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Felix Hoffmann, a German chemist, was searching for something to relieve his father's arthritis. In doing so, he "rediscovered" acetylsalicylic acid and in 1900, patented a stable process for developing it. Hence, we have aspirin.
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| Number | Title | Issue Date |
| 7388110 | Saccharide-measuring fluorescent monomer, saccharide-measuring fluorescent sensor substance, and implantable, saccharide-measuring sensor A fluorescent monomer compound represented by the following formula (1) is provided: wherein Q, Q′ and D3 may be the same or different, may be combined together into a fused ring, and are each a substituent sel... | 06/17/2008 |
| 7371247 | Method and apparatus for penetrating tissue A tissue penetrating system includes a plurality of penetrating members each having a tip. A penetrating member driver is coupled to the plurality of penetrating members. Each tip of a penetrating member is uncovered during launch of the penetrating member by the pe... | 05/13/2008 |
| 7331931 | Method and apparatus for penetrating tissue These and other objects of the present invention are achieved in a body fluid sampling system for use on a tissue site that includes an electrically powered drive force generator. A penetrating member is operatively coupled to the force generator. The force generato... | 02/19/2008 |
| 7324674 | Image processing device for fluorescence observation An image processing device having a very straightforward construction, for obtaining an image in which normal tissue and diseased tissue are easy to identify, comprises: an image synthesizing section that generates a synthesized image by synthesizing an image signal... | 01/29/2008 |
| 7316700 | Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties A lancing device, an embodiment of which controls the advancement and retraction of a lancet by monitoring the position of the lancet in conjunction with a lancet controller which incorporates a feedback loop for modulating the lancet driver to follow a predetermine... | 01/08/2008 |
| 7291117 | Method and apparatus for penetrating tissue These and other objects of the present invention are achieved in a body fluid sampling system for use on a tissue site that includes a voice coil based penetrating member driver. A plurality of penetrating members are included. A transport mechanism is configured to... | 11/06/2007 |
| 7258693 | Device and method for variable speed lancet A method of penetrating tissue is provided. The method comprises using a lancet driver to advance a lancet into the tissue; advancing the lancet at a first desired velocity in a first layer of tissue; advancing the lancet at a second desired velocity in a second lay... | 08/21/2007 |
| 7244265 | Method and apparatus for penetrating tissue These and other objects of the present invention are achieved in a body fluid sampling system for use on a tissue site that includes a drive force generator and a penetrating member operatively coupled to the force generator. The force generator moves the member alo... | 07/17/2007 |
| 7232451 | Method and apparatus for penetrating tissue A skin penetrating system has a housing member and a plurality of penetrating members positioned in the housing member. A tissue stabilizing device is coupled to the housing member. A user interface is configured to relay at least one of, skin penetrating performanc... | 06/19/2007 |
| 7229458 | Method and apparatus for penetrating tissue A tissue penetrating system includes a plurality of cartridges each with a distal port and a proximal port. A plurality of penetrating members are provided, each coupled to a cartridge and having a sharpened distal tip and a shaft portion slidably disposed within th... | 06/12/2007 |
| 7226461 | Method and apparatus for a multi-use body fluid sampling device with sterility barrier release A device for use with a gripper is provided. A cartridge is provided that defines a plurality of cavities. A plurality of penetrating members are at least partially contained in the cavities of the cartridge. The penetrating members are slidably movable to extend ou... | 06/05/2007 |
| 7203548 | Cavernous nerve stimulation via unidirectional propagation of action potentials Methods of using unidirectionally propagating action potentials (UPAPs) for cavernous nerve stimulation and for certain disorders are provided. Stimulators capable of creating such UPAPs include, but are not limited to, miniature implantable stimulators (i.e., micro... | 04/10/2007 |
| 7198606 | Method and apparatus for a multi-use body fluid sampling device with analyte sensing A device for use with a penetrating member driver to penetrate tissue is provided. A plurality of penetrating members are coupled to a single cartridge and are operatively couplable to the penetrating member driver. The penetrating members are movable to extend radi... | 04/03/2007 |
| 7182509 | Nanoliter osmometer and method of operation The invention is an apparatus for determining a temperature at which a phase change occurs in a fluid sample, a method for measuring a temperature at which a phase change occurs in a sample and a sample cell. An apparatus for determining a temperature at which a pha... | 02/27/2007 |
| 7081128 | Phototherapy device and method of use A device is provided, in direct skin contact, surrounding an injured area for the treatment, reduction of joint inflammation, edema and excitation of neural and muscular stimulation associated with human and mammal tissues. This therapeutic light source includes a m... | 07/25/2006 |
| 7041068 | Sampling module device and method A tissue penetration device and method of using same that may include a lancet module or sampling module. The sampling module may optionally be in a cartridge configuration and include sampling and analyzing functions, which may be integrated. ... | 05/09/2006 |
| 7025774 | Tissue penetration device A tissue penetration device and method of using same. The tissue penetration device may optionally include sampling and analyzing functions, which may be integrated. An embodiment provides control of a lancet used for sampling blood. Electric field coils or solenoid... | 04/11/2006 |
| 6927843 | Non-invasive measurement of skin bilirubin level The invention concerns a method and a device for non-invasive measurement of a tissue and in particular of the skin bilirubin level. The inventive device is characterized in that it comprises: a reading head (1) capable of sending several flashes of various s... | 08/09/2005 |
| 6882873 | Method and system for determining bilirubin concentration A system and method embodying the invention can be used to detect a characteristic or condition of a patient. A method embodying the invention may include the steps of illuminating a portion of a skin of the patient with light, detecting a frequency spectrum of ligh... | 04/19/2005 |
| 6852500 | Method for determining the concentration of glucose in a body fluid with glucose-containing perfusate The invention concerns a method and an arrangement for determining the concentration of glucose in a body fluid. In the microdialysis technology used for this purpose, perfusate containing glucose is transported in intermittent delivery pulses through a microdialysi... | 02/08/2005 |
| 6847835 | Transcutaneous bilirubin concentration measuring apparatus and a measurement data checking plate for use with the same Luminous fluxes from a xenon tube are introduced from one end of an optical fiber to an other end thereof and emerge therefrom. These luminous fluxes are incident of a skin of a person to be measured, and those diffused in the skin are incident on one end of an opti... | 01/25/2005 |
| 6596016 | Phototherapy of jaundiced newborns using garments containing semiconductor light-emitting devices A phototherapy garment contains a flexible backing material, a transparent liner, and a flexible printed circuit sheet containing surface-mounted light-emitting diodes (LEDs) positioned between the backing material and the liner. An infant is placed insid... | 07/22/2003 |
| 6192734 | Disposable calibration target A combined infection shield and calibration or reference target for use with a measuring instrument includes a removable calibration/reference layer. The removable calibration/reference layer has predetermined optical characteristics that can be utilized ... | 02/27/2001 |
| 6129664 | Method and apparatus for detecting and measuring conditions affecting color A method and apparatus for determining the condition of a test subject based on color uses a color measuring instrument to detect change in a color factor indicative of a condition such as a disease, spoilage, ageing, etc. A medical condition such as bili... | 10/10/2000 |
| 6128516 | Method and apparatus for detecting and measuring conditions affecting color A method and apparatus for determining the condition of a test subject based on color uses a color measuring instrument to detect change in a color factor indicative of a condition such as a disease, spoilage, ageing, etc. A medical condition such as bili... | 10/03/2000 |
| 6045502 | Analyzing system with disposable calibration device A system and method for calibrating a measurement instrument prior to making a measurement on a material or tissue includes utilizing a removable calibration device to calibrate the instrument, then removing a target portion of the calibration device so t... | 04/04/2000 |
| 5933226 | Attachment for a concentration measuring apparatus and a concentration measuring system An attachment is designed such that a concentration measuring apparatus is attachable to and detachable from it. Inside the leading end portion of the attachment, leading ends of two light guide members are provided opposite to each other so as to hold a ... | 08/03/1999 |
| 5924981 | Disposable calibration target A combined infection shield and calibration or reference target for use with a measuring instrument includes a removable calibration/reference layer. The removable calibration/reference layer has predetermined optical characteristics that can be utilized ... | 07/20/1999 |
| 5820556 | Method and apparatus for primarily ambulatory gastrointestinal registration A method for a preferably ambulatory measuring and registration of at least one parameter in relation to the bilirubin presence in a measuring region in the gastrointestinal tract of a patient to determine the bilirubin presence in the region. The method ... | 10/13/1998 |
| 5353790 | Method and apparatus for optical measurement of bilirubin in tissue A method and apparatus for the determination of bilirubin concentration in tissue such as skin, particularly neonatal skin. Light reflected from the skin under test is analyzed to determine bilirubin concentration in the skin, corrected for maturity-depen... | 10/11/1994 |
| 5259382 | Optical transcutaneous bilirubin detector A transcutaneous bilirubin detector comprising a source of light having spectral components absorbable and not absorbable by bilirubin, a handle assembly, electronic circuitry and a fiber optic bundle connecting the assembly to the light source and circui... | 11/09/1993 |
| 4267844 | Medical instrument for determining jaundice An electro-optical medical instrument is provided for measuring the presence of bilirubin in skin tissue. The instrument is preferably hand-held and self-contained and utilizes a source of flash light to provide sufficient energy in the desired wavelength... | 05/19/1981 |
| 4029085 | Method for determining bilirubin concentration from skin reflectance A method is disclosed for determining the bilirubin concentration in the blood serum of a person from measurement of the spectral reflectance of the skin. The disclosed method detects the severity of jaundice, a common neonatal condition, and enables dete... | 06/14/1977 |
