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| Number | Title | Issue Date |
| 7105001 | Surgical method and composition utilizing submucosal tissue to prevent incisional hernias A small intestine submucosa mesh is adapted for use in surgical abdominal closure routines. The submucosa mesh is incorporated into the normal surgical protocol for abdominal closure procedures. The submucosa mesh is applied to the abdominal incision area and mainta... | 09/12/2006 |
| 7070858 | Amorphous polymeric polyaxial initiators and compliant crystalline copolymers therefrom An absorbable crystalline, monocentric polyaxial copolymer comprising a central carbon or nitrogen atom and at least three axes, each of which includes an amorphous flexible component adjacent and originating from the central atom and a rigid, crystallizable compone... | 07/04/2006 |
| 7037324 | Knotless tissue anchor A radially expandable knotless tissue anchor including an expandable outer member defining a bore and an inner member slidably positioned within the bore. Relative longitudinal movement of the inner member relative to the expandable member causes a portion of the ex... | 05/02/2006 |
| 7026437 | Amorphous polymeric polyaxial initiators and compliant crystalline copolymers therefrom An absorbable crystalline, monocentric polyaxial copolymer comprising a central carbon or nitrogen atom and at least three axes, each of which includes an amorphous flexible component adjacent and originating from the central atom and a rigid, crystallizable compone... | 04/11/2006 |
| 7001410 | Bioabsorbable sealant Openings in a mammalian body made by any medical procedure or non-medical event are sealed with a bioabsorbable plug or sewn with a bioabsorbable suture. In one exemplary embodiment, the plug in dehydrated, unexpanded condition is pushed by a pushing device through ... | 02/21/2006 |
| 6977231 | Suturable adhesion-preventing membrane A suturable adhesion-preventing membrane has high suture strength, good biocompatibility, decomposition and absorption in a living body, sufficient adhesion-preventing effect, and desirable guided tissue regeneration. The membrane is composed of at least one non-wov... | 12/20/2005 |
| 6794485 | Amorphous polymeric polyaxial initiators and compliant crystalline copolymers therefrom An absorbable crystalline, monocentric polyaxial copolymer comprising a central carbon or nitrogen atom and at least three axes, each of which includes an amorphous flexible component adjacent and originating from the central atom and a rigid, crystallizable compone... | 09/21/2004 |
| 6773699 | Light energized tissue adhesive conformal patch Consistent with the present invention, tissue adhesive compositions and an associated laser exposure system are provided for bonding or sealing biological tissues. The compositions are comprised of chemically derivatized soluble collagen which is formulated to conce... | 08/10/2004 |
| 6183499 | Surgical filament construction We have discovered a surgical filament suitable for use as a suture or ligature that comprises a multifilament core having a plurality of filaments that are oriented having an external surface and internal interstices; and an outer coating that bonded to ... | 02/06/2001 |
| 5954748 | Gelatin coated gut suture A catgut suture includes a cross linked gelatin coating which is substantially insoluble in tubing or storage solution. The gelatin coating is formed by immersing the gut suture in aqueous gelatin solution, fixing the gelatin in a solution of cross linkin... | 09/21/1999 |
| 5931165 | Films having improved characteristics and methods for their preparation and use Gelatin film compositions are useful for immobilization over tissue, usually by the application of energy to the films. Exemplary films comprise cross-linked and non-cross-linked granular and non-granular gelatin sheets, typically including a plasticizer.... | 08/03/1999 |
| 5925065 | Coated gut suture A coated gut suture is prepared by applying a moisture-retaining substance to the gut suture, followed by coating the suture with a synthetic bioabsorbable polymer. A particularly useful moisture-retaining substance is glycerol. The synthetic bioabsorbabl... | 07/20/1999 |
| 5919473 | Methods and devices for delivering opioid analgesics to wounds via a subdermal implant An analgesic agent delivery system and method of treating postoperative pain comprising an analgesic agent such as morphine and an extended-release drug delivery device. The device may be placed in the vicinity of a wound and then provide an extended-rele... | 07/06/1999 |
| 5891167 | Collagen coated gut suture A catgut suture includes a dehydrothermal cross-linked collagen coating which is insoluble in tubing solution. The collagen coating is formed by immersing the gut suture in a solution of collagen in acidified water. Optionally, a plasticizer may be includ... | 04/06/1999 |
| 5725522 | Laser suturing of biological materials Methods and systems for endoscopic suturing of biological tissue are disclosed. Endoscopic instruments are described which serve to position a suture material at an anastomotic site and deliver laser radiation to the suture material to effect fusion. The ... | 03/10/1998 |
| 5690675 | Methods for sealing of staples and other fasteners in tissue Wounds in lung tissue are closed in a two step method consisting essentially of applying fasteners to a region adjacent to the wound, wherein the fasteners may cause penetrations. The fasteners are present in a preformed layer of collagen, fibrin, fibrino... | 11/25/1997 |
| 5618312 | Medical materials and manufacturing methods thereof Disclosed are a medical material and a production process thereof. The medical material has a membrane configuration and is produced by impregnating a membranous material with collagen or gelatin and then physically or chemically cross-linking protein mol... | 04/08/1997 |
| 5618313 | Absorbable polymer and surgical articles fabricated therefrom Absorbable copolymers are fabricated from a predominant component of dioxanone randomly copolymerized with minor amounts of other bioabsorbable monomers. The copolymers are useful in forming surgical articles, including both monofilament and multifilament... | 04/08/1997 |
| 5614587 | Collagen-based bioadhesive compositions Collagen-based compositions useful in the attachment of tissues, or the attachment of tissues to synthetic implant materials, are disclosed. The compositions comprise collagen crosslinked using a multifunctionally activated synthetic hydrophilic polymer. ... | 03/25/1997 |
| 5584857 | Suture coating and tubing fluid A coating and tubing fluid for sutures, especially gut sutures, is provided. The coating composition includes linseed oil, an organic solvent and a catalyst. The tubing fluid includes water, a softening agent, a C2 -C4 alcohol and a ... | 12/17/1996 |
| 5514181 | Absorbable structures for ligament and tendon repair A fully absorbable prosthesis (1) for the repair of damaged ligaments and/or tendons in the form of a multilayer spiral roll comprising the following spiral layers: a foraminous layer (2) of a synthetic bioabsorbable material; a bioabsorbable film (3); an... | 05/07/1996 |
| 5431639 | Treating wounds caused by medical procedures Incised or injured tissue is treated by introducing material that encourages healing to desired depths within the tissue. Particularly, the invention provides treatment of an access channel to a blood vessel by introducing to the tissue a hemostatic mater... | 07/11/1995 |
| 5399361 | Collagen-containing sponges as drug delivery compositions for proteins Collagen-containing sponges comprising an absorbable gelatin sponge, collagen, and an active ingredient are disclosed as are methods of enhancing wound healing of external and internal wounds using such sponges.... | 03/21/1995 |
| 5211644 | Process and apparatus for a dermal graft The process and apparatus for an autologous dermal graft transfer provides for the easy and accurate placement of dermal grafts during plastic surgery, typically for the filling of wrinkles or scars.... | 05/18/1993 |
| 5207670 | Photoreactive suturing of biological materials Materials and methods for photoreactive suturing of biological tissue are disclosed. The suture material includes a structure adapted for positioning at an anastomotic site and has at least a portion of the structure formed by a photoreactive crosslinking... | 05/04/1993 |
| 4511653 | Process for the industrial preparation of collagenous materials from human placental tissues, human collagenous materials obtained and their application as biomaterials This process of preparation consists in subjecting said placental tissue after pressing, grinding and washing in a neutral and acid medium to a treatment in alkaline medium at a temperature less than or equal to 10° C. and in then subjecting the portions... | 04/16/1985 |
| 4451397 | Method of preparing collagen products New and highly stable preparations containing collagen in association with mucopolysaccharides are obtained by combining a homogeneous gel or solution of crosslinked or decrosslinked collagen, and a solution of CSA or CSC, and bringing the pH to 7.... | 05/29/1984 |
| 4433688 | Method of coating a catgut suture Catgut suturing filament protected by a flexible polymer sheath that is slowly hydrolytically degradable and impervious to body fluid degratative enzymes. The sheath is prepared by coating the catgut filament with an isocyanate capped polyhydroxylated pol... | 02/28/1984 |
| 4394370 | Bone graft material for osseous defects and method of making same Complexes of reconstituted collagen and demineralized bone particles or reconstituted collagen and a solubilized bone morphogenetic protein fabricated in a sponge suitable for in vivo implantation in osseous defects are disclosed. Both demineralized bone ... | 07/19/1983 |
| 4378017 | Composite material of de-N-acetylated chitin and fibrous collagen A composite material of de-N-acetylated chitin and fibrous collagen, which may be prepared by bringing the de-N-acetylated chitin and the fibrous collagen into mutual contact in an aqueous acidic medium followed by deacidifying the obtained product, the f... | 03/29/1983 |
| 4350629 | Procedures for preparing composite materials from collagen and glycosaminoglycan This invention relates to crosslinked collagen and glycosaminoglycan materials, and to procedures for preparing such materials. It has been discovered that if collagen fibrils in an aqueous acidic solution are contacted with a crosslinking agent before be... | 09/21/1982 |
| 4347234 | Medicinally useful, shaped mass of collagen resorbable in the body A shaped mass resorbable in the body, comprises collagen and a bioresorbable binding agent for collagen, the binding agent being selected, e.g., from polymers of C2-16 -hydroxyalkanoic acids, polymers of natural amino acids, hydrolyzed c... | 08/31/1982 |
| 4280954 | Crosslinked collagen-mucopolysaccharide composite materials Composite materials are disclosed which are formed by contacting collagen with a mucopolysaccharide and subsequently covalently crosslinking the resultant polymer. These composite materials have a balance of mechanical, chemical and physiological properti... | 07/28/1981 |
| 4233360 | Non-antigenic collagen and articles of manufacture Collagen, available from domestic animals, is freed of noncollagen proteins, glycosaminoglycans and lipids by enzymatic treatment with a proteolytic enzyme to yield a product which is soluble in dilute acidic aqueous solutions (collagen in solution--CIS).... | 11/11/1980 |
| 4115928 | Freeze-dry process and product An improvement in freeze-drying of skin tissue for use in treating wounds and diseased areas of the body wherein un-frozen skin is partially dried and frozen by drawing a vacuum across the skin before commencing the freeze-dry process, resulting in a nove... | 09/26/1978 |
| 4034750 | Electrochemically linking collagen fibrils to animal tissue Skin-like collagen membranes are adapted for protecting a wound, lesion or the like on animal bodies. These collagen membranes are semipermeable and are electrochemically-linked to the damaged collagen fibrils of the animal body. This electrochemical biol... | 07/12/1977 |
| 4021522 | Method of forming collagen dispersions A method of preparing collagen fibre dispersions comprising treating a collagenous material such as hide corium with a solution containing an alkaline earth metal hydroxide and an alkaline earth hydroxide; coarsely dicing or mincing the collagen, and mech... | 05/03/1977 |
| 4016877 | Fibrous collagen derived web having hemostatic and wound sealing properties Non-woven, liquid-laid, fibrous web having hemostatic and adhesive properties adapted to seal a wound formed of fibers consisting of an ionizable, water-insoluble, partial salt of collagen, the web when placed on a saline solution disintegrating completel... | 04/12/1977 |
| 3988782 | Non-antigenic, non-thrombogenic infection-resistant grafts from umbilical cord vessels and process for preparing and using same Arteries and veins of umbilical cords are hardened and shaped by processes described. Prostheses in the form of tubes, patches and conduits are prepared from the shaped vessels. The prostheses are used as reinforcements and replacements for vessels, ducts... | 11/02/1976 |
| 3949755 | Surgical ligature A surgical ligature in which a sterile thread has a surface on which is a succession of areas, for example, lines or dots, of contrasting shades, whereby at least one of the shades appears dark through a film of blood and at least one of the shades appear... | 04/13/1976 |
