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Walt Disney was no Mickey Mouse inventor. He devised a serious animation camera which he patented. With the device, his company created "Snow White".
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| Number | Title | Issue Date |
| 6706034 | Process for agent retention in biological tissues An increase in agent residence time at a tissue site is provided for by the presence of a barrier. The barrier is a separate entity from the agent when introduced to the tissue. A binding member is included in the barrier for coupling the barrier to the surface of t... | 03/16/2004 |
| 6702850 | Multi-coated drug-eluting stent for antithrombosis and antirestenosis A stent having a multi-layered coating adhered to its surface which can prevent restenosis and thrombosis at the implant site. The stent coating is comprised of two layers. The first layer is a polymeric coating with one or more biologically active agent(... | 03/09/2004 |
| 6702849 | Method of processing open-celled microcellular polymeric foams with controlled porosity for use as vascular grafts and stent covers Porous vascular grafts and stent covers are formed of open-celled microcellular polymeric foams having a porosity that can be modified to be adapted for carrying and delivering different types of therapeutic drugs. A stent cover is formed of a tubular mem... | 03/09/2004 |
| 6699281 | Angioplasty stents A stent for use at an implant site in a vessel having recesses containing one or more active agents. The stent is a tubular body having a plurality of sinusoidal shaped annular elements and connection elements. The recesses are formed so as to leave subst... | 03/02/2004 |
| 6699282 | Method and apparatus for delivery of medication An implanted device such as a stent is provided which is capable of holding an induced charge or sufficient magnitude that the device may, by electrostatic means, attract the bioactive material to itself. The charge, either positive or negative, or relati... | 03/02/2004 |
| 6682545 | System and device for preventing restenosis in body vessels The present invention relates to a system and device for preventing stenosis and/or restenosis after an invasive procedure in a body vessel or cavity having an inner wall surface, the system comprising inserting a device coated with a growth arresting, li... | 01/27/2004 |
| 6663880 | Permeabilizing reagents to increase drug delivery and a method of local delivery A composition and a method for increasing the permeability of membrane junctions or cell membranes for delivery of a drug to target tissues are disclosed. Also disclosed are methods and devices for local drug delivery.... | 12/16/2003 |
| 6663590 | Vascular occlusal balloons and related vascular access devices and systems Vascular access systems and devices for facilitating repeated access to a blood vessel for the external treatment of blood, such as dialysis, and in intra-venous administration of medicines, such as heparin, for extended periods of time. The vascular acce... | 12/16/2003 |
| 6663662 | Diffusion barrier layer for implantable devices A diffusion barrier for an implantable device, such as a stent, carrying a therapeutic or bioactive substance is disclosed. The diffusion barrier reduces the rate at which the therapeutic or bioactive substance is released from the device. The diffusion b... | 12/16/2003 |
| 6660034 | Stent for increasing blood flow to ischemic tissues and a method of using the same An implantable stent for a vessel includes a tubular body having an inner and outer surface. The inner and outer surfaces are coated with therapeutic substances. The therapeutic substance of the inner surface, such as an angiogenic substance, can be relea... | 12/09/2003 |
| 6656162 | Implantable drug delivery stents Devices for the controlled release of one or more drugs are provided. The devices include an implantable stent, at least two reservoirs in the stent, and a release system contained in each of the at least two reservoirs, wherein the release system compris... | 12/02/2003 |
| 6652581 | Medical device with porous surface for controlled drug release and method of making the same The medical devices of the invention have a portion with a porous surface for release of at least one biologically active agent therefrom. The porous surface is made of a material such as a polymer having a plurality of voids. To load the porous surface w... | 11/25/2003 |
| 6653426 | Polymer compositions for intraluminal stent A polymer composition for use in forming a stent is described. The composition includes a monomer of an aliphatic ester of acrylic acid which has a glass transition temperature less than 25° C. and a second monomer that copolymerizes with the first monom... | 11/25/2003 |
| 6652575 | Stent with smooth ends A stent having at least one smooth end is disclosed. The stent may include a coating or coatings on one or both end portions to provide a smooth finish to reduce possible damage to body passages when the stent is deployed and delivered. The stent may also... | 11/25/2003 |
| 6645241 | Endoprosthesis that can be percutaneously implanted in the patient's body An endoprosthesis is provided. In one embodiment the endoprosthesis may include an elongated hollow structure that may be deliverable into a body lumen of a patient for dwelling therein. This structure may be expandable and may have an initial state of de... | 11/11/2003 |
| 6641607 | Double tube stent A stent or intraductal medical device manufactured from a tubular member having an inner tube tightly fitted into an outer tube is provided. Microdepots may be formed on the outer surface of the inner tube, and may contain radioactive, radiopaque or thera... | 11/04/2003 |
| 6641611 | Therapeutic coating for an intravascular implant The invention relates to a coating for an intravascular implant that prevents hyperproliferative vascular disease after a mechanical injury, such as angioplasty. The coating includes first and second agents, with the first agent acting on a calcium indepe... | 11/04/2003 |
| 6638520 | Structures and methods for promoting vascularization One aspect of the present invention provides implantable medical devices that comprise: (a) a device body; and (b) a surface layer attached to at least a portion of the device body, the surface layer comprising: (1) a surface layer body that defines an in... | 10/28/2003 |
| 6630000 | Method of using body tissue A method of using body tissue includes obtaining graft tissue. A medicinal substance is added to the graft tissue. The graft tissue is shaped to a predetermined configuration while the graft tissue is outside of a patient's body. The graft tissue is moved... | 10/07/2003 |
| 6629995 | Camptothecin conjugates Disclosed is a compound that includes a camptothecin conjugated to a lactone ring protecting moiety. Also disclosed are compositions and kits including the compound, and methods of making and using the compound.... | 10/07/2003 |
| 6626940 | Medical device activation system A medical device vibratory activation system is disclosed. The system includes an implantable appliance comprising a conductive material and a signal producing mechanism having a portion configured to be located relative to the implantable appliance. The ... | 09/30/2003 |
| 6627209 | Surgical stent and method for preventing occlusion of stented vessels and conduits after implantation of stents The invention is of the design for, and a method of use of, an improved surgical stent. The stent is coated with a slow-release calcium channel blocker agent which interrupts the accumulation or deposition of fibrotic tissue as occurs in the process of re... | 09/30/2003 |
| 6613082 | Stent having cover with drug delivery capability A prosthesis has a cylindrical stent and a cover provided about the outer periphery of the stent. The cover can be made from a water absorbent material, and a matrix of protein. The cover can be made from either tissue or hydrogel.... | 09/02/2003 |
| 6613083 | Stent device and method A stent for delivering a therapeutic dose of the immnuosupressant tacrolimus is disclosed.... | 09/02/2003 |
| 6613084 | Stent having cover with drug delivery capability A prosthesis has a stent, and a cover that covers a portion of the stent. The cover has at least two layers of materials that can define at least one chamber therebetween, with a drug loaded into the at least one chamber by a dug dispersing element. The c... | 09/02/2003 |
| 6605115 | Method and composition for inhibiting cardiovascular cell proliferation Cardiovascular cell proliferation in a blood vessel subjected to trauma, such as angioplasty, vascular graft, anastomosis, or organ transplant, can be inhibited by contacting the vessel with a polymer consisting of from 6 to about 30 amino acid subunits, ... | 08/12/2003 |
| 6592597 | Adhesive for attaching buttress material to a surgical fastening device A surgical stapling instrument for clamping and stapling tissue. The instrument has a handle and first and a second opposed tissue clamping members connected to the handle. The members are movable between an open position for receiving tissue therebetween... | 07/15/2003 |
| 6585763 | Implantable therapeutic device and method A system includes a first coil, a signal source and a first control module. The first control module regulates coupling between the signal source and the first coil. The system also includes an implantable device having a second coil coupled to a therapeu... | 07/01/2003 |
| 6585764 | Stent with therapeutically active dosage of rapamycin coated thereon Delivery of rapamycin locally, particularly from intravascular stent, directly from micropores in the stent body or mixed or bound to a polymer coating applied on stent, to inhibit neointimal tissue proliferation and thereby prevent restenosis. This inven... | 07/01/2003 |
| 6585761 | Prosthetic vein valve and method A prosthetic valve adapted to be inserted into a blood vessel and held in a desired position therein. The valve includes an annular support ring having a longitudinal axis and defining a substantially circular central opening for passage of blood. The sup... | 07/01/2003 |
| 6579313 | Methods for implanting cells A method for implanting cells onto a prosthesis includes the steps of: (a) providing a prosthesis including a porous tube, where at least 25% of the pores on the inner surface of the tube have diameters of more than about 40 μm, at least 25% of the pores... | 06/17/2003 |
| 6558422 | Structures having coated indentations In one aspect the present invention provides indented structures that each include (a) a body defining a plurality of indentations, substantially all of the plurality of indentations including a surface layer including a biologically active substance; and... | 05/06/2003 |
| 6551353 | Synthetic fibers for medical use and method of making the same A synthetic fiber is formed with a plurality of longitudinally-extending cavities (16, 54 and 64) which hold a medicament that is intended to be absorbed into tissue brought into contact with the fiber. The fiber can be formed by dissolving a soluble poly... | 04/22/2003 |
| 6530950 | Intraluminal stent having coaxial polymer member A stent for insertion into a lumen, having rigid regions and flexible regions along its length, and one or more polymer members coaxially disposed about the outer surface of the stent The polymer members are positioned over the rigid regions of the suppor... | 03/11/2003 |
| 6506437 | Methods of coating an implantable device having depots formed in a surface thereof The present invention provides methods of coating an implantable device, such as a stent or a graft, having a plurality of depots formed in a surface thereof. An exemplary method includes applying a composition including a polymer and a solvent to the imp... | 01/14/2003 |
| 6503954 | Biocompatible carrier containing actinomycin D and a method of forming the same A biocompatible carrier and a composition for forming the carrier are disclosed. The carrier is made from an ethylene vinyl alcohol copolymer which can serve as a reservoir, allowing for the local delivery and sustained release of actinomycin D. The carri... | 01/07/2003 |
| 6491720 | Angioplasty stent adapted to counter restenosis respective kit and components A stent structure includes a stent and one or more fibers disposed on the stent, the fiber adapted to provide a therapeutic agent. Nuclei containing therapeutic agents that impede restenosis may be included within the fiber or within separate particles th... | 12/10/2002 |
| 6485514 | Local delivery of therapeutic agents Disclosed are implants, stents, catheters, methods and kits for the local delivery of therapeutic agents that are preferentially cytotoxic or cytostatic with regards to proliferating cells to sites where proliferative cells are present.... | 11/26/2002 |
| 6471979 | Apparatus and method for delivering compounds to a living organism A method of treating or preventing vascular disease in a living organism. The method includes delivering an effective amount of a composition including a sex hormone, anti-hormone, sex-hormone agonist, steroid-hormone inhibitor/antagonist (partial or full... | 10/29/2002 |
| 6468304 | Implantable device covered with polymer capable of releasing biologically active substances A device which can be implanted in the body and comprises an electrically conducting support covered with a layer of electrically conducting polymer, to which layer is attached at least one biologically active substance of an anionic or cationic nature. T... | 10/22/2002 |
