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| Number | Title | Issue Date |
| 7300662 | Drug/drug delivery systems for the prevention and treatment of vascular disease A drug and drug delivery system may be utilized in the treatment of vascular disease. A local delivery system is coated with rapamycin or other suitable drug, agent or compound and delivered intraluminally for the treatment and prevention of neointimal hyperplasia f... | 11/27/2007 |
| 7229473 | Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent Methods of preparing intravascular stents with a polymeric coating containing macrocyclic lactone (such as rapamycin or its analogs), stents and stent graphs with such coatings, and methods of treating a coronary artery with such devices. The macrocyclic lactone-bas... | 06/12/2007 |
| 7223286 | Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent Methods of preparing intravascular stents with a polymeric coating containing macrocyclic lactone (such as rapamycin or its analogs), stents and stent graphs with such coatings, and methods of treating a coronary artery with such devices. The macrocyclic lactone-bas... | 05/29/2007 |
| 7217286 | Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent Methods of preparing intravascular stents with a polymeric coating containing macrocyclic lactone (such as rapamycin or its analogs), stents and stent graphs with such coatings, and methods of treating a coronary artery with such devices. The macrocyclic lactone-bas... | 05/15/2007 |
| 7175594 | Ophthalmic sulcus speculum Devices in accordance with certain embodiments of the present sulcus speculum are designed to be placed into the sulcus of an eye to perform one or more of the following functions: evacuation of fluid, opening of the lids, and application of drugs such as anesthetic... | 02/13/2007 |
| 6969371 | Lateral needle injection apparatus and method A device and method for delivering and injecting fluid into heart tissue utilizing a laterally directed needle to increase injectate (fluid) retention in the heart tissue. The device may comprise a catheter having a shaft wherein the distal end of the shaft includes... | 11/29/2005 |
| 6730120 | Medical device for delivering a therapeutic substance and method therefor A device useful for localized delivery of a therapeutic material is provided. The device includes a structure including a porous material; and a water-insoluble salt of a therapeutic material dispersed in the porous material. The water-insoluble salt is formed by co... | 05/04/2004 |
| 6544206 | Dialysis access system and method A method of and system for providing vascular access in a patient for hemodialysis involves attaching the distal end of an access catheter to the abdominal aorta of the patient and the proximal end of the access catheter to a portion of the patient to all... | 04/08/2003 |
| 6514978 | Thromboresistant materials incorporating pyrazinone protease inhibitors Thromboresistant materials are described which incorporate pyrazinone compounds of the Formula I: ##STR1## wherein X is O, NR11 or CH.dbd.N, R3 -R11, Ra, Rb, Rc, W, m, and n are set forth i... | 02/04/2003 |
| 5957901 | Catheter with improved spray pattern for pharmaco-mechanical thrombolysis therapy An improved catheter includes a double spiral configuration of infusion holes around the circumference and along the length of the catheter which provides an improved lateral dispersion of a thrombolytic fluid to more completely and quickly lyse a clot th... | 09/28/1999 |
| 5921958 | Intravascular catheter with distal tip guide wire lumen A catheter for use in angioplasty includes a shaft formed from an elongated metallic tube and has an inflatable balloon at its distal end. A plastic tube connects a distal end of the metallic tube to a proximal end of the balloon. The metallic and plastic... | 07/13/1999 |
| 5716981 | Anti-angiogenic compositions and methods of use The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and paclitaxel. Also provid... | 02/10/1998 |
| 5686409 | Antirestenosis protein A method of treating primary and recurrent atheromatous plaque development is provided. The method involves administering a therapeutically effective amount of SERP-1, admixed in a pharmaceutically acceptable carrier to the intimal or lumenal layer of art... | 11/11/1997 |
| 5591140 | Radiofrequency plasma treated polymeric surfaces having immobilized anti-thrombogenic agents Polymeric surfaces of medical devices or components of medical devices are provided that have enhanced biocompatibility properties. The polymeric surface presents an anti-thrombogenic, fibrinolytic or thrombolytic interface with body fluids such as blood ... | 01/07/1997 |
| 5575797 | Device for explanting a medical electrode device A device for explanting an electrode device, particularly an intravascular or intracardiac electrode device having an electrode cable and an electrode head arranged on the cable's distal end, is capable of simply and safely detaching fibrotic matter from ... | 11/19/1996 |
| 5571081 | Per-operational autotransfusion suction device A per-operational autotransfusion suction device has a suction cannular 1 with a tabular section nozzle 5, communicating with an inner passage 6, 9 in the cannula, the cannula passage being connected to a blood collecting recipient 41 in which a partial v... | 11/05/1996 |
| 5411472 | Low trauma blood recovery system Recovery of blood from a wound site (12) during a surgical procedure is accomplished with low blood trauma that enables collection of increased amounts of blood having relatively little structural damage for return to the surgical patient. Blood trauma is... | 05/02/1995 |
| 5324276 | Device and method for inhibiting intravascular device associated infection The present invention is directed to a device for reducing the risk of infection and/or clotting associated with the establishment and/or maintenance of fluid communication between apparatus external to the body and the interior of the body. The device in... | 06/28/1994 |
| 5320621 | Technique for incorporating an electrode within a nozzle A clip supports an elongated electrode within a nozzle of an electrosurgical handpiece used in gas electrocoagulation. The clip is preferably formed from a cylindrical tube which has been deformed into a configuration which has a central conduit-like sect... | 06/14/1994 |
| 5242384 | Blood pumping and processing system Blood is pumped by a pump, preferably a bi-concave diaphragm pump. When the blood pump is full of blood, this full condition is detected and a batch of blood is emptied completely from the pump for delivery to the patient. A second pump, also preferably a... | 09/07/1993 |
| 5205818 | Patency maintenance system A method and apparatus for maintaining the patency of a vein access device in which a dilute solution of an anticoagulant drug is slowly infused into the vein access device. The patency device includes a self-energized container and means for adding a med... | 04/27/1993 |
| 5188618 | Thrombus-mobilizing thoracostomy tube A thrombus-mobilizing thoracostomy tube includes fenestrations to enable drainage when introduced into a thoracic cavity, the tube including a balloon which may be inflated to dislodge and move blood clots, the balloon being connected to a first tube to e... | 02/23/1993 |
| 5171217 | Method for delivery of smooth muscle cell inhibitors A method and composition for delivering a drug to an affected intramural site for sustained release in conjunction with or following balloon catheter procedures, such as angioplasty. The drug, carried by microparticles of a physiologically-compatible, bio... | 12/15/1992 |
| 5163926 | Suction metering and mixing device A suction metering and mixing device is disclosed for collecting body fluids such as blood and simultaneously mixing an anticoagulant therewith. The device includes a suction passage having an inlet end and an opposite end for connection to a vacuum suppl... | 11/17/1992 |
| 5141501 | Suction metering and mixing device A suction metering and mixing device is disclosed for collecting body fluids such as blood and simultaneously mixing an anticoagulant therewith. The device includes a suction passage having an inlet end and an opposite end for connection to a vacuum suppl... | 08/25/1992 |
| 5100383 | Catheters permitting controlled diffusion A non-thrombogenic surface is provided by forming a reservoir from which anticoagulant solution can permeate through a flexible wall (5, 6) of bio-compatible permeable material. Such reservoirs can be used in catheters one form of which includes a hollow-... | 03/31/1992 |
| 5061777 | Thromboresistant polyetherurethane compounds and process for its production A thromboresistant segmented polyetherurethane compound wherein the polyether segment consists of 99 to 1% by weight of (a) a polytetramethylene ether segment having a number average molecular weight of 200 to 5,000 and 1 to 99% by weight of (b) a polyalk... | 10/29/1991 |
| 5047020 | Ionic heparin coating A non thrombogenic quaternary ammonium-heparin complex coating for a medical article comprising an amount of at least 50% by weight of one or more cationic quaternary ammonium organic salts having the following formula: ##STR1## Wherein R1 | 09/10/1991 |
| 4965112 | Method for applying a blood-compatible coating to polyether-urethane moulded articles and the polymether-urethane moulded articles coated in this way The invention relates to a method for applying a blood-compatible polyethlene oxide coating to polyether-urethane moulded articles like catheters, for instance oxygen sensor catheters. The so obtained blood-compatible articles may advantageously be used i... | 10/23/1990 |
| 4872867 | Compositions having antithrombogenic properties and blood contact medical devices using the same This invention is a composition having anti-thrombogenic properties, comprising as essential constituent components a polyurethane or polyurethane urea containing polytetramethylene oxide in its main chain, a water soluble and/or water swellable macromole... | 10/10/1989 |
| 4871357 | Ionic heparin coating A non thrombogenic quarternary ammonium/heparin complex coating for a medical article is disclosed where the organic cationic salt is an alkylbenzyldimethyl ammonium ion present in an amount of at least 50% by weight and having the following formula: ... | 10/03/1989 |
| 4772260 | Rectal catheter Particularly a rectal catheter for the removal of fluent material from the rectal cavity. The rectal catheter (18) comprises an elongated tubular member (20) forwardly insertable within the rectal cavity. The tubular member includes a pair of opposing eye... | 09/20/1988 |
| 4601697 | Long indwelling double bore catheter A long indwelling double bore catheter for dilution and sampling of blood on a continuing basis capable of being used for long periods of time. The long indwelling double bore catheter has a small mixing chamber with an opening of a cross-sectional area e... | 07/22/1986 |
| 4551131 | Autotransfusion system with anticoagulant delivery system A movable blood aspiration wand, especially for use in autotransfusion, carries with it a tank for anticoagulant replenished from an anticoagulant source fixed at a high source and is connected to a blood reservoir at a low elevation. Differences in wand ... | 11/05/1985 |
| 4540406 | Anticoagulant delivery system for use with an auto-transfusion system Anticoagulant is added to blood being aspirated through a hand-held wand having a venturi throat. The anticoagulant flows into the wand from a generally closed anticoagulant reservoir higher than the wand as replacement air flows into the anticoagulant ai... | 09/10/1985 |
| 4002170 | Anticoagulant delivery means for aspiration wand An anticoagulant delivery device forming part of an aspiration wand for use in connection with autologous blood transfusion wherein an anticoagulant is delivered along essentially the entire internal periphery of the aspiration wand in the vicinity of the... | 01/11/1977 |
| 3976081 | Laminar middle ear vent tube assembly A vent tube is disclosed which has improved resilient characteristics and heparinized poly-tetrafluoroethylene inner surface to prevent clotting of blood passing through it as it drains serious fluids and blood from middle ear to the exterior of the body.... | 08/24/1976 |
| 3965909 | Angiographic catheter and method of manufacture There is disclosed a multiwall catheter and a method for the manufacture thereof. The catheter comprises two co-extensive elongated continuous plastic tubes having an intermediate braid sheath extending to within a few inches of the composite tube end whe... | 06/29/1976 |
| 3964484 | Antiocoagulant metering device and method An aspiration wand assembly having an associated metering valve for metering liquid anticoagulant to blood aspirated by the wand. The metering valve includes a flexible diaphragm normally obstructing conduit which transmits anticoagulant from a remote sou... | 06/22/1976 |
| 3955573 | Anticoagulant delivery device and method An anticoagulant delivery device forming part of an aspiration wand and method for use in connection with autologous blood transfusion wherein an anticoagulant is delivered to and intimately mixed with aspirated blood in the vicinity of the aspiration tip... | 05/11/1976 |
