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| Number | Title | Issue Date |
| 7348175 | Bioreactor with plurality of chambers for conditioning intravascular tissue engineered medical products A microprocessor controlled and instrumented bioreactor for conditioning intravascular tissue engineered medical products. One bioreactor design including an integrated pump to provide a relatively small volume of fluid nutrient. The microprocessor control providing... | 03/25/2008 |
| 7332689 | Tacking method and apparatus An apparatus for tacking a multi-lumen tubular assembly together comprises a laser, an optical member and a placement tray for retaining the tubular assembly. A portion of the optical member defines a window that is substantially transparent to laser energy emitted ... | 02/19/2008 |
| 7279183 | Method of reducing thrombosis and complications after arterial angioplasty using stent coated with magnesium-based compound Treatment with magnesium produces a inhibition of acute stent thrombosis under high-shear flow conditions without any hemostatic or significant hemodynamic complications. ... | 10/09/2007 |
| 7094418 | Crosslinkable macromers A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue implant or on the porous surface of a prosthetic device. The macromer s... | 08/22/2006 |
| 7077860 | Method of reducing or eliminating thrombus formation An implantable stent is coated with a material that attracts heparin and with which heparin forms a bond. The stent is exposed to a heparin containing solution just prior to implantation or is first implanted and then exposed to heparinized blood. As heparin becomes... | 07/18/2006 |
| 6849262 | Vascular coating composition This invention relates to methods of coating the lumenal surface of a blood vessel, or other tissue cavity, and to compositions suitable for use in same. ... | 02/01/2005 |
| 6729356 | Endovascular graft for providing a seal with vasculature A graft provided with a flexible sealing member to substantially prevent blood from leaking between the graft a lumen into which the graft is placed. In one embodiment, the flexible sealing member may be pressed against the vascular wall by an outwardly biased sprin... | 05/04/2004 |
| 6699282 | Method and apparatus for delivery of medication An implanted device such as a stent is provided which is capable of holding an induced charge or sufficient magnitude that the device may, by electrostatic means, attract the bioactive material to itself. The charge, either positive or negative, or relati... | 03/02/2004 |
| 6692772 | Prevention of in-stent thrombosis and complications after arterial angioplasty with stent placement using magnesium Treatment with magnesium produces a inhibition of acute stent thrombosis under high-shear flow conditions without any hemostatic or significant hemodynamic complications.... | 02/17/2004 |
| 6605114 | Heparin delivery method A method for delivering heparin, wherein an implantable stent is coated with a material that attracts heparin and with which heparin forms a bond. The stent is exposed to a heparin containing solution just prior to implantation or is first implanted and t... | 08/12/2003 |
| 6602287 | Stent with anti-thrombogenic coating A glycocalyx-like material is applied to a stent in order to mimic the outer surface of the cells lining arteries and veins to prevent thrombogenesis. The glycocalyx material is applied over a base layer of a fluorocarbon that is applied directly to the s... | 08/05/2003 |
| 6537202 | Method for polishing surgical stents A method for polishing radially expandable surgical stents is disclosed where fluid abrasive media M flows over surfaces of the stent 10 causing the surfaces of the stent 10 to be polished and streamlined. The stent 10 is temporarily provided with cylindr... | 03/25/2003 |
| 6491624 | Device for peroperative exploration of a cardiovascular system A device for exploration of the cardiovascular system of human or animal bodies includes a generally transparent blind tube delimiting a cavity in which can be disposed an optical display device, the open end of the tube being shaped to be ensleeved axial... | 12/10/2002 |
| 6416995 | Bioreactor mediated recellularization of natural and tissue engineered vascular grafts The invention provides a device and process for recellularizing essentially acellular or devitalized tissue grafts, including for example essentially acellular or devitalized vascular tissue grafts, derived from human or animal sources, or as constructed ... | 07/09/2002 |
| 6410044 | Crosslinkable macromers A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue implant or on the porous surface of a prosthetic device. The... | 06/25/2002 |
| 6254631 | Stent with enhanced friction A stent for placement in a body lumen is fabricated by forming a tube having an un-deployed diameter sized for the tube to be placed on a deployment balloon and advanced through a body lumen to a deployment site. The tube is expandable upon inflation of t... | 07/03/2001 |
| 6162247 | Vascular graft impregnated with a heparin-containing collagen sealant A heparin-collagen dispersion is provided for impregnating a vascular prosthesis with heparin and collagen. The dispersion is prepared at an alkaline pH to allow the addition of heparin without causing the agglutination of collagen from the dispersion. Th... | 12/19/2000 |
| 5951586 | Intraluminal stent Intraluminal stents and methods of manufacturing intraluminal stents are disclosed in which the stents have a plurality of recesses in the body of the stent, at least some of the recesses preferably providing a plurality of passageways between the inner a... | 09/14/1999 |
| 5935161 | Non-migrating vascular prosthesis and minimally invasive placement system therefor A graft assembly for securely positioning a graft at a predetermined location across an abdominal aortic aneurysm. The assembly includes a resilient self-expanding anchor that is secured to the graft. The anchor is characterized as being at least as long ... | 08/10/1999 |
| 5935168 | Glutaraldehyde-fixed bioprostheses Methods for treating glutaraldehyde-fixed collagenous tissues to mitigate there propensity for subsequent calcification and to improve durability. Collagenous tissues which have been harvested and cross-linked by glutaraldehyde are exposed to a carboxyl a... | 08/10/1999 |
| 5899936 | Treated tissue for implantation and methods of preparation This disclosure includes a method for generating a functional hybrid bioprosthesis. Tissue formed naturally of interstitial collagens is treated to kill native cells and remove potentially immunologically active soluble molecules. Then it may be treated s... | 05/04/1999 |
| 5855802 | Method and apparatus for forming a tubular article having a perforated annular wall A method for forming a tubular article having a perforated annular wall, such as a surgical stent, includes coating the exterior and interior cylindrical surfaces of a tubular member with a photoresist, exposing selected portions of the photoresist coated... | 01/05/1999 |
| 5804366 | Method and apparatus for sodding microvessel cells onto a synthetic vascular graft An apparatus for sodding onto the inner lumenal surface of a synthetic graft of harvested and concentrated microvessel endothelial cells from liposuctioned fat tissues, which harvested cells are formed into a "pellet" of isolated endothelial cells in loos... | 09/08/1998 |
| 5800538 | Biodegradable polymeric endoluminal sealing process A novel process for paving or sealing the interior surface of a tissue lumen by entering the interior of the tissue lumen and applying a polymer to the interior surface of the tissue lumen. This is accomplished using a catheter which delivers the polymer ... | 09/01/1998 |
| 5800542 | Sterilization by gamma irradiation A method of treating a reconstituted biopolymeric implant which includes the steps of exposing the implant to an aqueous environment so that a final water content of the implant ranges from 5% by weight to a maximal water absorption capacity; and sealing ... | 09/01/1998 |
| 5772695 | Treated tissue for implantation and methods of treatment and use Tissue which is suitable for transplant is treated with a growth factor and cells which populate the tissue and native cells must be removed, they cannot be "masked" reduce immunogenicity; this increases the longevity of the tissue upon transplant. The pr... | 06/30/1998 |
| 5766238 | Expandable stents and method for making same The invention is directed to an expandable stent for implantation in a body lumen, such as an artery, and a method for making it from a single length of tubing. The stent consists of a plurality of radially expandable cylindrical elements generally aligne... | 06/16/1998 |
| 5755788 | Prosthesis and implants having liposomes bound thereto and methods of preparation Prostheses and implants are provided which have bound liposomes which are freeze-thaw and dehydration stable and which resist infection and thrombosis development in the body. Stabilizing agents are used, including saccharide stabilizing agents. Prosthesi... | 05/26/1998 |
| 5746691 | Method for polishing surgical stents A method for polishing radially expandable surgical stents is disclosed where fluid abrasive media M flows over surfaces of the stent 10 causing the surfaces of the stent 10 to be polished and streamlined. The stent 10 is temporarily provided with cylindr... | 05/05/1998 |
| 5718723 | Artificial blood vessel and process for producing the same This invention provides a more functionalized artificial blood vessel which can be organized by independently designing its inner and outer surfaces and endowing them with respectively different biocompatibilities, as well as a process for producing the s... | 02/17/1998 |
| 5693098 | Fibrin D-domain multimer prostheses and methods for their production Methods for coating a prosthetic surface with anti-thrombogenic, or anti-coagulant, proteins are disclosed. The methods involve contacting a surface of a prosthetic material with a composition containing multimers of fibrin degradation products. These mul... | 12/02/1997 |
| 5679659 | Method for making heparinized biomaterials An improved method of making a medical device having immobilized heparin on a blood-contacting surface in which heparin is admixed with sufficient periodate to react with not more than two sugar units per heparin molecule in a buffer solution having a pH ... | 10/21/1997 |
| 5679112 | Calcification-resistant materials and methods of making same through use of multivalent cations Bioprosthetic materials, either natural or synthetic, are treated with trivalent iron cations, or salts, to prevent in vivo calcification. Such bioprosthetic materials include porcine aortic valve leaflets, bovine pericardium, aortic homografts, biocompat... | 10/21/1997 |
| 5674298 | Calcification-resistant bioprosthetic tissue and methods of making same Naturally-derived bioprosthetic materials are treated with epoxide crosslinking agents. In some embodiments, the tissue is crosslinked with low molecular weight epoxides in aqueous solutions at high pH levels. In other embodiments, the tissue is crosslink... | 10/07/1997 |
| 5674722 | Genetic modification of endothelial cells Endothelial cells transduced with genetic material encoding a polypeptide or protein of interest and, optionally, a selectable marker, as well as methods for making and using the transduced endothelial cells are disclosed. Such endothelial cells are usefu... | 10/07/1997 |
| 5674290 | Water-stabilized biopolymeric implants A method of treating a reconstituted biopolymeric implant which includes the steps of exposing the implant to an aqueous environment so that a final water content of the implant ranges from 5% by weight to a maximal water absorption capacity; and sealing ... | 10/07/1997 |
| 5645587 | Prevention of calcification and degeneration of biological tissue grafts for implantation in humans The present invention relates to chemical treatment for prevention of calcification and degeneration of biological tissue grafts used as a whole or in a part as heart valve substitutes, substitutes of blood vessel, pericardial substitutes, and surgical me... | 07/08/1997 |
| 5634879 | Process for preparing a porous graft containing endothelial cells A process for the production of prostheses wherein endogenic tissue material is substantially mechanically comminuted and, if necessary, additionally enzymatically digested to tissue particles, whose sizes fall within very narrow limits. A preshaped carri... | 06/03/1997 |
| 5599352 | Method of making a drug eluting stent An intraluminal stent comprising fibrin and an elutable drug is capable of providing a treatment of restenosis.... | 02/04/1997 |
| 5591222 | Method of manufacturing a device to dilate ducts in vivo A device for dilating ducts in vivo, comprising a balloon-tipped catheter to which a cylindrical stent prepared by knitting or braiding or weaving biodegradable fibers to easily reduce diameter of the cylinder to a predetermined value is attached in a com... | 01/07/1997 |
