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| Number | Title | Issue Date |
| 8140141 | Devices and methods for fluorescent inspection and/or removal of material in a sample An apparatus is provided that includes a light-emitting component, a light-detecting component, a lock-in amplifier, a frequency generator that is operatively linked to the lock-in amplifier and the light-emitting component, a speaker capable of emitting an audio si... | 03/20/2012 |
| 8082016 | Measurement of cardiac output and blood volume by non-invasive detection of indicator dilution A system for evaluating the cardiovascular system parameters using indicator dilution and non-invasive or minimally invasive detection and calibration methods are disclosed. Intravascular indicators are stimulated, and emissions patterns detected for computation of ... | 12/20/2011 |
| 7966051 | Fluorescent agent concentration measuring apparatus, dose control apparatus, administration system, fluorescent agent concentration measuring method, and dose control method A fluorescent agent accumulation concentration measuring apparatus is configured to include a single-wavelength LED to radiate excitation light to a test bottle loaded in the inside, a barrier filter to transmit only fluorescence from the test bottle, a photorecepto... | 06/21/2011 |
| 7873398 | Saccharide-measuring fluorescent monomer, saccharide-measuring fluorescent sensor substance, and implantable, saccharide-measuring sensor A saccharide-measuring fluorescence sensor substance including a copolymer of at least the following two compounds (I) and (II) is provided: (I) a fluorescent monomer compound represented by the following formula (1): formula (1) | 01/18/2011 |
| 7792561 | Fiber optic device for sensing analytes A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. An optical conduit, preferably an optical fiber has an optical system at the proximal end of the optical conduit. A sensing element is attached to ... | 09/07/2010 |
| 7751863 | Optical determination of ph and glucose Embodiments of the present invention are directed to an optical sensor capable of measuring two analytes simultaneously with a single indicator system. In preferred embodiments, the sensor comprises a fluorescent dye having acid and base forms that facilitate ratiom... | 07/06/2010 |
| 7590437 | Measurement of cardiac output and blood volume by non-invasive detection of indicator dilution A system for evaluating the cardiovascular system parameters using indicator dilution and non-invasive or minimally invasive detection methods is disclosed. Intravascular indicators are stimulated, and emissions patterns detected for computation of cardiac output, c... | 09/15/2009 |
| 7496392 | Fiber optic device for sensing analytes A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is described. An optical conduit, preferably an optical fiber, has an optical system at the proximal end of the optical conduit. A sensing element is attached to... | 02/24/2009 |
| 7474906 | Method for dye injection for the transcutaneous measurement of cardiac output A system for evaluating the cardiovascular system parameters using indicator dilution and non-invasive or minimally invasive detection and calibration methods are disclosed. Intravascular indicators are stimulated, and emissions patterns detected for computation of ... | 01/06/2009 |
| 7450980 | Intracorporeal substance measuring assembly An intracorporeal substance measuring assembly to be provided in an embedded-type substance sensor for detecting and measuring an intercorporeal analyte includes: a detection layer containing at least one fluorescent indicator for generating fluorescence according t... | 11/11/2008 |
| 7417164 | Fluorescent dyes for use in glucose sensing A novel class of compounds that includes HPTS-Cys-MA, and methods of making them are disclosed herein. The class of compounds including HPTS-Cys-MA are useful as fluorescent dyes for analyte detection. ... | 08/26/2008 |
| 7402426 | Detection of biological molecules by differential partitioning of enzyme substrates and products This invention relates to a method and apparatus for detecting a biological molecule associated with enzyme activity in a sample. The invention is applicable to detecting a microorganism associated with an enzyme in a sample such as water, food, soil, or a biologica... | 07/22/2008 |
| 7368085 | Analyte detector An analyte detector including a device having a surface, wherein the device is capable of detecting a charge adjacent to the surface. The surface includes a plurality of molecules bonded thereto, wherein the molecules have a structure (I): | 05/06/2008 |
| 7365844 | Vision enhancement system for improved detection of epithelial neoplasia and other conditions Systems and methods for diagnosing epithelial neoplasia and other conditions includes, in a representative embodiment, providing the human eyes with a filter to observe the autofluorescence of a tissue sample. Using optimized wavelengths from a filtered light source... | 04/29/2008 |
| 7338778 | Luminescent method for determining cell oxygen consumption The present invention relates to methods for detection and evaluation of metabolic activity of eukaryotic and/or prokaryotic cells based upon their ability to consume dissolved oxygen. The methods utilize a luminescence detection system which makes use of the sensit... | 03/04/2008 |
| 7335259 | Growth of single crystal nanowires The present invention provides nanowires which are substantially straight and substantially free of nanoparticles and methods for making the same The nanowires can be made by seeded approaches, wherein nanocrystals bound to a substrate are used to promote growth of ... | 02/26/2008 |
| 7330120 | Remote measurement of motion employing RFID A system and method for making measurements using and RFID system includes a transceiver, a transponder and a sensor configured within the transponder. The transceiver is configured to send and receive radio frequency signals. The transponder is configured to receiv... | 02/12/2008 |
| 7328059 | Imaging of light scattering tissues with fluorescent contrast agents A system and method for non-invasive biomedical optical imaging and spectroscopy with low-level light is described. The technique includes a modulated light source coupled to tissue to introduce excitation light. Fluorescent light emitted in response to the excitati... | 02/05/2008 |
| 7320675 | Method and apparatus for modulating cellular metabolism during post-ischemia or heart failure A drug delivery system detects a cardiac condition indicative of a need for increasing a cardiac metabolic level and, in response, releases a drug into tissue or blood to shift a source of metabolically synthesized energy fueling cardiac contraction from fatty acid ... | 01/22/2008 |
| 7321791 | Spectral imaging of deep tissue Apparatus and methods are provided for the imaging of structures in deep tissue within biological specimens, using spectral imaging to provide highly sensitive detection. By acquiring data that provides a plurality of images of the sample with different spectral wei... | 01/22/2008 |
| 7316700 | Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties A lancing device, an embodiment of which controls the advancement and retraction of a lancet by monitoring the position of the lancet in conjunction with a lancet controller which incorporates a feedback loop for modulating the lancet driver to follow a predetermine... | 01/08/2008 |
| 7315752 | Method and device for determining a light transport parameter in a biological matrix A method for the selective determination of the scattering index μs of a scattering biological matrix, in particular for the purpose of non-invasive determination of the concentration of glucose in the skin, by means of detection measurements, in each of... | 01/01/2008 |
| 7309867 | Methods and apparatus for characterization of tissue samples The invention provides methods for determining the probability that a given region of a tissue sample contains tissue of a given category, such as CIN 1 (cervical intraepithelial neoplasia, grade 1), CIN 2/3 (cervical intraepithelial neoplasia grades 2 and/or 3), no... | 12/18/2007 |
| 7302289 | Readable probe array for use A disposable high density optically readable polydeoxynucleotide array with integral fluorescence excitation and fluorescence emission channels is described. The compact array size allows integration into several types of interventional devices such as catheters, gu... | 11/27/2007 |
| 7289835 | Multivariate analysis of green to ultraviolet spectra of cell and tissue samples This invention relates to methods for processing in vivo skin auto-fluorescence spectra for determining blood glucose levels. The invention also relates to methods of classifying cells or tissue samples or quantifying a component of a cell or tissue using a multivar... | 10/30/2007 |
| 7289836 | Optical-based sensing devices An optical-based sensor for detecting the presence or amount of an analyte using both indicator and reference channels. The sensor has a sensor body with a source of radiation embedded therein. Radiation emitted by the source interacts with indicator membrane indica... | 10/30/2007 |
| 7286224 | Time-multiplexed scanning light source for multi-probe, multi-laser fluorescence detection systems An apparatus images a surface. An imager stage linearly translates the surface in a first direction. A light path has a first end defining an input aperture perpendicular to the first direction and parallel to the surface, and a second end defining an output apertur... | 10/23/2007 |
| 7282723 | Methods and apparatus for processing spectral data for use in tissue characterization The invention provides methods for processing tissue-derived spectral data for use in a tissue classification algorithm. Methods of the invention comprise application of spectral and/or image masks for automatically separating ambiguous or unclassifiable spectral da... | 10/16/2007 |
| 7277210 | Measuring spectral lines from an analyte using multiplexed holograms and polarization manipulation An optical apparatus in which multiplexed holograms are used to achieve wavelength selectivity and polarization manipulation is used to facilitate near-normal incidence of light on the holograms. The polarization manipulation allows light reflected from the hologram... | 10/02/2007 |
| 7267648 | Magnifying image pickup unit for an endoscope, an endoscope for in vivo cellular observation that uses it, and endoscopic, in vivo cellular observation methods An endoscope observation system for in vivo cellular observation is disclosed that includes an illumination optical system having a light source for supplying illumination light to an object, an objective optical system that forms a magnified image of the object suc... | 09/11/2007 |
| 7266401 | Measuring analytes from an electromagnetic spectrum using a wavelength router Weak signals scattered from analytes at multiple wavelengths can be summed to illuminate either a single detector or a multiplicity of detectors, offering the possibility of concentrating the spectral energy on a smaller total detector area. In addition, a method is... | 09/04/2007 |
| 7260248 | Image processing using measures of similarity The invention provides methods of relating a plurality of images based on measures of similarity. The methods of the invention are useful in the segmentation of a sequence of colposcopic images of tissue, for example. The methods may be applied in the determination ... | 08/21/2007 |
| 7257439 | Brain-machine interface systems and methods A system and method for interfacing a brain with a machine. An exemplary embodiment of the present invention employs a vascular approach in which one or more nano-electrodes are deployed in vasculature having a close geometric relationship with proximal innervation.... | 08/14/2007 |
| 7248908 | Method for measuring the concentration of a substance in a living body and device for measuring the same concentration A fluorescence indicator is injected into a living body from a container via an injecting inlet to be chemically reacted with a substance in the living body. Then, an excitation light is irradiated to the living body from an excitation light source. Then, the thus o... | 07/24/2007 |
| 7248182 | Measurement system having at least one replaceable sensor A measurement system having an analyzer unit (2; 102) and at least one replaceable sensor (1; 101). Each sensor has a transponder (13) in which sensor-specific data is stored. The analyzer unit has an antenna (21) for wireless readout of ... | 07/24/2007 |
| 7248906 | Method and device for monitoring analyte concentration by optical detection A method and device are provided for the determination of the concentration of compounds in body tissue. The method utilises optical methods based on the interaction of light with compounds, whereby the concentration of the compound under analysis is determined. The... | 07/24/2007 |
| 7244232 | Process for identifying cancerous and/or metastatic cells of a living organism A process for identifying and treating cells in a living organism. The cells are labeled, circulated within the organism, detected with an implanted detector, and then either isolated or ablated. ... | 07/17/2007 |
| 7239287 | Wireless communication device having conductive elements antenna An antenna coupled to a wireless communication device that is comprised of a series of conductive elements that form a conductor when placed under a force. The conductor is coupled to a wireless communication device to provide an antenna so that the wireless communi... | 07/03/2007 |
| 7238371 | Triggered release from proteinoid microspheres The invention provides proteinoid microsphere made up of a mixture of thermally condensed amino acids that are crosslinked with a bis dithiol crosslinker reagent. The proteinoid microspheres of the invention may be used to encapsulate a material or a compound and to... | 07/03/2007 |
| 7239916 | Method and apparatus for automatic implantable medical lead recognition and configuration An automated identification and configuration system for use with an implantable medical device (IMD) is disclosed. The system includes a first communication circuit that is attached to, or otherwise carried by, a detachable component associated with the IMD such as... | 07/03/2007 |
