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| Number | Title | Issue Date |
| 7309359 | Allogenic/xenogenic implants and methods for augmenting or repairing intervertebral discs Allogenic or xenogenic materials are used to provide intervertebral disc nucleus implants and/or annular plugs. The allogenic or xenogenic materials comprise natural disc annulus material, which may have a portion of the anterior longitudinal ligament attached. The ... | 12/18/2007 |
| 6855167 | Spinal intervertebral implant, interconnections for such implant and processes for making A cortical bone implant is formed of two or more planks of bone which are connected with one or more offset pins. The pins may be right circular cylinders inserted into a corresponding offset bore which offset bends the inserted pin. The bending creates compression ... | 02/15/2005 |
| 6736848 | Method and apparatus for using formable polymers for orthopedic support An orthopedic implant is formed from a sheet of moldable material such as a polymer or a bioresorbable material using an instrument. The material is heated above its glass transition temperature so that it can be formed into the desired shape of the implant. Then th... | 05/18/2004 |
| 6736853 | Method of using tissue cage The present invention relates to a method of utilizing body tissue by forming an implant that includes body tissue positioned in a cage. The cage is formed of material which expands when exposed to body fluid and the cage is positioned in a patient's body at a locat... | 05/18/2004 |
| 6702856 | Method of using Tissue A method of using body tissue includes removing tissue from a donor site and separating at least one component from the tissue while maintaining the tissue cells in a viable condition. The viable tissue cells are then implanted in a patient. The tissue ce... | 03/09/2004 |
| 6464729 | Reconstituted mineralized cartilage tissue A biological material comprising a continuous layer of cartilaginous tissue reconstituted in vitro which contains components associated with cartilage mineralization. The biological material may be cultured with a mineralizing agent to form a mineralized ... | 10/15/2002 |
| 6436138 | Process for producing flexible sheets from demineralized, elongate, bone particles A process for fabricating shaped material from demineralized bone particles includes the steps of applying a liquid slurry of demineralized bone particles to a support, removing excess liquid form the demineralized bone particles to provide a cohering sha... | 08/20/2002 |
| 6387693 | Method for producing cartilage tissue and implants for repairing enchondral and osteochondral defects as well as arrangement for carrying out the method Cartilage tissue and implants comprising tissue are produced in vitro starting from cells having the ability to form an extracellular cartilage matrix. Such cells are brought into a cell space (1) and are left in this cell space for producing an extracell... | 05/14/2002 |
| 6355705 | Anaesthetic bone cement A polymethacrylate or other bone cement composition having analgesic properties is described. Bone cements containing up to 5% by weight of a local anaesthetic agent, such as lidocaine, have been demonstrated to elute sufficient lidocaine to provide an an... | 03/12/2002 |
| 6340369 | Treating degenerative disc disease with harvested disc cells and analogues of the extracellular matrix Living intervertebral disc cells are harvested, cultured and combined with type-specific collagen-glycosaminoglycan extracellular matrix analogues to restore disc function and eliminate pain in patients with disc disease. In the preferred embodiment, the ... | 01/22/2002 |
| 6224913 | Conditioning of bioactive glass surfaces in protein containing solutions Conditioning of the surface of silica-based glass or ceramic by differential immersion in a serum protein-containing solution, and the resultant microporous Ca--P surface layer having serum-protein like organic molecules, as defined herein intermingled th... | 05/01/2001 |
| 6217614 | Process for treating bone tissue and corresponding implantable biomaterials The present invention concerns a process for treating bone tissue of animal or human origin, and a corresponding implantable biomaterial. According to the present invention, a fluid in the supercritical state is caused to penetrate throughout the bone tis... | 04/17/2001 |
| 6206923 | Flexible implant using partially demineralized bone Implantable devices useful for creating bony fusion particularly in intervetebral spinal fusion. The device is formed of bone and has an at least partially demineralized portion between two rigid bone portions creating an area of flexibility. In one appli... | 03/27/2001 |
| 6143030 | Impaction allograft form and method of orthopaedic surgery using same A method of performing orthopaedic surgery on a bone includes the steps of: preparing an allograft form including a plurality of allograft bone particles with a predetermined outside shape (e.g., cylindrical or implant shaped); freezing the allograft form... | 11/07/2000 |
| 6136030 | Process for preparing porous bioceramic materials A process for preparing porous bioceramic materials includes the following steps: (a) using the cancellous bone of animals, (b) removing organic substances in the cancellous bone by thermal processing to obtain de-organic cancellous bone, (c) soaking the ... | 10/24/2000 |
| 6132463 | Cell seeding of ceramic compositions The present invention provides a synthetic, poorly-crystalline apatitic (PCA) calcium phosphate material seeded with cells. Preferably, the cells are tissue-forming or tissue-degrading cells. The compositions provided by the present invention are useful f... | 10/17/2000 |
| 5935853 | Human epithelial cell matrix and uses therefor A method of growing epithelial cells by contacting the cells with the extracellular matrix deposited or secreted by human MCF-10A mammary epithelial cells. The MCF-10A matrix stimulates cell attachment and hemidesmosome formation in epithelial cells conta... | 08/10/1999 |
| 5839899 | Method and apparatus for growing jaw bone utilizing a guided-tissue regeneration plate support and fixation system A method of growing jaw bone and the related guided-tissue regeneration plate support and fixation system employed in the method where an isolated and protected space free from tissue impingement, occlusal loading, chewing forces or muscular pressure is c... | 11/24/1998 |
| 5807554 | Herbal formulations with nacre Various complex formulations including the nacre form of calcium as a primary constituent are provided for dealing with a number of human ailments including insomnia, skin inflammation and itching, and anxiety disorders, and for increasing bone density. F... | 09/15/1998 |
| 5725579 | Process for treating bone tissue and corresponding implantable biomaterials The present invention concerns a process for treating bone tissue of animal or human origin, and a corresponding implantable biomaterial. According to the present invention, a fluid in the supercritical state is caused to penetrate throughout the bone tis... | 03/10/1998 |
| 5607689 | Latex element designed to achieve guided tissue regeneration in periodontal dental therapy An element designed to achieve tissue regeneration in periodontal dental therapy, comprising a membrane insertable under the gingiva and made from a non-resorbable, biologically acceptable, non-porous elastomer material having a thickness in the range of ... | 03/04/1997 |
| 5573771 | Medicinal bone mineral products The invention provides a purified particulate bone mineral product for use in medicine, the particles of said mineral being substantially free from all endogenous organic material and having at least at the surface thereof resorbable, physiologically comp... | 11/12/1996 |
| 5569308 | Methods for use in bone tissue regeneration The present invention provides methods for use in bone tissue regeneration containing a barrier material and a graft material. The barrier material can be calcium sulfate, while the graft material can be any suitable material, including a composite graft ... | 10/29/1996 |
| 5556430 | Flexible membranes produced from organic bone matrix for skeletal repair and reconstruction A flexible, organic bone matrix which is adapted for use during the in vivo repair, replacement or reformation of preselected portions of a mammalian or animal skeletal system comprising a continuous sheet of completely or partially demineralized natural ... | 09/17/1996 |
| 5556429 | Joint resurfacing system A system for resurfacing orthopedic joints by arthroscopic means. The system involves a method that includes the delivery of a curable biomaterial, and the use of minimally invasive means to prepare an injury site, and then deliver, cure and shape a curab... | 09/17/1996 |
| 5541106 | Cell matrix stimulated attachment and hemidesmosome assembly A method for growing epithelial cells in vitro is described, The matrix secreted by 804G rat bladder carcinoma cells is able to stimulate cell attachment and hemidesmosome formation in cells grown on the matrix, Human epithelial cells grown on the 804G ma... | 07/30/1996 |
| 5516532 | Injectable non-immunogenic cartilage and bone preparation Ground bone or cartilage particles are demineralized by extraction with a low ionic strength buffer such as 20 mM HEPES containing a chelating agent and protease inhibitors, then extracted with an acidic solution such as 0.3M citric acid, pH 4.0, containi... | 05/14/1996 |
| 5263498 | Method of arthroscopically preparing an articular bone surface Methods and apparatus for prosthetic knee replacement permit preparation of tibial plateau and femoral condyle surfaces and implant of tibial and femoral protheses components with the use of arthroscopic surgical techniques. The bone surfaces are resected... | 11/23/1993 |
| 5226914 | Method for treating connective tissue disorders The present invention is directed to various processes and devices for utilizing isolated and culturally expanded marrow-derived mesenchymal cells (i.e. mesenchymal stem cells) for treating skeletal and other connective tissue disorders.... | 07/13/1993 |
| 5137534 | Method for producing dental and medical bone prosthesis and bone prosthesis produced thereby A method for producing a dental and medical bone prosthesis comprising the step of: adding an aqueous acidic solution of an organic or inorganic acid, such as phosphoric acid, citric acid, or acetic acid, to a fixable granulated bone prosthesis comprising... | 08/11/1992 |
| 5133756 | Process for producing a bone replacement material According to a process for producing a bone replacement material, natural bones are used as raw material, the soft parts of the bones are removed, as well as any residual organic substances, and the remaining osseous substance is finally sintered at tempe... | 07/28/1992 |
| 5124316 | Method for periodontal regeneration A method for promoting bone, periodontium or ligament growth of a mammal comprising applying to the bone periodontium or ligament a growth-promoting amount of a composition comprising a partially purified or purified polypeptide growth factor.... | 06/23/1992 |
| 5092883 | Method for promoting soft connective tissue growth and repair in mammals A material with chemically induced surface charges is employed to foster formation of mammalian hard and soft connective tissues. The material may be in the form of beads such as ion exchange resins. Bead materials with a negative surface charge stimulate... | 03/03/1992 |
| 5053050 | Compositions for repair of cartilage and bone A defect is provided in cartilage or bone, or both, to excize damaged or pathological tissue, and it is filled with an implant having capability for complete regeneration of the skeletal tissue as a chondrogenic or osteogenic phenotype. The implant compri... | 10/01/1991 |
| 5041138 | Neomorphogenesis of cartilage in vivo from cell culture Methods and artificial matrices for the growth and implantation of cartilaginous structures and surfaces are disclosed. In the preferred embodiments, chondrocytes are grown on biodegradable, biocompatible fibrous polymeric matrices. Optionally, the cells ... | 08/20/1991 |
| 5035711 | Transcutaneously implantable element A transcutaneously implantable element in which at least a portion thereof in contact with the cutaneous tissue of a living body is composed of a ceramic material comprising, as the main raw material, at least one member selected from the group consisting... | 07/30/1991 |
| 5026397 | Transcutaneously implantable element A transcutaneously implantable element in which at least a portion thereof in contact with the cutaneous tissue of a living body is composed of a ceramic material comprising, as the main raw material, at least one member selected from the group consisting... | 06/25/1991 |
| 4988358 | Method for promoting hard tissue growth and repair in mammals A material with chemically induced surface charges is employed to foster formation of mammalian hard and soft connective tissues. The material may be in the form of beads such as ion exchange resins. Bead materials with a negative surface charge stimulate... | 01/29/1991 |
| 4882149 | Pharmaceutical depot preparation Pharmaceutical depot preparation for implantation into base tissue comprising natural bone mineral from which the naturally associated fat and bone-proteins have been removed whereby said bone is sterile and non-allergenic, said bone mineral having absorb... | 11/21/1989 |
| 4801299 | Body implants of extracellular matrix and means and methods of making and using such implants A sterile body implant is derived from a body structure having as its major protein component collagens in the form of extracellular matrix. The body structure is treated to remove cellular membranes, nucleic acids, lipids and cytoplasmic components. Such... | 01/31/1989 |