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"What, sir, would you make a ship sail against the wind and currents by lighting a bonfire under her deck? I pray you, excuse me, I have not the time to listen to such nonsense."
Napoleon Bonaparte ; When told of the Robert Fulton steamboat
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| Number | Title | Issue Date |
| 6117166 | Apparatus and methods for grafting blood vessel tissue Apparatus and methods especially useful for facilitating grafting of healthy blood vessel tissue onto the internal wall of a blood vessel are described. In one embodiment, the apparatus includes a vascular graft secured to an expandable, wire mesh endovas... | 09/12/2000 |
| 6117979 | Process for making a bioprosthetic device and implants produced therefrom Bioprosthetic devices made of collagen-based material having collagen amine groups and collagen carboxyl groups are provided as well as methods for their formation. The methods comprise combining an epoxy functionalized crosslinking agent with the collage... | 09/12/2000 |
| 6087552 | Method of producing fused biomaterials and tissue It is a general object of the invention to provide a method of effecting tissue repair or replacement using a biomaterial. It is a specific object of the invention to provide a biomaterial suitable for use as a stent, for example, a vascular stent, or as ... | 07/11/2000 |
| 6060640 | Multiple-layer, formed-in-place immunoisolation membrane structures for implantation of cells in host tissue A permeable structure forms a chamber to hold living cells. The structure includes a first permeable region surrounding at least a portion of the chamber having a conformation that, when implanted in host tissue, substantially blocks penetration of host c... | 05/09/2000 |
| 5575815 | Local polymeric gel therapy A method for providing a synthetic barrier made of biocompatible polymeric materials in vivo which involves application of a material to a tissue or cellular surface such as the interior surface of a blood vessel, tissue lumen or other hollow space, is di... | 11/19/1996 |
| 5549700 | Segmented prosthetic articulation A ball and socket prosthetic joint device. A plurality of curved rigid segments are embedded within and extend out of a polymeric cushion to form a discontinuous hemispherical bearing surface for slidable engagement with a continuous hemispherical bearing... | 08/27/1996 |
| 5492826 | Apparatus and method for seeding endothelial cells An apparatus and method for culturing living endothelial cells is provided. The apparatus comprises a cell growth container, which in a preferred embodiment is a synthetic graft, heat crimped at both ends. The apparatus further comprises a rotation contai... | 02/20/1996 |
| 5383928 | Stent sheath for local drug delivery This invention provides a sheath for encompassing at least a portion of a stent to locally deliver a drug to an arterial wall or lumen into which the stent has been inserted, comprising a polymer and a drug incorporated within the polymer, the polymer she... | 01/24/1995 |
| 5230693 | Implantable prosthetic device for implantation into a human patient having a surface treated with microvascular endothelial cells The present invention provides a synthetic or naturally occurring implant, such as a vascular graft, for implantation into a human patient. Uncultured, microvascular endothelial cells, isolated from microvascular endothelial cell rich tissue are disposed ... | 07/27/1993 |
| 5171261 | Vascular prosthesis, manufacturing method of the same, and substrate for vascular prothesis The invention relates to a vascular prosthesis wherein, fragments of biological tissues such as vascular tissues, connective tissues, fat tissues and muscular tissues and/or cells composing vascular walls such as vascular endothelial cells, smooth muscle ... | 12/15/1992 |
| 4932964 | Artificial body for a prosthesis A prosthesis wall for an artificial organ, e.g. an artificial arterial blood vessel, to be coated without gaps on one side with biologically active epithelial, e.g. endothelial cells is provided with a structure of open continuous micropores a few microns... | 06/12/1990 |
| 4902289 | Multilayer bioreplaceable blood vessel prosthesis Process for forming a multilayer blood vessel prosthesis. Each layer is formed from bioreplaceable materials which include those produced by contacting collagen with an aminopolysaccharide and subsequently covalently crosslinking the resluting polymer, po... | 02/20/1990 |
| 4820626 | Method of treating a synthetic or naturally occuring surface with microvascular endothelial cells, and the treated surface itself The present invention provides a novel method of treating a synthetic or naturally occurring implant, such as a vascular graft, intended for implantation in a human patient, comprising obtaining human microvascular rich tissue from that patient; separatin... | 04/11/1989 |
| 4804381 | Artificial vessel The arterial vessel is made of a microporous membrane having pores which are filled with a permeable gel or which are closed over by a thin porous layer. A monolayer of endothelial cells is provided on the internal surface for exposure to the blood flow a... | 02/14/1989 |
| 4804382 | Artificial vessel The artificial vessel has a membrane of at least semi-permeable bio-inert synthetic material with a monolayer of endothelial cells on the internal surface and a layer of smooth elastic fiber-generating muscle cells on the outer surface. The membrane may b... | 02/14/1989 |
| 4795459 | Implantable prosthetic device with lectin linked endothelial cells An implantable prosthetic device made of biocompatible polymer and having a substantially continuous layer of autologus living cells attached via oligosaccharidelectin recognition linkages.... | 01/03/1989 |
| 4686098 | Encapsulated mouse cells transformed with avian retrovirus-bovine growth hormone DNA, and a method of administering BGH in vivo Recombinant DNA constructs having an avian retroviral long terminal repeat (LTR) ligated to the bovine growth hormone gene, were co-transformed into a mammalian cell (mouse) culture in order to obtain a stable cell culture secreting large amounts of bovin... | 08/11/1987 |
| 4681588 | Biomaterial Material for use in a biological environment is produced by subjecting a sheet of parietal pleura to glutaraldehyde tanning. The pleura is stretched and cleansed of excessive tissue to result in a membrane of substantially uniform thickness prior to tanni... | 07/21/1987 |
| 4662885 | Percutaneously deliverable intravascular filter prosthesis An intravascular prosthesis comprises a lining rolled upon itself around an axis so that it is introducible into a vascular lumen. An inflatable channel is included for unrolling the lining when the prosthesis is positioned within the lumen so that the li... | 05/05/1987 |
| 4648881 | Implantable biological tissue and process for preparation thereof A process for the preparation of implantable biological tissue, and in particular bioprosthetic heart valves, which are prone to calcification after implantation. The process includes treatment of tissue with solutions prior to implantation which have bee... | 03/10/1987 |
| 4647283 | Implantable biological tissue and process for preparation thereof A process for the preparation of implantable biological tissue, and in particular bioprosthetic heart valves, which are prone to calcification after implantation. The process includes treatment of tissue with solutions prior to implantation which have bee... | 03/03/1987 |
| 4575372 | Intraocular lens and method of manufacture using ultrasonic bonding An intraocular lens loop, with an eyelet formed on the loop, and a method of forming the eyelet employing ultrasound energy. There is also disclosed a special fixture for use in manufacturing the eyelet loop.... | 03/11/1986 |
| 4553272 | Regeneration of living tissues by growth of isolated cells in porous implant and product thereof A method of repair of patient tissues by implant including providing a living cell sample which is introduced into an implant member having a porous open structure. The cell sample may be cultured in the implant. The implant is secured to the patient, as ... | 11/19/1985 |
| 4502159 | Tubular prostheses prepared from pericardial tissue Novel tubular prostheses, e.g. vascular or ureteral prostheses, prepared by sewing the opposed edges of a sheet of pericardial tissue together with a thread to form a longitudinal seam are disclosed. By disposing the thread in a suitable configuration alo... | 03/05/1985 |
| 4485097 | Bone-equivalent and method for preparation thereof A bone-equivalent, useful in the fabrication of prostheses, is disclosed which is prepared from a hydrated collagen lattice contracted by fibroblast cells and containing demineralized bone powder.... | 11/27/1984 |
| 4485096 | Tissue-equivalent and method for preparation thereof A tissue-equivalent, useful in the treatment of burns or other skin wounds and in the fabrication of prostheses, is disclosed which is prepared from a hydrated collagen lattice contracted by a contractile agent, such as fibroblast cells or blood platelets... | 11/27/1984 |
| 4466139 | Vascular prostheses A vascular prosthesis is produced by subjecting a length of animal ureter to glutaraldehyde tanning. The lumen of the ureter is dilated and the ureter is set in the dilated configuration by the tanning process. The ureter may be strengthened by a surround... | 08/21/1984 |
| 4309776 | Intravascular implantation device and method of using the same An intravascular device having a chamber for containing transplanted cells. The device is adapted to be implanted in a wall of a blood vessel with a porous chamber-forming wall of the chamber providing an interface between the cells in the chamber and the... | 01/12/1982 |
| 3974526 | Vascular prostheses and process for producing the same A process for producing tubular prostheses for use in vascular reconstructive surgery is described. The invention comprises chemically and structurally modifying the veins and arteries of the human umbilical cord to obtain a vascular grafting material whi... | 08/17/1976 |
| 3938524 | Compliant mandrel and mandrel assembly for growing graft tubes A mandrel of sponge rubber or gel has a tension element for withdrawing the mandrel from a graft tube grown from living tissue. In a first embodiment the tension element comprises a strip of cloth embedded in a sponge rubber mandrel. In a second embodimen... | 02/17/1976 |
