provide... | 11/28/2006 |
| 7125837 | Elastin-based compositions The present invention provides screening methods that use organisms or cells that lack function in one or both elastin genes. These methods are useful in identifying drugs for the prevention and treatment of obstructive vascular diseases, such as atherosclerosis, va... | 10/24/2006 |
| 7108717 | Stent covered with heterologous tissue A covered stent assembly comprising a tubular, expandable stent having a metallic framework covered with a cylinder of biocompatible, non-thrombogenic expandable material, such as heterologous tissue. In a preferred embodiment, the metallic framework is positioned c... | 09/19/2006 |
| 7078163 | Process for reducing mineralization of tissue used in transplantation A method of making a tissue-derived implantable medical device that includes contacting the tissue with a composition comprising at least one oxidizing agent prior to implantation of the medical device. ... | 07/18/2006 |
| 7053051 | Methods of preparing crosslinked materials and bioprosthetic devices Methods for making crosslinked material, such as collagen-based material, and bioprosthetic devices. The crosslinked material includes hydroxyl groups, carboxyl groups, and amine groups prior to crosslinking. The methods include removing at least a portion of the ze... | 05/30/2006 |
| 7029434 | Methods for treating implantable biological tissues to mitigate post—implantation calcification A method for treating fixed biological tissue inhibits calcification of the biological tissue following implantation thereof in a mammalian body. The method includes placing the biological tissue in contact with glutaraldehyde and then heating the glutaraldehyde. Al... | 04/18/2006 |
| 7001551 | Method of forming a composite bone material implant A method of forming a bone composite, comprising: providing bone tissue; grinding said bone tissue to form ground tissue; molding the ground bone tissue into a bone composite; applying a binder to the bone composite; applying a vacuum to the mold, and optionally mil... | 02/21/2006 |
| 6962814 | Decellularized tissue engineered constructs and tissues New methods for producing tissue engineered constructs and engineered native tissues are disclosed. The methods include producing a tissue engineered construct by growing cells in vitro on a substrate and then decellularizing the construct to produce a decellularize... | 11/08/2005 |
| 6878168 | Treatment of bioprosthetic tissues to mitigate post implantation calcification Bioprosthetic tissues are treated by immersing or otherwise contacting fixed, unfixed or partially fixed tissue with a glutaraldehyde solution that has previously been heat-treated or pH adjusted prior to its contact with the tissue. The prior heat treating or pH ad... | 04/12/2005 |
| 6837907 | Method for debriding bone, and bone debrided thereby The invention is directed to a method of debriding bone including incubating the bone and associated soft tissue, with one or more debriding solutions where the debriding solution may include one or more alkaline solutions. Incubation is optionally carried out with ... | 01/04/2005 |
| 6761735 | Heart valve fixation process and apparatus A method and apparatus for limiting longitudinal stretch during fixation of a harvested aortic root including valve leaflets and the product produced. The apparatus includes an inflow plug inserted into the inflow section of the aortic root and having an apertured t... | 07/13/2004 |
| 6630001 | Compliant dehyrated tissue for implantation and process of making the same A process for preparing pliable soft tissue specimen which are resistant to cracking and devoid of viable cells includes the steps of treating native soft tissue obtained from a donor by a gradually increasing gradient of aliphatic alcohol or other suitab... | 10/07/2003 |
| 6592618 | In vitro modification of cardiac valvular xenografts The present invention is directed to methods for obtaining heart valves from a donor animal that have a reduced tendency to cause inflammation when implanted into a human patient. The valves produced by this method should be less likely to undergo post-su... | 07/15/2003 |
| 6561970 | Methods for treating implantable biological tissues to mitigate the calcification thereof and bioprosthetic articles treated by such methods A method for treating fixed biological tissue inhibits calcification of the biological tissue following implantation thereof in a mammalian body. The method includes placing the biological tissue in contact with glutaraldehyde and then heating the glutara... | 05/13/2003 |
| 6547827 | Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby A method for fixation of biological tissues, and bioprosthetic devices prepared by such method. The method generally comprises the steps of A) fixing the tissue, B) treating the tissue with a mixture of i) a denaturant, ii) a surfactant and iii) a crossli... | 04/15/2003 |
| 6540790 | Tanning leather Leather is tanned by cross-linking collagen with tris(hydroxymethyl)phosphine or a condensate of a tetrakis(hydroxymethyl)phosphonium salt with an amide or amine in a main tannage or retannage.... | 04/01/2003 |
| 6302909 | Calcification-resistant biomaterials The invention involves a bioprosthetic article including a biocompatible material having at least one bound exogenous storage structure, the storage structures having collectively greater than about 0.5 mg metal cations per gram of biocompatible material.... | 10/16/2001 |
| 6294041 | Method for an osteoimplant manufacture The invention relates to an osteoimplant fabricated from a solid aggregate of bone derived elements possessing chemical linkages between their adjacent surface-exposed collagen. Also described are various other components which can be incorporated into th... | 09/25/2001 |
| 6231614 | Method for tissue fixation The present invention provides an epoxy compound that has a hydrocarbon backbone, that is water-soluble, and which does not contain an ether or ester linkage in its backbone. Examples of suitable epoxide agents include mono- or diepoxides that have the fo... | 05/15/2001 |
| 6200640 | Polymer composition and process for treating leather and fur skins Aqueous solutions or dispersions of copolymers obtainable by free-radical copolymerization of (a) from 20 to 90% by weight of at least one monoethylenically unsaturated C4-6 -dicarboxylic acid or the anhydride thereof, as component A, (b) from 5 to ... | 03/13/2001 |
| 6166184 | Process for making a bioprosthetic device Methods for making bioprosthetic devices made of collagen-based material having collagen amine groups and collagen carboxyl groups are provided. The methods include blocking at least a portion of the collagen amine groups with a blocking agent, activating... | 12/26/2000 |
| 6027530 | System, apparatus and method for chemical fixation of stentless cardiac valvular bioprostheses A system, apparatus and method for tanning of a stentless aortic bioprosthesis, and articles manufactured by such method. The system includes a circulating bath which contains a tanning solution, and a support insert apparatus upon which the bioprosthesis... | 02/22/2000 |
| 6008292 | Method for inhibiting calcification of aldehyde-fixed bioprosthetic materials A method for preparing collagenous biological tissues for use as implantable bioprosthetic material, and articles prepared thereby. The method generally comprises the steps of a) contacting the tissue with an aldehyde fixative to effect cross-linking of t... | 12/28/1999 |
| 5948123 | Coloring method for hides A coloring method, wherein coloring agent or pigment is injected into active cells of an animal hide before the hide is harvested, and a coloring agent injection device with one or more needles, which are injected into the active cells of the hide of an a... | 09/07/1999 |
| 5935168 | Glutaraldehyde-fixed bioprostheses Methods for treating glutaraldehyde-fixed collagenous tissues to mitigate there propensity for subsequent calcification and to improve durability. Collagenous tissues which have been harvested and cross-linked by glutaraldehyde are exposed to a carboxyl a... | 08/10/1999 |
| 5931969 | Methods and apparatuses for treating biological tissue to mitigate calcification A method for treating fixed biological tissue inhibits calcification of the biological tissue following implantation thereof in a mammalian body. The method includes placing the biological tissue in contact with a treatment solution, inducing relative tis... | 08/03/1999 |
