...that in the early 1940s GE engineer James Wright was charged with a task of utmost importance to the war effort: develop a cheap substitute for rubber that could be used to produce tires, gas masks and a whole host of military gear. Wright tackled the task diligently -- and wound up inventing Silly Putty.
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| Number | Title | Issue Date |
| 6081736 | Implantable enzyme-based monitoring systems adapted for long term use Improved implantable monitoring systems suitable for long-term in vivo use to measure the concentration of one or more prescribed substances, such as glucose are described herein. In particular, an implantable enzyme-based glucose monitoring system is des... | 06/27/2000 |
| 6071391 | Enzyme electrode structure A biosensor comprises a space part for sucking and housing a sample formed of two upper and lower plates, the two plates being stuck together by an adhesive layer, the space part for sucking and housing the sample being constituted so as to be partially o... | 06/06/2000 |
| 6023629 | Method of sampling substances using alternating polarity of iontophoretic current A method for sampling of a substance from a subject is provided, which comprises placing one or more sampling chambers on a collection site on a tissue surface on the subject; conducting electric current through the tissue to extract a substance from the ... | 02/08/2000 |
| 6001067 | Device and method for determining analyte levels Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices, that result in the delivery of a dependable flow of blood to deliver sa... | 12/14/1999 |
| 5993411 | Portable automatic syringe device and injection needle unit thereof A portable automatic syringe device having a configuration including a separable rotating shaft adapted to provide a drive force to a piston included in the automatic syringe device so that the rotating shaft can be separated, along with the piston, from ... | 11/30/1999 |
| 5989409 | Method for glucose sensing A method for measuring the concentration of glucose diffused from a source to a working electrode which assembly includes a scavenging electrode is disclosed. The electrode of the invention is comprised of 1) a working electrode; 2) a scavenging electrode... | 11/23/1999 |
| 5985129 | Method for increasing the service life of an implantable sensor Methods are described for extending the service life of implantable sensors having a silver-containing anodic reference electrode maintained at a high impedance, at least one noble metal cathodic working electrode, and at least one noble metal anodic coun... | 11/16/1999 |
| 5964993 | Glucose sensor A sensor that is capable of accurately measuring glucose and other analytes in low oxygen environments is provided. The sensor employs an enzyme-containing membrane comprising a semi-interpenetrating polymer network which is infiltrated by an enzyme. The ... | 10/12/1999 |
| 5954685 | Electrochemical sensor with dual purpose electrode The present invention provides an electrode assembly for use in a transdermal analyte sensor operating in an alternating polarity mode in which a single electrode element provides both the counter electrode and iontophoretic electrode functions. By combin... | 09/21/1999 |
| 5954643 | Insertion set for a transcutaneous sensor An improved insertion set is provided for transcutaneous placement of a sensor such as a glucose sensor at a selected site within the body of a patient. The insertion set comprises a mounting base defining an upwardly open channel for receiving and suppor... | 09/21/1999 |
| 5916156 | Electrochemical sensors having improved selectivity and enhanced sensitivity The present invention describes electrochemical sensors, preferably electrochemical biosensors, in which the reference electrode and the measuring electrode are separated from one another by a porous, electrically nonconductive sheet material.... | 06/29/1999 |
| 5914026 | Implantable sensor employing an auxiliary electrode An implantable sensor comprising a biocompatible electroconductive case which houses a measuring electrode, a reference electrode, an auxiliary electrode, and an electronic circuit for measuring the response of the measuring electrode where the measuring ... | 06/22/1999 |
| 5882494 | Polyurethane/polyurea compositions containing silicone for biosensor membranes A homogenous polymer composition useful as a membrane for biosensors is disclosed. The polymer composition comprises the reaction products of a diisocyanate, a hydrophilic diol or diamine, and a silicone material. An aliphatic diol or diamine may also be ... | 03/16/1999 |
| 5842983 | Biosensor Biosensor for amperometric measurements wherein the measuring electrode (34) is made of an electrically conductive carrier made of carbon which is saturated with a platinum metal in colloidal form wherein a lead-off contact (10) of vitreous carbon runs fr... | 12/01/1998 |
| 5827183 | Method of measuring chemical concentration iontophoretically using impermeable mask A method for measuring the concentration of a chemical present in a blood stream of a mammalian subject is disclosed. The method involves contacting the subject's skin with a sensor assembly comprised of an ionically conducting material which contacts the... | 10/27/1998 |
| 5820622 | Analyte-controlled liquid delivery device and analyte monitor A liquid delivery device comprising a housing having a lower surface for application to the skin of a subject and having a reservoir and a gas generation chamber therein separated by a displaceable membrane. Gas generated by an electrolytic cell under the... | 10/13/1998 |
| 5820551 | Strip electrode with screen printing A sensor system that detects a current representative of a compound in a liquid mixture features a two-electrode strip adapted for releasable attachment to signal readout circuitry. The strip comprises an elongated support (preferably flat) adapted for re... | 10/13/1998 |
| 5807375 | Analyte-controlled liquid delivery device and analyte monitor A liquid delivery device comprising a housing having a lower surface for application to the skin of a subject and having a reservoir and a gas generation chamber therein separated by a displaceable membrane. Gas generated by an electrolytic cell under the... | 09/15/1998 |
| 5800420 | Analyte-controlled liquid delivery device and analyte monitor A liquid delivery device comprising a housing having a lower surface for application to the skin of a subject and having a reservoir and a gas generation chamber therein separated by a displaceable membrane. Gas generated by an electrolytic cell under the... | 09/01/1998 |
| 5791344 | Patient monitoring system A patient monitoring system measures the concentration of a particular substance in a patient's tissue, blood, or other bodily fluids, provides an indication of the rate of change of such concentration, and determines whether the measured concentration an... | 08/11/1998 |
| 5776324 | Electrochemical biosensors An electrochemical biosensor for determining the level of a target chemical in a biological fluid includes an electrochemical system including a enzyme substrate which reacts with the target chemical to yield a system signal related to the concentration i... | 07/07/1998 |
| 5771891 | Apparatus and method for non-invasive blood analyte measurement A non-invasive blood analyte concentration monitor. The monitor includes a stimulator applying a stimulus to an endogenous tissue responsive to the stimulus and a detector for detecting a response of an endogenous tissue to the stimulus. Also provided is ... | 06/30/1998 |
| 5771890 | Device and method for sampling of substances using alternating polarity A method for sampling of a substance from a subject is provided, which comprises placing one or more sampling chambers on a collection site on a tissue surface on the subject; conducting electric current through the tissue to extract a substance from the ... | 06/30/1998 |
| 5752512 | Apparatus and method for non-invasive blood analyte measurement A non-invasive blood analyte concentration monitor. The monitor includes a stimulator applying a stimulus to an endogenous tissue responsive to the stimulus and a detector for detecting a response of an endogenous tissue to the stimulus. Also provided is ... | 05/19/1998 |
| 5746898 | Electrochemical-enzymatic sensor An electrochemical-enzymatic sensor for the determination of substances, in particular glucose, in body fluids, which possesses a good long-term stability, includes: a sensor electrode of electrocatalytically inactive carbon, a counterelectrode, a referen... | 05/05/1998 |
| 5735273 | Chemical signal-impermeable mask A chemical signal-impermeable mask is positioned in the electrolyte flow such that the mask is between a source of chemical signal and a working electrode which senses the chemical signal transported from the source (e.g., by diffusion). The configuration... | 04/07/1998 |
| 5728281 | Implantable medical device including an arrangement for measuring a blood property having a carbon reference electrode An implantable medical device for in vivo electrochemical measurements of blood properties, such as measurements of, inter alia, oxygen pressure, glucose and pH, avoids the problem with the reference electrodes currently in use which cause inflammatory re... | 03/17/1998 |
| 5711861 | Device for monitoring changes in analyte concentration The invention provides an electrochemical sensor system for measuring analyte concentrations in a sample fluid. The invention is particularly useful for measuring analytes such as glucose in a patient. An implantable glucose sensor includes a disc-shaped ... | 01/27/1998 |
| 5708247 | Disposable glucose test strips, and methods and compositions for making same An improved disposable glucose test strip for use in a test meter of the type which receives a disposable test strip and a sample of blood from a patient and performs an electrochemical analysis is made using a working formulation containing a filler, an ... | 01/13/1998 |
| 5704354 | Electrocatalytic glucose sensor An electrocatalytic sensor in catheter type of construction for determining glucose in body fluids, especially in the blood, having the following features: a tubular body made of bio-compatible material that is subdivided into three sections, a sleeve-sha... | 01/06/1998 |
| 5694932 | Sensor array A sensor is used to detect a substance component in an aqueous solution. This sensor has electrically conducting and mutually insulated electrodes (7) which can be connected to a data-recording device. A sensor membrane array responsive to substance compo... | 12/09/1997 |
| 5682884 | Strip electrode with screen printing A sensor system that detects a current representative of a compound in a liquid mixture features a two-electrode strip adapted for releasable attachment to signal readout circuitry. The strip comprises an elongated support (preferably flat) adapted for re... | 11/04/1997 |
| 5680858 | Method and apparatus for in vivo determination of the concentration in a body fluid of metabolically significant substances A method for in vivo determination of the concentration in a body fluid of metabolically significant substance comprises storing of a needle with a sensor in a liquid-filled ampoule, brief insertion of the needle into a patient, recording of the output si... | 10/28/1997 |
| 5665222 | Soybean peroxidase electrochemical sensor An electrochemical biosensor able to measure hydrogen peroxide which is stable at temperatures near 37° C. or in excess of 37° C. for sustained periods of time and in biological environments. The electrochemical biosensor contains a thermostable peroxid... | 09/09/1997 |
| 5660163 | Glucose sensor assembly A glucose monitoring system continuously measures the glucose concentration in a patient's blood, provides an indication of the rate of change of such concentration, and determines whether the measured concentration and rate of change are within certain p... | 08/26/1997 |
| 5645710 | Glucose sensor and assay method A redox electrode for the rapid detection of glucose in aqueous media and a method for its use are provided. The redox electrode comprises an electrically conductive member such as copper, and a redox membrane in direct contact with said electrically cond... | 07/08/1997 |
| 5628890 | Electrochemical sensor An electrode strip for use in an electrochemical sensor for measuring a compound in a sample is provided, including an electrode support, a reference or counter electrode disposed on the support, a working electrode spaced from the reference or counter el... | 05/13/1997 |
| 5569591 | Analytical or monitoring apparatus and method Cellular biological material (such as living tissue) is analysed or monitored by applying an AC electrical potential across the biological material so as to produce a nonlinear dielectric spectrum, and obtaining a detectable signal corresponding to the re... | 10/29/1996 |
| 5553616 | Determination of concentrations of biological substances using raman spectroscopy and artificial neural network discriminator The concentration of a substance, such as glucose, in a biological sample, such as human tissue (e.g. the skin of an index finger) is non-invasively determined by directing the output beam of a laser diode onto and into the skin so as to cause Raman scatt... | 09/10/1996 |
| 5553613 | Non invasive blood analyte sensor A device for the non-invasive measurement of the concentration of a specific analyte, particularly glucose, in arterial blood flowing in a patient's body part, which device comprises a solid first portion having a surface profile adapted to be held agains... | 09/10/1996 |