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| Number | Title | Issue Date |
| 8137409 | Method of installing a transcutaneous prosthesis A method of installing a transcutaneous prosthesis which includes a first component, a second component adapted for location between the bone and the skin, the second component having a surface treatment for stimulation of fibroblastic cell proliferation and attachm... | 03/20/2012 |
| 8118877 | Porous membranes for use with implantable devices A membrane for implantation in soft tissue comprising a first domain that supports tissue ingrowth, disrupts contractile forces typically found in a foreign body response, encourages vascularity, and interferes with barrier cell layer formation, and a second domain ... | 02/21/2012 |
| 7963997 | Device for regeneration of articular cartilage and other tissue An implantable device for facilitating the healing of voids in bone, cartilage and soft tissue is disclosed. A preferred embodiment includes a cartilage region comprising a polyelectrolytic complex joined with a subchondral bone region. The cartilage region, of this... | 06/21/2011 |
| 7901462 | Implants with textured surface and methods for producing the same Compositions and methods are provided for preparing a metal substrate having a uniform textured surface with a plurality of indentations with a diameter in the nanometer and micrometer range. The textured surface is produced by exposing the substrate to an etching f... | 03/08/2011 |
| 7879109 | Continuous phase composite for musculoskeletal repair A composite material for positioning in the anatomy to form a selected function therein. The composite may be resorbable over a selected period of time. The composite may allow for selected bone ingrowth as absorption of the composite occurs. ... | 02/01/2011 |
| 7722616 | Use of a biological material containing three-dimensional scaffolds of hyaluronic acid derivatives for the preparation of implants in arthroscopy and kit for instruments for implanting said biological material by arthroscopy The invention relates to use of a biological material containing cells supported on three-dimensional scaffolds containing at least one hyaluronic acid derivative for the preparation of grafts suitable for application by arthroscopy, and a kit of surgical instrument... | 05/25/2010 |
| 7410502 | Medical prosthetic devices having improved biocompatibility The invention relates to a medical prosthetic device having a metal material, such as titanium or an alloy thereof, where the surface parts of the metal material are coated with a layer of a corresponding hydroxide material, such as titanium hydroxide. Preferably, t... | 08/12/2008 |
| 7407510 | Orbital implant coating having differential degradation A coating for an orbital implant where the coating has an anterior portion having a different, longer term bioabsorbability than a posterior portion. This allows the implant to have a smooth surface for insertion and to provide reduced irritation to neighboring tiss... | 08/05/2008 |
| 7404819 | Implantable prosthesis An implantable prosthesis and a method of repairing an anatomical defect, such as a tissue or muscle wall defect, by promoting tissue growth thereto, while limiting the incidence of postoperative adhesions between a portion of the prosthesis and tissue or organs. Th... | 07/29/2008 |
| 7364592 | Biointerface membrane with macro-and micro-architecture Disclosed herein are biointerface membranes including a macro-architecture and a micro-architecture co-continuous with and bonded to and/or located within at least a portion of the macro-architecture. The macro- and micro-architectures work together to manage and ma... | 04/29/2008 |
| 7347876 | Method for expansion of epithelial stem cells Transplantation of epithelial stem cells, cultured ex vivo on specifically treated amniotic membrane, yields, with that amniotic membrane, a surgical graft having expanded epithelial stem cells. The method of creating this graft and the graft itself are simple and e... | 03/25/2008 |
| 7296998 | Hydrophilic high density PTFE medical barrier A medical barrier includes a sheet of unsintered substantially unexpanded hydrophilic polytetraflouroethylene (PTFE) polymer material having a density in a range of about 1.2 gm/cc to about 2.3 gm/cc, and preferably in the range of about 1.45 gm/cc to about 1.55 gm/... | 11/20/2007 |
| 7208171 | Injectable and bioadhesive polymeric hydrogels as well as related methods of enzymatic preparation The invention is related to biomimetic gels that are prepared enzymatically, using a transglutaminase to cross-link polymer-peptide conjugates of rational design. ... | 04/24/2007 |
| 7198798 | Methods and devices for promoting endothelial morphogenesis In one aspect the present invention provides methods for promoting endothelial morphogenesis. The methods of this aspect of the invention include the step of providing to one or more endothelial cells an amount of an osteoprotegerin sufficient to promote endothelial... | 04/03/2007 |
| 7192450 | Porous membranes for use with implantable devices A membrane for implantation in soft tissue comprising a first domain that supports tissue ingrowth, disrupts contractile forces typically found in a foreign body response, encourages vascularity, and interferes with barrier cell layer formation, and a second domain ... | 03/20/2007 |
| 7163563 | Unitary surgical device and method Unitary surgical devices (10) are disclosed. One group of the illustrated devices has a pair of biocompatible, bioresorbable anchors (16,18) connected to fixed lengths suture. The anchors (16,18) and fixed length of suture are connected to each ... | 01/16/2007 |
| 7160592 | Polymer coating for medical devices Coatings are provided in which surfaces may be activated by covalently bonding a silane derivative to the metal surface, covalently bonding a lactone polymer to the silane derivative by in situ ring opening polymerization, and depositing at least one layer of a poly... | 01/09/2007 |
| 7147813 | Neovascularization promoting membrane for bioimplants A method of addressing a condition of a living body comprising the steps of using an energy beam to form a set of pores in a work piece biocompatible membrane. The pores should have a mean area of less than 500 μm through the biocompatible membrane, thereby produci... | 12/12/2006 |
| 7131997 | Tissue treatment A method of treating tissue includes placing substantially spherical polymer particles in the tissue. The particles include an interior region having relatively large pores and a first region substantially surrounding the interior having fewer relatively large pores... | 11/07/2006 |
| 7108721 | Tissue regrafting The present invention is based on the discovery of new methods for obtaining a tissue graft. The method can be carried out, for example, by implanting a biocompatible scaffold into a mammal and then removing the scaffold from the mammal. The scaffold is implanted in... | 09/19/2006 |
| 7101398 | Prosthetic facet joint ligament This invention relates to a spinal facet joint ligament. ... | 09/05/2006 |
| 7060103 | Tissue repair fabric A prosthesis, which, when implanted into a mammalian patient, serves as a functioning replacement for a body part, or tissue structure, and will undergo controlled biodegradation occurring concomitantly with bioremodeling by the patients living cells. The prosthesis... | 06/13/2006 |
| 7056337 | Natural tissue stent A medical implant made from multiple layers of non-synthetic, natural tissues is provided. The medical device includes openings that extend radially through the wall of the medical implant. One advantage of the medical implant is that a synthetic support structure i... | 06/06/2006 |
| 7052518 | Artificial bone and tissue engineering carrier An artificial bone comprising a calcium phosphate-based ceramic porous body having a plurality of pores which are three-dimensionally distributed throughout an entire region of the porous body including a surface thereof and have a diameter ranging from 0.01 μm to ... | 05/30/2006 |
| 7049396 | Synthetic peptides that inhibit leukocyte superoxide anion production and/or attract leukocytes Methods of inhibiting leukocyte O2− production and attracting leuckocytes using specific peptides are disclosed. These peptides include the proline-arginine (PR)-rich antimicrobial peptide known as PR-39 and truncated analogs thereof. These p... | 05/23/2006 |
| 7037332 | Medical device with coating that promotes endothelial cell adherence A medical device coated with one or more antibodies and one or more layers of a matrix is disclosed. The antibodies or fragments thereof react with an endothelial cell surface antigen. Also disclosed are compositions and methods for producing the medical device. The... | 05/02/2006 |
| 7014661 | Transcutaneous prosthesis A transcutaneous prosthesis is disclosed comprising a first component (1) shaped for implantation into a bone (2), a second component (4) intended for location between the bone (2) and the skin, and a third component (5) intended f... | 03/21/2006 |
| 7001421 | Stent with phenoxy primer coating The present invention provides a system for treating a vascular condition, which includes a catheter; a stent coupled to the catheter, the stent including a stent framework; a phenoxy primer coating operably disposed on the stent framework; and a drug-polymer coatin... | 02/21/2006 |
| 6991652 | Tissue engineering composite The invention provides a biocompatible composite for use in a living subject for purposes of repairing damaged tissues and reconstructing a new tissue. The composite includes a biodegradable or absorbable three-dimensional support construct, a liquid or viscous flui... | 01/31/2006 |
| 6974625 | Oxidized zirconium on a porous structure for bone implant use A composition, a medical implant constructed from the composition, and a method of making the composition are described. The composition is a composite material, comprising a porous, reticulated, open cell network having at least part of its surface coated with blue... | 12/13/2005 |
| 6962814 | Decellularized tissue engineered constructs and tissues New methods for producing tissue engineered constructs and engineered native tissues are disclosed. The methods include producing a tissue engineered construct by growing cells in vitro on a substrate and then decellularizing the construct to produce a decellularize... | 11/08/2005 |
| 6929946 | Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells A gene delivery vehicle having been provided with at least a tissue tropism for cells selected from the group of smooth muscle cells, endothelial cells, and/or liver cells. The tissue tropism is generally provided by a virus capsid, such as one comprising protein fr... | 08/16/2005 |
| 6931327 | System and methods for processing analyte sensor data Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the ... | 08/16/2005 |
| 6918927 | Coated implantable medical device A medical device (10) includes a structure (12) adapted for introduction into a patient, the structure (12) being formed of a preferably non-porous base material (14) having a roughened or textured surface (16). The structure (1... | 07/19/2005 |
| 6916483 | Bioabsorbable plugs containing drugs Bioabsorbable modular drug delivery devices having shapes and sizes adapted to be inserted within a mating receptacle on the surface of an implantable prosthesis are disclosed. The devices may be attached to one another to create custom drug delivery devices having ... | 07/12/2005 |
| 6875386 | Neovascularization promoting membrane for bioimplants A method of producing a biocompatible microporous membrane comprising the steps of providing a biocompatible membrane and using an energy beam to form a set of pores having a minor axis of less than 15 μm through the biocompatible membrane. One embodiment includes ... | 04/05/2005 |
| 6872387 | Three-dimensional hydrogel/cell system Methods and compositions are described that provide scaffolds for the support of cells. The scaffolds of the present invention have structural uniformity and desirable mechanical properties that make them suitable for a variety of uses, including uses for in vitro t... | 03/29/2005 |
| 6840962 | Tissue engineered tendons and ligaments Connective tissue, including neo-tendons and ligaments, has been constructed using biodegradable synthetic scaffolds seeded with tenocytes. The scaffolds are preferably formed from biodegradable fibers formed of a polymer such as polyglycolic acid-polylactic acid co... | 01/11/2005 |
| 6783554 | Pile mesh prosthesis A method and apparatus relating to a biocompatible soft tissue implant is disclosed. The implant, in the form of a prosthesis, is constructed of a knitted pile mesh material arranged into either a 3-dimensional structure or a planar shape or structure. The material ... | 08/31/2004 |
| 6746488 | Method and apparatus for hindering osteolysis in porous implants A prosthetic implant, and method for making same, is described. The prosthetic implant preferably has a porous coating containing a plurality of pores therein. A biodegradable material is introduced into the pores, preferably under vacuum conditions, and substantial... | 06/08/2004 |
