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| Number | Title | Issue Date |
| 7909886 | Tissue repair fabric This invention is directed to prosthesis, which, when implanted into a mammalian patient, serves as a functioning replacement for a body part, or tissue structure, and will undergo controlled biodegradation occurring concomitantly with bioremodeling by the patient's... | 03/22/2011 |
| 7232886 | Method for the manufacture of recombinant unhydroxylated collagen polypeptide fibres, and recombinant unhydroxylated collagen polypeptide fibres obtained thereby The present invention relates to a process for the production of fibres of an unhydroxylated recombinant collagen polypeptide, and the fibres obtained thereby, as well as to uses of such fibres as a biomaterial. ... | 06/19/2007 |
| 7214344 | Method for treatment of biological tissues to mitigate post-implantation calcification and thrombosis A method of treating a biological tissue including contacting the biological tissue with an aqueous sterilizing solution, and maintaining the aqueous sterilizing solution at a temperature of about 50° C. for a time period of about 1 to 2 days. The method of treatin... | 05/08/2007 |
| 7211040 | Vein harvesting system and method A system and a method for harvesting a section of a blood vessel from a patient's body for further use. The system includes an expandable hood that creates a workspace for the dissection and removal of the vessel and a telescoping device that has tools at its distal... | 05/01/2007 |
| 7179637 | Apparatus and method for using intestinal segments or their substitutes in high-throughput analysis of compound absorption An apparatus for high-throughput analysis of compound absorption in a controlled environment that closely resembles in-vivo conditions. The apparatus includes at least one tissue-receiving enclosure that is capable of interfacing (e.g., via transfer of fluids, elect... | 02/20/2007 |
| 7084082 | Collagen material and its production process The objective of the present invention is to provide a collagen material that possesses physical properties to an extent that allows suturing while still maintaining the biochemical properties inherently possessed by collagen, and retains its shape for a certain amo... | 08/01/2006 |
| 7060103 | Tissue repair fabric A prosthesis, which, when implanted into a mammalian patient, serves as a functioning replacement for a body part, or tissue structure, and will undergo controlled biodegradation occurring concomitantly with bioremodeling by the patients living cells. The prosthesis... | 06/13/2006 |
| 6964685 | Biologic replacement for fibrin clot The invention provides compositions and methods for repairing intra-articular and extra-articular tissue including ligament, meniscus, cartilage, tendon, and bone. The method includes contacting the ends of an injured tissue from a patient with a composition. The re... | 11/15/2005 |
| 6893653 | Chemical cleaning of biological material The invention is directed to collagenous tissues which have been treated to remove non-collagenous components such as cells, cellular debris, and other extracellular matrix components, such as proteoglycans and glycosaminoglycans, normally found in native tissues. T... | 05/17/2005 |
| 6890351 | Method for treating diseased or damaged organs A bioremodelable prosthesis for treating a patient with a diseased or damaged organs comprising a first layer that contains acid-extracted fibrillar or non-fibrillar collagen, and a second layer derived from the tunica submucosa of the small intestine that provides ... | 05/10/2005 |
| 6705986 | Vein harvesting system and method A system and a method for harvesting a section of a blood vessel from a patient's body for further use. The system includes an expandable hood that creates a workspace for the dissection and removal of the vessel and a telescoping device that has tools at its distal... | 03/16/2004 |
| 6630001 | Compliant dehyrated tissue for implantation and process of making the same A process for preparing pliable soft tissue specimen which are resistant to cracking and devoid of viable cells includes the steps of treating native soft tissue obtained from a donor by a gradually increasing gradient of aliphatic alcohol or other suitab... | 10/07/2003 |
| 6592618 | In vitro modification of cardiac valvular xenografts The present invention is directed to methods for obtaining heart valves from a donor animal that have a reduced tendency to cause inflammation when implanted into a human patient. The valves produced by this method should be less likely to undergo post-su... | 07/15/2003 |
| 6547827 | Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby A method for fixation of biological tissues, and bioprosthetic devices prepared by such method. The method generally comprises the steps of A) fixing the tissue, B) treating the tissue with a mixture of i) a denaturant, ii) a surfactant and iii) a crossli... | 04/15/2003 |
| 6391052 | Stent with collagen A method of depositing collagen coatings on a metal surface, namely metal stents, by electrodeposition.... | 05/21/2002 |
| 5458636 | Prosthetic device for repair and replacement of fibrous connective tissue A sterile, surgically implantable prosthetic device for replacement of fibrous connective tissue is disclosed. The invention includes a series of nonabsorbable longitudinal threads that accept longitudinal stresses, and a series of closely spaced, nonabso... | 10/17/1995 |
| 5397354 | Method and device for removing a toxic substance from blood A method for removing a toxic substance from a patient utilizes a filtering device defining a first fluid flow path and a second fluid flow path. The filtering device also includes a semipermeable membrane separating the first fluid flow path and the seco... | 03/14/1995 |
| 5092883 | Method for promoting soft connective tissue growth and repair in mammals A material with chemically induced surface charges is employed to foster formation of mammalian hard and soft connective tissues. The material may be in the form of beads such as ion exchange resins. Bead materials with a negative surface charge stimulate... | 03/03/1992 |
| 4902289 | Multilayer bioreplaceable blood vessel prosthesis Process for forming a multilayer blood vessel prosthesis. Each layer is formed from bioreplaceable materials which include those produced by contacting collagen with an aminopolysaccharide and subsequently covalently crosslinking the resluting polymer, po... | 02/20/1990 |
| 4814120 | Process for the preparation of collagen tubes A process for preparing collagen tubes includes extruding an aqueous gel containing about 1.5% native collagen through a cylindrical spinneret equipped with a central concentric tube designed to receive a part of a coagulation bath, followed by coagulatio... | 03/21/1989 |
| 4806595 | Method of preparing antithrombogenic medical materials In a method of preparing an antithrombogenic medical material having a heparinized collagen as an antithrombogenic component, there is provided a method comprising the steps of fixing a protamine to a collagen through a polyepoxy compound, and heparinizin... | 02/21/1989 |
| 4801299 | Body implants of extracellular matrix and means and methods of making and using such implants A sterile body implant is derived from a body structure having as its major protein component collagens in the form of extracellular matrix. The body structure is treated to remove cellular membranes, nucleic acids, lipids and cytoplasmic components. Such... | 01/31/1989 |
| 4800603 | Tissue fixation with vapor The invention provides for tissue fixation by subjecting the tissue to the vapor of a fixative while the tissue is unstressed. The tissue may be rotated during fixation to avoid collecting condensed fixative at localized areas of the tissue. Intermittent ... | 01/31/1989 |
| 4772288 | Method for producing implantable ligament and tendon prostheses and prostheses produced thereby A method of making implantable ligament and tendon prostheses from natural collagen-containing tissues is described. The tissues used are those wherein the collagen fibers are aligned in one direction such as in ligaments or tendons. The method comprises ... | 09/20/1988 |
| 4695281 | Medical material The medical material according to this invention contains collagen, which as been chemically modified by saccinylation of thermal --NH2 groups of said chains attached to poly peptide chains of the collagen so that the --NH2 groups ar... | 09/22/1987 |
| 4629458 | Reinforcing structure for cardiovascular graft The reinforced tubular graft structure is particularly adapted for cardiovascular use and is made of collagenous tissue with a reinforcing fibrous structure surrounding the lumen. The fibrous structure comprises a coiled monofilament which can have a text... | 12/16/1986 |
| 4485096 | Tissue-equivalent and method for preparation thereof A tissue-equivalent, useful in the treatment of burns or other skin wounds and in the fabrication of prostheses, is disclosed which is prepared from a hydrated collagen lattice contracted by a contractile agent, such as fibroblast cells or blood platelets... | 11/27/1984 |
| 4485097 | Bone-equivalent and method for preparation thereof A bone-equivalent, useful in the fabrication of prostheses, is disclosed which is prepared from a hydrated collagen lattice contracted by fibroblast cells and containing demineralized bone powder.... | 11/27/1984 |
| 4378017 | Composite material of de-N-acetylated chitin and fibrous collagen A composite material of de-N-acetylated chitin and fibrous collagen, which may be prepared by bringing the de-N-acetylated chitin and the fibrous collagen into mutual contact in an aqueous acidic medium followed by deacidifying the obtained product, the f... | 03/29/1983 |
| 4319363 | Vascular prostheses Vascular prosthesis suitable for use as a surgical graft is produced by implanting a rod or tube in a living host animal such as a sheep and allowing collagenous tissue to grow on the implant to form a coherent tubular wall of collagenous tissue. The impl... | 03/16/1982 |
| 4300243 | Process for the preparation of preserved transplants Biological collagenous material is preserved by dehydrating utilizing an organic water-miscible solvent.... | 11/17/1981 |
| 4098571 | Substitute blood vessel and a process for preparing the same A process for preparing a heterograft substitute blood vessel comprises digesting a properly pretreated pig blood vessel with a digesting solution containing an animal proteolytic enzyme so as to retain collagenous and elastic fiber constituents substanti... | 07/04/1978 |
| 4083066 | Heterologous arterial transplants In a process for the preparation of heterologous arterial transplants comprising freeing young animal arteries of surrounding tissue, ligating collateral branches, subjecting the resulting arteries to proteolysis to remove elastic fibers and muscle tissue... | 04/11/1978 |