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| Number | Title | Issue Date |
| 7557249 | Spirobifluorene derivatives, their preparation and uses thereof The invention concerns Spirobifluorene derivatives having the general formula (II) and the corresponding, radical anions that can be represented via the general formula (II): in which K, L, M and N, the same or different fr... | 07/07/2009 |
| 7446229 | Bicyclic cannabinoids Bicyclic-cannabinoids and methods of preparation and use are presented. These compounds, when administered in a therapeutically effective amount to an individual or animal, results in a sufficiently high level of that compound in the individual or animal to cause a ... | 11/04/2008 |
| 7439407 | Fluorinated pentacene derivative and method of producing same Fluorinated pentacene derivatives, for example, the novel compounds tetradecafluoropentacene, 5,6,7,12,13,14-hexafluoropentacene, 5,7,12,14-tetrafluoropentacene, and 6,13-difluoropentacene, and intermediates therefor are provided. And a method of producing fluorinat... | 10/21/2008 |
| 7435757 | 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17β-hydroxy steroid dehydrogenase type 1 The invention relates to new 2-substituted D-homo-estra-1,3,5(10)-trienes of general formula I in which R2 means a C1-C8-alkyl group, a C1-C | 10/14/2008 |
| 7432284 | Estrogen receptor modulators The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a v... | 10/07/2008 |
| 7432303 | Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good activity as angiogenesis inhibitors. The present inventi... | 10/07/2008 |
| 7285683 | Bicyclic and tricyclic cannabinoids Novel bicyclic-cannabinoids and hexahydrocannabinol analogs are presented. These compounds, when administered in a therapeutically effective amount to an individual or animal, results in a sufficiently high level of that compound in the individual or animal to cause... | 10/23/2007 |
| 7265248 | Compositions and methods for the treatment of malaria A colchicine derivative and a method of using a colchicine derivative as a pharmacological agent in the treatment of malaria are provided. ... | 09/04/2007 |
| 7230139 | Diterpenoid compounds, compositions thereof and their use as anti-cancer or anti-fungal agents The present invention relates to Diterpenoid Compounds, compositions comprising an effective amount of a Diterpenoid Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering an effective amount of a Diterpenoid... | 06/12/2007 |
| 7217844 | Diterpenoid compounds, compositions thereof and their use as anti-cancer or anti-fungal agents The present invention relates to Diterpenoid Compounds, compositions comprising an effective amount of a Diterpenoid Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering an effective amount of a Diterpenoid... | 05/15/2007 |
| 7214818 | Method for synthesizing bisphosphonate The invention relates to a novel multi step synthesis of 3-(N-methyl-N-pentyl) amino-1-hydroxypropane-1,1-diphosphonic acid, monosodium salt, monohydrate, of the formula ... | 05/08/2007 |
| 7153979 | Triterpene derivatives and remedies for liver diseases A triterpene derivative useful for the treatment of hepatic disorders is disclosed. This compound comprises as an active ingredient a triterpene derivative represented by the following formula (I) or a salt thereof: | 12/26/2006 |
| 7138394 | Vehicle for topical delivery of anti-inflammatory compounds A vehicle for topical delivery which contains a liquid eutectic mixture of hydrophobic compounds. ... | 11/21/2006 |
| 7119360 | Light-emitting polymers and electronic devices using such polymers Novel pentaphenylenes having the following general formula are described; These polymers generally exhibit blue electroluminescence and are useful in electronic devices. A novel diketone compound having a low LUM... | 10/10/2006 |
| 7115720 | Therapeutic and diagnostic compounds, compositions, and methods The invention provides a complex comprising a) a compound formula I: wherein R1, X and n have any of the values described in the specification, or a pharmaceutically acceptable salt thereof; and b) a r... | 10/03/2006 |
| 7101917 | Mitochrondrial permeability transition pore affinity labels and modulators Methods of utilizing compounds of general formulas I and II as modulators and affinity labels of the MPTP complex are elucidated. Furthermore, methods for modulating the activity of the MPTP complex, methods for determining the presence of a component of the MPTP co... | 09/05/2006 |
| 7097823 | High dose radionuclide complexes for bone marrow suppression The present invention relates to a method of suppressing bone marrow (BM) and treating conditions that arise in or near bone such as cancer, myeloproliferative diseases, autoimmune diseases, infectious diseases, metabolic diseases or genetic diseases, with compositi... | 08/29/2006 |
| 7094885 | Skeletal-targeted radiation to treat bone-associated pathologies The present invention relates to a method of suppressing bone marrow (BM) and treating conditions that arise in or near bone such as cancer, myeloproliferative diseases, autoimmune diseases, infectious diseases, metabolic diseases or genetic diseases, with compositi... | 08/22/2006 |
| 7087599 | Estrogen receptor modulators The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a v... | 08/08/2006 |
| 7070759 | High dose radionuclide complexes for bone marrow suppression The present invention relates to a method of suppressing bone marrow (BM) and treating conditions that arise in or near bone such as cancer, myeloproliferative diseases, autoimmune diseases, infectious diseases, metabolic diseases or genetic diseases, with compositi... | 07/04/2006 |
| 7057076 | Bicyclic and tricyclic cannabinoids Novel bicyclic-cannabinoids and hexahydrocannabinol analogs are presented. These compounds, when administered in a therapeutically effective amount to an individual or animal, results in a sufficiently high level of that compound in the individual or animal to cause... | 06/06/2006 |
| 7053249 | Metal chelates and methods of using them for time-resolved fluorescence β-diketone fluorescent tags are disclosed, particularly those enabling the use of excitation energy in the near visible or visible spectrum. In some cases, these tags allow the use of cost-effective excitation devices such as LED's. The compounds form fluorescent c... | 05/30/2006 |
| 7045116 | Treatment of osteomyelitis with radiopharmaceuticals This invention relates to medical uses of radiopharmaceuticals. Specifically, the present invention relates to the use of radiopharmaceuticals to treat osteomyelitis. The present invention provides improved system and methods of for the direct delivery of radiopharm... | 05/16/2006 |
| 7022664 | 1,2 Substituted 2,3-dihydro-1H-5,9 dioxacyclohepta[F]indden-7-ones and 7-substituted benzo[B][1,4]dioxepin-3-ones The invention relates to 1,2-substituted 2,3-dihydro-1H-5,9-dioxacyclohepta[f]inden-7-ones and 7-substituted benzo[b][1,4]dioxepin-3-ones and to the use of these compounds in fragrance compositions. ... | 04/04/2006 |
| 6949557 | Hydroanthracene based compounds as anticancer agents The invention relates to the use of novel anthracene based compounds for the inhibition or prevention of the growth or multiplication of cancer cells, and to therapeutic compositions containing such compounds. The invention relates more specifically to the use of hy... | 09/27/2005 |
| 6939845 | Fragrance precursors The present invention provides a fragrance precursor of formula I: that is capable of forming a fragrant ketone of formula II: and a fragrant lactone of formula III: | 09/06/2005 |
| 6903238 | Substituted indenones as estrogenic agents This invention provides estrogen receptor modulators of formula I, having the structure R1, R2, and R3 are as defined in the specification, or a pharmaceutically acceptable salt thereof... | 06/07/2005 |
| 6894073 | Use of diterpene compound as a therapeutic agent of inflammation, immune disease or cancer The disclosure concerns novel use of diterpene compound as a therapeutic agent of inlfammation, immune disease or cancer. More particularly, the present invention relates to novel use of diterpene compound that include kamebanin, kamebacetal A, kamebakaurin, and exi... | 05/17/2005 |
| 6887904 | Substituted arylcycloalkanes, compositions containing them and use thereof Substituted arylcycloalkanes, compositions containing them and use thereof. The present invention relates especially to substituted arylcycloalkanes with therapeutic activity, which may be used such as in oncology. ... | 05/03/2005 |
| 6852894 | Tribenzoyl compounds An oxygen scavenging composition or system is provided comprising an oxygen scavenging material, a photoinitiator, and at least one catalyst effective in catalyzing an oxygen scavenging reaction, wherein the photoinitiator comprises a benzophenone derivative contain... | 02/08/2005 |
| 6800785 | Process for the synthesis of estrogen receptor modulators The present invention relates to processes for the synthesis of intermediates useful for the synthesis of estrogen receptor modulators. The process includes new methods for annelating 5-, 6- and 7-membered cycloalkenones onto an indanone. ... | 10/05/2004 |
| 6777447 | Derivatives of benzylidene cyclohexanone, benzylidene cyclopentanone, and benzylidene acetone, and therapeutic uses thereof Benzylidene cyclohexanone, cyclopentanone and acteone derivatives and therapeutic methods of using same are disclosed. The compounds are non-toxic and exhibit potent anti-inflammatory, antibacterial and antioxidation activity. Also, certain compounds of the inventio... | 08/17/2004 |
| 6686486 | Process for effecting allylic oxidation A procedure for oxidizing organic compounds having allylic hydrogen atom(s) involving the steps of reactively contacting the organic compound with a combination of a periodic acid or metal periodate and an alkyl hydroperoxide under conditions of normal as... | 02/03/2004 |
| 6617473 | Production of dibenzosuberenone derivatives by catalytic dehydrogenation The invention relates to a preparation process for derivatives by catalytic dehydrogenation of dibenzosuberone derivatives.... | 09/09/2003 |
| 6528489 | Mycotoxin derivatives as antimitotic agents The present invention provides a treatment for mammalian diseases characterized by aberrant cell proliferation. The treatment consists of administering therapeutically active dosages of antibiotic inhibitors such as efrapeptin oligopeptides or mycotoxin d... | 03/04/2003 |
| 6518316 | Cytokine production and tyrosine kinase inhibitors A compound of formula (I), wherein X is .dbd.O, .dbd.N--OR6, ଲNHR or ଲOH wherein R6 is H or C1 -C6 alkyl, bond a is oriented γ or δ and R is H, C1 -C6 alkyl which is un... | 02/11/2003 |
| 6462075 | Chalcone and its analogs as agents for the inhibition of angiogensis and related disease states The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good activity as angiogenesis inhibitors. The pres... | 10/08/2002 |
| 6459001 | Tricyclic compounds, their preparation process and the intermediates of this process, their use as medicaments and the pharmaceutical compositions containing them The subject of the invention is the products of formula (I): ##STR1## in which R1, R2, R3, R4, R5 and G are as defined in the description, the dotted lines represent an optional second bond, as well a... | 10/01/2002 |
| 6428912 | Electron transport material and light emitting diode that contains the electron transport material An improved multilayer light emitting device includes novel compounds for use as the electron transporting layer. In particular, the novel compounds are novel aluminum cheltates (e.g. tris(9-oxidophenalenone) aluminum [Al(9-opo)3 ] and tris(6-o... | 08/06/2002 |
| 6414167 | Octafluorotricyclodecane derivatives and processes for producing same The invention relates to a novel octafluorotricyclodecane derivative represented by the general formula (1), ##STR1## where R1 is a hydrogen atom, a halogen atom, a hydrocarbon group or a halogenated hydrocarbon group, m is 0 or 1, and R2 | 07/02/2002 |
