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Class 568/819 - Bicyclo ring system


Subclass of Class 568 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the polycyclo ring system consists of
No. of patents: 129
Last issue date: 11/16/2010


1        
NumberTitleIssue Date
7834222Process for the preparation of bicyclo[3.1.0]hexanols
A process for the preparation of a the formula (I): which process comprises the intramolecular cyclopropanation of an epoxide of me formula (II); in the presence of 0.05 to 0.75 equivalents of a secondary amine base and at least one equivalent of an alkyl lithium ba...
11/16/2010
7829746Process for the preparation of calcipotriol
A process for the preparation of calcipotriol at least including: (a) reacting a C-22 phenylsulfonyl derivative of cholecalciferol of Formula 2, wherein R1 and R2 are the same or different and represent hydroxyl protecting groups, with a silyl ...
11/09/2010
7786331Fragrance composition
A method of making a decalin alcohol; the alcohol is applied as a component in a fragrance composition containing 0.0005 to 10% by mass as component (a), represented by formula (1a), and 90 to 99.9995% by mass of one or more polycyclic woody-amber fragrances as comp...
08/31/2010
7645911Process for preparation of paricalcitol and intermediates thereof
The invention relates to a novel process for the preparation of Paricalcitol and intermediates thereof. ...
01/12/2010
7488854Diterpenoid compounds imparting stress resistance to plants
The present invention provites a compound having the following structure: wherein, in the formula: X is selected from the group consisting of hydroxy, substituted hydroxy, halogen, ...
02/10/2009
7375062Substituted hydrogenated naphthalene derivatives and their use in fragrance formulations
The present invention is directed to novel compounds of the general formula wherein R is selected from the group consisting of hydrogen, a straight, branched or cyc...
05/20/2008
7112700Efficient and economic asymmetric synthesis of nootkatone, tetrahydronootkatone, their precursors and derivatives
An inexpensive, stereoselective synthesis for nootkatone, tetrahydronootkatone, and their derivatives is disclosed. The starting materials used in the synthesis are inexpensive. The principal starting material, (−)-β-Pinene, is on the GRAS list (generally recogni...
09/26/2006
7105500Process for the antimicrobial treatment of fiber materials
A process for the antimicrobial treatment of fiber materials, comprising applying to the fiber material an inclusion complex of a fiber-reactive cyclodextrin derivative with an antimicrobial agent selected from the group consisting of (a) halogeno-o-hydroxydiphenyl ...
09/12/2006
7071366Processes for obtaining (-)-guaiol and the use thereof
A process for obtaining oils of sesquiterpenes and sesquilactones and (−)-guaiol from the oil of Callitris intratropica, processes for encapsulation of the oil from Callitris intratropica, and the various uses of the oil and the encapsulated oil are ...
07/04/2006
6921842Hydrogenated aromatic oligomers and process for preparing the same
The hydrogenated aromatic oligomer of this invention is represented by the following formula (1) (A-F)n-A  (1) (wherein A is a segment comprising mainly a polycyclic aromatic compound, a phenol and at least partly hydrogenated prod...
07/26/2005
6867335Uncatalysed addition reactions
The present invention relates to process wherein (+)-2-carene epoxide is coupled with a compound X—Y that contains nucleophilic and electrophilic moieties, to produce a compound of formula (5). The reaction mixture consists essentially of a source of (+)-2-carene ...
03/15/2005
6717017Total synthesis of antitumor acylfulvenes
The present invention provides a method of synthesizing compounds of formula (I) or (II): wherein R1 is hydrogen, R′ is (C1-C4)alkyl and X is a hydroxyl protecting group. ...
04/06/2004
6642424Intermediates and improved processes for the preparation of neplanocin A
Intermediate compounds, including 2-(t-butyldimethylsilyloxymethyl)-3,4-[(dimethylmethylene)dioxy]-5-hydroxy -tricyclo[5.2.1.02,6 ]dec-8-ene, which are useful for the synthesis of neplanocin A having strong antitumor activity. Improved processes...
11/04/2003
6548715Structural analogues of vitamin D
A compound of the formula I: ##STR1## in which P is hydrogen or alkyl; Y and Y' are each hydrogen or, when taken together, represent a group .dbd.CH2 ; W and W' are each hydrogen; X is selected from the group consisting of a hydroxyalkyl, a hydroxya...
04/15/2003
6245952Reduction of carbonyl compounds by a silane in the presence of a zinc catalyst
The present invention relates to a process for the preparation of alcohols by reduction of the carbonyl function in substrates belonging to the class of aldehydes, ketones, esters or lactones, which substrates may contain unsaturated functions other than ...
06/12/2001
6214888Dermatological compounds
The present invention relates to novel monocyclic and bicyclic monoterpene diols that stimulate melanogenesis in mammalian skin, hair, wool or fur, and, are useful for treating or preventing various skin and proliferative disorders, neurodegenerative dise...
04/10/2001
6177586Vitamin D3 derivative and production process thereof
The starting materials for a production process of a vitamin D3 derivative are disclosed, e.g., a cyclopentene derivative represented by the formula (1-2): ##STR1## wherein R11 is a hydrogen atom, tri(C1 to C
01/23/2001
6160184Total synthesis of antitumor acylfulvenes
The present invention provides a method of synthesizing compounds of ##STR1## wherein R and R' are independently (C1 -C4)alkyl....
12/12/2000
6156935Chiral phosphorus-based ligands
A chiral phosphorus-based ligand, in single enantiomer form, which is capable of complexing a transition metal atom and of acting as a ligand in asymmetric chemical catalysts, which comprises the partial structure R1 R2 P--O--C--X--Y--C--...
12/05/2000
5929291Odorants
The invention relates to compounds of the general formula ##STR1## in which R1 to R7 are, independently, H, methyl or ethyl, R8 +R9 together form methylene (--CH2 --) or a single bond, or R1...
07/27/1999
5917096Process for the preparation of ଲ-caryophyllene alcohol
The present invention discloses a new process for the preparation of ଲ-caryophyllene alcohol, in which the sesquiterpene fraction at 110-120° C./6 mmHg in Chinese pinus massoniana oleoresin composition undergoes isomerization in the presence of sul...
06/29/1999
5905074Vitamin D derivative
A compound of the formula ##STR1## useful for treating vitamin D dependent disorders....
05/18/1999
5847226Process for the preparation of nootkatone
A method for preparing nootkatone, nootkatol or mixtures thereof by oxidizing valencene, wherein the valencene is exposed to an oxygenated atmosphere in a suitable reaction medium and in the presence of an unsaturated fatty acid hydroperoxide, and the noo...
12/08/1998
5733866Methyl substituted hexahydroindanols and alkyl ethers thereof, organoleptic uses thereof, processes for preparing same and process intermediates therefor
Described are methyl substituted hexahydroindanols and alkyl ethers thereof defined according to the generic structure: ##STR1## wherein R7 represents hydrogen or C1 -C3 alkyl; wherein R1 represents methyl ...
03/31/1998
5723632Total synthesis of antitumor acylfulvenes
The present invention provides a method of synthesizing compounds of formula (I): ##STR1## wherein R and R' are independently (C1 -C4)alkyl....
03/03/1998
5597932Intermediate for the preparation of 19-nor vitamin D compounds
The invention is drawn to a compound having the following formula ##STR1## in which X1 and X2, which may be the same or different, represent hydrogen or a hydroxy-protecting group, X4 is hydrogen, A is selected from -...
01/28/1997
5581004Preparation and use of (2-butene-1,4-diyl) magnesium complexes in organic synthesis
The magnesium complexes of cyclic hydrocarbons and conjugated dienes, such as 1,2-dimethylenecycloalkanes and 1,3-butadienes, are readily prepared in high yields using highly reactive magnesium. Reactions of these (2-butene-1,4-diyl)magnesium reagents wit...
12/03/1996
5574196Process for preparing alkanols
A process for preparing tertiary alkanols which comprises the step of oxidizing with ozone a saturated hydrocarbon having a tertiary carbon center in the presence of a carboxylic acid and for a sufficient period of time and at suitable temperature and pre...
11/12/1996
5525745Intermediates in the preparation of 19-nor vitamin D compounds
The invention describes intermediates for use in the synthesis of 1଱-hydroxy-19-nor-vitamin D compounds. The intermediates have the following formula: ##STR1## The disclosed process includes (a) the construction of a 5,8-diol-6-yne interme...
06/11/1996
5508392Use of vitamin D glycosides, vitamin D orthoester glycosides, vitamin D analog glycosides and vitamin D analog orthoester glycosides for the treatment of osteoporosis
The present invention relates to methods for the treatment of prevention of osteoporosis by the administration of a vitamin D glycoside or vitamin D orthoester glycoside, or an analog thereof....
04/16/1996
5498734Preparation and use of (2-butene-1,4-diyl)magnesium complexes in organic synthesis
The magnesium complexes of cyclic hydrocarbons containing conjugated dienes, such as 1,2-dimethylenecycloalkanes, and 1,3-butadienes, are readily prepared in high yields using highly reactive magnesium. Reactions of these (2-butene-1,4 diyl)magnesium reag...
03/12/1996
5457245Process for preparation of calcitriol lactone and related intermediates
A process for synthesizing (23S,25R)-calcitriol lactone and related Vitamin D analogs comprises reacting protected enantiomerically pure glycidol or 2-alkylglycidol with protected De-A,B-8ଲ-hydroxy-24-nor-cholan-23-al, removing the protective groups...
10/10/1995
5430196Preparation of 19-nor vitamin D compounds
A synthesis of 1଱-hydroxy-19-nor-vitamin D compounds comprises (a) the construction of a 5,8-diol-6-yne intermediate by joining ring-A and ring-C/D portions of the desired end product via the condensation of an acetylenic derivative containing the C...
07/04/1995
5422365Naphthalene compounds
A compound selected from those of formula (I): ##STR1## wherein: R1, R'1 and R2 are each selected, independently of the others, from hydrogen and an alkyl radical, the two R2 groups being in the cis positio...
06/06/1995
5420366Process for the preparation of optically active 2-arylcyclohexanols
The present invention provides a process for preparing optically active 2-arylcyclohexanol and its esters and ethers and which process comprises the step of subjecting 1-aryl-cyclohexane-1,2 diol and its diethers and diesters to hydrogenolysis conditions ...
05/30/1995
5405870Carbacyclin compounds; pharmaceutical compositions and method of use
Compounds of formula (Ic): ##STR1## having valuable platelet-aggregation inhibitory activities useful for the prophylaxis and treatment of such diseases as thrombosis and pharmaceutical compositions containing said compounds....
04/11/1995
5399587Biologically active compounds
The present invention relates to novel potassium channel agonists which are useful in activating the calcium activated Maxi-K potassium channel in mammalian neuronal and smooth muscle tissue. The claimed compounds are of the general formula: ##STR1##...
03/21/1995
5292971Flourine-substituted vicinal and method for their preparation, and their use
Fluorine-substituted vicinal glycols of the formula ##STR1## in which the substituents R1 to R4, independently of one another, have the following meanings: R1 to R4 =H, fluorine, C1 - to C18...
03/08/1994
52833451ଲ,7,8-trihydroxy vitamin D2, 1.smallcircle.,7,8-trihydroxy vitamin D3 and their derivatives and method of manufacturing these chemicals
There are disclosed novel compounds that can be used to derive therefrom a fragment that corresponds to an A-ring which is to be comined with fragments which respectively correspond to C- and D-rings in synthetic formation of vitamin D3 derivat...
02/01/1994
5241089Polyhydrodimethylnaphthalene spirofuran derivatives, organoleptic uses thereof and process for preparing same
Described are polyhydrodimethylnaphthalene spirofuran derivatives defined according to the generic structure: ##STR1## wherein the dashed line represents a carbon-carbon single bond or a carbon-carbon double bond a process for preparing same and uses...
08/31/1993
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