3M employee and church chorister Art Fry needed something to temporarily mark pages in his hymnal. He was in luck because his colleague, Spencer Silver, accidentally developed a glue that was too weak for other purposes. After initially discouraging consumer response, Post-it Notes became a hit in 1979.
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| Number | Title | Issue Date |
| 7834222 | Process for the preparation of bicyclo[3.1.0]hexanols A process for the preparation of a the formula (I): which process comprises the intramolecular cyclopropanation of an epoxide of me formula (II); in the presence of 0.05 to 0.75 equivalents of a secondary amine base and at least one equivalent of an alkyl lithium ba... | 11/16/2010 |
| 7829746 | Process for the preparation of calcipotriol A process for the preparation of calcipotriol at least including: (a) reacting a C-22 phenylsulfonyl derivative of cholecalciferol of Formula 2, wherein R1 and R2 are the same or different and represent hydroxyl protecting groups, with a silyl ... | 11/09/2010 |
| 7786331 | Fragrance composition A method of making a decalin alcohol; the alcohol is applied as a component in a fragrance composition containing 0.0005 to 10% by mass as component (a), represented by formula (1a), and 90 to 99.9995% by mass of one or more polycyclic woody-amber fragrances as comp... | 08/31/2010 |
| 7645911 | Process for preparation of paricalcitol and intermediates thereof The invention relates to a novel process for the preparation of Paricalcitol and intermediates thereof. ... | 01/12/2010 |
| 7488854 | Diterpenoid compounds imparting stress resistance to plants The present invention provites a compound having the following structure: wherein, in the formula: X is selected from the group consisting of hydroxy, substituted hydroxy, halogen, ... | 02/10/2009 |
| 7375062 | Substituted hydrogenated naphthalene derivatives and their use in fragrance formulations The present invention is directed to novel compounds of the general formula wherein R is selected from the group consisting of hydrogen, a straight, branched or cyc... | 05/20/2008 |
| 7112700 | Efficient and economic asymmetric synthesis of nootkatone, tetrahydronootkatone, their precursors and derivatives An inexpensive, stereoselective synthesis for nootkatone, tetrahydronootkatone, and their derivatives is disclosed. The starting materials used in the synthesis are inexpensive. The principal starting material, (−)-β-Pinene, is on the GRAS list (generally recogni... | 09/26/2006 |
| 7105500 | Process for the antimicrobial treatment of fiber materials A process for the antimicrobial treatment of fiber materials, comprising applying to the fiber material an inclusion complex of a fiber-reactive cyclodextrin derivative with an antimicrobial agent selected from the group consisting of (a) halogeno-o-hydroxydiphenyl ... | 09/12/2006 |
| 7071366 | Processes for obtaining (-)-guaiol and the use thereof A process for obtaining oils of sesquiterpenes and sesquilactones and (−)-guaiol from the oil of Callitris intratropica, processes for encapsulation of the oil from Callitris intratropica, and the various uses of the oil and the encapsulated oil are ... | 07/04/2006 |
| 6921842 | Hydrogenated aromatic oligomers and process for preparing the same The hydrogenated aromatic oligomer of this invention is represented by the following formula (1) (A-F)n-A (1) (wherein A is a segment comprising mainly a polycyclic aromatic compound, a phenol and at least partly hydrogenated prod... | 07/26/2005 |
| 6867335 | Uncatalysed addition reactions The present invention relates to process wherein (+)-2-carene epoxide is coupled with a compound X—Y that contains nucleophilic and electrophilic moieties, to produce a compound of formula (5). The reaction mixture consists essentially of a source of (+)-2-carene ... | 03/15/2005 |
| 6717017 | Total synthesis of antitumor acylfulvenes The present invention provides a method of synthesizing compounds of formula (I) or (II): wherein R1 is hydrogen, R′ is (C1-C4)alkyl and X is a hydroxyl protecting group. ... | 04/06/2004 |
| 6642424 | Intermediates and improved processes for the preparation of neplanocin A Intermediate compounds, including 2-(t-butyldimethylsilyloxymethyl)-3,4-[(dimethylmethylene)dioxy]-5-hydroxy -tricyclo[5.2.1.02,6 ]dec-8-ene, which are useful for the synthesis of neplanocin A having strong antitumor activity. Improved processes... | 11/04/2003 |
| 6548715 | Structural analogues of vitamin D A compound of the formula I: ##STR1## in which P is hydrogen or alkyl; Y and Y' are each hydrogen or, when taken together, represent a group .dbd.CH2 ; W and W' are each hydrogen; X is selected from the group consisting of a hydroxyalkyl, a hydroxya... | 04/15/2003 |
| 6245952 | Reduction of carbonyl compounds by a silane in the presence of a zinc catalyst The present invention relates to a process for the preparation of alcohols by reduction of the carbonyl function in substrates belonging to the class of aldehydes, ketones, esters or lactones, which substrates may contain unsaturated functions other than ... | 06/12/2001 |
| 6214888 | Dermatological compounds The present invention relates to novel monocyclic and bicyclic monoterpene diols that stimulate melanogenesis in mammalian skin, hair, wool or fur, and, are useful for treating or preventing various skin and proliferative disorders, neurodegenerative dise... | 04/10/2001 |
| 6177586 | Vitamin D3 derivative and production process thereof The starting materials for a production process of a vitamin D3 derivative are disclosed, e.g., a cyclopentene derivative represented by the formula (1-2): ##STR1## wherein R11 is a hydrogen atom, tri(C1 to C | 01/23/2001 |
| 6160184 | Total synthesis of antitumor acylfulvenes The present invention provides a method of synthesizing compounds of ##STR1## wherein R and R' are independently (C1 -C4)alkyl.... | 12/12/2000 |
| 6156935 | Chiral phosphorus-based ligands A chiral phosphorus-based ligand, in single enantiomer form, which is capable of complexing a transition metal atom and of acting as a ligand in asymmetric chemical catalysts, which comprises the partial structure R1 R2 P--O--C--X--Y--C--... | 12/05/2000 |
| 5929291 | Odorants The invention relates to compounds of the general formula ##STR1## in which R1 to R7 are, independently, H, methyl or ethyl, R8 +R9 together form methylene (--CH2 --) or a single bond, or R1... | 07/27/1999 |
| 5917096 | Process for the preparation of ଲ-caryophyllene alcohol The present invention discloses a new process for the preparation of ଲ-caryophyllene alcohol, in which the sesquiterpene fraction at 110-120° C./6 mmHg in Chinese pinus massoniana oleoresin composition undergoes isomerization in the presence of sul... | 06/29/1999 |
| 5905074 | Vitamin D derivative A compound of the formula ##STR1## useful for treating vitamin D dependent disorders.... | 05/18/1999 |
| 5847226 | Process for the preparation of nootkatone A method for preparing nootkatone, nootkatol or mixtures thereof by oxidizing valencene, wherein the valencene is exposed to an oxygenated atmosphere in a suitable reaction medium and in the presence of an unsaturated fatty acid hydroperoxide, and the noo... | 12/08/1998 |
| 5733866 | Methyl substituted hexahydroindanols and alkyl ethers thereof, organoleptic uses thereof, processes for preparing same and process intermediates therefor Described are methyl substituted hexahydroindanols and alkyl ethers thereof defined according to the generic structure: ##STR1## wherein R7 represents hydrogen or C1 -C3 alkyl; wherein R1 represents methyl ... | 03/31/1998 |
| 5723632 | Total synthesis of antitumor acylfulvenes The present invention provides a method of synthesizing compounds of formula (I): ##STR1## wherein R and R' are independently (C1 -C4)alkyl.... | 03/03/1998 |
| 5597932 | Intermediate for the preparation of 19-nor vitamin D compounds The invention is drawn to a compound having the following formula ##STR1## in which X1 and X2, which may be the same or different, represent hydrogen or a hydroxy-protecting group, X4 is hydrogen, A is selected from -... | 01/28/1997 |
| 5581004 | Preparation and use of (2-butene-1,4-diyl) magnesium complexes in organic synthesis The magnesium complexes of cyclic hydrocarbons and conjugated dienes, such as 1,2-dimethylenecycloalkanes and 1,3-butadienes, are readily prepared in high yields using highly reactive magnesium. Reactions of these (2-butene-1,4-diyl)magnesium reagents wit... | 12/03/1996 |
| 5574196 | Process for preparing alkanols A process for preparing tertiary alkanols which comprises the step of oxidizing with ozone a saturated hydrocarbon having a tertiary carbon center in the presence of a carboxylic acid and for a sufficient period of time and at suitable temperature and pre... | 11/12/1996 |
| 5525745 | Intermediates in the preparation of 19-nor vitamin D compounds The invention describes intermediates for use in the synthesis of 1-hydroxy-19-nor-vitamin D compounds. The intermediates have the following formula: ##STR1## The disclosed process includes (a) the construction of a 5,8-diol-6-yne interme... | 06/11/1996 |
| 5508392 | Use of vitamin D glycosides, vitamin D orthoester glycosides, vitamin D analog glycosides and vitamin D analog orthoester glycosides for the treatment of osteoporosis The present invention relates to methods for the treatment of prevention of osteoporosis by the administration of a vitamin D glycoside or vitamin D orthoester glycoside, or an analog thereof.... | 04/16/1996 |
| 5498734 | Preparation and use of (2-butene-1,4-diyl)magnesium complexes in organic synthesis The magnesium complexes of cyclic hydrocarbons containing conjugated dienes, such as 1,2-dimethylenecycloalkanes, and 1,3-butadienes, are readily prepared in high yields using highly reactive magnesium. Reactions of these (2-butene-1,4 diyl)magnesium reag... | 03/12/1996 |
| 5457245 | Process for preparation of calcitriol lactone and related intermediates A process for synthesizing (23S,25R)-calcitriol lactone and related Vitamin D analogs comprises reacting protected enantiomerically pure glycidol or 2-alkylglycidol with protected De-A,B-8ଲ-hydroxy-24-nor-cholan-23-al, removing the protective groups... | 10/10/1995 |
| 5430196 | Preparation of 19-nor vitamin D compounds A synthesis of 1-hydroxy-19-nor-vitamin D compounds comprises (a) the construction of a 5,8-diol-6-yne intermediate by joining ring-A and ring-C/D portions of the desired end product via the condensation of an acetylenic derivative containing the C... | 07/04/1995 |
| 5422365 | Naphthalene compounds A compound selected from those of formula (I): ##STR1## wherein: R1, R'1 and R2 are each selected, independently of the others, from hydrogen and an alkyl radical, the two R2 groups being in the cis positio... | 06/06/1995 |
| 5420366 | Process for the preparation of optically active 2-arylcyclohexanols The present invention provides a process for preparing optically active 2-arylcyclohexanol and its esters and ethers and which process comprises the step of subjecting 1-aryl-cyclohexane-1,2 diol and its diethers and diesters to hydrogenolysis conditions ... | 05/30/1995 |
| 5405870 | Carbacyclin compounds; pharmaceutical compositions and method of use Compounds of formula (Ic): ##STR1## having valuable platelet-aggregation inhibitory activities useful for the prophylaxis and treatment of such diseases as thrombosis and pharmaceutical compositions containing said compounds.... | 04/11/1995 |
| 5399587 | Biologically active compounds The present invention relates to novel potassium channel agonists which are useful in activating the calcium activated Maxi-K potassium channel in mammalian neuronal and smooth muscle tissue. The claimed compounds are of the general formula: ##STR1##... | 03/21/1995 |
| 5292971 | Flourine-substituted vicinal and method for their preparation, and their use Fluorine-substituted vicinal glycols of the formula ##STR1## in which the substituents R1 to R4, independently of one another, have the following meanings: R1 to R4 =H, fluorine, C1 - to C18... | 03/08/1994 |
| 5283345 | 1ଲ,7,8-trihydroxy vitamin D2, 1.smallcircle.,7,8-trihydroxy vitamin D3 and their derivatives and method of manufacturing these chemicals There are disclosed novel compounds that can be used to derive therefrom a fragment that corresponds to an A-ring which is to be comined with fragments which respectively correspond to C- and D-rings in synthetic formation of vitamin D3 derivat... | 02/01/1994 |
| 5241089 | Polyhydrodimethylnaphthalene spirofuran derivatives, organoleptic uses thereof and process for preparing same Described are polyhydrodimethylnaphthalene spirofuran derivatives defined according to the generic structure: ##STR1## wherein the dashed line represents a carbon-carbon single bond or a carbon-carbon double bond a process for preparing same and uses... | 08/31/1993 |