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| Number | Title | Issue Date |
| 8438911 | Chromatography system with fluid intake management A method of determining a leak in a pumping system includes determining a metered flow rate of a fluid through a first channel, determining a measured flow rate within the channel, and identifying an amount of a leak in the pumping system as the difference between t... | 05/14/2013 |
| 8438910 | Shear valve with DLC comprising multi-layer coated member A shear valve for use in a high performance liquid chromatography system, the shear valve comprising a first shear valve member and a second shear valve member, wherein at least one of the first and second shear valve members is adapted to be moved with respect to t... | 05/14/2013 |
| 8397553 | Liquid chromatography detector and flow controller therefor A flow controller for use with a liquid chromatography detector. The flow controller includes a flow channel comprising an inlet portion, a control channel portion in communication with the inlet portion, and an outlet portion in communication with said control chan... | 03/19/2013 |
| 8191405 | Solvent delivery device and analytical system Disclosed herein is a stable solvent delivery device capable of delivering solvent both at high pressure and at constant flow rate. A solvent delivery device comprises a plurality of plungers which reciprocate in the respective pump chambers including an eluent char... | 06/05/2012 |
| 8047060 | Method and apparatus for sample injection in liquid chromatography The present invention provides a method and apparatus for substantially eliminating destructive transients of pressure or flow rate which can degrade the efficiency and useful lifetime of chromatography columns. The present invention enables a substantially constant... | 11/01/2011 |
| 7992429 | Chromatography system with fluid intake management A liquid chromatograph includes a mobile phase supplying apparatus including liquid-feeding pumps to feed mobile phases, liquid-feeding flow paths, a mixer to mix the mobile phases, at least one control device to control each liquid-feeding pump, flow rate measuring... | 08/09/2011 |
| 7987701 | Real-time, on-line analysis for the quantification of total haloacetic acid and trihalomethane species in drinking water supplies Capillary membrane sampling-flow injection analyzer (CMS-FIA) analyses of drinking water samples for quantity measurements of total trihalomethane and haloacetic acid contaminants therein are provided. With the necessity to chlorinate drinking water to remove harmfu... | 08/02/2011 |
| 7980119 | Auto-sampler cleaning mechanism An auto-sampler cleaning mechanism is provided, which is capable of maintaining the supply of a liquid in a non-time-consuming manner when a cleaning solution is supplied. The auto-sampler cleaning mechanism of the present invention includes: a sample-metering sampl... | 07/19/2011 |
| 7905133 | Variable ratio flow splitter for a flowstream A splitter for a pressurized primary flowstream of a mobile phase is provided. The splitter comprises a first splitting stage that divides the primary flowstream between a major split flowstream and a minor split flowstream by means of a first and a second restricti... | 03/15/2011 |
| 7861576 | Apparatus for analyzing sample using centrifugal force and inertia A sample analyzing apparatus using centrifugal force and inertia including a rotating body composed of a disk including upper and lower thin-films; a plurality of chambers composed of a polygonal space parts in the rotating body and including apertures on one side c... | 01/04/2011 |
| 7797989 | Sample injector, in particular for high-power liquid chromatography A device for feeding samples to a separating device and for collecting sample fractions generated by means of the separating device, especially for high-performance liquid chromatography, with a first switch valve unit, which has at least eight ports and two switch ... | 09/21/2010 |
| 7637147 | Ultrahigh-pressure dual on-line solid phase extraction/capillary reverse-phase liquid chromatography system An ultrahigh-pressure dual on-line solid phase extraction/capillary reverse-phase liquid chromatography (DO-SPE/cRPLC) system is provided. The system comprises: a sample loading valve into which a first solvent and a sample to be analyzed are loaded; a first column ... | 12/29/2009 |
| 7631542 | Chromatography system with fluid intake management A variety of methods for operating a chromatography system are presented. Specifically, methods for operating a pumping system within a chromatography system are presented. The methods presented are directed to pumping apparatus in which very small amounts of fluid ... | 12/15/2009 |
| 7624626 | Dynamic flow liquid chromatography The present invention provides apparatus and methods for detection of an analyte in liquid chromatography with increased detection sensitivity and signal resolution. ... | 12/01/2009 |
| 7600415 | Chromatography system with waste output A variety of methods for operating a chromatography system are presented. Specifically, methods for operating a pumping system within a chromatography system are presented. The methods presented are directed to pumping apparatus in which very small amounts of fluid ... | 10/13/2009 |
| 7578173 | Chromatography system with flow sensing A variety of methods for operating a chromatography system are presented. Specifically, methods for operating a pumping system within a chromatography system are presented. The methods presented are directed to pumping apparatus in which very small amounts of fluid ... | 08/25/2009 |
| 7574901 | Flow path switching valve, high performance liquid chromatography using the same and analytical method thereof A flow path switching valve is provided, in which an impact due to the pressure change when a flow path is switched is prevented from being generated. (A) A rotor slot 1c allows an analysis infusion pump 11 to be connected to an analytical colum... | 08/18/2009 |
| 7454959 | Method and device for providing defined fluid flow, especially for use in liquid chromatography The invention relates to a method for providing a defined fluid flow, especially for use in liquid chromatography. According to the method, a constant total flow (f0) is subdivided into an internal excess flow (fie) in an excess branch and into... | 11/25/2008 |
| 7402283 | Electrolytic eluent generator and method of use An acid or base is generated in an aqueous solution by the steps of: (a) providing a source of first ions adjacent an aqueous liquid in a first acid or base generation zone, separated by a first barrier (e.g., anion exchange membra... | 07/22/2008 |
| 7393508 | Valve arrangement The valve arrangement comprises a predetermined number of individual valve functionalities, arranged in a manner parallel to each other. A fixed connector plate (3) has a number of sample funnel tubes (6) and output connections (8) for forward t... | 07/01/2008 |
| 7337654 | Method of forming a needle for auto-sampler In a method of forming a needle for an auto-sampler successively collecting liquid samples from plural sample containers, a parent material forming the needle is coated with a coating material having a chemical activity small than that of the needle. Then, the coate... | 03/04/2008 |
| 7337653 | Liquid chromatography specimen filling method A sample injection apparatus and sample injection method capable of sufficiently reducing carry-over, having simple cleaning means for a short cleaning time period, a small influence of vibration of the cleaning means, and a small error in the amount of injected sam... | 03/04/2008 |
| 7324864 | Apparatus and method for measuring forces imparted on valve assemblies of metered dose delivery containers during manufacture thereof An axial force measurement apparatus (40) comprises a head member (42) adapted for receiving force imparted by an external force-applying source, and a transducer (44) such as a load cell for measuring the amount of force applied to the head mem... | 01/29/2008 |
| 7240572 | Vacuum assisted affinity chromatography device and method Sample preparation device and method particularly useful for large volume capture and small volume elution. The device comprising a manifold, a sample holder or reservoir, and a filter unit containing chromatography media such that a filtration path is established b... | 07/10/2007 |
| 7234269 | Animal test chamber An animal test chamber has one or more side walls, a ceiling, and a floor to define an internal space in which animals can be housed and exposed to a chemical agent, a door, a port for introducing animals, an exhaust port, and one or more of the following four featu... | 06/26/2007 |
| 7214320 | Systems and methods for high throughput sample analysis Systems and methods for analyzing a plurality of samples in parallel include a plurality of liquid phase separation regions, a plurality of microfluidic storage regions, and a common mass spectrometer. Samples are separated in parallel in the separation regions to y... | 05/08/2007 |
| 7195461 | Liquid chromatographic method and system To economically perform preparatory chromatography, a plurality of pumps each having a corresponding one of a plurality of pistons and a corresponding one of a plurality of cylinders are driven by one motor to draw and pump solvent simultaneously into corresponding ... | 03/27/2007 |
| 7178414 | Automation of liquid phase microextraction A method and apparatus for automatically performing liquid microextraction on liquid samples includes the steps of controlling movement of a syringe between a cleaning station, a sample station containing a plurality of discrete sample vials and an instrument inject... | 02/20/2007 |
| 7163379 | Gradient liquid feed pump system, and liquid chromatograph A gradient liquid feed pump system capable of liquid feed in a correct mixing ratio even in the case of liquid feed in which the mixing ratio varies. Specifically, it comprises a first plunger pump for sucking and delivering an eluate, a second the first and second ... | 01/16/2007 |
| 7153476 | Large capacity acid or base generator apparatus Method and apparatus for generating an acid or base, e.g. for chromatographic analysis of anions. For generating a base the method includes the steps of providing a cation source in a cation source reservoir, flowing an aqueous liquid stream through a base generatio... | 12/26/2006 |
| 7147364 | Mixer and liquid analyzer provided with same The invention provides a mixer capable of mixing two kinds of liquids with each other while varying a mixing ratio in a wide range of the flow rates thereof by causing the two liquids in trace amounts to come into contact with each other, or a mixer capable of mixin... | 12/12/2006 |
| 7141161 | Gradient pump apparatus A gradient pump apparatus which is capable of continuously and precisely feeding, to a chromatograph, eluents at intervals of certain time and at a constant flow rate in units of nano-liter per minute while the composition of two or more eluent components is changed... | 11/28/2006 |
| 7138051 | Chromatography system, method and software for the separation of biomolecules The present invention relates to methods, systems and software for optimising the separation of a sample of biomolecules eluted from a chromatography column in which the concentration of a second component added to an elution buffer is varied in order to form an elu... | 11/21/2006 |
| 7128142 | Apparatus and methods for improved fluid displacement in subterranean formations Apparatus and methods for determining suitable displacement fluids for use in subterranean cementing operations, and methods of cementing that use such displacement fluids, are provided. Examples of apparatus include apparatus for evaluating fluids. An example of a ... | 10/31/2006 |
| 7091044 | Partial modulation via pulsed flow modulator for comprehensive two-dimensional liquid or gas chromatography This invention is a method and device for use with multi-dimensional chromatography that utilizes partial modulation. An analyte-bearing sample is subjected to a first dimension of chromatography. Thereafter the separated analyte-bearing sample is diluted with a mod... | 08/15/2006 |
| 7066011 | Liquid chromatograph and analysis system The present invention aims to provide a liquid chromatograph, an analysis system, and a gradient elution method, which are designed to permit a gradient change of eluent with higher precision and also permit a high sensitive detection or analysis. For attaining the ... | 06/27/2006 |
| 7063785 | Pump for liquid chromatography The invention provides a pump for liquid chromatography excellent in feeding liquid stably at an extremely low flow rate with high accuracy and in discharging bubbles at startup. At startup, a first plunger feeds solvent at a large flow rate to discharge bubb... | 06/20/2006 |
| 7063513 | Liquid chromatograph pump with dual cylinders and dual plungers In a pump for feeding a liquid for chromatography, first and second plungers form first and second volumes respectively together with first and second chambers, the first plunger is prevented from changing the first volume sufficiently for feeding the liquid between... | 06/20/2006 |
| 7048517 | Pump as a pressure source for supercritical fluid chromatography The invention is a device and method in a high-pressure chromatography system, such as a supercritical fluid chromatography (SFC) system, that uses a pump as a pressure source for precision pumping of a compressible fluid. The preferred exemplary embodiment comprise... | 05/23/2006 |
| 6989129 | Automated capillary liquid chromatography small volume analysis system A system for automatically performing liquid chromatography analysis of low volume liquid chemical samples at nanosecond flow rates using an analysis column that integrates a pre-concentration trapping column and a chromatography separation column terminating at an ... | 01/24/2006 |