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| Number | Title | Issue Date |
| 7214824 | Substituted -sulfonylaminobenzyl-2-phenoxyacetamide compounds as VR1 receptor agonists This invention provides a compound of the formula (I): wherein R1 represents a (C1–C6)alkyl group; R2 represents a hydrogen atom, a halogen atom, a hydroxy group, a (... | 05/08/2007 |
| 7169952 | Process to prepare sulfonamides A process for the preparation of a sulfonamide of formula (II), comprising reacting at elevated temperature an aniline of formula (I), with a sulfonating agent A of the formula R1—SO2-Z in the presence of a catalytic amount of either: (i) an ... | 01/30/2007 |
| 7022738 | α-ketoamide derivative and use thereof The present invention provides a compound represented by the formula (I): wherein R1, R2 and R3 each represents a lower alkyl group. ... | 04/04/2006 |
| 6919375 | Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same Compounds having a metalloproteinase inhibitory activity, represented by the formula (I), its optically active isomers, their pharmaceutically acceptable salts, or hydrates thereof. ... | 07/19/2005 |
| 6743929 | Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors Sulfonamide-containing hydroxyethylamine compounds are effecive as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. ... | 06/01/2004 |
| 6706755 | Cyclopentane heptan(ene) acyl sulfonamide, 2-alkyl or 2-arylalkyl, or 2-heteroarylalkenyl derivatives as therapeutic agents The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound represented by the general formula I; | 03/16/2004 |
| 6596863 | Medical composition containing nitroetheneamine Derivative or salt there of as active constituent Process for producing a nitroetheneamine derivative ##STR1## or its stereoisomer, its tautomer or a salt thereof comprising reacting a compound of the formula ##STR2## with a compound of the formula R6 --CH2 NO2 to obtain ... | 07/22/2003 |
| 6583318 | Method for synthesis of -sulfonamido amide, carboxylic acid and hydroxamic acid derivatives A method of synthesizing -sulfonamido amide, carboxylic acid or hydroxamic acid derivatives comprising providing a set of polymer-bound reactant(s) (sulfonamide, aldehyde or ketone, isocyanide or acid) to react with three sets of the other three re... | 06/24/2003 |
| 6451792 | Medical composition containing nitroetheneamine derivative or salt thereof as active constituent A medical composition containing, as an active constituent, a nitroetheneamine derivative represented by the formula (I): ##STR1## wherein the substituents are as defined in the disclosure, its stereoisomers, its tautomers or a salt thereof.... | 09/17/2002 |
| 6221914 | Sulfonamide bridging compounds that inhibit tryptase activity The present invention is directed to compounds which are capable of inhibiting the activity of tryptase. Such compounds are useful in the treatment or prevention of inflammatory disease, particularly those disease states which are mediated by mast cell ac... | 04/24/2001 |
| 6124333 | Metalloproteinase inhibitors Therapeutically active hydroxamic acid derivatives, processes for their preparation, pharmaceutical compositions containing them, and the use of such compounds in medicine. The compounds are inhibitors of metalloproteinases involved in tissue degradation.... | 09/26/2000 |
| 6124332 | Metalloproteinase inhibitors Therapeutically active hydroxamic acid derivatives, processes for their preparation, pharmaceutical compositions containing them, and the use of such compounds in medicine. The compounds are inhibitors of metalloproteinases involved in tissue degradation.... | 09/26/2000 |
| 5965588 | Sulfonylalkanoylamino hydroxyethylamimo sulfonamides useful as retroviral protease inhibitors Sulfonamide-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.... | 10/12/1999 |
| 5672615 | Arylsulfonamido-substituted hydrodxamic acids Disclosed are the compounds of formula I ##STR1## wherein R and R1 together with the chain to which they are attached or R1 and R2 together with the carbon atom to which they are attached form a ring; pharmaceutically... | 09/30/1997 |
| 5663174 | Aromatic sulfonamide derivatives, their use as enzyme inhibitors and pharmaceutical compositions containing them Aromatic sulfonamide derivatives, particularly benzenesulfonamide, 4-fluorobenzenesulfonamide, 5-chloro-1-naphthalenesulfonamide and 5-isoquinolinesulfonamide derivatives are provided that inhibit Ca2+ -dependent enzymes and proteins such as Ph... | 09/02/1997 |
| 5659061 | Tumor protease activated prodrugs of phosphoramide mustard analogs with toxification and detoxification functionalities The composition, synthesis, and applications of tumor associated protease activated prodrugs of phosphoramide mustard, isophosphoramide mustard and analogs with detoxification functionalities are described. These drugs release a cytotoxic phosphoramide mu... | 08/19/1997 |
| 5599982 | Process for preparing enantiomerically pure imidazo[4,5,1-JK][1,4]-benzodiazepin-2(1H)-thiones Process for preparing enantiomerically pure imidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-thiones of formula ##STR1## starting from 2,6-dihalo-3-nitrobenzyl derivatives (II) and suitably N-protected 1,2-diaminopropanes (III) ##STR2## Novel enan... | 02/04/1997 |
| 5552419 | Arylsulfonamido-substituted hydroxamic acids The invention relates to the compounds of formula I ##STR1## pharmaceutically acceptable prodrug derivatives and pharmaceutically acceptable salts thereof; methods for preparation thereof; pharmaceutical compositions comprising said compounds; and a ... | 09/03/1996 |
| 5534654 | Aromatic-sulfonamide-type hydroxamic acid derivative A novel hydroxamic acid compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof having cell growth inhibition, vascularization inhibition activities and the like. The compounds of the present invention possess inhibitory activities... | 07/09/1996 |
| 5521219 | Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors Sulfonamide-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.... | 05/28/1996 |
| 5510388 | Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors Sulfonamide-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.... | 04/23/1996 |
| 5510531 | Proteinase inhibitor A Novel N-substituted peptidyl compound represented by the general formula (1): ##STR1## where R1 is a straight-chained or branched acyl group having 2-10 carbon atoms, a branched, cyclic or bridged cyclic alkyloxycarbonyl group havin... | 04/23/1996 |
| 5508294 | Sulfonylalkanoylamino hydroxyethlamino sulfonamides useful as retroviral protease inhibitors Sulfonamide-containing hydroxethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.... | 04/16/1996 |
| 5506242 | Arylsufonamido-substituted hydroxamic acids The invention relates to a method of inhibiting metalloellastase activity, of inhibiting the degradation of elastin, or of treating macrophage metalloelastase dependent conditions in mammals which comprises administering to a mammal in need thereof an eff... | 04/09/1996 |
| 5455258 | Arylsulfonamido-substituted hydroxamic acids Particularly the invention relates to the compounds of formula I ##STR1## (a) wherein Ar is carbocyclic or heterocyclic aryl; R is hydrogen, lower alkyl, carbocyclic aryl-lower alkyl, carbocyclic aryl, heterocyclic aryl, biaryl, biaryl-lower alkyl, hetero... | 10/03/1995 |
| 5403853 | Substituted N-aryl-1,2-diaminocyclobutene-3,4-diones The compounds of the formula: ##STR1## wherein R1 and R2 are, independently, hydrogen, straight or branched chain alkyl or mono- or bi-cyclic alkyl; A is a substituted phenyl group containing one or two substituents selected fro... | 04/04/1995 |
| 5274162 | Antineoplastic drugs with bipolar toxification/detoxification functionalities The composition, methods of synthesis, and applications of a new class of tumor selective antineoplastic drugs is described. These novel antineoplastic agents are of the general structure: A-C-B. The agents are designed with two key functionalities: a tri... | 12/28/1993 |
| 5057623 | Organic fluorine compound An organic fluorine compound represented by the general formula Rf -(X)h -R-M wherein Rf is a group selected from the following (a) and (b); ##STR1## X denotes a linking group selected from --O--, --S--, and --COO--, h den... | 10/15/1991 |
| 4885027 | Herbicidal arylmethylenesulfonamido-acetamide and thioacetamide derivatives Arylmethylenesulfonamidoacetamide and thioacetamide derivatives and arylmethylenesulfonamidoester intermediates therefor. The compounds are useful as selective herbicides especially with respect to the prevention and elimination of barnyardgrass in grass ... | 12/05/1989 |
| 4855286 | Renin-inhibiting di- and tripeptides, a process for their preparation, agents containing them, and their use The invention relates to compounds of the formula ##STR1## in which R1 is absent or denotes hydrogen, alkyl or acyl, A denotes an acyl radical or an amino acid residue, B denotes an amino acid residue, and R2, R3 and ... | 08/08/1989 |
| 4826960 | Novel reactions of bicyclic amide acetals with reactive protic compounds having the formula HN(R')YR2 The process for the reaction of bicyclic amide acetals with reactive protic compounds of the general Formula ##STR1## wherein Y represents a member selected from the group consisting of ##STR2## R1 represents a member selected from th... | 05/02/1989 |
| 4789677 | N-alkyl-[N-[N-alkyl-N-[4-(4-quinolinylamino)benzoyl]ami no]alkyl]benzenesulphonamides New compounds having the formula I ##STR1## where one of A and B is CH or N, the other of A and B is CH, Q is lower alkylene, R is lower alkyl, X1 is halogen or trifluoromethyl and X2 and X3 are independently selected... | 12/06/1988 |
| 4618710 | Preparation of optically active ketones An optically active alpha-amino acid derivative having the formula: ##STR1## wherein: X is OH, Cl, Br, I, or OCOR3 ; Y is a radical selected to stabilize the alpha carbon atom of the alpha-amino acid derivative sufficiently to prevent significa... | 10/21/1986 |
| 4582855 | Aromatic and esters of hydroxypropylamines Novel compounds of the general formula ##STR1## wherein Ar represents a substituted or unsubstituted aromatic or heterocyclic group; W represents alkylene of from 1 to about 10 carbon atoms; and B represents --NR2 COR1, --NR | 04/15/1986 |
| 4540794 | Method for preparing 5-mercapto-1,2,3-thiadiazole salts A method for preparing a 5-mercapto-1,2,3-thiadiazole salt represented by the general formula (I) is disclosed: ##STR1## the method comprises the steps of: providing a sulfonylhydrazone derivative represented by the general formula (II): ##STR2#... | 09/10/1985 |
| 4313005 | Inhibiting amidine formation during hydrogenation of organo nitriles This invention relates to a process for reducing amidine formation during reduction of organonitriles. The process comprises including a boron compound in the reaction medium in sufficient amount to complex the amidine compound as it is formed.... | 01/26/1982 |
| 4281011 | Insecticidal N-methyl-N-(benzene sulfonic acid methylamide-N'-sulfenyl)-carbamic acid oxime esters N-methyl-N-(benzene sulfonic acid methylamide-N'-sulfenyl)-carbamic acid esters of the formula ##STR1## in which X is halogen, C1 -C6 alkyl or hydrogen, and R is a phenyl, naphthyl, benzodioxolanyl or indanyl radical optionally ... | 07/28/1981 |
| 4261925 | Surfactants Surfactants having an HLB of from about 12 to about 20, preferably 14 to about 20, are disclosed which correspond to formulas I and II: ##STR1## wherein: R1 is a nonpolymerizable hydrocarbyl or inertly-substituted hydrocarbyl group of at l... | 04/14/1981 |
| 4218476 | Anti-thrombotic N-alkylthioakylamino benzenesulfonamides New compounds of the general formula I ##STR1## wherein R1 and R2 each independently represent an alkyl group containing 1 to 4 carbon atoms, or an alkoxy group containing 1 to 3 carbon atoms, or halogen, R3 represent... | 08/19/1980 |
| 4165258 | Plasminogen activating enzyme-specific competitive inhibitor A novel plasminogen activating enzyme-specific competitive inhibitor is disclosed consisting of an amino-terminated -N-substituted aminocarboxylic acid, such as -N-benzylsulfonyl-p-aminophenylalanine, or the acid derivatives thereof. Th... | 08/21/1979 |
