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| Number | Title | Issue Date |
| 7438850 | Sterilization method for the production of implantable or transplantable biological material The sterilization of biological material of animal or human origin, which is to be used as an implant or transplant, is performed according to a validated sterilization method with a margin of safety of 106 germs by which harmful microorganisms are physic... | 10/21/2008 |
| 7422607 | Anti-calcification treatments for heart valves and vascular grafts The present invention provides processes for fixation of biological tissue and/or post-fixation treatment of such tissue that result in modified tissues with reduced susceptibility to in vitro calcification when used in prosthetic devices. The invention also relates... | 09/09/2008 |
| 7416884 | Bioreactor and methods for tissue growth and conditioning A bioreactor and methods of using same for making tissue constructs and for conditioning tissue-engineered constructs and harvested tissues such as cryopreserved tissues. The bioreactor allows for static and dynamic culture/conditioning. The bioreactor is dual chamb... | 08/26/2008 |
| 7347876 | Method for expansion of epithelial stem cells Transplantation of epithelial stem cells, cultured ex vivo on specifically treated amniotic membrane, yields, with that amniotic membrane, a surgical graft having expanded epithelial stem cells. The method of creating this graft and the graft itself are simple and e... | 03/25/2008 |
| 7348175 | Bioreactor with plurality of chambers for conditioning intravascular tissue engineered medical products A microprocessor controlled and instrumented bioreactor for conditioning intravascular tissue engineered medical products. One bioreactor design including an integrated pump to provide a relatively small volume of fluid nutrient. The microprocessor control providing... | 03/25/2008 |
| 7326564 | Flow system for medical device evaluation and production In some embodiments, a flow system includes a medical device mount, fluid and a conduit containing the fluid and medical device mount. The conduit is mounted on an assembly that moves the conduit along with the medical device mount to induce relative motion of the f... | 02/05/2008 |
| 7318998 | Tissue decellularization The present invention relates, in general, to tissue decellularization and, in particular to a method of treating tissues, for example, heart valves, tendons and ligaments, so as to render them acellular and thereby limit mineralization and/or immunoreactivity upon ... | 01/15/2008 |
| 7267686 | Implantable prosthetic valve A prosthetic valve for implantation within a fluid conducting lumen within a body includes an elongate generally cylindrical radially collapsible valve body scaffold defining a fluid passageway therethrough for retentive positioning within the lumen. A radially coll... | 09/11/2007 |
| 7244242 | Valve treatment catheter and methods The invention provides a catheter for insertion into a biological passage which contains a first flowing fluid, the catheter including a tubular member having a proximal end and a distal end; a fluid delivery lumen contained within the tubular member; an inflatable ... | 07/17/2007 |
| 7214344 | Method for treatment of biological tissues to mitigate post-implantation calcification and thrombosis A method of treating a biological tissue including contacting the biological tissue with an aqueous sterilizing solution, and maintaining the aqueous sterilizing solution at a temperature of about 50° C. for a time period of about 1 to 2 days. The method of treatin... | 05/08/2007 |
| 7179637 | Apparatus and method for using intestinal segments or their substitutes in high-throughput analysis of compound absorption An apparatus for high-throughput analysis of compound absorption in a controlled environment that closely resembles in-vivo conditions. The apparatus includes at least one tissue-receiving enclosure that is capable of interfacing (e.g., via transfer of fluids, elect... | 02/20/2007 |
| 7084082 | Collagen material and its production process The objective of the present invention is to provide a collagen material that possesses physical properties to an extent that allows suturing while still maintaining the biochemical properties inherently possessed by collagen, and retains its shape for a certain amo... | 08/01/2006 |
| 7060103 | Tissue repair fabric A prosthesis, which, when implanted into a mammalian patient, serves as a functioning replacement for a body part, or tissue structure, and will undergo controlled biodegradation occurring concomitantly with bioremodeling by the patients living cells. The prosthesis... | 06/13/2006 |
| 7029434 | Methods for treating implantable biological tissues to mitigate post—implantation calcification A method for treating fixed biological tissue inhibits calcification of the biological tissue following implantation thereof in a mammalian body. The method includes placing the biological tissue in contact with glutaraldehyde and then heating the glutaraldehyde. Al... | 04/18/2006 |
| 7008591 | Supercritical fluid extraction process for tissue preparation The present invention provides methods for preparing tissue for incorporation into xenografts and bioprosthetic devices. The methods of the invention make use of supercritical fluids to remove infectious materials and chemical agents from tissues, as well as to perm... | 03/07/2006 |
| 6998265 | Method and apparatus to grow and mechanically condition cell cultures An apparatus (10) to grow cell cultures includes an anchor (14) potted to a flexible membrane (12) and an anchor stem (16) to which cells attach. A jig (18) having a trough (46) and at least one passage (52) is positi... | 02/14/2006 |
| 6881569 | Apparatus and method for evaluating tissue engineered biological material An apparatus and method that allows the visualization of leakage of cell culture media through a conduit wall of a tissue-engineered biological construct such as a semilunar heart valve or valve graft under controlled physiologic conditions. The apparatus and method... | 04/19/2005 |
| 6761735 | Heart valve fixation process and apparatus A method and apparatus for limiting longitudinal stretch during fixation of a harvested aortic root including valve leaflets and the product produced. The apparatus includes an inflow plug inserted into the inflow section of the aortic root and having an apertured t... | 07/13/2004 |
| 6758865 | Soft tissue xenografts A method for preparing a soft tissue xenograft includes the steps of removing at least a portion of a soft tissue from a non-human animal to provide a xenograft; washing the xenograft in saline and alcohol; subjecting the xenograft to cellular disruption treatment; ... | 07/06/2004 |
| 6755863 | Rotator cuff repair using engineered tissues Living fibrocytes are combined with rotator cuff extracellular matrix obtained from recently deceased human or animal donors to eliminate pain in patients with tendonitis and other rotator cuff deficiencies. According to the method, fibrocytes from a living donor, p... | 06/29/2004 |
| 6699286 | Method and apparatus for making a ligament repair using compressed tendons A method and apparatus of making repairs with graft ligaments. In one form, the method for graft ligament reconstruction comprises (i) harvesting a graft ligament consisting entirely of soft tissue; (ii) compacting the graft ligament through compression s... | 03/02/2004 |
| 6673339 | Prosthetic kidney and its use for treating kidney disease The invention is directed to a prosthetic kidney, to methods of making a prosthetic kidney and to methods of treating kidney disease with a prosthetic kidney. The prosthetic kidney comprises nephron analogs on the exterior surface and an enclosed porous m... | 01/06/2004 |
| 6668836 | Method for tissue expansion using pulsatile motion A method of increasing the rate of expansion of tissue area and volume, either in vivo or in vitro, which comprises preparing a tissue for expansion and subjecting the tissue to stretching forces, wherein the stretching forces are alternatively increased ... | 12/30/2003 |
| 6630001 | Compliant dehyrated tissue for implantation and process of making the same A process for preparing pliable soft tissue specimen which are resistant to cracking and devoid of viable cells includes the steps of treating native soft tissue obtained from a donor by a gradually increasing gradient of aliphatic alcohol or other suitab... | 10/07/2003 |
| 6592618 | In vitro modification of cardiac valvular xenografts The present invention is directed to methods for obtaining heart valves from a donor animal that have a reduced tendency to cause inflammation when implanted into a human patient. The valves produced by this method should be less likely to undergo post-su... | 07/15/2003 |
| 6561970 | Methods for treating implantable biological tissues to mitigate the calcification thereof and bioprosthetic articles treated by such methods A method for treating fixed biological tissue inhibits calcification of the biological tissue following implantation thereof in a mammalian body. The method includes placing the biological tissue in contact with glutaraldehyde and then heating the glutara... | 05/13/2003 |
| 6547827 | Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby A method for fixation of biological tissues, and bioprosthetic devices prepared by such method. The method generally comprises the steps of A) fixing the tissue, B) treating the tissue with a mixture of i) a denaturant, ii) a surfactant and iii) a crossli... | 04/15/2003 |
| 6521179 | Sterilization Allograft tissue prostheses, as well as tissue valves for replacement of defective heart valves and other tissue-engineered products (TEPs), are effectively sterilized by treatment with a coupling agent known to create amide linkages between amines and ca... | 02/18/2003 |
| 6503504 | Delivery of bioactive compounds to an organism Disclosed herein is a method of delivering a bioactive compound to an organism that involves growing individual cells in vitro under conditions that allow the formation of an organized tissue, at least a subset of the cells containing a foreign DNA sequen... | 01/07/2003 |
| 6464729 | Reconstituted mineralized cartilage tissue A biological material comprising a continuous layer of cartilaginous tissue reconstituted in vitro which contains components associated with cartilage mineralization. The biological material may be cultured with a mineralizing agent to form a mineralized ... | 10/15/2002 |
| 6455309 | Proteoglycan-reduced soft tissue xenografts The invention provides an article of manufacture comprising a substantially non-immunogenic soft tissue xenograft for implantation into humans. The invention further provides methods for preparing a soft tissue xenograft by removing at least a portion of ... | 09/24/2002 |
| 6398819 | Method and construct for producing graft tissue from an extracellular matrix Using animal tissues as starting materials, a method is described for producing extracellular matrix particulates. The invention includes an embodiment wherein the matrix particulates are applied to collagen scaffolds, which can be seeded with living cell... | 06/04/2002 |
| 6365149 | Porous tissue scaffoldings for the repair or regeneration of tissue The present patent describes a three-dimensional interconnected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These foams can be made from a blend of absorbable and biocompatible polymers ... | 04/02/2002 |
| 6197061 | In vitro production of transplantable cartilage tissue cohesive cartilage produced thereby, and method for the surgical repair of cartilage damage The present invention is directed to a transplantable cartilage matrix and a method for its in vitro production.... | 03/06/2001 |
| 6197296 | Tissue equivalents A method of forming a tissue equivalent is described. A length of polyester tube is threaded over a mandrel (H) and attached at either end by clips at A and D. A block (F) is then screwed into place. The polyester is then pre-soaked by injecting through T... | 03/06/2001 |
| 6197325 | Supplemented and unsupplemented tissue sealants, methods of their production and use This invention provides methods for the localized delivery of supplemented tissue sealants, wherein the supplemented tissue sealants comprise at least one composition which is selected from one or more antibodies, analgesics, anticoagulants, anti-inflamma... | 03/06/2001 |
| 6177514 | Blocked functional reagants for cross-linking biological tissues A method for cross-linking biological tissue is provided which uses as a cross-linking agent a low molecular weight, substantially monomeric polyfunctional aldehyde formed in situ or just prior to cross-linking. The polyfunctional aldehyde is essentially ... | 01/23/2001 |
| 6175514 | Content addressable memory device A content addressable memory device is provided which may include a novel CAM cell structure which reduces the total power dissipated by the CAM and improves the match time for the CAM. The novel CAM cell structure may include a CMOS implemented compare c... | 01/16/2001 |
| 6110212 | Elastin and elastin-based materials It is a general object of the invention to provide a method of effecting repair or replacement or supporting a section of a body tissue. Specifically to provide an elastin or elastin-based biomaterial suitable for use as a stent, for example, a vascular s... | 08/29/2000 |
| 5994325 | Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers The present invention relates to the discovery that biocompatible anionic polymers can effectively inhibit fibrosis, scar formation, and surgical adhesions. The invention is predicated on the discovery that anionic polymers effectively inhibit invasion of... | 11/30/1999 |
