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| Number | Title | Issue Date |
| 8185367 | Systems and methods for reconstructing gene networks in segregating populations The reconstruction of genetic networks in mammalian systems is one of the primary goals in biological research, especially as such reconstructions relate to elucidating not only common, polygenic human disease, but living systems more generally. The present inventio... | 05/22/2012 |
| 8180615 | System and method for simulation, modeling and scheduling of equipment preparation in batch process manufacturing facilities A method and system for simulating, modeling and scheduling equipment preparation procedures in the biopharmaceutical production process is described herein. The use of process vessels in batch process manufacturing is optimized through the use of peak load scheduli... | 05/15/2012 |
| 8175860 | Method of inhibiting the growth of A method of identifying a drug candidate to a target protein for inhibiting shikimate pathway comprising (a) performing a molecular program for computing a molecule conformation and orientation relative to an active site of the target protein and selecting top-rank ... | 05/08/2012 |
| 8170852 | Data structures and methods for modeling metabolism The invention provides an in silico model for determining a S. cerevisiae physiological function. The model includes a data structure relating a plurality of S. cerevisiae reactants to a plurality of S. cerevisiae reactions, a constraint set for... | 05/01/2012 |
| 8160854 | Method of managing and displaying gene expression data A method visually and clearly manages and displays a large amount of gene expression data obtained using a large number of DNA chips. The types of DNA chip are displayed in a leftmost column of a matrix, parameters such as times in a time series, treatment methods, ... | 04/17/2012 |
| 8140312 | Method and system for determining analyte levels Methods and apparatus for analyte level estimation are provided. ... | 03/20/2012 |
| 8140311 | Computer aided ligand-based and receptor-based drug design utilizing molecular shape and electrostatic complementarity Methods related to the generation of shape signatures representing molecular shape, and using shape signatures in both ligand-based and receptor-based molecular design. Ray-tracing is used to explore the volume interior to a ligand, or the space exterior to a recept... | 03/20/2012 |
| 8131527 | FGFR pharmacophore compounds The present invention relates to FGFR pharmacophores, and in particular to compounds which are capable of binding to FGFR with greater affinity than their binding to VEGFR and methods of identifying such compounds using the pharmacophore. The present invention furth... | 03/06/2012 |
| 8126690 | Algorithms to predict clinical response, adherence, and shunting with thiopurines A method of using a variable set from complete blood counts and blood chemistry panels to generate a machine learned algorithm for determining the effectiveness of thiopurine treatment on inflammatory bowel disease (IBD) patients using CART, boosted trees, random fo... | 02/28/2012 |
| 8117020 | Method to determine the degree and stability of blood glucose control in patients with diabetes mellitus via creation and continuous updating of new statistical indicators Systems and methods for determining a stability of a blood glucose concentration of a patient are provided. The system comprises a processor that may be programmed to receive blood glucose concentration test results each taken from the patient at a different time ov... | 02/14/2012 |
| 8112260 | Methods for identifying protein specificity of brain cells that evoke a given mental state that does not contain smaller constituents The invention provides methods for identifying brain cells that determine and can evoke subjective states that do not contain smaller constituents, by establishing a correspondence between intrinsic function of a cell type with its hierarchy of constitutively-expres... | 02/07/2012 |
| 8108190 | Programmable joint simulator with force and motion feedback A joint simulator for duplicating the biomechanical properties of body segments with joints. In one embodiment, the joint simulator includes a body model of the body segment to be simulated, controllable drive elem... | 01/31/2012 |
| 8099268 | Tooth modeling The present disclosure includes dental appliances, devices, and methods of making and using such appliances. In one embodiment, a method for tooth modeling includes receiving a patient information file for a treatment plan patient and analyzing the patient informati... | 01/17/2012 |
| 8095350 | Three-dimensional structure of the APOBEC 2 structure, uses thereof, and methods for treating chronic and infectious diseases Three-dimensional structure of APOBEC-2 and other structure models of APOBEC proteins obtained by computer modeling that bear similarity with a root-mean-square deviation (RMSD) of 2.0 with the APOBEC-2 monomer, dimer or tetramer. Uses of the three-dimensional struc... | 01/10/2012 |
| 8090562 | Predicting risk of major adverse cardiac events Measurement of circulating ST2 and natriuretic peptide (e.g., NT-proBNP) concentrations is useful for the prognostic evaluation of subjects, in particular for the prediction of adverse clinical outcomes, e.g., mortality, transplantation, and heart failure. ... | 01/03/2012 |
| 8086432 | Molecular motor A molecular motor in which multiple concentric cylinders (or nested cones) rotate around a common longitudinal axis. Opposing complementary surfaces of the cylinders or cones are coated with complementary motor protein pairs (such as actin and myosin). The actin and... | 12/27/2011 |
| 8082135 | Method and system for modeling bone structure The present invention relates to scanning confocal microscopy used to systematically quantify characteristic collagen fibril orientations by position within the lamellar thickness of secondary osteons along the osteon radial direction. Fully calcified lamellar speci... | 12/20/2011 |
| 8073666 | Systems and methods for ordering oligonucleotides A system is described for ordering oligonucleotides through a network, such as the Internet. The system provides a mechanism for validating the data provided by a customer, and then displaying graphical images to represent any data that has errors. The system can al... | 12/06/2011 |
| 8060353 | Flow cytometer remote monitoring system Generally, computer implemented remote monitoring system which generates a viewable reduced byte data representation for each one of a plurality of analyzed instrument signals. Specifically, a flow cytometer remote monitoring system which generates a viewable reduce... | 11/15/2011 |
| 8060354 | System and method for determining a nutritional diet for a canine or feline animal Selecting the nutrition for an animal or animal group comprises performing a diagnostic test to obtain first data. A data base that comprises first data relating a genomic analysis of a bodily fluid or tissue sample from an animal to a physiological condition and op... | 11/15/2011 |
| 8055491 | System and methods for optimized drug delivery and progression of diseased and normal cells Systems for recommending an optimal treatment protocol for a specific individual are disclosed. The systems comprise generally a system model, a plurality of treatment protocols, a system model modifier, wherein said system model is modified by the system model modi... | 11/08/2011 |
| 8036867 | Method and apparatus for analysis of molecular configurations and combinations Computing units are determined for performing molecular docking calculations in parallel with the number of computing units and the width of the data paths allocated by relative complexity of operations. Data can be expected to arrive at downstream computing units a... | 10/11/2011 |
| 8036868 | Intergrated systems and methods of virtual or live microscope slide presentation A method for creating a virtual slide is provided. A virtual slide is a digital representation of an area of interest of a microscopic slide. One method is to use a motorized microscope that can move a specimen with respect to a microscopic objective. With such a sy... | 10/11/2011 |
| 8032346 | System and method for high-content oncology assay The present invention provides an apparatus, system, method and computer program and computer program product for analyzing cellular samples. One embodiment of the apparatus and method provides a multiparameter assay that provides information with respect to cell pr... | 10/04/2011 |
| 8027824 | Protein switches incorporating cytochrome Cin monolayers and method for producing same A biomolecular electronic switch includes a first electrical contact, a second electrical contact, a programmable monolayer of either cytochrome c or cytochrome c3 or bovine serum hormone sandwiched between the first and second electrical contacts and a s... | 09/27/2011 |
| 8027822 | Interactive, internet supported health and fitness management system A wellness system monitors the controlled progress of patients under surveillance and includes a server base station which is generally off-site, a web-site interface and a local station at the point-of-use, which is generally a health or fitness center. A unique da... | 09/27/2011 |
| 8027821 | Method for determining gene knockouts A method for determining candidates for gene deletions and additions using a model of a metabolic network associated with an organism, the model includes a plurality of metabolic reactions defining metabolite relationships, the method includes selecting a bioenginee... | 09/27/2011 |
| 8027823 | Methods and system for viewing genomic data A computer-implemented method for viewing experimental data is provided. In certain embodiments the method comprises: a) inputting genomic array data and cytogenetic data into a computer memory; and b) producing a graphical user interface comprising: i) a chromosoma... | 09/27/2011 |
| 8019582 | Automated diagnostic system and method Structure-based processing includes a method of diagnosing diseases that works by arranging diseases, symptoms, and questions into a set of related disease, symptom, and question structures, such as objects or lists, in such a way that the structures can be processe... | 09/13/2011 |
| 8010332 | Hydrophobic moment of multi-domain proteins Techniques for protein structure analysis are provided. In one aspect, an apparatus for characterizing a multi-domain protein structure comprises the following steps. For at least one domain, a hydrophobic dipole, e.g., defined as a first-order hydrophobic moment of... | 08/30/2011 |
| 8010331 | System reconstruction: integrative analysis of biological data The process of System Reconstruction is used to integrate sequence data, clinical data, experimental data, and literature into functional models of disease pathways. System Reconstruction models serve as informational “skeletons” for integrating various types of... | 08/30/2011 |
| 8005659 | Simulation of coupled objects A simulator for simulating a first object and a second object that is coupled to the first object is disclosed. The simulator models the first and second objects as a plurality of segments, with each segment having a plurality of nodes connected by one or more edges... | 08/23/2011 |
| 8000949 | Methods for identification of novel protein drug targets and biomarkers utilizing functional networks The process of System Reconstruction is used to integrate sequence data, clinical data, experimental data, and literature into functional models of disease pathways. System Reconstruction models serve as informational skeletons for integrating various types of high-... | 08/16/2011 |
| 8000948 | Methods for identifying compounds for treating disease states The process of System Reconstruction is used to integrate sequence data, clinical data, experimental data, and literature into functional models of disease pathways. System Reconstruction models serve as informational “skeletons” for integrating various types of... | 08/16/2011 |
| 7991601 | Isolated GRP94 ligand binding domain polypeptide and nucleic acid encoding same, crystalline form of same, and screening methods employing same An isolated GRP94 ligand binding domain polypeptide, a three-dimensional crystal structure of the same, and methods of using the same to design modulators of Hsp90 proteins. ... | 08/02/2011 |
| 7983887 | Fast computational methods for predicting protein structure from primary amino acid sequence The present invention provides a method utilizing primary amino acid sequence of a protein, energy minimization, molecular dynamics and protein vibrational modes to predict three-dimensional structure of a protein. The present invention also determines possible inte... | 07/19/2011 |
| 7979259 | Diabetes care management system A diabetes care management system for managing blood glucose levels associated with diabetes comprising a computing device and an insulin delivery device. The computing device generally includes (i) a memory comprising one or more optimal blood glucose values, one o... | 07/12/2011 |
| 7979258 | Self-calibration of mass spectra using robust statistical methods The use of a robust statistical method for self-calibration of a measuring instrument, such as a mass spectrometer, is disclosed. The method involves the use of differences in mass and complementary pairs for example, to estimate calibration parameters. Self-calibra... | 07/12/2011 |
| 7949507 | Diabetes care management system A diabetes care management system for managing blood glucose levels associated with diabetes comprising a computing device and an insulin delivery device. The computing device generally includes (i) a memory comprising one or more optimal blood glucose values, one o... | 05/24/2011 |
| 7949506 | Method for determining and compensating for a weight loss energy gap The present invention provides a weight loss maintenance system. The invention incorporates supplements (dietary, pharmaceutical or neutraceutical) that aid in maintaining weight loss as well as physical activity. The invention further provides a personal plan that ... | 05/24/2011 |
