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| Number | Title | Issue Date |
| 8163956 | Inhibitors of GLYT1 transporters A compound of the formula (I): wherein R1, R2, R3, R4, Ar, A, n and m are defined herein, is disclosed as a GlyT1 inhibitor; pharmaceutical compositions containing the compound of the formula (I) are also disclosed as are ... | 04/24/2012 |
| 8158825 | Modified malonate derivatives The present invention relates to a novel class of modified malonate derivatives. The modified malonate compounds can be used to treat cancer. The modified malonate compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing termin... | 04/17/2012 |
| 8093424 | Tetralin and indane derivatives and uses thereof Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, p, q, Ar, R1 and R2 are as defined herein. Also provided are methods for preparing, compositions com... | 01/10/2012 |
| 8017803 | Process for the preparation of tamsulosin and intermediates thereof A process for producing tamsulosin of formula I and pharmaceutically acceptable addition salts, thereof comprises the steps of: a) Reacting compound R,R-[2-(4-methoxy-phenyl)-1-methyl-ethyl]-(1-phenyl-ethyl)-am... | 09/13/2011 |
| 7842838 | Pyrro[1,2-]pyridazinone intermediates The invention is directed to pyrro[1,2-b]pyridazinone compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus. ... | 11/30/2010 |
| 7538246 | Synthesis of optically pure(r)-5-(2-amynopropyl)-2-methoxybenzenesulphonamide The present invention relates to a new process for the preparation of optically pure(R)-5-(2-aminopropyl)-2-methoxybenzenesulphonamide, which is an intermediate in the synthesis of tamsulosin. ... | 05/26/2009 |
| 7511175 | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-i... | 03/31/2009 |
| 7476762 | Methods for preparing sulfonamide compounds Methods for preparing substituted phenylsulfonamide compounds of the following structure are provided: or a pharmaceutically acceptable salt thereof, wherein, R1-R7 are defined herein. ... | 01/13/2009 |
| 7442836 | Phenethanolamine derivatives for treatment of respiratory diseases The present invention relates to novel compounds of Formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases. ... | 10/28/2008 |
| 7442719 | Methods using phenethanolamine derivatives for treatment of respiratory diseases The present invention relates to novel compounds of Formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases. ... | 10/28/2008 |
| 7442837 | Phenethanolamine derivatives for treatment of respiratory diseases The present invention relates to novel compounds of Formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases. ... | 10/28/2008 |
| 7439393 | Phenethanolamine derivatives for treatment of respiratory diseases The invention relates to 4-{(1R)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol; and salts and solvates thereof, including those which are pharmaceutically acceptable, along with formulations thereof, combinations there... | 10/21/2008 |
| 7402696 | Benzene compounds The present invention provides novel benzene compounds presented by the following formulas, and analogs thereof, that exert an ACC activity-inhibiting effect that is effective in the treatment of obesity, hyperlipemia, fatty liver, hyperglycemia, impaired glucose to... | 07/22/2008 |
| 7393873 | Arylsulfonamide derivatives N-aryl arylsulfonamide derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway. ... | 07/01/2008 |
| 7378550 | Process for preparing reverse transcriptase inhibitors The present invention is directed to processes for the synthesis of intermediates useful in the preparation of non-nucleoside reverse transcriptase inhibitors. ... | 05/27/2008 |
| 7375120 | Peptide deformylase inhibitors Novel PDF inhibitors and novel methods for their use are provided. ... | 05/20/2008 |
| 7361787 | Phenethanolamine derivatives for treatment of respiratory diseases The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases ... | 04/22/2008 |
| 7329780 | Method of preparing optically pure phenethylamine derivatives Provided is a method of preparing an optically pure compound having formula 1 or its salts. The method includes: reacting (R)-2-(4-methoxy-3-aminosulfonyl-phenyl)-1 -methylethylamine or its salts with a compound selected from the group consisting of chloroacetic aci... | 02/12/2008 |
| 7321063 | Sulfonamide inhibitors of aspartyl protease The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. T... | 01/22/2008 |
| 7317023 | Diaryl ether β2 adrenergic receptor agonists The invention provides novel β2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with β2 adrenergic receptor... | 01/08/2008 |
| 7312359 | Tetralin and indane derivatives and uses thereof Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, p, q, Ar, R1 and R2 are as defined herein. Also provided are methods f... | 12/25/2007 |
| 7312345 | Process for the preparation of dronedarone The present invention provides, according to an aspect thereof, a novel process for the preparation of dronedarone [1] and pharmaceutically acceptable salts thereof. According to a preferred embodiment, the process comprises N-acetylating of p-anisidine or p-pheneti... | 12/25/2007 |
| 7285565 | Benzamides and related inhibitors of factor Xa Novel benzamide compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders. ... | 10/23/2007 |
| 7271280 | Process for preparing a biaryl compound A process for preparing an optically active biaryl compound the formula (4): which comprises reacting an aromatic sulfonic acid ester compound of the formula (1): ... | 09/18/2007 |
| 7256204 | Amine compounds, their production and use A compound of the formula: wherein Ar is an aromatic ring assembly group which may be substituted or a fused aromatic group which may be substituted; X is (i) a bond, (ii) —S—, —SO— or —SO2â€... | 08/14/2007 |
| 7250447 | Acylsulfamide inhibitors of factor VIIa Compounds having the general formula I are useful for inhibiting serine protease enzymes, such as Tissue Factor VIIa, factor Xa, thrombin and kallikrein and have improved permeability properties. These compounds may be used in methods of preventing and/or treating c... | 07/31/2007 |
| 7244755 | Hydroxypropylamines Disclosed are compounds of formula I: and the pharmaceutically acceptable salts thereof wherein the variables RN, R1, R2, R3, RP and RC are define... | 07/17/2007 |
| 7238839 | Process for the resolution of racemic (R,S) -5-(2-(2-(2- ethoxyphenoxy) ethylamino)Propyl)-2-methoxybenzene sulfonamide (tamsulosin), its novel R and S isomers and their salts and processes for their preparation An improved process is described to resolve a racemic mixture in any proportion of 5-(2-(2-(2-ethoxyphenoxy)ethylamino)propyl)-2-methoxy benzene sulfonamide as a free base or some of its salts, with BPA either S or R form to obtain enantiomerically highly pure R and... | 07/03/2007 |
| 7232923 | Method of hydroaminating N-alkenoylcarbamates with primary aromatic amines The invention provides methods for hydroaminating N-alkenoyl carbamates with aromatic amines. ... | 06/19/2007 |
| 7232929 | Amide derivatives of 2,2,3,3-tetramethylcyclopropane carboxylic acid The invention relates to new 2,2,3,3-tetramethylcyclopropane carboxamide derivative compounds, pharmaceutical compositions thereof and uses thereof for treating psychotic disorders, neurodegenerative diseases, epilepsy and pain. ... | 06/19/2007 |
| RE39682 | Farnesyl derivatives and pharmaceutical compositions containing them Novel farnesyl derivatives which are inhibitors of the prenylated protein methyltransferase enzyme, and useful as anti-cancer drugs, have the following formula: wherein R1represents f... | 06/05/2007 |
| RE39667 | 3,3-Diphenylpropylamines, their use and preparation The invention relates to 3,3-diphenylpropylamines of formula (I), wherein R1 signifies hydrogen or methyl, R2 and R3 independently signify hydrogen, methyl, methoxy, hydroxy, carbamoyl, sulphamoyl or halogen, and X represents a terti... | 05/29/2007 |
| 7220914 | Zwitterionic compounds and photovoltaic cells containing same Zwitterionic compounds, photovoltaic cell charge carrier layers containing such compounds, photovoltaic cells including such charge carrier layers, and related methods are disclosed. ... | 05/22/2007 |
| 7217832 | 5-amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: wherein R1 is a hydrogen atom or an optionally substituted lower alkyl group; | 05/15/2007 |
| 7208526 | Styrylsulfonamides The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, pharmace... | 04/24/2007 |
| 7208524 | 5-amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: wherein R1 is a hydrogen atom or an optionally substituted lower alkyl group; | 04/24/2007 |
| 7208528 | Polyamine analogues as therapeutic and diagnostic agents Novel inhibitors of polyamine transport having inhibition constants two orders of magnitude lower than those of known compounds are disclosed. These polyamine analogues are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine t... | 04/24/2007 |
| 7205434 | Sulphonamides for control of beta-amyloid production There is disclosed a novel class of sulphonamido-substituted bridged bicycloalkyl derivatives comprising a substitute on the bridgehead position. The compounds modulate the production of the β-amyloid precursor protein, and hence are useful in the treatment of Alzh... | 04/17/2007 |
| 7169952 | Process to prepare sulfonamides A process for the preparation of a sulfonamide of formula (II), comprising reacting at elevated temperature an aniline of formula (I), with a sulfonating agent A of the formula R1—SO2-Z in the presence of a catalytic amount of either: (i) an ... | 01/30/2007 |
| 7166738 | Non-nucleoside reverse transcriptase inhibitors The present invention provides compounds for treating or preventing an HIV infection, or treating AIDS or ARC comprising administering a compound according to formula I where Ar, R1—R5, R7a, R7b, R7c, R8 | 01/23/2007 |
