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| Number | Title | Issue Date |
| 8180579 | Real time gamma-ray signature identifier A real time gamma-ray signature/source identification method and system using principal components analysis (PCA) for transforming and substantially reducing one or more comprehensive spectral libraries of nuclear materials types and configurations into a correspond... | 05/15/2012 |
| 8180580 | Method for identifying a compound that modulates SIR2 protein activity The present invention relates to a method for identifying compounds that modulate the activity of sirtuin deacetylase protein family members. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid re... | 05/15/2012 |
| 8155892 | Means for identifying a strain isolated from a clinical sample at the species and/or subspecies level The invention relates to a method for identifying a strain isolated from a clinical sample, at the species and/or subspecies level, using MALDI-TOF-MS analysis comprising a step of classifying the germ in a group before performing the MALDI-TOF-MS analysis. ... | 04/10/2012 |
| 8140500 | Spectral measurement with assisted data analysis A system is provided wherein spectrometer measurements, and/or measurements from other analytical instruments, are transmitted to a processing station which determines the component substances of the sample(s) subjected to the measurements. The names of the componen... | 03/20/2012 |
| 8135546 | Moment analysis of tertiary protein structures Techniques for analyzing protein structures, such as a tertiary protein structure, are provided. A centroid of the residue centroids is calculated. The centroid of the residue centroids is used as a spatial origin of a global linear hydrophobic moment. The correlati... | 03/13/2012 |
| 8131481 | Database supported nanocrystal structure identification by lattice-fringe fingerprinting with structure factor extraction Candidate structures for nanocrystal and other specimens are obtained based on a specimen complex spectrum that is determined as a Fourier transform of a phase-contrast electron micrograph. The specimen can also be assessed based on an amplitude portion of the compl... | 03/06/2012 |
| 8126656 | Molecular design method and computer-readable storage medium A computer-implemented molecular design method constructs and stores a data structure including an atomic data structure, a bond axis data structure, a molecular data structure, an auxiliary data structure, and an event data structure, with respect to data of a give... | 02/28/2012 |
| 8112233 | Selective resonance of chemical structures Chemical compositions may be selectively or preferentially excited by the application of scores comprising a series of at least four differing energy inputs. The differing energy inputs of the specified series are selected to resonate each of a group of resonant str... | 02/07/2012 |
| 8099245 | Crystallographic structure of proline racemase and uses therefor The present invention provides the crystal structure of the Trypanosoma cruzi PRACA proline racemase. Methods of modelling drugs that treat or prevent infection by T. cruzi are also provided, as are the drugs that are identified. ... | 01/17/2012 |
| 8050873 | Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase The crystal structure of ligand-bound EGLN1 catalytic domain of prolyl hydroxylase is disclosed. These coordinates are useful in computer aided drug design for identifying compounds that regulate EGLN1 prolyl hydroxylase and thereby regulate HIF-regulated disorders.... | 11/01/2011 |
| 8019557 | Cavity induced allosteric modification of intermolecular interactions and methods of identifying compounds that effect the same Method of identifying compounds that modulate intermolecular interactions between a target protein and a modifier are disclosed. Pharmaceutical composition comprising compounds that inhibit intermolecular interactions between a target protein and a modifier are disc... | 09/13/2011 |
| 7979216 | Method for determining a gas compositional origin from carbon material thermal degradation At least one type of carbon material susceptible to generate a gas G is selected. Then, a model is built from the carbon isotopic composition of a gas P generated by thermal degradation of this type of carbon material. The model is calibrated by calibrating the kine... | 07/12/2011 |
| 7966133 | Method of identifying a potential substrates of an O-methyltransferase The invention provides crystalline O-methyltransferases and isolated non-native O-methyltransferases as well as sets of their structural coordinates. Also provided are methods of predicting the activity or substrate specificity of putative O-methyl-transferases, met... | 06/21/2011 |
| 7945396 | Molecular force field assignment method, molecular force field assignment apparatus and molecular force field assignment program A molecular force field assignment method for assigning a molecular force field to a molecule having a desired molecular structure, includes a step of specifying a combination according to whether or not an interatomic distance between a first and second atoms, obta... | 05/17/2011 |
| 7920972 | G-matrix Fourier transformation (GFT) nuclear magnetic resonance (NMR) experiments for resonance assignment and structure determination of organic molecules The present invention discloses a suite of G2FT and GFT NMR experiments that can be used for complete resonance assignments of proteins and for obtaining structural (conformational and orientational) constraints for determining high resolution three-dimen... | 04/05/2011 |
| 7908094 | Method for preparing maltogenic alpha-amylase variants The inventors have modified the amino acid sequence of a maltogenic alpha-amylase to obtain variants with improved properties, based on the three-dimensional structure of the maltogenic alpha-amylase Novamyl. The variants have altered physicochemical properties, e.g... | 03/15/2011 |
| 7904252 | Method for measuring a structural change in a protein A method of easily and speedily determining what structural change is experienced by a target protein upon contact and binding of any arbitrary compound to the target protein; a method of selecting and screening a compound for use in the method; and a computer progr... | 03/08/2011 |
| 7904253 | Determination of chemical composition and isotope distribution with mass spectrometry A method for determining elemental composition of ions from mass spectral data, comprising obtaining at least one mass measurement from mass spectral data; obtaining a search list of candidate elemental compositions whose exact masses fall within a given mass tolera... | 03/08/2011 |
| 7877214 | Hydrophobic moment of multi-domain proteins Techniques for protein structure analysis are provided. In one aspect, a method of analyzing a multi-domain protein structure comprises the following steps. For at least one domain, a hydrophobic dipole, e.g., defined as a first-order hydrophobic moment of the domai... | 01/25/2011 |
| 7831395 | Quantification of adsorbed molecular contaminant using thin film measurement A test method for measuring adsorbed molecular contamination uses a test structure that includes a substrate comprising a plurality of separated test sites having a plurality separate thicknesses having a base design thickness and a designed thickness interrelations... | 11/09/2010 |
| 7826982 | Method of identifying inhibitors using a 3-D structure of RAC-1 GTPASE The preferred embodiments generally relate to methods and compositions that affect the GTP-binding activity of members of the Rho family GTPases, preferably Rac (Rac1, Rac2 and/or Rac3), such compositions include compounds that modulate the GTP/GDP exchange activity... | 11/02/2010 |
| 7801689 | Systems and methods for tracking the composition of distilled spirits in production and storage Systems, methods, and apparatus for propagating distilled spirit composition throughout production are disclosed. The composition of distilled spirits in each of a plurality of containers is tracked. A first distilled spirit from a first container in the plurality o... | 09/21/2010 |
| 7801688 | CrystalSym process The CrystalSym process is a logical process. It enables users of the process to easily construct symmetric systems of objects within a 3D virtual space. This process utilizes the gamut of the crystallographic 3D space filling symmetry groups of which there are 230, ... | 09/21/2010 |
| 7797112 | Method of identifying a FabK protein inhibitor using a three-dimensional structure of FabK protein The present invention relates to a FabK (enoyl-acyl carrier protein reductase) protein derived from a Thermotoga maritima strain. In the present invention, the active site and the three-dimensional crystal structure of the protein are determined, a novel inhi... | 09/14/2010 |
| 7792645 | Three-dimensional structure of chalcone isomerase and methods of use thereof This disclosure provides crystalline flavonoid or flavanone isomerases, isolated non-native isomerase having the structural coordinates of said crystalline isomerase, and nucleic acids encoding such non-native isomerase. Also disclosed are methods of predicting the ... | 09/07/2010 |
| 7778782 | Peroxisome proliferation activated receptor alpha (PPARα) signatures The present invention includes methods and apparatus for use in rapid testing for and prediction of a PPARα response (i.e. a response similar to that of PPARα agonists). The invention includes a PPARα response signature comprising a set of twenty genes. The inven... | 08/17/2010 |
| 7751987 | Method and system for predicting amino acid sequences compatible with a specified three dimensional structure A method for predicting an amino acid sequence compatible with a three-dimensional (3D) structure of a protein. A reduced virtual representation of the 3D structure is constructed, and, for each position along the representation, its solvent accessibility is determi... | 07/06/2010 |
| 7751988 | Lead molecule cross-reaction prediction and optimization system A method for the prediction of adverse cross-reactions between lead candidate biomolecules and potential reactant molecules, often biopolymers, is described. In a computational system, reactions are modeled within a suitable environment, in order to determine a reac... | 07/06/2010 |
| 7747395 | Method of inhibitor design and identification using a 3-D structure of human peptide deformylase The present invention provides the three-dimensional structure of human mitochondrial Homo sapiens peptide deformylase (HsPDF) protein, and HsPDF complexed to a binding compound, such as a PDF inhibitor. This crystallographic information will aid in the ident... | 06/29/2010 |
| 7729868 | Method for analyzing structure of glycoprotein The present invention provides a simplified method for analyzing a structure of glycoprotein capable of conducting a peptide sequence analysis, a sugar chain sequence analysis, and an analysis of a sugar chain binding site accurately and rapidly using a mass spectro... | 06/01/2010 |
| 7711497 | Method of identifying calcium-binding sites in gamma-crystallin useful for management of cataract The present invention relates to a method of identifying calcium binding sites in gamma-crystallin useful in calcium-based homeostasis for the management of Cataract, said method comprising steps of isolating gamma-crystallin from eye lens, studying binding of calci... | 05/04/2010 |
| 7706984 | Method and device for identifying molecular species The invention relates to a device and a method for analyzing the interaction between one or more molecular species the method comprising the steps of creating streams of digital data, transferring the stream of digital data through a substrate, manipulating the mole... | 04/27/2010 |
| 7684934 | Pattern recognition of whole cell mass spectra A method for reproducibly analyzing mass spectra from different sample sources is provided. The method deconvolutes the complex spectra by collapsing multiple peaks of different molecular mass that originate from the same molecular fragment into a single peak. The d... | 03/23/2010 |
| 7680609 | Biopolymer automatic identifying method The invention aims to provide a highly accurate automatic biopolymer determination technique utilizing mass spectrometry whereby calibration prior to measurement or the addition of an internal standard to a sample can be eliminated. The biopolymer automatic identify... | 03/16/2010 |
| 7672791 | Method of performing three-dimensional molecular superposition and similarity searches in databases of flexible molecules The virtual screening of a database of molecules is based on explicit three-dimensional molecular superpositions. The torsional flexibility of the database molecules is taken fully into account, and an arbitrary number of conformation-dependent molecular features ma... | 03/02/2010 |
| 7657385 | Structure-based hepatitis C virus drug design The extracellular loop of CD81 is a cellular receptor for the E2 protein of hepatitis C virus. A CD81 crystal structure has been elucidated and is provided for use in the structure-based design of compounds which bind to CD81 and thus block the binding of HCV. Metho... | 02/02/2010 |
| 7653495 | Cavity induced allosteric modification of intermolecular interactions and methods of identifying compounds that effect the same Method of identifying compounds that modulate intermolecular interactions between a target protein and a modifier are disclosed. Pharmaceutical composition comprising compounds that inhibit intermolecular interactions between a target protein and a modifier are disc... | 01/26/2010 |
| 7630838 | Method for identifying agents that interact with beta-site APP cleaving enzyme (BACE) This invention is directed to the three dimensional crystal structure of Beta-site APP Cleaving Enzyme (BACE), and to the use of this structure in rational drug design methods to identify agents that may interact with active sites of BACE. Such agents may represent ... | 12/08/2009 |
| 7623972 | Detection of presence of chemical precursors Methods and systems for determining if one or more target molecules are present in a gas, by exposing a functionalized carbon nanostructure (CNS) to the gas and measuring an electrical parameter value EPV(n) associated with each of N CNS sub-arrays. In a first embod... | 11/24/2009 |
| 7610156 | Methods for rational pegylation of proteins The present invention relates to the use of simulation technology to rationally optimize the locations and sizes of attached polymeric moieties for modification of therapeutic proteins and the proteins generated from this method. ... | 10/27/2009 |
