Did You Know...
...that Thomas Edison's patent application on his phonograph was approved by the Patent Office in just seven weeks? In contrast, it took Gordon Gould, the inventor of the laser, 30 years to obtain his patent -- finally awarded in 1988!
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| Number | Title | Issue Date |
| 8026395 | Process for the synthesis of anti-neoplasia agent VNP40101M The present invention relates to simple, safe, high-yield methods of synthesizing VNP40101M, 1,2-bis(methylsulfonyl)-2-(2-chloroethyl)-2-(methylaminocarbonyl)hydrazine, an anti-neoplasia agent. One particularly preferred method uses methyl chloroformamide in a one-p... | 09/27/2011 |
| 7432286 | Pharmaceutically active sulfonyl hydrazide derivatives The present invention is related to sulfonyl hydrazide derivatives for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such sulfonyl hydrazide derivatives. Said sulfonyl hydrazide derivatives are efficient modulators of... | 10/07/2008 |
| 7135487 | Sulphonamide derivatives The present invention relates to novel sulphonamide derivatives, to processes for their preparation and to pharmaceutical compositions containing them. ... | 11/14/2006 |
| 6908947 | Sulfonamide-substituted fused 7-membered ring compounds, their use as a medicament, and pharmaceutical preparations comprising them The present invention relates to compounds of formula I, in which X1, X2, X3, X4, Y1, Y2, Y3, Y4, R(3), R(4) and R(5) have the meanings mentioned in the specification, their preparation and their use, in particular in ... | 06/21/2005 |
| 6809119 | Branched chain amino acid-dependent aminotransferase inhibitors and their use in the treatment of neurodegenerative diseases The invention relates to BCAT inhibitors and the use thereof for treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic la... | 10/26/2004 |
| 6730704 | 1-(aryloxy)propionoyl-2-arylsulfonyl hydrazines, process for preparation thereof and use thereof as hypoglycemic agents The present invention relates to 1-(aryloxy)propionoyl-2-arylsulfonyl hydrazines useful as hypoglycemic agents, and to a process for synthesis thereof. The present invention also relates to the synthesis of 1-(aryloxy)propionoyl-2-arylsulfonyl hydrazines as new hypo... | 05/04/2004 |
| 6727282 | Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors Succinoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. ... | 04/27/2004 |
| 6693136 | Fluorenes and anthracenes that inhibit P2X3 and P2X2/3 containing receptors Compounds of formula (I) ##STR1## are novel P2X3 and P2X2 /P2X3 containing receptor antagonists and are useful in treating pain, urinary incontinence, and bladder overactivity.... | 02/17/2004 |
| 6482909 | Compounds useful for control agents for living-type free radical polymerization Control agents that have a nitrogen-nitrogen bond covalently bonded to a thiocarbonyl moiety are provided for living-type free radical polymerization of a wide variety of monomers. These control agents provide superior properties for control of the polyme... | 11/19/2002 |
| 6459001 | Tricyclic compounds, their preparation process and the intermediates of this process, their use as medicaments and the pharmaceutical compositions containing them The subject of the invention is the products of formula (I): ##STR1## in which R1, R2, R3, R4, R5 and G are as defined in the description, the dotted lines represent an optional second bond, as well a... | 10/01/2002 |
| 6433017 | Amphiphilic polyamine compounds In accordance with the present invention, there are provided amphiphilic polyamine compounds and derivatives thereof having the property of promoting transfection of polynucleotides and polypeptides into cells, and formulations comprising said compounds.... | 08/13/2002 |
| 6348499 | Amphiphilic polyamide compounds Amphiphilic polyamide compounds and derivatives thereof having the property of promoting transfection of polynucleotides and polypeptides into cells, and formulations comprising said compounds.... | 02/19/2002 |
| 6333349 | Sulfonamide-substituted fused 7-membered ring compounds, their use as a medicament, and pharmaceutical preparations comprising them The present invention relates to compounds of formula I, ##STR1## in which X1, X2, X3, X4, Y1, Y2, Y3, Y4, R(3), R(4) and R(5) have the meanings mentioned in the specification, their preparation and their use, in particular in pharmaceuticals. The compoun... | 12/25/2001 |
| 6291464 | Aminopiperazine derivatives This invention relates to new aminopiperazine derivatives having the potentiation of the cholinergic activity, etc., and represented by general formula [I]. ##STR1## wherein R1 is lower alkyl, etc., R2 is aryl, etc., A is ##STR2## or --SO | 09/18/2001 |
| 6284795 | Sulfonamide compounds and methods of treating atherosclerosis and restenosis The present invention provides compounds having the Formula I ##STR1## The present invention also provides methods of treating or preventing atherosclerosis, coronary heart disease, and restenosis using the compounds of Formula I, and pharmaceutical compo... | 09/04/2001 |
| 6265446 | Hydrazine derivatives Hydrazine derivatives of the formula ##STR1## wherein R1 represents lower alkyl, lower alkenyl, lower cycloalkyl, lower cycloalkyl-lower alkyl, aryl or aryl-lower alkyl, R2 represents heterocyclyl or NR5 R6, R | 07/24/2001 |
| 6235787 | Hydrazine derivatives Hydrazine derivatives of the formula ##STR1## wherein Y is CO or SO2 ; R1 is lower alkyl, lower alkenyl, lower cycloalkyl, lower cycloalkyl-lower alkyl, aryl or aryl-lower alkyl; R2 is lower alkyl, halo-lower alkyl, aryl-l... | 05/22/2001 |
| 6221907 | Tricyclic compounds having activity specific for integrins, particularly alphanubeta3 integrins, method for preparing same, intermediates therefor, use of said compounds as drugs, and pharmaceutical compositions containing same The subject of the invention is the products of formula (I): ##STR1## in which R1, R2, R3, R4, R5 and G are as defined in the description, the dotted lines represent an optional second bond, as well a... | 04/24/2001 |
| 6172108 | Hydrazide compounds Compounds of formula (I): R--NH--A--CO--NH--NH--(W)n --Z (I) wherein: n is 0 or 1, W represents --CO-- or S(O)r wherein r is 0, 1 or 2, Z represents a group selected from aryl, arylalkyl, heteroaryl and heteroarylalkyl, each optionally substi... | 01/09/2001 |
| 6153795 | Ethyleneimine-containing resins, manufacture, and use for chemical separations Water-insoluble polymer resins containing ethylenediamine subunits which are N-substituted with a functional group chosen from the group consisting of --H, --CS2, --CH2 PO3 H, and --CH3, or which are N-quarterni... | 11/28/2000 |
| 6114372 | Peptidyl compounds having MMP and TNF inhibitory activity Compounds of formula (I) having MMP and TNF inhibitory activity. ##STR1##... | 09/05/2000 |
| 6011177 | Process for 4-sulfonamidolphenyl hydrazines 4-Sulfonamidophenyl hydrazines are prepared by reaction between the hydrazine, optionally substituted, and the corresponding 4-substituted benzenesulfonamides, where the 4-substitution is an appropriate leaving group, in the presence of water and the abse... | 01/04/2000 |
| 5989774 | Photographic material containing a new hydrazide type A silver halide photographic material is disclosed containing a new type of hydrazide compound represented by following general formula I, the different symbols of which are defined in the description. ##STR1## In a preferred embodiment Q is pyridini... | 11/23/1999 |
| 5981138 | Hydrazine compound and silver halide photographic light-sensitive material using the same A hydrazine compound represented by the following formula (I): Ar1 --NH--NH--G1 --R1 (I) wherein Ar1 represents an aromatic group; G1 represents a carbonyl group, a sulfonyl group, a sulfo... | 11/09/1999 |
| 5877217 | N-acylaminoalkyl-hydrazinecarboximidamides The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging) using compounds of the following formula I ##STR1## wherein alk is a straight or branched chain alkylene group containing from 2 ... | 03/02/1999 |
| 5856353 | Sulfonamide inhibitors of aspartyl protease The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical ... | 01/05/1999 |
| 5814656 | Selective prevention of organ injury is sepsis and shock using selective release of nitric oxide vulnerable organs A method for the treatment of mammalian tissue injured or at risk of injury during sepsis or shock including the administration to a mammal a diazeniumdiolate which releases a therapeutically effective amount of nitric oxide sufficient to protect the tiss... | 09/29/1998 |
| 5747535 | Selective thrombin inhibitors The present invention relates to a novel selective thrombin inhibitor having the following formula (I), which is also effective by oral administration: ##STR1## in which R1 represents acetyl substituted with aryl or aryloxy, or repres... | 05/05/1998 |
| 5637619 | Antitumor 2-aminocarbonyl-1, 2-bis(methylsulfonyl)-1-(substituted)hydrazines The present invention relates to novel 2-aminocarbonyl-1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazines and 2-aminocarbonyl-1,2-bis(methylsulfonyl)-1-methylhydrazines, and their use to treat malignant tumors. The agents are especially useful in the ... | 06/10/1997 |
| 5608109 | Insecticidal hydrazine derivatives The present invention relates to a hydrazine derivative represented by the formula (I): ##STR1## (wherein each of Ar1 and Ar2 is a substituted or unsubstituted phenyl group, a substituted or unsubstituted heteroaryl group, or th... | 03/04/1997 |
| 5461076 | Hydrazones Compounds of formula I ##STR1## wherein A, X, Z and R1 -R5 are as defined in the description, and their salts have valuable pharmaceutical properties and are effective especially against tumors. They are prepared in a manner kno... | 10/24/1995 |
| 5455262 | Mercaptosulfide metalloproteinase inhibitors Novel mercaptosulfide matrix metalloproteinase inhibitors of the Formula I, ##STR1## wherein: n is 0 or 1; R1 is selected from the group consisting of hydrogen, lower alkyl, amino lower alkyl, carbamoyl lower alkyl, PhtN(lower alkyl), TsNH(lowe... | 10/03/1995 |
| 5380944 | Benzhydrazone derivatives as an intermediate for the production of triazole derivatives A novel benzhydrazone derivative has a general formula [I]: ##STR1## (wherein R1 is a lower alkyl group, R2 and R3 are same or different halogen atoms and Z is a chlorine atom or an amino group) and is useful as an in... | 01/10/1995 |
| 5366997 | Oxygen substituted derivatives of nucleophile-nitric oxide adducts as nitric oxide donor prodrugs There are disclosed cardiovascularly active compounds possessing antihypertensive properties, and pharmaceutical compositions containing these agents and a method of treating cardiovascular disorders with the compounds. The active components of the pharma... | 11/22/1994 |
| 5367093 | Insecticidal phenylhydrazine derivatives Compounds having the structural formula ##STR1## where X, Y, R and Z are defined in the specification are disclosed. The compounds of this invention are effective for controlling mites, nematodes, rice planthopper, tobacco budworm, and southern corn ... | 11/22/1994 |
| 5274098 | Amidinophenylalanine derivatives, process for their preparation, their use and compositions containing them Amidinophenylalanine derivatives, a process for their preparation, their use and pharmaceutical compositions which contain these compounds are described.... | 12/28/1993 |
| 5256820 | 1-alkyl-2-acyl-1,2-disulfonylhydrazines Novel antineoplastic 1-alkyl-2-acyl-1,2-disulfonylhydrazine having the following formula and methods of therapy using those antineoplastic compounds: ##STR1## where R1 and R2 are (independently) alkyl, cycloalkyl, aryl, ara... | 10/26/1993 |
| 5198566 | N-substituted-3-(substituted hydrazino)-benzenesulfonamides Disclosed herein are N-substituted-3-(substituted hydrazino)benzenesulfonamide derivatives of the formula (I): ##STR1## wherein R1 and CF3, COOH or CCl=CClCOOH, R2 is H, Cl, C1 -C3 alkyl or C | 03/30/1993 |
| 5101072 | Sulfonylhydrazines and their use as antineoplastic agents and as antitrypanosomal agents Sulfonylhydrazines of the formula RSO2 N(CH2 CH2 X)N(SO2 CH3)2, wherein R is an alkyl or an aryl and X is a halogen or OSO2 Y, wherein Y is an alkyl or an aryl. Such sulfonylhydr... | 03/31/1992 |
| 5041545 | 2-hydroxybenzophenone hydrazides and derivatives thereof Hydrazide functionalized 2-hydroxybenzophenone ultraviolet light and heat stabilizers and derivatives are disclosed having the general formula: ##STR1## wherein R1, R2, R3, R4, R5, R6, X, Y... | 08/20/1991 |
