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| Number | Title | Issue Date |
| 6434409 | Determination of glucose concentration in tissue The present invention concerns a method for determining and monitoring tissue glucose concentration. Additionally, the present invention concerns a measuring apparatus to determine and monitor glucose concentration.... | 08/13/2002 |
| 6418332 | Test plug and cable for a glucose monitor Methods and apparatuses for electrically connecting a medical glucose monitor to a glucose sensor set, as well as for testing the operation of the glucose monitor, monitor cable and glucose sensor set are provided. In one embodiment, an electric cable com... | 07/09/2002 |
| 6413393 | Sensor including UV-absorbing polymer and method of manufacture A sensor is provided that includes at least one functional coating layer that includes a UV-absorbing polymer. Methods for making the inventive sensors are also provided.... | 07/02/2002 |
| 6405066 | Implantable analyte sensor An implantable analyte sensor includes a substrate, electrodes on the substrate, and a membrane on the electrodes. The membrane can comprise elemental silicon and has a glucose diffusion test result of at least 1 mg/dl in 330 min., and an albumin diffusio... | 06/11/2002 |
| 6400974 | Implanted sensor processing system and method for processing implanted sensor output A quantitative measurement system includes an external unit and an internal unit are provided for obtaining quantitative analyte measurements, such as within the body. In one example of an application of the system, the internal unit would be implanted ei... | 06/04/2002 |
| 6370410 | Methods of producing an assembly for use in a monitoring device A chemical signal-impermeable mask is positioned in the electrolyte flow such that the mask is between a source of chemical signal and a working electrode which senses the chemical signal transported from the source (e.g., by diffusion). The configuration... | 04/09/2002 |
| 6366805 | Time frame synchronization of medical monitoring signals The present invention provides a system and method for establishing a synchronized time frame for signals in a medical monitoring system. In particular, the present invention provides a system and method for synchronizing the time frame of stimulation sig... | 04/02/2002 |
| 6363271 | Amniotic fluid alerting device A device for implantation on the cervix of a pregnant female that provides a means by which a female patient or her health caregiver is notified of the rupture of membranes by the release of amniotic fluid. The device comprises a housing manufactured from... | 03/26/2002 |
| 6360888 | Glucose sensor package system A glucose sensor package system that includes a glucose sensor and a protective package that indicates exposure to temperature changes to indicate proper temperature control. Also covered are methods of transporting and sterilizing the package. In additio... | 03/26/2002 |
| 6361951 | Electrochemical detection of nucleic acid hybridization A method of detecting a nucleic acid (e.g., DNA, RNA) that contains at least one preselected base (e.g., adenine, guanine, 6-mercaptoguanine, 8-oxo-guanine, and 8-oxo-adenine) comprises (a) reacting the nucleic acid with a transition metal complex capable... | 03/26/2002 |
| 6356776 | Device for monitoring of physiological analytes Methods and devices are provided for measuring the concentration of target chemical analytes present in a biological system. Device configuration and/or measurement techniques are employed in order to reduce the effect of interfering species on sensor sen... | 03/12/2002 |
| 6349230 | Blood measuring instrument A blood measuring instrument for measuring a specific component of blood. The instrument has a platelike chip (2) for sucking sampled blood, and a measuring instrument body (1) including a connector (3) into which the chip (2) is plugged. The chip (2) has... | 02/19/2002 |
| 6349229 | Body fluid testing device An examination system for bodily fluids includes a vessel-like examination unit having an opening, a sensor for examining the bodily fluids, and a bodily-fluids-oozing device. This system is further provided with a pump for decompressing the inside of the... | 02/19/2002 |
| 6346387 | Detection of binding reactions using labels detected by mediated catalytic electrochemistry A method of detecting binding interactions and target molecules, such as proteins, protein fragments, recombinant proteins, recombinant protein fragments, extracellular matrix proteins, ligands, carbohydrates, steroids, hormones, drugs, drug candidates, i... | 02/12/2002 |
| 6341232 | Methods of producing collection assemblies, laminates, and autosensor assemblies for use in transdermal sampling systems The invention relates generally to methods of producing consumable components of a device used for measuring the concentration of target chemical analytes present in a biological system. More particularly, the invention relates methods of producing collec... | 01/22/2002 |
| 6321101 | Method and device for determination of concentration In a method and a device for electrochemical determination of the concentration of at least one dissolved chemical entity in a liquid medium, a measurement voltage U is impressed on a working electrode, in contact with the liquid medium, relative to a cou... | 11/20/2001 |
| 6309350 | Pressure/temperature/monitor device for heart implantation A medical monitoring apparatus designed to be implanted in the vascular system is capable of sensing and transmitting via a telemetry link to an external monitor both pressure and temperature information. An internally or externally powered microcircuit c... | 10/30/2001 |
| 6309351 | Methods for monitoring a physiological analyte A method for continual monitoring of a physiologic analyte in a subject includes steps of contacting the subject with a collection reservoir such that the analyte can move from the subject into the collection reservoir, the contents of the collection rese... | 10/30/2001 |
| 6299578 | Methods for monitoring a physiological analyte A method for continual monitoring of a physiologic analyte in a subject includes steps of contacting the subject with a collection reservoir such that the analyte can move from the subject into the collection reservoir, the contents of the collection rese... | 10/09/2001 |
| 6287452 | Electrode for the electrochemical detection of nitric oxide Nitric oxide-specific electrodes are useful for in situ detection of nitric oxide in biomedical applications and have at least a surface region thereof which is capable of forming complexes with nitric oxide, for example, nitrosyl complexes. The nitric ox... | 09/11/2001 |
| 6284478 | Subcutaneous glucose electrode A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow "one-point" in vivo calibration, i.e., to have zero output current at zero glucose concentration, eve... | 09/04/2001 |
| 6280604 | Electrode materials, systems and methods for the electrochemical detection of nitric oxide Nitric oxide-specific electrodes are useful for in situ detection of nitric oxide in biomedical applications and have at least a surface region capable of forming complexes with nitric oxide. The nitric oxide complexes formed at the surface of the electro... | 08/28/2001 |
| 6275717 | Device and method of calibrating and testing a sensor for in vivo measurement of an analyte A method of calibrating an analyte sensor in vivo, by providing a first predetermined stimulus to the sensor when the sensor is applied to a subject to produce a first sensor signal, measuring the first sensor signal, and determining a calibration functio... | 08/14/2001 |
| 6272364 | Method and device for predicting physiological values A method and device are provided for measuring the concentration of target chemical analytes present in a biological system, and then predicting a future or past concentration of an analyte using a series of such measurements. One important application of... | 08/07/2001 |
| 6269261 | Health care instrument containing oxidation-reduction potential measuring function The invention aims to provide a health care instrument adapted to measure oxidation-reduction potential in human being, animal, fish and shellfish, plant, vegetable as well as water, air or earth surrounding those organisms and thereby to determine a leve... | 07/31/2001 |
| 6267722 | Point of care diagnostic systems Systems and methods for medical diagnosis or risk assessment for a patient are provided. These systems and methods are designed to be employed at the point of care, such as in emergency rooms and operating rooms, or in any situation in which a rapid and a... | 07/31/2001 |
| 6264615 | Method for diagnosing the presence and extent of halitosis activity A method and apparatus for diagnosing the presence and extent of halitosis activity are disclosed. A method includes assaying for the presence of sulfides on the surface of a subject's tongue in order to determine the concentrations of sulfides in the flu... | 07/24/2001 |
| 6259937 | Implantable substrate sensor An implantable substrate sensor has electronic circuitry and electrodes formed on opposite sides of a substrate. A protective coating covers the substrate, effectively hermetically sealing the electronic circuitry under the coating. Exposed areas of the e... | 07/10/2001 |
| 6236873 | Electrochemical sensor In a method and apparatus for eliminating the influence of double-layer capacitance in electrochemical measurements of the concentration of oxygen in blood using a working electrode, a reference electrode and a counter-electrode in contact with blood, a f... | 05/22/2001 |
| 6233471 | Signal processing for measurement of physiological analysis A method is provided for continually or continuously measuring the concentration of target chemical analytes present in a biological system, and processing analyte-specific signals to obtain a measurement value that is closely correlated with the concentr... | 05/15/2001 |
| 6224550 | Method for monitoring the level of an osmotically active component in body fluid and device for carrying out said method A method for monitoring changes in the level of an osmotically active component, such as for instance glucose, or in healthy humans, such as athletes for monitoring the level of lactic acid in the muscles is described. The key feature of the method is tha... | 05/01/2001 |
| 6216023 | Method and apparatus for determining differences between regional CO2 and systemic CO2 measurements Methods and apparatus for determining the difference between a regional CO2 partial pressure of a selected body organ of a mammalian subject, such as the gut, and a systemic CO2 partial pressure of the subject. The regional CO2 | 04/10/2001 |
| 6212416 | Device for monitoring changes in analyte concentration The invention provides an electrochemical sensor system for measuring analyte concentrations in a fluid sample. The invention is particularly useful for measuring analytes such as glucose in a patient. An implantable glucose sensor includes a disc-shaped ... | 04/03/2001 |
| 6210326 | Microsensor for determination of glucose and other analysis in liquids based on affinity viscosimetry A microsensor for the determination of glucose and other analytes in liquids, based on affinity viscosimetry. The sensor based on affinity viscosimetry with stable working properties can be sufficiently minaturized for implantation in the organism. The se... | 04/03/2001 |
| 6212417 | Biosensor A highly reliable biosensor is provided which is reduced in influences of any interfering substance or preexisting oxygen in a sample solution. The biosensor comprises an electrode system including a working electrode, a counter electrode and a third elec... | 04/03/2001 |
| 6201980 | Implantable medical sensor system An implantable chemical sensor system for medical applications is described which permits selective recognition of an analyte using an expandable biocompatible sensor, such as a polymer, that undergoes a dimensional change in the presence of the analyte. ... | 03/13/2001 |
| 6201979 | Chemical signal-impermeable mask A chemical signal-impermeable mask is positioned in the electrolyte flow such that the mask is between a source of chemical signal and a working electrode which senses the chemical signal transported from the source (e.g., by diffusion). The configuration... | 03/13/2001 |
| 6198954 | Urine sugar detecting device and method of fabricating the same A urine sugar detecting device including (a) a urine sugar sensor including a contact electrode and a cover film covering the contact electrode therewith, (b) a cartridge encasing the urine sugar sensor in fluid tight except the contact electrode, and (c)... | 03/06/2001 |
| 6198953 | Method and system for continuous sweat collection and analysis The method and system of the invention provide especially for continuously obtaining and analyzing, on a real time basis, sweat from a selected area of skin on the body of a person, especially a neonate, being diagnosed for cystic fibrosis, by causing swe... | 03/06/2001 |
| 6186946 | Urinalysis stick for animals A urinalysis stick for animals comprising a chemical reaction agent at an end, a color sample showing the discoloration stage at a rear end, and a half cut portion or a half fold portion provided in the middle of the stick for tearing off or folding the s... | 02/13/2001 |
