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| Number | Title | Issue Date |
| 7365196 | Sulphonamido-substituted bridged bicycloalkyl derivatives A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of and/or prevention of Alzheimer's disease. ... | 04/29/2008 |
| 7332608 | Anthranilamides and methods of their use The present invention is related to a process for preparing anthranilamides of formula I, in which R(1) to R(7) have the meanings indicated herein, a process for their preparation, their use as medicaments, and p... | 02/19/2008 |
| 7265220 | Amino acid derivatives, method for production thereof and pharmaceutical compositions comprising said derivative Compound of formula (I): wherein: R1 represents aryl, heteroaryl or alkyl which is optionally substituted, or a group of formula —(CO)—CR6R7NR8R9 ... | 09/04/2007 |
| 7235690 | Anthranilamides and methods of their use The present invention is related to anthranilamides of formula I, in which R(1) to R(7) have the meanings indicated herein, a process for their preparation, their use as medicaments, and pharmaceutical preparations con... | 06/26/2007 |
| 7183320 | Benzoylsulfonamides and sulfonylbenzamidines for use as antitumour agents The present invention provides antitumor compounds of the formula (I), and antitumor methods ... | 02/27/2007 |
| 7169952 | Process to prepare sulfonamides A process for the preparation of a sulfonamide of formula (II), comprising reacting at elevated temperature an aniline of formula (I), with a sulfonating agent A of the formula R1—SO2-Z in the presence of a catalytic amount of either: (i) an ... | 01/30/2007 |
| 7161032 | Sulfonamide derivatives, insecticides for agricultural and horticultural use, and usage thereof Sulfonamide derivatives represented by general formula (I) or salts thereof; insecticides for agricultural and horticultural use containing the same as the active ingredient; and usage thereof: [wherein A is opti... | 01/09/2007 |
| 7161033 | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to ... | 01/09/2007 |
| 7161031 | Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders Compounds useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula I: wherein: Ar, X, X1, g, R and R3 are as defined herein. ... | 01/09/2007 |
| 7138418 | Pentafluorobenzenesulfonamides and analogs The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states... | 11/21/2006 |
| 7041691 | Compounds for the modulation of PPARγ activity Modulators of PPARγ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity. ... | 05/09/2006 |
| 6995285 | ABCA-1 elevating compounds The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary artery dis... | 02/07/2006 |
| 6962929 | Pentafluorobenzenesulfonamides and analogs The invention provides methods and compositions relating to novel pentafluorophenylsulfonamide derivatives and analogs and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states... | 11/08/2005 |
| 6927224 | Selective estrogen receptor modulators The present invention provides, inter alia, triphenylethylene derivatives, such as, 3-{4-[6-(3-Methoxy-phenyl)-8,9-dihydro-7H-benzocyclohepten-5-yl]-phenyl}-acrylic acid, as selective estrogen receptor modulators. Also provided are methods for the treatment and/or p... | 08/09/2005 |
| 6919369 | Serine protease inhibitors Compounds having the structure shown below are useful to inhibit serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein. These compounds may be used in methods of preventing and/or treating clotting disorders. | 07/19/2005 |
| 6908947 | Sulfonamide-substituted fused 7-membered ring compounds, their use as a medicament, and pharmaceutical preparations comprising them The present invention relates to compounds of formula I, in which X1, X2, X3, X4, Y1, Y2, Y3, Y4, R(3), R(4) and R(5) have the meanings mentioned in the specification, their preparation and their use, in particular in ... | 06/21/2005 |
| 6881753 | Potassium channel inhibitors and method Indanes, benzopyrans and analogues thereof are potassium channel inhibitors and blockers of IKur and have the structure: where A, B, D, Q, X1, R, R1, X2 and R2 are as defined... | 04/19/2005 |
| 6818765 | Benzene-sulphonamide derivatives and their uses Benzene-sulphonamide derivatives complying with the general formula (I): in which the different symbols have different meanings, their optical isomers and the salts pharmacologically acceptable of these derivatives, as... | 11/16/2004 |
| 6743929 | Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors Sulfonamide-containing hydroxyethylamine compounds are effecive as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. ... | 06/01/2004 |
| 6713650 | ABCA-1 elevating compounds The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary artery dis... | 03/30/2004 |
| 6646009 | N-(aryl)-2-arylethenesulfonamides and therapeutic uses thereof N-(Aryl)-2-arylethenesulfonamides and pharmaceutically acceptable salts and compositions thereof are useful as antiproliferative agents, including, for example, anticancer agents. They are also useful as radioprotective agents.... | 11/11/2003 |
| 6645992 | Malonamid and malonamic ester derivatives with antithrombotic activity, their preparation, and their use Compounds of formula I, ##STR1## in which R1, R2, A, and B having the definitions set forth in the claims, are valuable pharmacologically active compounds, which exhibit a strong antithrombotic effect and are suitable, for example, f... | 11/11/2003 |
| 6583318 | Method for synthesis of -sulfonamido amide, carboxylic acid and hydroxamic acid derivatives A method of synthesizing -sulfonamido amide, carboxylic acid or hydroxamic acid derivatives comprising providing a set of polymer-bound reactant(s) (sulfonamide, aldehyde or ketone, isocyanide or acid) to react with three sets of the other three re... | 06/24/2003 |
| 6538159 | -sulfin-and -sulfonamino acid amides The invention relates to -sulfin- and -sulfonamino acid amides of the general formula I ##STR1## including the optical isomers thereof and mixtures of such isomers, wherein n is a number zero or one; R1 is C1 -C12... | 03/25/2003 |
| 6538016 | -sulfin-and -sulfonamino acid amides The invention relates to -sulfin- and -sulfonamino acid amides of the general formula I ##STR1## including the optical isomers thereof and mixtures of such isomers, wherein n is a number zero or one; R1 is C1 -C12... | 03/25/2003 |
| 6521663 | Aminoguanidinyl- and Alkoxyguanidinyl-substituted phenyl acetamides as protease inhibitors Phenyl acetamide compounds are described, including compounds of Formula I: ##STR1## or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R3 -R6, R11, B, Y and W are set forth in the specification. Th... | 02/18/2003 |
| 6518245 | Treatment of arrhythmias via inhibition of a multifunctional calcium/calmodulin-dependent protein kinase This invention provides a method for treating or preventing arrhythmias in a human subject comprising the administration of an effective amount of a calcium/calmodulin-dependent protein kinase inhibitor. Also provided are pharmaceutical compositions compr... | 02/11/2003 |
| 6495604 | Cycloalkene derivatives, process for producing the same, and use The present invention provides a compound represented by the formula: ##STR1## wherein R represents an aliphatic hydrocarbon group optionally having substituents, an aromatic hydrocarbon group optionally having substituents, a heterocyclic group optionall... | 12/17/2002 |
| 6472393 | Serine protease inhibitors Compounds having the structure shown below wherein A, B, N1, N2, X, Y, Q, R2, R5 and R6 are as defined herein are useful to inhibit serine protease enzymes, such as TF/factor VIIa factor Xa, thrombin ... | 10/29/2002 |
| 6436967 | Process for preparing prodrugs of benzenesulfonamide-containing cox-2 inhibitors This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to prodrugs of compounds which selectively inhibit cyclooxygenase-2. The use of non-steroidal antiinflammatory drugs (NSAIDs) in treating pain and the swelli... | 08/20/2002 |
| 6433017 | Amphiphilic polyamine compounds In accordance with the present invention, there are provided amphiphilic polyamine compounds and derivatives thereof having the property of promoting transfection of polynucleotides and polypeptides into cells, and formulations comprising said compounds.... | 08/13/2002 |
| 6395737 | Malonic acid derivatives, processes for their preparation, for their use and pharmaceutical compositions containing them New compounds for the inhibition of blood clotting proteins, and more particularly, to malonic acid derivatives of the formula I, ##STR1## wherein R(1), R(2), R(3), R(4), R(5), and R(6) have the meanings indicated in the claims. The compounds of formula I... | 05/28/2002 |
| 6348499 | Amphiphilic polyamide compounds Amphiphilic polyamide compounds and derivatives thereof having the property of promoting transfection of polynucleotides and polypeptides into cells, and formulations comprising said compounds.... | 02/19/2002 |
| 6342512 | Sulfonylcarboxamide derivatives, process for their preparation and their use as pharmaceuticals Sulfonylcarboxamide derivatives of formula I, their physiologically acceptable salts and/or physiologically functional derivatives, methods of making these compounds, their use for preparing medicines for the prevention and treatment of hyperlipidemia and... | 01/29/2002 |
| 6335460 | -and ଲ-amino acid hydroxyethlamino sulfonamides useful as retroviral protease inhibitors - and ଲ-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.... | 01/01/2002 |
| 6333349 | Sulfonamide-substituted fused 7-membered ring compounds, their use as a medicament, and pharmaceutical preparations comprising them The present invention relates to compounds of formula I, ##STR1## in which X1, X2, X3, X4, Y1, Y2, Y3, Y4, R(3), R(4) and R(5) have the meanings mentioned in the specification, their preparation and their use, in particular in pharmaceuticals. The compoun... | 12/25/2001 |
| 6242493 | Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment Compounds of formula I: ##STR1## as well as pharmaceutically acceptable salts, hydrates and esters thereof, are disclosed. The compounds are useful for treating or preventing prostaglandin mediated diseases. Pharmaceutical compositions containing such com... | 06/05/2001 |
| 6221888 | Sulfonamides as cell adhesion inhibitors Compounds of Formula I are antagonists of VLA-4 and/or 댔ଲ.sub.7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical ... | 04/24/2001 |
| 6211197 | Prostaglandin receptor ligands Compounds and methods for treating prostaglandin mediated diseases, and certain pharmaceutical compositions thereof are disclosed. The compounds are represented by formula II: Ar1 --W--Ar2 --X--Q II The compounds of the invention are str... | 04/03/2001 |
| 6200967 | Anticoagulant agents This invention relates to a compound of the Formula I X--C(O)--Y--G--R I (wherein X, Y, G and R have the values defined in the description), or a pharmaceutically acceptable salt thereof, processes and intermediates for the preparation of such a compound or s... | 03/13/2001 |
