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| Number | Title | Issue Date |
| 7779677 | Liquid chromatographic analyzer and liquid chromatography analysis An apparatus for liquid chromatography which detects ingredients by an electrolytic device, wherein the apparatus can detect many kinds of substances in high sensitivity by making possible to apply a wider range of electrolyzing voltage than former apparatus. | 08/24/2010 |
| 7410558 | Method and apparatus for determining a total concentration of a component in a mixture of components The invention relates to a method and apparatus for determining a total concentration of a component in a sample, including a reactor for oxidizing or reducing the sample, a chromatographic column coupled to the reactor for separating the component in the sample, an... | 08/12/2008 |
| 7278329 | Chromatography system with blockage determination There is provided a method that includes, (a) monitoring a pressure on a fluid being conveyed through an intake tube into a chamber by a pump, (b) determining a deviation of the pressure from a predefined value, (c) determining a blockage of the intake tube based on... | 10/09/2007 |
| 7267796 | Preparative liquid chromatograph using plural detectors The preparative liquid chromatograph uses a plurality of detectors including a mass spectrometer, and a chromatogram generator is provided for generating a plurality of chromatograms each corresponding to each of the plurality of detectors. The plurality of chromato... | 09/11/2007 |
| 7214320 | Systems and methods for high throughput sample analysis Systems and methods for analyzing a plurality of samples in parallel include a plurality of liquid phase separation regions, a plurality of microfluidic storage regions, and a common mass spectrometer. Samples are separated in parallel in the separation regions to y... | 05/08/2007 |
| 7125478 | Microscale electrophoresis devices for biomolecule separation and detection The present invention relates to microfabrication and utilization of microscale electrophoresis devices as well as the separation and detection of biomolecules in microscale electrophoresis devices. The device of the present invention utilizes novel fabrication and ... | 10/24/2006 |
| 7028537 | Coupling electrochemistry to mass spectrometry and high performance liquid chromatography A hyphenated technique based on the combination of high performance liquid chromatography (HPLC), electrochemical (coulometric) oxidation (EC) and electrospray ionization (ESI)- or atmospheric pressure chemical ionization (APCI)-mass spectrometry (MS), allows access... | 04/18/2006 |
| 6989129 | Automated capillary liquid chromatography small volume analysis system A system for automatically performing liquid chromatography analysis of low volume liquid chemical samples at nanosecond flow rates using an analysis column that integrates a pre-concentration trapping column and a chromatography separation column terminating at an ... | 01/24/2006 |
| 6984308 | Electrochemical analysis of coenzyme Q10 and reduced coenzyme Q10 This invention relates to an apparatus and method for the simultaneous and rapid determination of CoQ10 and CoQ10H2 concentrations in human samples using HPLC-EC. The electrochemical reactions are monitored at electrodes that measure... | 01/10/2006 |
| 6984525 | Method for automated isolation of fractions in multichannel separation systems A method to collect a plurality of target zones from a plurality of channels. The method includes introducing a plurality of compound mixtures into a plurality of microchannels on a microfabricated chip or a capillary tube. Optical signal measured at a detector wind... | 01/10/2006 |
| 6976384 | Parallel detection chromatography systems High throughput liquid chromatography systems include multiple separation columns and multiple flow-through detection regions in sensory communication with a common radiation source and a multi-channel detector. Preferred detector types include a multi-anode photomu... | 12/20/2005 |
| 6952946 | Method for the gas chromatographic analysis of a sample, and analyzer In a gas chromatograph, an injected sample for analysis (3) is passed through a separation device (5) to separate components present in the sample; at the end of the separation device, selected components are detected by a detector (12) and dete... | 10/11/2005 |
| 6936174 | Method for controlling an evaporative light scattering detector which is coupled to a liquid chromatography column Method allowing control of an evaporative light scattering detector which is coupled to a liquid chromatography column, substantially independently of the elution conditions for the chromatographic separation. A given adjustable constant calibrated volume of ... | 08/30/2005 |
| 6904784 | Liquid chromatographic method and system To economically perform preparatory chromatography, a plurality of pumps each having a corresponding one of a plurality of pistons and a corresponding one of a plurality of cylinders are driven by one motor to draw and pump solvent simultaneously into corresponding ... | 06/14/2005 |
| 6858435 | Method and system for peak parking in liquid chromatography-mass spectrometer (LC-MS) analysis A reconfigurable multi-mode post-column analysis system improves resolution of liquid chromatography detection data by providing a parking or MS/MS detection mode in which flow of column eluent is substantially reduced to provide greater analysis time within a singl... | 02/22/2005 |
| 6755074 | Liquid chromatographic method and system To economically perform preparatory chromatography, a plurality of pumps each having a corresponding one of a plurality of pistons and a corresponding one of a plurality of cylinders are driven by one motor to draw and pump solvent simultaneously into corresponding ... | 06/29/2004 |
| 6668624 | Method and apparatus for analyzing organic macromolecular component and application thereof A method and an apparatus for efficiently analyzing an organic macromolecular component contained in a sample with high precision are provided. The method and the apparatus for analyzing the organic macromolecular component are based on a flow analysis me... | 12/30/2003 |
| 6668623 | Method and apparatus for analyzing organic macromolecular component and application thereof A method and apparatus for efficiently analyzing an organic macromolecular component contained in a sample with high precision are provided. The method and apparatus for analyzing the organic macromolecular component are based on a flow analysis method wi... | 12/30/2003 |
| 6613235 | Method of detecting sample ions by continuous electrochemical regeneration of a stationary phase An apparatus and method for electrochemically modifying the retention of a species on a chromatography material is disclosed. The apparatus comprises a housing having an effluent flow channel adapted to permit fluid flow therethrough. The effluent flow ch... | 09/02/2003 |
| 6425284 | Method and apparatus for gas-assisted suppressed chromatography Ionic species in an aqueous sample stream are analyzed by (a) chromatographically separating the ionic species in the presence of an aqueous eluent solution comprising electrolyte to form a chromatographic effluent, (b) suppressing the electrolyte in the ... | 07/30/2002 |
| 5905195 | Method for analyzing total reactive sulfur The invention relates to a method for determining total reactive sulfur in a crude oil or fraction thereof using a mass spectrometer or gas chromatograph and mass spectrometer. Selecting fragment ions characteristic of reactive sulfur species enables the ... | 05/18/1999 |
| 5900152 | Apparatus to reduce inhomogeneities in optical flow cells A capillary tube used to transfer a liquid sample into a detection cell following separation by a chromatographic system is modified by plugging or otherwise severely restricting its flow. Near its plugged end, said tube is drilled to provide a plurality ... | 05/04/1999 |
| 5861124 | Method and apparatus for detecting denaturation of nucleic acid An apparatus for detecting denaturation of a nucleic acid, including: denaturation condition controlling means for controlling condition of denaturation under which a double-stranded nucleic acid is separated into a first single-stranded nucleic acid and ... | 01/19/1999 |
| 5837135 | Chromatography and related apparatus system Proposed is an improvement in a detection and recording system in the conventional chromatography in which the chromatographic signals are detected by means of a single detector sometimes to cause difficulties in resolution of the signal of minor componen... | 11/17/1998 |
| 5759405 | Apparatuses and methods for electrochemically modifying the retention of species on chromatography material An apparatus and method for electrochemically modifying the retention of a species on a chromatography material is disclosed. The apparatus comprises a housing having an effluent flow channel adapted to permit fluid flow therethrough. The effluent flow ch... | 06/02/1998 |
| 5676830 | Method and apparatus for reducing band broadening in chromatographic detectors A capillary tube used to transfer a liquid sample into a detection cell following separation by a chromatographic system is modified by plugging or otherwise severely restricting its flow. Near its plugged end, said tube is drilled to provide a plurality ... | 10/14/1997 |
| 5641893 | Chromatographic separation apparatus An apparatus for the monitoring of a column chromatography separation process includes a segmented column with a seal positioned at the joint defined by the segments of the column. A connector is provided for connecting the segments of the column together... | 06/24/1997 |
| 5633171 | Intermittent electrolytic packed bed suppressor regeneration for ion chromatography A method and apparatus for ion analysis by ion chromatography uses periodic electrolytic regeneration of a packed bed suppressor. First and second sets of columns, suppressors and detectors connected in series are linked by appropriate valving so that the... | 05/27/1997 |
| 5627643 | Method and detector for separation processes The present invention comprises a method Of detecting and quantifying components separated by capillary electrophoresis or other techniques using thin capillaries in the separation. The method of the present invention comprises irradiating the whole or la... | 05/06/1997 |
| 5597734 | Ion chromatography using frequent regeneration of batch-type suppressor An ion chromatography method for analysis of a plurality of analyte ions in a sequence of samples in which ion chromatography is performed on a sample, which is passed to a non-precipitating suppressor ion exchange resin and analyzed, the suppressor being... | 01/28/1997 |
| 5580435 | System for detecting components of a sample in electrophoretic separation A substrate defines a group therein having three sections: a first and third sections having dimensions larger than the outside dimensions of two capillaries and a second section separating the first and third sections with dimensions small than the outsi... | 12/03/1996 |
| 5545304 | Ion current detector for high pressure ion sources for monitoring separations The present invention relates generally to any application involving the monitoring of signal arising from ions produced by electrospray or other high pressure (>100 torr) ion sources. The present invention relates specifically to an apparatus and method ... | 08/13/1996 |
| 5540825 | Noise suppressing capillary separation system A noise-suppressing capillary separation system for detecting the real-time presence or concentration of an analyte in a sample is provided. The system contains a capillary separation means through which the analyte is moved, a coherent light source that ... | 07/30/1996 |
| 5399256 | Electrochemical detector cell An electrochemical detector cell includes a first block having a planar first working surface, and a first working electrode embedded in the first block member. The first working electrode includes analyte contacting surface disposed co-planarly with the ... | 03/21/1995 |
| 5389221 | Two dimensional separation system A combination liquid chromatography and capillary electrophoresis separation system is disclosed. The system comprises a flow gating interface having an effluent channel and a gating channel formed therein. The gating channel transversely intersects the e... | 02/14/1995 |
| 5316630 | Methods for chromatography analysis A method is described for the normalization and standardization of variabilities of electropherograms obtained with conductometric capillary electrophoresis. The variabilities may be associated with differences in the sample injection volume between two o... | 05/31/1994 |
| 5310463 | On-column junction for capillary columns An electrophoretic or chromatographic separation capillary containing a fluid defines a bore therein through which a sample travels and separates into components. The tube has a side wall defining a through hole therein which is surrounded by a medium inc... | 05/10/1994 |
| 5306412 | Method and apparatus for improving electrospray ionization of solute species The subject invention teaches the use of mechanical vibration to enhance the electrostatic dispersion of sample solutions into the small, highly charged droplets that can produce ions of solute species for mass spectrometric analysis. Such vibration turns... | 04/26/1994 |
| 5306403 | Raman-based system for DNA sequencing-mapping and other separations DNA sequencing and mapping are performed by using a Raman spectrometer with a surface enhanced Raman scattering (SERS) substrate to enhance the Raman signal. A SERS label is attached to a DNA fragment and then analyzed with the Raman spectrometer to ident... | 04/26/1994 |
| 5290520 | Analytic separation arrangement and method for the analysis of chemical samples An analytic separation arrangement includes a system of tubes including a separation zone, preferably a separation column, which tubes upstream the separation zone are connected with reservoirs for a carrier and a chemical sample to be seperated and analy... | 03/01/1994 |
