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3M employee and church chorister Art Fry needed something to temporarily mark pages in his hymnal. He was in luck because his colleague, Spencer Silver, accidentally developed a glue that was too weak for other purposes. After initially discouraging consumer response, Post-it Notes became a hit in 1979.
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| Number | Title | Issue Date |
| 8083715 | Puncture device The present invention provides a puncture device and an administration device in which a puncture needle can be stuck certainly to a predetermined region of a skin. The puncture device and the administration device of the present invention are provided with a punctu... | 12/27/2011 |
| 8079982 | Injection catheter with needle electrode An injection catheter for infusing therapeutic and diagnostic agents into the heart is provided. The injection catheter comprises a catheter body comprising a flexible tubing having proximal and distal ends and at least one lumen therethrough. A tip section comprisi... | 12/20/2011 |
| 8007466 | System and method for delivering fluid into flexible biological barrier A system and method for delivering fluid into a flexible biological barrier employs a microneedle structure wherein a final position of microneedles (12) inserted into the biological barrier (14) is generally sideways projecting from the delivery confi... | 08/30/2011 |
| 8007467 | Device for vein stabilization Apparatuses and methods for performing and aiding venipuncture. The apparatuses of the present invention provide the medical practitioner with an improved tool for performing venipuncture methods. The apparatus preferably includes a handle that is connected to a plu... | 08/30/2011 |
| 7988667 | Piercing tool A piercing tool (1) can safely and reliably pierce a piercing needle (411) into a skin layer. The piercing tool (1) comprises a belt-like flexible fixing member (2) having an opening (3) formed for raising skin, and a piercing need... | 08/02/2011 |
| 7824371 | Fingertip-positioned artery stabilizer An artery stabilizer device, which is held in place by a technician over a targeted artery using just one or two fingertips of the technician's hand, is provided for stabilizing the artery while the user inserts the needle of a syringe into the artery. A pair of sta... | 11/02/2010 |
| 7645262 | Biocompatible bonding method and electronics package suitable for implantation The invention is directed to a method of bonding a hermetically sealed electronics package to an electrode or a flexible circuit and the resulting electronics package that is suitable for implantation in living tissue, such as for a retinal or cortical electrode arr... | 01/12/2010 |
| 7427279 | Method of closing an opening in a wall of a heart Disclosed is a closure catheter, for closing a body cavity such as a vessel, or the left atrial appendage of the heart. The closure catheter includes a plurality of deployable tissue anchors, which may be laterally deployed into surrounding tissue. The anchors may t... | 09/23/2008 |
| 7371247 | Method and apparatus for penetrating tissue A tissue penetrating system includes a plurality of penetrating members each having a tip. A penetrating member driver is coupled to the plurality of penetrating members. Each tip of a penetrating member is uncovered during launch of the penetrating member by the pe... | 05/13/2008 |
| 7354401 | Ultrasound sex determination for sorting of avian hatchlings A method for making a sex determination in avian hatchlings involves the following activities. A process line is equipped to process an endless plurality of hatchlings. The process line has an ultrasound inspection station for the hatchlings. The ultrasound inspecti... | 04/08/2008 |
| 7331931 | Method and apparatus for penetrating tissue These and other objects of the present invention are achieved in a body fluid sampling system for use on a tissue site that includes an electrically powered drive force generator. A penetrating member is operatively coupled to the force generator. The force generato... | 02/19/2008 |
| 7332469 | Intrapleural single-chain urokinase alone or complexed to its soluble receptor protects against pleural adhesions The present invention relates to methods of preventing or decreasing the severity of scarring in a subject comprising: obtaining a pharmaceutical composition comprising a single chain urokinase plasminogen activator molecule (scuPA) or a scuPA mimetic; and administe... | 02/19/2008 |
| 7316700 | Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties A lancing device, an embodiment of which controls the advancement and retraction of a lancet by monitoring the position of the lancet in conjunction with a lancet controller which incorporates a feedback loop for modulating the lancet driver to follow a predetermine... | 01/08/2008 |
| 7291117 | Method and apparatus for penetrating tissue These and other objects of the present invention are achieved in a body fluid sampling system for use on a tissue site that includes a voice coil based penetrating member driver. A plurality of penetrating members are included. A transport mechanism is configured to... | 11/06/2007 |
| 7258693 | Device and method for variable speed lancet A method of penetrating tissue is provided. The method comprises using a lancet driver to advance a lancet into the tissue; advancing the lancet at a first desired velocity in a first layer of tissue; advancing the lancet at a second desired velocity in a second lay... | 08/21/2007 |
| 7244265 | Method and apparatus for penetrating tissue These and other objects of the present invention are achieved in a body fluid sampling system for use on a tissue site that includes a drive force generator and a penetrating member operatively coupled to the force generator. The force generator moves the member alo... | 07/17/2007 |
| 7235056 | Body fluid sampling device and methods of use A device for sampling body fluid includes a housing having a sleeve at a forward end thereof which is displaceable in response to being pressed against a user's skin to trigger the firing of a lancet. After the lancet is removed from the incision, the sleeve is repe... | 06/26/2007 |
| 7232451 | Method and apparatus for penetrating tissue A skin penetrating system has a housing member and a plurality of penetrating members positioned in the housing member. A tissue stabilizing device is coupled to the housing member. A user interface is configured to relay at least one of, skin penetrating performanc... | 06/19/2007 |
| 7229458 | Method and apparatus for penetrating tissue A tissue penetrating system includes a plurality of cartridges each with a distal port and a proximal port. A plurality of penetrating members are provided, each coupled to a cartridge and having a sharpened distal tip and a shaft portion slidably disposed within th... | 06/12/2007 |
| 7226461 | Method and apparatus for a multi-use body fluid sampling device with sterility barrier release A device for use with a gripper is provided. A cartridge is provided that defines a plurality of cavities. A plurality of penetrating members are at least partially contained in the cavities of the cartridge. The penetrating members are slidably movable to extend ou... | 06/05/2007 |
| 7226440 | Method and device for accessing a pericardial space A method for accessing a pericardial space of a heart of a mammalian patient is disclosed comprising: guiding a catheter through a coronary sinus of the heart and to a cardiac vein; advancing said catheter to a distal segment of the cardiac vein; intentionally punct... | 06/05/2007 |
| 7198606 | Method and apparatus for a multi-use body fluid sampling device with analyte sensing A device for use with a penetrating member driver to penetrate tissue is provided. A plurality of penetrating members are coupled to a single cartridge and are operatively couplable to the penetrating member driver. The penetrating members are movable to extend radi... | 04/03/2007 |
| 7141040 | Safety intravenous starter An intravenous starter device having means for safely disposing of the needle. The intravenous starter device has a first tube having a first end for insertion into a patient and an outer tube in fluid communication with the first tube and having an opening for rece... | 11/28/2006 |
| 7115110 | Method and apparatus for closing a body lumen Disclosed is a closure catheter, for closing a body cavity such as a vessel, or the left atrial appendage of the heart. The closure catheter includes a plurality of deployable tissue anchors, which may be laterally deployed into surrounding tissue. The anchors may t... | 10/03/2006 |
| 7113821 | Tissue electroperforation for enhanced drug delivery The present invention relates to a method and a device for transporting a molecule through a mammalian barrier membrane of at least one layer of cells comprising the steps of: ablating the membrane with an electric current from a treatment electrode; and utilizing a... | 09/26/2006 |
| 7077821 | Implant system and method for bulking tissue A system for placing an implant in the body includes an elongated member having at least one inner lumen extending from a proximal end portion of the member to an opening in a distal end portion of the member. At least one compressible implant is in the inner lumen ... | 07/18/2006 |
| 7066922 | Transdermal transport device with suction A transdermal transport device includes a reservoir for holding a formulation of an active principle, and one or more needles. Each needle has a bore through which the formulation is transported between the reservoir and a biological body, and has an end portion tha... | 06/27/2006 |
| 7066908 | Method and apparatus for indicating or covering a percutaneous puncture site Systems and methods are disclosed for identifying and deploying a protective cover about a percutaneous puncture site formed by a hypodermic needle. In the preferred embodiment, a marking agent or puncture site covering, the latter of which preferably takes the form... | 06/27/2006 |
| 7063693 | Methods and tools for accessing an anatomic space A tubular access sleeve and suction tool for accessing an anatomic surface or anatomic space and particularly the pericardium to access pericardial space and the epicardial surface of the heart in a minimally invasive manner are disclosed. A suction tool trunk exten... | 06/20/2006 |
| 7060054 | Suction piece for or on a device administering an injectable product A suction piece for a device for administering an injectable product, the suction piece including a suction chamber having a chamber opening rim via which the suction piece may be placed on a tissue, a connection part in order to produce a mechanical connection to t... | 06/13/2006 |
| 7041068 | Sampling module device and method A tissue penetration device and method of using same that may include a lancet module or sampling module. The sampling module may optionally be in a cartridge configuration and include sampling and analyzing functions, which may be integrated. ... | 05/09/2006 |
| 7027478 | Microneedle array systems The present invention relates to systems of microneedle arrays to align and form optical components. Active components such as lasers are combined with optical fibers. Microneedles are fabricated using techniques such as laser drilled Kapton, and combined with optic... | 04/11/2006 |
| 7025774 | Tissue penetration device A tissue penetration device and method of using same. The tissue penetration device may optionally include sampling and analyzing functions, which may be integrated. An embodiment provides control of a lancet used for sampling blood. Electric field coils or solenoid... | 04/11/2006 |
| 7014625 | Needle insertion device The invention relates to a needle insertion device comprising a housing with a mounting surface adapted for application to the skin of a subject, where the mounting surface defines a general plane and has a needle aperture formed therein. Adhesive means is arranged ... | 03/21/2006 |
| 7001344 | Blood sampling device with diaphragm actuated lancet A device and method to obtain a blood sample in a sealed configuration. The device includes a sampling assembly having a driver, a lancet, and a blood reservoir, and a pad having a proximal side and a distal side. The proximal side of the pad conforms to the shape o... | 02/21/2006 |
| 6994691 | Injection apparatus An injection apparatus is described for making an injection at a predetermined depth in skin, including: a skin positioning member for positioning on a patch of skin within an area of skin such that at least a part of the patch of skin may be held elevated above or ... | 02/07/2006 |
| 6971999 | Intradermal delivery device and method The subject intradermal delivery device provides for penetration to a fixed depth without requiring special expertise by the user. The device consists of a syringe nested inside an inner shell and an outer shell. An elongated annular channel is formed between the in... | 12/06/2005 |
| 6918908 | Methods and apparatus for accessing and stabilizing an area of the heart A tubular suction tool for accessing an anatomic surface or anatomic space and particularly the pericardium to access pericardial space and the epicardial surface of the heart to implant cardiac leads in a minimally invasive manner are disclosed. The suction tool in... | 07/19/2005 |
| 6817986 | Jet injector with data logging system for use in compliance and dose monitoring programs An integral data logging system for a jet injector includes at least one electrical switch that changes state (e.g. from OFF to ON) during an injection procedure. The switch(es) are connected to an electrical circuit having a microprocessor, a clock and an electroni... | 11/16/2004 |
| 6786898 | Methods and tools for accessing an anatomic space A tubular access sleeve and suction tool for accessing an anatomic surface or anatomic space and particularly the pericardium to access pericardial space and the epicardial surface of the heart in a minimally invasive manner are disclosed. A suction tool trunk exten... | 09/07/2004 |
