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Felix Hoffmann, a German chemist, was searching for something to relieve his father's arthritis. In doing so, he "rediscovered" acetylsalicylic acid and in 1900, patented a stable process for developing it. Hence, we have aspirin.
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| Number | Title | Issue Date |
| 8172907 | Method for the production of a biologically active prosthetic device for the reconstruction of bone tissue and the prosthetic device itself The invention relates to a method for the production of a biologically active prosthetic device for the reconstruction of bone tissue comprising the steps of: a CAT (Computerized Axial Tomography) scan of the patient and obtaining a three-dimensional electronic mode... | 05/08/2012 |
| 8147560 | Implant and method for the production of an implant An implant for insertion into a human or animal body which comprises at least one implant part is provided. The at least one implant part has a base member which is produced from an implant material and has a surface which is designed at least partially in the form ... | 04/03/2012 |
| 8043382 | Reinforced medical implants Medical implants having a ceramic body reinforced with a plurality of metal wires. Methods of making the implant and methods of implanting the medical implant are also provided. ... | 10/25/2011 |
| 7998219 | Hydroxyapatite with controllable size and morphology A ceramic powder of non-agglomerated non-aggregated phase-pure hydroxyapatite having a controllable morphology. Also presented is a film of phasepure crystalline hydroxyapatite grains having a controllable morphology. Methods for preparing the same are also provided... | 08/16/2011 |
| 7942934 | Osteoinductive calcium phosphates The invention relates to a porous osteoinductive calcium phosphate material having an average grain size in a range of 0.1-1.50 μm, having a porosity consisting essentially only of micropores in a size range of 0.1-1.50 μm, and having a surface area percentage of ... | 05/17/2011 |
| 7896926 | Method of surface oxidizing zirconium and zirconium alloys and resulting product A coating of blue-black or black oxidized zirconium of uniform and controlled thickness on a zirconium or zirconium alloy material is accomplished through the oxidative treatment of an amorphous zirconium or zirconium alloy substrate having an altered surface roughn... | 03/01/2011 |
| 7857860 | Bone void filler and method of manufacture Bone void filler pieces that are conducive to packing or nesting when a plurality of pieces are located in a cavity in random orientation. The bone void filler of the present invention includes a higher bulk packing density and a porosity of less than 80% to provide... | 12/28/2010 |
| 7803194 | Sintered body of titanium compound The present invention provides a sintered body of titanium compound obtained by sintering the titanium compound and a method for producing the same. A titanium compound represented by the formula (1) or (2) below is sintered. [Ca10(PO4 | 09/28/2010 |
| 7419714 | Composite of polymer or ceramic materials and component made of such a composite A composite of polymer or ceramic material has reinforcing fibers. The composite is for use in manufacturing medical implants like osteosynthesis plates, endoprostheses, screw coupling elements, surgical instruments, and similar components. The fibers and fibrous pa... | 09/02/2008 |
| 7416564 | Porous bioceramics for bone scaffold and method for manufacturing the same The present invention provides a porous bioceramics for bone scaffold. The porous bioceramics according to the present invention comprises a biocompatible porous ceramic substrate having the property to thermal-decompose hydroxyapatite in contact with it; a fluorapa... | 08/26/2008 |
| 7393362 | Hip prosthesis A hip prosthesis has a shaft which is implantable in the femur, a ball head anchored on the shaft, a socket in which the ball head is movably supported, and a bipolar shell placed between the ball head and the socket, whereby the ball head rotates in the bipolar she... | 07/01/2008 |
| 7393405 | Hydraulic cement based on calcium phosphate for surgical use A hydraulic cement is based on calcium phosphate for surgical use, and includes three components. The first component includes α-tricalcium phosphate powder particles. The second, component includes calcium sulphate dehydrate. The third component includes water. Fu... | 07/01/2008 |
| 7387846 | Electrolytic deposition of coatings for prosthetic metals and alloys An article coated with an electrolytically deposited bio-compatible composite layer useful as an internal prosthetic device is disclosed. The bio-compatible composite coating that is electrolytically deposited onto the article comprises hydroxyapatite and chitosan. ... | 06/17/2008 |
| 7377943 | Surface treated metallic implant and blasting material The invention relates to a metallic implant, which has vitreous-crystalline bioactive material on the surface thereof. According to the invention, a metallic implant base body arranged on the surface of the particles has a bioactive, vitreous-crystalline material co... | 05/27/2008 |
| 7368010 | Calcium aluminate clinker as a refractory aggregate with and without barium addition and use thereof The present invention provides for a refractory aggregate composition comprising an improved calcium aluminate clinker having the formula CnAx wherein C is calcium oxide and A is aluminum oxide, wherein n is an integer from about 1 to about 12,... | 05/06/2008 |
| 7357976 | Ceramic molded body and metal matrix composite The ceramic molded body of the present invention includes spherical cells of a spherical bubble plurally formed therein: in the ceramic molded body the spherical cells neighboring each other are communicated through communication porosities and form a three-dimensio... | 04/15/2008 |
| 7353153 | Method and system for modeling bone structure The present invention discloses a structural and mechanical model and modeling methods for human bone based on bone's hierarchical structure and on its hierarchical mechanical behavior. The model allows for the assessment of bone deformations, computation of strains... | 04/01/2008 |
| 7348060 | Porous and spherical calcium phosphate particle comprising metal ion, and porous multilayer calcium phophate particle A porous and spherical calcium phosphate particle which is substituted with a metal ion or has a metal ion carried on the surface thereof, and has a particle diameter of 0.1 to 100 μm. The calcium phosphate particle is a novel functional particle which is useful, f... | 03/25/2008 |
| 7332452 | CaO-SiO-based bioactive glass and sintered calcium phosphate using same A bioactive glass having a composition substantially comprising 30 to 60 mol % of CaO, 40 to 70 mol % of SiO2 and 20 mol % or less of Na2O has low glass transition temperature and/or crystallization temperature, and a sintered calcium phosphate... | 02/19/2008 |
| 7309361 | Biologic modular tibial and femoral component augments for use with total knee arthroplasty The use of biologic and/or biologically reabsorbable materials to provide temporary stability after a surgical joint procedure is provided. Exemplary embodiments of the invention provide biologic and/or biologically reabsorbable cam and/or post linings mounted to re... | 12/18/2007 |
| 7283940 | Multidirectional morphology and mechanics of osteonic lamellae The present invention discloses a structural and mechanical model and modeling methods for human bone based on bone's hierarchical structure and on its hierarchical mechanical behavior. The model allows for the assessment of bone deformations, computation of strains... | 10/16/2007 |
| 7244301 | Heat generating biocompatible ceramic materials An injectable heat generating biocompatible ceramic compositions based on hydraulic calcium aluminate, which can be used for therapeutic treatment in vivo, such as tumour treatment, pain control, vascular treatment, drug activation etc, when curing in situ, and whic... | 07/17/2007 |
| 7244445 | Conformable, absorbable, solid composite preforms and their use for bone tissue engineering The present invention is directed to an absorbable, conformable composite preform for use in making a solid bone filler which is an absorbable mixture of oppositely charged, solid microparticulate polyelectrolytes encased in a sealed, flexible, absorbable copolyeste... | 07/17/2007 |
| 7241316 | Devices and methods for treating defects in the tissue of a living being An implant for deployment in select locations or select tissue for regeneration of tissue is disclosed. The implant comprising collagen and or other bio-resorbable materials, where the implant may also be used for therapy delivery. Additionally, the implant may be ... | 07/10/2007 |
| 7235107 | Devices and methods for treating defects in the tissue of a living being An implantable material for deployment in select locations or select tissue for tissue regeneration is disclosed. The implant comprises collagen, ceramics, and or other bio-resorbable materials or additives, where the implant may also be used for therapy delivery. A... | 06/26/2007 |
| 7223414 | Silica-calcium phosphate bioactive composite for improved synthetic graft resorbability and tissue regeneration A resorbable silica-calcium phosphate bioactive composite that finds utility for drug delivery. The bioactive composite is loaded with a pharmaceutical composition and releases a therapeutically effective amount of a pharmaceutical composition for periods of up the ... | 05/29/2007 |
| 7212958 | Method and system for modelling bone structure The present invention discloses a structural and mechanical model and modeling methods for human bone based on bone's hierarchical structure and on its hierarchical mechanical behavior. The model allows for the assessment of bone deformations, computation of strains... | 05/01/2007 |
| 7169372 | Method for producing nano-sized crystalline hydroxyapatite A mechanism and technological process for synthesizing nano-sized crystalline hydroxyapatite. In particular, for producing nano-sized crystalline hydroxyapatite whose particles have nano dimensions in length “l”, width “d” and thickness “h”, wherein “h... | 01/30/2007 |
| 7166133 | Devices and methods for treating defects in the tissue of a living being An implant for deployment in select locations or select tissue for regeneration of tissue is disclosed. The implant comprising collagen and or other bio-resorbable materials, where the implant may also be used for therapy delivery. Additionally, the implant may be ... | 01/23/2007 |
| 7156880 | Devices and methods for treating defects in the tissue of a living being An implantable material for deployment in select locations or select tissue for tissue regeneration is disclosed. The implant comprises collagen, ceramics, and or other bio-resorbable materials or additives, where the implant may also be used for therapy delivery. A... | 01/02/2007 |
| 7148163 | Glass as sintering aid and open-pore molded body and method for manufacturing same The present invention relates to a glass used as a sintering aid for a resorbable molded body containing calcium phosphate as well as to a method for manufacturing said molded body. According to the invention, the material is β-tricalcium phosphate and the glass ha... | 12/12/2006 |
| 7147666 | Monolithic implants with openings A monolithic bioresorbable implant includes optimally designed openings to treat tissue disorders or drug delivery. Preferably, the implant is made from calcium salts. A method of filling a recipient treatment site includes the step of disposing the monolithic biore... | 12/12/2006 |
| 7127383 | Modeling viscoelastic torsional properties of osteons The present invention provides a geometric/material computer model of hierarchical bone based upon the viscoelastic properties of longitudinal and alternate osteons. The viscoelastic properties of osteons include, for example, mechanical properties and osteon conten... | 10/24/2006 |
| 7124067 | System and method for modeling bone structure The present invention discloses a structural and mechanical model and modeling methods for human bone based on bone's hierarchical structure and on its hierarchical mechanical behavior. The model allows for the assessment of bone deformations, computation of strains... | 10/17/2006 |
| 7122057 | Method and apparatus for engineered regenerative biostructures such as hydroxyapatite substrates for bone healing applications An engineered regenerative biostructure (erb) for implantation into a human body as a bone substitute, which includes an internal microstructure, mesostructure and/or macrostructure to provide improved bone in-growth, and methods for making the erb. Under one aspect... | 10/17/2006 |
| 7119038 | Method for making a porous calcium phosphate article The present invention discloses a method for making a porous calcium phosphate article including i) preparing a shaped article from a paste containing a calcium phosphate cement, a pore-forming powder and a setting liquid; ii) immersing the shaped article in an imme... | 10/10/2006 |
| 7087540 | Resorbable bone replacement and bone formation material The invention relates to a resorbable bone replacement and bone formation material (augmentation material) based on porous β-tricalcium phosphate (β-TCP). ... | 08/08/2006 |
| 7083672 | Method and product for phosphosilicate slurry for use in dentistry and related bone cements The present invention is directed to magnesium phosphate ceramics and their methods of manufacture. The composition of the invention is produced by combining a mixture of a substantially dry powder component with a liquid component. The substantially dry powder comp... | 08/01/2006 |
| RE39196 | Nanocrystalline apatites and composites, prostheses incorporating them, and method for their production Methods for synthesis of nanocyrstalline apatites are presented, as well as a series of specific reaction parameters that can be adjusted to tailor, in specific ways, properties in the recovered product. Particulate apatite compositions having aveage crystal size of... | 07/18/2006 |
| 7052518 | Artificial bone and tissue engineering carrier An artificial bone comprising a calcium phosphate-based ceramic porous body having a plurality of pores which are three-dimensionally distributed throughout an entire region of the porous body including a surface thereof and have a diameter ranging from 0.01 μm to ... | 05/30/2006 |
