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| Number | Title | Issue Date |
| 7268252 | Binaphthol derivatives and their use in optical resolution or optical transformation Disclosed herein are novel binaphthol derivatives and methods for the optical resolution of amino acids or amino alcohols and for the optical transformation of D, L-forms of amino acids using the same. ... | 09/11/2007 |
| 7220784 | Substituted stilbenes and their reactions The present invention relates to stilbene and quinone compounds related to combretastatin A-4 and their use as anticancer compounds and prodrugs. The compounds include those with an alkyl group on the double bond of cis or trans-stilbenes, compounds with one or more... | 05/22/2007 |
| 7179946 | Copper complexes and their use The invention relates to copper complexes of phosphorus compounds, to a process for their preparation and to their use in catalytic coupling reactions. ... | 02/20/2007 |
| 7126031 | Bridged bi-aromatic ligands, catalysts, processes for polymerizing and polymers therefrom New ligands and compositions with bridged bis-aromatic ligands are disclosed that catalyze the polymerization of monomers into polymers. These catalysts with metal centers have high performance characteristics, including higher comonomer incorporation into ethylene/... | 10/24/2006 |
| 7122708 | High-functionality polyether polyols and preparation thereof The invention relates to high-functionality polyether polyols of the general formula where each R′1 is an unsubstituted or substituted aliphatic or aromatic radical and each R′2 is an un... | 10/17/2006 |
| 7115784 | Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds The present invention relates to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the nitrogen atom of an amide or a... | 10/03/2006 |
| 7045660 | Compounds as PDE IV and TNF-inhibitors This invention is directed to a [di(ether or thioether)heteroaryl or fluoro substituted aryl] compound or an N-oxide thereof or a pharmaceutically acceptable salt thereof, which is useful for inhibiting the production or physiological effects of TNF in the treatment... | 05/16/2006 |
| 6864397 | Difluoromethyl ether derivative and process for producing the same The present invention provides a process for producing a difluoromethyl ether derivative simple and efficient process for producing the difluoromethyl ether derivative represented by Formula (1d′) or a difluoromethyl ether derivative represented by Formula (1c′)... | 03/08/2005 |
| 6841502 | Bridged bi-aromatic ligands, catalysts, processes for polymerizing and polymers therefrom New ligands and compositions with bridged bis-aromatic ligands are disclosed that catalyze the polymerization of monomers into polymers. These catalysts with metal centers have high performance characteristics, including higher comonomer incorporation into ethylene/... | 01/11/2005 |
| 6835786 | (Meth)acrylate compound and cured product thereof There are provided a polyfunctional (meth)acrylate compound which has the excellent properties of polyphenylene ether and is excellent in heat resistance and electric characteristics and excellent in reactivity by introducing a polyfunctional (meth)acrylate group in... | 12/28/2004 |
| 6822114 | Process for production of fluoroalkoxy-substituted benzamides and their intermediates Roflumilast and new key intermediates therefor are prepared by processes involving use of carbonylation technology. Good overall yields can be achieved using available starting materials. The starting material for the process can be catechol, an o-R1-phen... | 11/23/2004 |
| 6770463 | Process for the preparation of chiral isofluoroenes There is provided a process for the preparation of a chiral insecticidal and acaricidal compound of formula I. Also provided are intermediate compounds useful in the process of the present invention. ... | 08/03/2004 |
| 6750372 | Process for producing aryl ether A method for producing an aryl ether produced by bonding an aryloxy of hydroxyaryl with an organic group of organic halogen, which comprises reacting hydroxyaryl with organic halogen in gaseous carbon dioxide or supercritical carbon dioxide in the presence of base a... | 06/15/2004 |
| 6703504 | Conformationally constrained compounds as dendrimer cores There are provided novel chemical compounds and their uses in the preparation of polymers and oligomers, and the preparation of such compounds. In certain embodiments there are provided dendritic polymers and oligomers, of a type having at least four poly... | 03/09/2004 |
| 6689922 | Vitamin D analogues The invention concerns novel bi-aromatic compounds having the formula: ##STR1## which are analogs of vitamin D, the process of preparing them, as well as their use in pharmaceutical compositions in human or veterinary medicine, particularly in dermatology... | 02/10/2004 |
| 6610705 | Process for the preparation of diaryl naphthyl methanes The invention relates to novel diaryl naphthyl methane compounds having general formula I as shown herein below, and said compounds useful in the treatment of esterogen related disease or syndrome, ##STR1## Pharmaceutical compositions comprising said nove... | 08/26/2003 |
| 6608212 | Process for preparing vinylaromatic compounds The present invention provides a process for preparing a vinylaromatic compound comprising reacting an arylmetal reagent selected from arylmagnesium reagents and aryllithium reagents with a vinylphosphate in the presence of a palladium catalyst. The prese... | 08/19/2003 |
| 6596907 | Process for the preparation of 4,4'-dihalogen-o-hydroxydiphenyl compounds A description is given of a three-step process for the preparation of 4,4'-dihalogen-o-hydroxydiphenyl compounds of formula (1) which comprises: a) hologenating an alkoxyphenol of formula (6) (=a1), reacting the resulting halogenated phenol com... | 07/22/2003 |
| 6583307 | Convenient and efficient Suzuki-Miyaura cross-coupling catalyzed by a palladium/diazabutadiene system A Pd(OAc)2 /diazabutadiene system has been developed for the catalytic cross-coupling of aryl halides with arylboronic acids. A combination of the diazabutadiene DAB-Cy (1, N,N'-Dicyclohexyl-1,4-dizabutadiene) and Pd(OAc)2 was found ... | 06/24/2003 |
| 6573278 | Aryl sulfonamides and analogues thereof and their use in the treatment of neurodegenerative diseases The present invention relates to new aryl ether sulphonamides and analogues, processes for their preparation and their use for the treatment of neurodegenerative disorders, in particular for the prophylaxis and treatment of neurodegenerative disorders, in... | 06/03/2003 |
| 6555287 | Non-subliming, difunctionalized ultraviolet dyes for use in anti-reflective coatings An improved light attenuating compound for use in the production of microdevices is provided. Broadly, the light attenuating compound is difunctional and can be directly incorporated (either physically or chemically) into photolithographic compositions su... | 04/29/2003 |
| 6552213 | Stereoselective route to produce tris-O-substituted-(E)-1-(3,5-dihydroxyphenyl)-2-(4-hydroxyphenyl)ethene, an intermediate in the synthesis of trans-resveratrol The present invention relates to a new stereoselective method for the preparation of tris-O-substituted-(E)-1-(3,5-dihydroxyphenyl)-2-(4-hydroxyphenyl)ethene derivative of the formula (I) which is a key intermediate in the synthesis of trans-resverat... | 04/22/2003 |
| 6552214 | Antimicrobial compound A compound comprises a blocked halogenated hydroxydiphenyl ether of the formula: ##STR1## where X1 is a halogen, X2 is chlorine or bromine, X3 is hydrogen, chlorine or bromine, X4 is chlorine, bromine, alkyl hav... | 04/22/2003 |
| 6541673 | Process for oxyalkylating phenolic compounds Phenolic polyether polyols are prepared by a two stage oxyalkylation process, a first stage performed at a high oxyalkylation temperature and a second stage at a lower oxyalkylation temperature. Despite the use of high temperature during oxyalkylation, po... | 04/01/2003 |
| 6528676 | Estrogenic compounds as anti-mitotic agents The application discloses methods of treating mammalian diseases characterized by abnormal cell mitosis by administering estradiol derivatives including those comprising colchicine or combretastatin A-4 structural motifs of the general formulae found belo... | 03/04/2003 |
| 6444858 | Method of reducing flock during alkoxylation The present invention provides a method for alkoxylating organic compounds comprising contacting an organic compound adapted to be alkoxylated with an alkylene oxide in a reaction vessel under conditions effective to alkoxylate the organic compound. The a... | 09/03/2002 |
| 6433227 | USE OF TRIS (TRIFLUORO METHYLSULFONYL) METHANE, IN ADDITION TO ALKALINE METAL SALTS AND ALKALINE-EARTH METAL SALTS THEREOF AS CATALYSTS DURING C-C BONDING SYNTHESES AND THE NOVEL MG SALT OF TRIS (TRIFLUORO METHYLSULFONYL) METHANE Compounds are used as catalysts according to general formula (1) M+x (C(SO2 CF3)3)x, whereby x is equal to 1 or 2; M represents one hydrogen or alkaline metal atom when x equals 1; and M represents on... | 08/13/2002 |
| 6420130 | Optical molecular sensors for cytochrome P450 activity The invention provides a compound, useful as an optical probe or sensor of the activity of at least one cytochrome P450 enzyme, and methods of using the compound to screen candidate drugs, and candidate drugs identified by these methods. The optical probe... | 07/16/2002 |
| 6379590 | Method for making unsymmetrically substituted fluorenyl compounds for nonlinear optical applications A new method for producing unsymmetrically substituted fluorenyl compounds, one step of which is the preparation of 2,7-disubstituted fluoren-9-one derivatives via the nucleophilic substitution of a compound of the formula D ##STR1## wherein A' is se... | 04/30/2002 |
| 6369265 | Use of a catalyst system comprising nickel, palladium, or platinum and imidazoline-2-ylidene or imidazolidine-2-ylidene in kumada coupling reactions This invention provides a process for conducting Kumada coupling reactions. The processes of the present invention make use of N-heterocyclic carbenes as ancillary ligands in Kumada couplings of aryl halides. A Kumada coupling can be carried out by mixing... | 04/09/2002 |
| 6350875 | Synthesis of cyclooctatetraene derivatives and their use as electron transporters in organic light emitting diodes The synthesis of asymmetric tetrasubstituted cyclooctatetraenes ("COTs") and the use of said compounds in organic light emitting diodes is reported, wherein said COTs represent a class of wide gap electron transporters that are readily deposited in vacuum... | 02/26/2002 |
| 6333080 | Liquid-crystal alkenyltolan derivative, liquid-crystal composition, and liquid-crystal display element A liquid crystalline alkenyltolan derivative expressed by the general formula Ct H2t-1 --G--(CH2)m --A1 --B1 --(A2 --B2)n --(A3 --B3)p... | 12/25/2001 |
| 6323376 | Process for preparing alkoxy or arylmethoxy aroxyethanes The present invention is a novel process, with or without solvent, for manufacture of compounds of the formula ##STR1## wherein P is selected from phenyl and naphthyl; wherein R1 and R2 and R3 are each independently selected ... | 11/27/2001 |
| 6320081 | O-Nitro(thio)phenol derivatives, and their preparation The invention relates to novel o-nitrophenol derivatives and o-nitrothiophenol derivatives of the following structure: ##STR1## where: A1 to A3 are--independently of one another--H, F, CH3, CF3, OCH3,... | 11/20/2001 |
| 6312618 | Polar diphenyldiacetylene liquid crystals A new class of asymmetric polar diphenyldiacetylene liquid crystal compounds and method for preparation are disclosed. The new class of liquid crystal compounds comprises the basic structure: ##STR1## Wherein R1 is an alkenyl group having the g... | 11/06/2001 |
| 6281250 | Retinyl ethers, derivatives and analogues and inhibition of breast carcinogenesis The present invention is directed to retinyl ethers, derivatives and analogues and their use in inhibiting breast carcinogenesis or breast cancer cell growth.... | 08/28/2001 |
| 6239317 | Process for the production of halogeno-o-hydroxydiphenyl compounds There is described a four step process for the production of halogeno-o-hydroxydiphenyl compounds having the formula ##STR1## in which X is --O--or --CH2 --; m is 1 to 3; and n is 1 or 2; wherein in the first step, a diphenyl compound is chlorinated... | 05/29/2001 |
| 6211416 | Method for producing enol ethers Enol ethers of the formula I ##STR1## where R1 is an aliphatic, cycloaliphatic, araliphatic, aromatic or heterocyclic radical which may carry further substituents which do not react with acetylenes or allenes, and the radicals R, independently ... | 04/03/2001 |
| 6198008 | Process for the preparation of 5-bromo-2-fluorobenzeneboronic acid A process is disclosed for the preparation of 5-bromo-2-fluorobenzeneboronic acid, which is useful as an intermediate in the preparation of a non-ester pyrethroid compound. The compound can be, for example, a fluoroolefin, which is useful as a pesticide.... | 03/06/2001 |
| 6177154 | Alkoxybenzene derivative, liquid-crystal composition, and liquid-crystal display element Disclosed are (a) liquid crystalline compounds which are essential as component of the liquid crystal compositions, are excellent in miscibility with other liquid crystal compositions, particularly in the miscibility at low temperatures, and expressed by ... | 01/23/2001 |
