Did You Know...
...that Charles Goodyear performed some of his experiments on rubber while in debtor's prison? He was there so often he referred to it as his "hotel". Chronically in debt because of poor business sense and ill health, Goodyear depended on the generosity of friends and family. Even after he unlocked the secret to vulcanizing rubber, he was unable to improve his financial situation. When he died, his estate was $200,000 in debt.
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| Number | Title | Issue Date |
| 7928266 | Dialdehyde compound, preparation method thereof, and synthetic method of carotenoids using the same The novel C dialdehyde compound which can be efficiently utilized in the synthesis of carotenoid compounds based on the sulfone chemistry, the preparation method of the same, and the expeditious and practical synthetic processes for lycopene and β-carotene by the u... | 04/19/2011 |
| 7893303 | Polyarylene, process for producing the same, solid polyelectrolyte, and proton-conductive film A polyarylene having a structural unit shown by the following formula (1) is disclosed. wherein X and Y indicate a divalent organic group or a single bond, Z shows an oxygen atom or a sulfur atom, R represents at least one ... | 02/22/2011 |
| 7417059 | Substituted aromatic-ring compounds, process for producing the same and use The present invention is directed to a class of cyclohexene derivatives bearing sulfamoyl and ester groups which have an inhibitory activity on nitric oxide (NO) production and cytokine production, and are useful as an agent for the prophylaxis and/or treatment of d... | 08/26/2008 |
| 7411088 | Stereoselective synthesis of a 4,4-disubstituted cyclohexanepropanoic acid There is provided stereoselective route to a compound of formula I: wherein R represents H or an alkali metal, Ar1 represents 4-chlorophenyl and Ar2 represents 2,5-difluorophenyl. ... | 08/12/2008 |
| 7385086 | Antimicrobial compounds This invention provides compounds and methods for treating, with said compound, a mycobacterial infection by administering to an animal a pharmaceutical composition containing a compound having the formula R—SOn-Z-CO—Y, where R is an alkyl groups havi... | 06/10/2008 |
| 7307191 | Organic peroxyacid precursors This present invention provides materials for use as solid or concentrated chemical precursors for the production of organic peroxy acids (peracids). Organic peroxy acids are formed using a precursor according to the invention when they are combined with hydrogen pe... | 12/11/2007 |
| 7196229 | Benzoylcyclohexenone derivatives The invention relates to benzoylcyclohexenone derivatives of general formula (I) wherein the variables R1 to R10 and n have the designation cited in claim 1. The invention also relates to the salts of the same and the use of said derivat... | 03/27/2007 |
| 7087693 | Polymerization process involving diacyl peroxides The invention relates to a process to make and use specific diacyl peroxides in polymerization reactions. The peroxides are produced and used in a polymerization process within a short timeframe in order to overcome stability issues associated with them. ... | 08/08/2006 |
| 7067538 | MCP-1 receptor antagonists and methods of use thereof The present invention relates to sulfones that are useful in the treatment of chemokine-mediated disorders. In certain embodiments, the present invention concerns the compounds that are MCP-1 receptor antagonists. ... | 06/27/2006 |
| 7022441 | Silver-free black-and-white thermographic materials containing a benzoquinone and methods of imaging Silver-free, aqueous-based direct thermographic materials are designed to have image tone with near neutral density. Without the use of organic silver salts containing reducible silver ions, the image is formed using a color developing agent precursor that releases ... | 04/04/2006 |
| 7005549 | Peracid precursors for antimicrobial use This disclosure describes unique chemical structures for use as solid or concentrated chemical precursors to the production of peroxy acids when combined with hydrogen peroxide or a hydrogen peroxide precursor such as percarbonates or perborates. Peroxy acids (perac... | 02/28/2006 |
| 6963017 | Preparation of preparing substituted indanones A process for the preparation of indanones of the formula II from indanones of the formula I or of indanones of the formula IIa from indanones of the formula Ia comprises reacting an indanone of the formula I or Ia wit... | 11/08/2005 |
| 6815563 | Method for producing bicyclic 1,3-diketones A process for preparing bicyclic 1,3-diketones of the formula I where R1, R2, R3 and R4 are hydrogen, C1-C4-alkyl, C1-C4 | 11/09/2004 |
| 6803463 | Process for the preparation of pyrazolopyridine derivatives A process for the preparation of a compound of formula (I) and pharmaceutically acceptable derivatives thereof in which: R0 is halogen, C1-6alkyl, C1-6 | 10/12/2004 |
| 6717008 | Derivatives of C2-substituted indan-1-ol compounds, methods for their preparation and use Derivatives of C2-substituted indan-1-ol compounds, processes for their preparation and their use are disclosed. In particular, the invention relates to compounds of the formula I and to their physiologically acceptable ... | 04/06/2004 |
| 6713654 | Antimicrobial compounds This invention provides methods for treating a mycobacterial infection by administering to an animal a pharmaceutical composition containing a compound having the formula R—SOn—Z—CO—Y, where R is an alkyl group having 6-20 carbons; Z is a radical ... | 03/30/2004 |
| 6673780 | Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses The present invention relates to novel sulfoxide and bis-sulfoxide compounds, compositions comprising sulfoxide and bis-sulfoxide compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucos... | 01/06/2004 |
| 6599861 | Herbicides Compounds of formula I ##STR1## wherein the substituents are defined as in claim 1, as well as the agronomically acceptable salts, isomers and enantiomers of these compounds, as well as the agronomically acceptable salts/N-oxides/isomers/enantiomers ... | 07/29/2003 |
| 6495713 | Synthesis of ketosulfone esters This invention encompasses a process for making a compound of Formula A ##STR1## These compounds are intermediates useful in the preparation of certain non-steroidal anti-inflammnatory agents.... | 12/17/2002 |
| 6492514 | Bifunctional photoinitiators suitable for photopolymerization and photopolymerizable systems containing the same The present invention relates to compounds of general formula (I) ##STR1## wherein X1 and X2 are different form each other and have the meanings reported in the following description Y is a simple bond, C1 -C12 linea... | 12/10/2002 |
| 6482567 | Oxime sulfonate and N-oxyimidosulfonate photoacid generators and photoresists comprising same New photoacid generator compounds ("PAGs") are provided and photoresist compositions that comprise such compounds. In particular, non-ionic PAGs are provided that contain an oxime sulfonate group, and/or an N-oxyimidosulfonate group. PAGs of the invention... | 11/19/2002 |
| 6452052 | Aniline disulfide derivatives for treating allergic diseases Methods and compositions for preventing or treating allergic diseases of the eye, nose, skin, ear, gastrointestinal tract, airways or lung and preventing or treating manifestations of systemic mastocytosis are disclosed. The compositions contain a mast ce... | 09/17/2002 |
| 6444857 | Process for producing vitamin A aldehyde and intermediate for producing the same There are disclosed an alcohol derivative of formula (1): ##STR1## wherein Ar is an optionally substituted aryl group and R is a straight or branched C1-C3 lower alkyl group, and the wavy line depicted by ##STR2## indicates a single bond and stereochemist... | 09/03/2002 |
| 6379590 | Method for making unsymmetrically substituted fluorenyl compounds for nonlinear optical applications A new method for producing unsymmetrically substituted fluorenyl compounds, one step of which is the preparation of 2,7-disubstituted fluoren-9-one derivatives via the nucleophilic substitution of a compound of the formula D ##STR1## wherein A' is se... | 04/30/2002 |
| 6350892 | Trifluoromethyl ketone analogs as selective cPLA2 inhibitors Selective inhibitors of the cPLA2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula ##STR1## where (R'), p, D, Y, Z, Ra, R | 02/26/2002 |
| 6348622 | Vitamin a related compounds and process for producing the same There is provided a compound of the formula[I]: ##STR1## wherein R represents a hydrogen atom or a protective group for a hydroxyl group; and A represents a hydrogen atom, a halogen atom or a group of the formula A1: ##STR2## Q represents Q3: ##STR3#... | 02/19/2002 |
| 6326499 | Omega chain modified 15-hydroxyeicosatetraenoic acid derivatives and methods of their use for the treatment of dry eye Omega chain modified 15-HETE derivatives and methods of their use for treating dry eye are disclosed.... | 12/04/2001 |
| 6297402 | Ketosulfone derivatives and process for producing the same There is provided a ketosulfone derivative represented by the formula (I): ##STR1## wherein Ar represents an aryl group which may be substituted, and R1 ' and R2 ' represent a hydrogen atom or a protective group of a hydroxyl group a... | 10/02/2001 |
| 6294289 | Cyano-substituted methide and amide salts Amide and methide salts, comprising in the case of an amide salt one cyano (--CN) group, and in the case of a methide salt, two cyano groups are described in applications requiring a high degree of ionic dissociation. The salts are especially useful as el... | 09/25/2001 |
| 6284915 | Process for preparing 2-amino malonic acid derivatives and 2-amino-1,3-propanediol derivatives, and intermediates for preparing the same A process for preparing 2-amino malonic acid derivatives of formula (1): ##STR1## wherein A is linear or branched chain alkylene having from 1 to 10 carbon atoms, R1 is linear or branched chain alkyl having from 2 to 20 carbon atoms, R2 | 09/04/2001 |
| 6274758 | Asymmetric hydrogenation of vinyl sulfones A process for the preparation of an enantioenriched sulfone of formula (1), which comprises asymmetric hydrogenation of vinyl sulfone of formula (2) ##STR1## wherein R1 and R2 are each independently a hydrocarbon group of less than 2... | 08/14/2001 |
| 6262277 | Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake Provided are novel benzothiepines, derivatives, and analogs thereof; pharmaceutical compositions containing them; and methods of using these compounds and compositions in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions... | 07/17/2001 |
| 6255496 | Trifluoromethyl ketone analogs as selective cPLA2 inhibitors Selective inhibitors of the cPLA2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula ##STR1##... | 07/03/2001 |
| 6232503 | Alkynyl aryl sulfones The present invention provides compounds having the formula ##STR1## wherein R1, R2, R3, R4, and R5 are independently hydrogen, chlorine, bromine, fluorine, iodine, substituted or unsubstituted linear... | 05/15/2001 |
| 6211411 | Process for producing retinal and intermediate for producing the same There are disclosed sulfone aldehyde derivatives of the Formula (1): ##STR1## wherein Ar is an optionally substituted aryl group, a process for producing retinal by using the same, and an intermediate for producing the sulfone aldehyde derivative.... | 04/03/2001 |
| 6204387 | Process for making diaryl pyridines useful as COX-2 inhibitors The invention encompasses a process for making compounds of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1##... | 03/20/2001 |
| 6201027 | Substituted ଲ diketones and their use The invention relates to the compounds of formula I: ##STR1## wherein one of X1 and X2 is MeSO2 and the other one is hydrogen or halogen and X3 is hydrogen or halogen. These compounds have been found to be usefu... | 03/13/2001 |
| 6183648 | Process for purification of organic sulfonates and novel product A process for producing a low sulfate organic sulfonate/sulfate aqueous solution from a soluble sulfate containing organic sulfonate/sulfate which comprises forming an aqueous solution of organic sulfonate/sulfate; and passing the aqueous solution of the ... | 02/06/2001 |
| 6172265 | Ketosufone derivatives and process for producing the same There is provided a ketosulfone derivative represented by the formula (I): ##STR1## wherein Ar represents an aryl group which may be substituted, and R1 ' and R2 ' represent a hydrogen atom or a protective group of a hydroxyl group a... | 01/09/2001 |
| 6130334 | Process for making 2-aryl-3-aryl-5-halo pyridines useful as COX-2 inhibitors The invention encompasses a process for making compounds of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases.... | 10/10/2000 |
