Did You Know...
...that in the early 1940s GE engineer James Wright was charged with a task of utmost importance to the war effort: develop a cheap substitute for rubber that could be used to produce tires, gas masks and a whole host of military gear. Wright tackled the task diligently -- and wound up inventing Silly Putty.
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| Number | Title | Issue Date |
| 7834213 | Colorant compound and method of manufacturing the same as well as blue resist composition for use in color filter containing the same The present invention provides (I) a method of manufacturing a triphenylmethane colorant that can suppress the sub-reactions in conversion to a sulfonamide and is industrially advantageous, (II) a colorant compound that has both excellent spectral characteristics an... | 11/16/2010 |
| 7777076 | Macrocyclic inhibitors of BCL proteins Macrocyclic compounds of formula (I), in which B1 and X1 taken together are alkylene which is unsubstituted or substituted with ═O and having one CH2 moiety unreplaced or replaced with CH═CH, O, NH or N(alkyl), which inhibit the ... | 08/17/2010 |
| 7671235 | Tetralin and indane derivatives and uses thereof Compounds of the formula I, II or III: or pharmaceutically acceptable salts thereof, wherein m, n, q, Ar, R1, R2, R3, R4 and R5 are as defined herein. Also pr... | 03/02/2010 |
| 7388008 | Lysine based compounds The present invention provides lysine based compounds of the formula; and when the compound of formula I comprises an amino group, pharmaceutically acceptable ammonium salts thereof, wherein R1 may be, for exampl... | 06/17/2008 |
| 7256204 | Amine compounds, their production and use A compound of the formula: wherein Ar is an aromatic ring assembly group which may be substituted or a fused aromatic group which may be substituted; X is (i) a bond, (ii) —S—, —SO— or —SO2... | 08/14/2007 |
| 7250526 | Transfer hydrogenation process and catalyst A catalytic transfer hydrogenation process is provided. The catalyst employed in the process is a metal hydrocarbyl complex which is coordinated to defined bidentate ligands substituted with at least one group selected from an optionally substituted sulphonated hydr... | 07/31/2007 |
| 7232817 | α- and β-amino acid hydroxyethlamino sulfonyl urea derivatives useful as retroviral protease inhibitors α- and β-amino acid hydroxyethylamino sulfonyl urea derivative compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. ... | 06/19/2007 |
| RE39682 | Farnesyl derivatives and pharmaceutical compositions containing them Novel farnesyl derivatives which are inhibitors of the prenylated protein methyltransferase enzyme, and useful as anti-cancer drugs, have the following formula: wherein R1represents f... | 06/05/2007 |
| 7227035 | Bis-aryl sulfonamides Compounds are provided that act as potent antagonists of chemokine receptors. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of chemokine receptor-mediated diseases, and as controls i... | 06/05/2007 |
| 7208526 | Styrylsulfonamides The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, pharmace... | 04/24/2007 |
| 7169952 | Process to prepare sulfonamides A process for the preparation of a sulfonamide of formula (II), comprising reacting at elevated temperature an aniline of formula (I), with a sulfonating agent A of the formula R1—SO2-Z in the presence of a catalytic amount of either: (i) an ... | 01/30/2007 |
| 7163942 | Sulfonamide compounds for the treatment of neurodegenerative disorders The present invention relates to compounds of the Formula I wherein R1, R2, R3, m, and n are as defined. Compounds of the Formula I have activity inhibiting production of Aβ-pept... | 01/16/2007 |
| 7161006 | Sulphones for inhibition of gamma secretase The invention provides compounds of formula I: which are inhibitors of γ-secretase and hence useful in the treatment or prevention of Alzheimer's disease. ... | 01/09/2007 |
| 7161031 | Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders Compounds useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula I: wherein: Ar, X, X1, g, R and R3 are as defined herein. ... | 01/09/2007 |
| 7122571 | Substituted hydrazones as inhibitors of cyclooxygenase-2 Compounds useful as inhibitors of cyclooxygenase-2 activity have the formulae I or Ia: wherein: Q1, Q2, n, m, X, Y and R are as defined herein. | 10/17/2006 |
| 7026477 | Process for preparing substituted phenylsulfonylureas from sulfonyl halides The invention relates to a preparation process for a compound (I) or a salt thereof, in which Q, X*, Y, Z, R, R1, R2 and R3 are as defined in claim 1, | 04/11/2006 |
| 6919375 | Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same Compounds having a metalloproteinase inhibitory activity, represented by the formula (I), its optically active isomers, their pharmaceutically acceptable salts, or hydrates thereof. ... | 07/19/2005 |
| 6908947 | Sulfonamide-substituted fused 7-membered ring compounds, their use as a medicament, and pharmaceutical preparations comprising them The present invention relates to compounds of formula I, in which X1, X2, X3, X4, Y1, Y2, Y3, Y4, R(3), R(4) and R(5) have the meanings mentioned in the specification, their preparation and their use, in particular in ... | 06/21/2005 |
| 6890956 | Cyclohexyl sulphones as gamma-secretase inhibitors Compounds of formula I: inhibit the processing of APP by gamma-secretase, and hence are useful in treating or preventing Alzheimer's disease. ... | 05/10/2005 |
| 6838483 | Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same Compounds having a metalloproteinase inhibitory activity, represented by the formula (I), its optically active isomers, their pharmaceutically acceptable salts, or hydrates thereof. ... | 01/04/2005 |
| 6734182 | Aryl sulfonamides and sulfamide derivatives and uses thereof This invention is directed to novel aryl sulfonamide and sulfamide compounds which bind selectively to and inhibit the activity of the human Y5 receptor. This invention is also related to uses of these compounds for the treatment of feeding disorders such as obesity... | 05/11/2004 |
| 6720424 | Aminobenzoic acid derivatives Aminobenzoic acid derivatives represented by Formula (1) as follows: (wherein, R1 represents a hydrogen atom, a C1-6alkyl group, or the like; R2 represents a hydrogen atom, a C1-6 | 04/13/2004 |
| 6699884 | Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation Methods of treating cyclooxygenase-2 mediated disorders comprising administering to a subject a therapeutically effective amount of one or more fluoro-substituted benzenesulfonyl compounds corresponding to Formula I: ##STR1## wherein A, X, n, R1... | 03/02/2004 |
| 6583318 | Method for synthesis of -sulfonamido amide, carboxylic acid and hydroxamic acid derivatives A method of synthesizing -sulfonamido amide, carboxylic acid or hydroxamic acid derivatives comprising providing a set of polymer-bound reactant(s) (sulfonamide, aldehyde or ketone, isocyanide or acid) to react with three sets of the other three re... | 06/24/2003 |
| 6583161 | Benzenesulfonamides and benzamides as therapeutic agents The invention provides compounds, compositions and methods relating to novel aromatic derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particul... | 06/24/2003 |
| 6552086 | Sulfonamide derivatives The present invention provides certain sulfonamide derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.... | 04/22/2003 |
| 6541422 | Method for improving the selectivity of 1,3-cyclohexanedione herbicide A method of selectively controlling undesirable vegetation in crops by using a postemergent application of an herbicidally effective amount of a metal chelate of a 2-(substituted benzoyl)-1,3-cyclohexanedione compound to the locus of such undesirable vege... | 04/01/2003 |
| 6538159 | -sulfin-and -sulfonamino acid amides The invention relates to -sulfin- and -sulfonamino acid amides of the general formula I ##STR1## including the optical isomers thereof and mixtures of such isomers, wherein n is a number zero or one; R1 is C1 -C12... | 03/25/2003 |
| 6538016 | -sulfin-and -sulfonamino acid amides The invention relates to -sulfin- and -sulfonamino acid amides of the general formula I ##STR1## including the optical isomers thereof and mixtures of such isomers, wherein n is a number zero or one; R1 is C1 -C12... | 03/25/2003 |
| 6521667 | Calcilytic compounds The present invention features calcilytic compounds. "Calcilytic compounds" refer to compounds able to inhibit calcium receptor activity. Also described are the use of calcilytic compounds to inhibit calcium receptor activity and/or achieve a beneficial e... | 02/18/2003 |
| 6498253 | Acylated aminophenylsulfonylureas, processes for their preparation and their use as herbicides and plant growth regulators Compounds of the formula (I) and salts thereof ##STR1## in which W1, W2, R, n, R1, R2, R4, X, Y and Z are as defined in claim 1 and R3 is an acyl radical, are suitable as herbicides and pla... | 12/24/2002 |
| 6489365 | Amidine derivatives, the preparation and use thereof as medicaments with Itb4 antagonistic effect Compounds of the formula ##STR1## which is explained more fully in the specification, may be prepared by conventional methods and used therapeutically in conventional galenic preparations.... | 12/03/2002 |
| 6455502 | Compounds and compositions as protease inhibitors The present invention relates to novel N-cyanomethyl amides which are cysteine protease inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.... | 09/24/2002 |
| 6448293 | Diphenyl ether compounds useful in therapy A compound of general formula (I), or pharmaceutically acceptable salts, solvates or polymorphs thereof; wherein; R1 and R2, which may be the same or different, are hydrogen, C1 -C6 alkyl, (CH2)m... | 09/10/2002 |
| 6414020 | Amidino protease inhibitors Amidino and benzamidino compounds, including compounds of the formula: ##STR1## wherein R1 -R4, R6 -R9, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically accepta... | 07/02/2002 |
| 6362230 | Sulphonamide derivatives The present invention provides novel sulphonamide derivatives which are useful for potentiating glutamate receptor function in a mammal requiring treatment, processes for their preparation, and pharmaceutical compositions containing them.... | 03/26/2002 |
| 6342512 | Sulfonylcarboxamide derivatives, process for their preparation and their use as pharmaceuticals Sulfonylcarboxamide derivatives of formula I, their physiologically acceptable salts and/or physiologically functional derivatives, methods of making these compounds, their use for preparing medicines for the prevention and treatment of hyperlipidemia and... | 01/29/2002 |
| 6333349 | Sulfonamide-substituted fused 7-membered ring compounds, their use as a medicament, and pharmaceutical preparations comprising them The present invention relates to compounds of formula I, ##STR1## in which X1, X2, X3, X4, Y1, Y2, Y3, Y4, R(3), R(4) and R(5) have the meanings mentioned in the specification, their preparation and their use, in particular in pharmaceuticals. The compoun... | 12/25/2001 |
| 6333337 | Potassium channel inhibitors Compounds useful as potassium channel inhibitors and especially useful for the treatment of cardiac arrhythmias and cell proliferative disorders are described.... | 12/25/2001 |
| 6221914 | Sulfonamide bridging compounds that inhibit tryptase activity The present invention is directed to compounds which are capable of inhibiting the activity of tryptase. Such compounds are useful in the treatment or prevention of inflammatory disease, particularly those disease states which are mediated by mast cell ac... | 04/24/2001 |
