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| Number | Title | Issue Date |
| 8057418 | Devices and methods for extracorporeal ablation of circulating cells Methods and devices are provided for the extracorporeal ablation of target cells circulating in blood of an organism. Exogenous material introduced into the blood preferentially associates with target cells (e.g. cancer cells, bacteria, viruses) in the blood. An ext... | 11/15/2011 |
| 7442546 | Method of modulating inflammatory response A method of immunomodulation by contacting the bodily fluid of a patient with renal tubule cells outside of the kidney. ... | 10/28/2008 |
| 7408045 | Adsorbent of high-mobility-group protein and body fluid-purification column An adsorbent of high-mobility-group proteins (HMG protein) which can remove HMG protein in body fluid is disclosed. The adsorbent according to the present invention has a water-insoluble carrier on which (a) substance(s) having (a) hydrogen-bondable functional group... | 08/05/2008 |
| 7404806 | Hemo-aide An apparatus and method for modifying viruses and bacteria in a closed loop system that irradiates the fluid multiple times through the same channel. The apparatus consists of a cuvette, an irradiation station, two ultraviolet light sources, a peristaltic pump, and ... | 07/29/2008 |
| 7374677 | Two stage hemofiltration that generates replacement fluid The present invention relates to a system for two-stage blood dialysis of a patient. In one embodiment, the system comprises a first filtration device for receiving the blood from the patient and for producing a first filtrate and processed blood. The system further... | 05/20/2008 |
| 7314460 | Extracorporeal pathogen reduction system The invention relates to an apparatus system and methods for treatment of virus-infected or pathogen-loaded human blood components separated from normal components comprising a separation apparatus and treatment apparatus system that inactivate pathogens in an extra... | 01/01/2008 |
| 7309488 | Adsorbents for dilated cardiomyopathy An adsorbent which comprises a water-insoluble carrier and a compound, which is immobilized on said carrier, having a binding affinity for an antibody against β1-adrenoceptor and/or an antibody against M2 muscarinic receptor exhibits a remarkably large adsorptive c... | 12/18/2007 |
| 7303540 | User interface for blood treatment device A graphical user interface (GUI) for medical instruments for a Renal Replacement Therapy that enables an operator to select and review a series of settings for an extracorporeal pump console and implement the settings in batch manner. The GUI automatically adjusts o... | 12/04/2007 |
| 7244232 | Process for identifying cancerous and/or metastatic cells of a living organism A process for identifying and treating cells in a living organism. The cells are labeled, circulated within the organism, detected with an implanted detector, and then either isolated or ablated. ... | 07/17/2007 |
| 7229427 | Irradiation and filter device for treatment of blood A method and apparatus for preventing and treating septicemia in patient blood is provided. The extracorporeal system includes an antimicrobial device to inactivate at least 99% of bloodborne microorganisms, a hemoconcentrator/filtration unit to remove approximately... | 06/12/2007 |
| 7226429 | Method for removal of viruses from blood by lectin affinity hemodialysis The present invention relates to a method for using lectins that bind to pathogens having high mannose surface glycoproteins or fragments thereof which contain high mannose glycoproteins, to remove them from infected blood or plasma in an extracorporeal setting. Acc... | 06/05/2007 |
| 7220236 | Method for eliminating HIV in human blood and a device for treating AIDS with non-pharmacotherapy The invention provides a method for eliminating HIV in human blood and a device for treating AIDS with non-pharmacotherapy. The method includes (1) pumping the blood containing HIV virus into a soft thin plastic tube while adding air through a T-tube at a definite f... | 05/22/2007 |
| 7105093 | Processing set and methods for processing and treating a biological fluid Apparatus, systems and methods are disclosed for treating a biological fluid with light. A container of biological fluid is introduced into a fluid treatment chamber where it is contacted with light provided by one or more light sources in proximity to the fluid tre... | 09/12/2006 |
| 7056507 | Adsorbent for eliminating hepatitis C virus, adsorber, and adsorption method An adsorbent for removing hepatitis C virus which has the ability to adsorb HCV particles, particularly immune-complex HCV particles, from a patient's body blood safely and with high efficiency and high selectivity for enhancing the efficacy of interferon therapy, a... | 06/06/2006 |
| 7022322 | treatment of cardiomyopathy by removal of autoantibodies Immunoapheresis treatment for cardiomyopathy comprises passing the patient's plasma over a column having coupled thereto a specific ligand for human immunoglobulin, thereby removing a significant portion of the immunoglobulin from the patient's plasma, and then rein... | 04/04/2006 |
| 6881408 | Immunoadsorber for use in sepsis therapy The invention relates to immunoadsorbers for use in sepsis therapy, in particular for removal of complement factors and lipopolysaccharides (LPS) and, if need be, further sepsis mediators such as TNF and interleukins from body fluids, methods for their production an... | 04/19/2005 |
| 6866846 | Patient-specific immunoadsorbers for the extracorporeal apheresis and methods for their preparation A process for preparing a patient-specific immunoadsorber, which comprises (i) extracting a body fluid from a patient having an immunopathological condition, the fluid containing immune complexes that are relevant to that immunopathological condition, (ii) contactin... | 03/15/2005 |
| 6774102 | Extracorporeal endotoxin removal method This invention describes blood treating material having the capacity to selectively remove endotoxin and cytokine inducing substances from blood or plasma by extracorporeal adsorption for therapeutic septic shock treatment. The endotoxin adsorption ligands of the in... | 08/10/2004 |
| 6773412 | User interface for blood treatment device A graphical user interface for a medical instruments for a Renal Replacement Therapy is disclosed that includes a pictogram representation of the fluid path of an extracorporeal blood circuit that represents fluid lines, pumps and sensors. To assist the user in resp... | 08/10/2004 |
| 6713252 | Method for removing and reducing hepatitis C virus Described is a method of removing and reducing HCV from the blood of an HCV-infected patient, which comprises carrying out, once a day for at least 5 straight days, a treatment of bringing the blood into contact with an adsorptive carrier having a higher affinity fo... | 03/30/2004 |
| 6653131 | Method of treating systemic inflammatory response syndrome A method for treating systemic inflammatory response syndrome (SIRS) by contacting the bodily fluid of a patient with renal tubule cells outside of the kidney.... | 11/25/2003 |
| 6630315 | Process for preparing major histocompatibility antigen class II protein and materials in which the same is bound This invention provides a process for producing major histocompatibility antigen class II protein (hereinafter referred to as "MHC class II" for short) which occurs on the surfaces of antigen-presenting cells and the like, and MHC class II-bound materials... | 10/07/2003 |
| 6623441 | Blood-purifying apparatus and artificial kidney using the same An artificial kidney capable of cleaning blood, like a kidney of a healthy body, by any person even at home which is small in the size and simple in the structure and handling, without requiring any pharmaceutical solution. A metabolic end product separation c... | 09/23/2003 |
| 6600014 | Adsorbent for eliminating hepatitis C virus, adsorber, and adsorption method An adsorbent for removing hepatitis C virus which has the ability to adsorb HCV particles, particularly immune-complex HCV particles, from a patient's body blood safely and with high efficiency and high selectivity for enhancing the efficacy of interferon... | 07/29/2003 |
| 6544727 | Methods and devices for the removal of psoralens from blood products Methods and devices for the removal of psoralens and psoralen photoproducts from blood products are described. The methods include contacting a psoralen- and irradiation-treated blood product with a resin capable of adsorbing psoralens and psoralen photop... | 04/08/2003 |
| 6528057 | Method for removal of HIV and other viruses from blood This invention discloses a method for reducing the viral load by removal of viruses or fragments or components thereof from the blood by extracorporeally circulating blood through hollow fibers which have in the porous exterior surface, immobilized affini... | 03/04/2003 |
| 6498007 | Methods of treatment of disease using adsorbent carriers The invention relates to a method for the removal of leucocytes from blood which comprises bringing blood that comprises infected leucocytes into contact with an adsorbent carrier that has a greater affinity for infected, activated and/or defective leucoc... | 12/24/2002 |
| 6491655 | Methods for treating hemophilia A and B and AIDS and devices used therein The present invention provides a method for treating Hemophilia A or B which comprises implanting in fluid communication with the bloodstream of a mammal in need of such treatment a permeable membrane having one or more walls, a hollow chamber therewithin... | 12/10/2002 |
| 6464976 | Methods and compositions for reducing immune response The present invention provides an apparatus and method to diminish the pre-existing immune response to the administration of a therapeutic virus by the selective elimination of antiviral antibodies from the serum. The present invention provides a chromato... | 10/15/2002 |
| 6433149 | Compounds and methods for inhibiting cancer metastasis Agents for inhibiting cancer metastasis are provided. The methods comprise administering to a patient an antimetastatic agent that comprises one or more of: (a) a peptide sequence that is at least 50% identical to an OB-cadherin CAR sequence; (b) a non-pe... | 08/13/2002 |
| 6407212 | Method for the removal of causative agent(s) of transmissible spongiform encephalopathies from protein solutions For separating non-conventional transmissible agents (NCTAs), i.e. causative agent(s), of transmissible spongiform encephalopathies (TSEs) from a solution of a protein susceptible to contamination with NCTAs, particularly from blood products, at least one... | 06/18/2002 |
| 6391657 | Removal of viruses from protein solutions by ultrafiltration The invention relates to the removal of viruses from aqueous solutions, as a rule protein solutions, by ultrafiltration. This entails the viruses to be removed being increased in size by incubation with a high molecular weight receptor binding thereto, pr... | 05/21/2002 |
| 6365147 | Methods for removing endotoxins from biological solutions using immobilized metal affinity chromatography The present invention relates to methods for depleting endotoxin from biological solutions by exposure of solutions containing endotoxin to an immobilized metal affinity chromatography matrix composed of a metal ion such as iron (III) bounds to a resin, w... | 04/02/2002 |
| 6325939 | Surface modified polymer beads A polymeric resin is disclosed in the form of beads or particles having a coating thereon which renders the resin blood compatible. The resin comprises divinylbenzene monomer which has a porosity, pore size, and surface area suitable for absorbtion of unh... | 12/04/2001 |
| 6231536 | Method and compositions for treatments of cancers A method to treat cancer uses ultrapheresis, refined to remove compounds of less than 120,000 daltons molecular weight, followed by administration of replacement fluid, to stimulate the patient's immune system to attack solid tumors. In the preferred embo... | 05/15/2001 |
| 6180016 | Microbiological water filtering A method and device for the filtration and/or purification of fluids water or other solutions containing microbiological contaminants, such as fluids containing including bacteria and/or viruses, where the fluid water is passed through a purification mate... | 01/30/2001 |
| 6133431 | Adsorbent for immunoglobulins and complexes thereof, adsorption method, and adsorption device An adsorbent that exhibits a high specificity in adsorbing immunoglobulins and/or complexes thereof, is extremely reduced in the lowering of the adsorption characteristic during sterilization or storage, is highly stable and safe, and is prepared by immob... | 10/17/2000 |
| 5888511 | Treatment of autoimmune diseases, including AIDS The present disclosure concerns the treatment of a patient with autoimmune disease, including AIDS, by neutralizing, removing or inhibiting different types of interferons, tumor necrosis factor, HLA class II antigens, IgE, and other pathological factors a... | 03/30/1999 |
| 5783454 | Method for the preparation of free radical pharmaceuticals using selenium conjugates The invention provides a method for making a selenium-carrier conjugate by covalently attaching (i) an organic selenium compound selected from the group consisting of RSeH, RSeR, RSeR', RSeSeR and RSeSeR', wherein R and R' are each an aliphatic residue co... | 07/21/1998 |
| 5753227 | Extracorporeal affinity adsorption methods for the treatment of atherosclerosis, cancer, degenerative and autoimmune diseases Extracorporeal affinity adsorption treatments which are aimed at the substantial removal of two or more compounds that are etiological in the pathogenesis of diseases in man provide effective therapeutic intervention means for these diseases. The methods ... | 05/19/1998 |